ENSG00000089094

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000377069 ENSG00000089094 HEK293_OSMI2_2hA HEK293_TMG_2hB KDM2B protein_coding protein_coding 17.54518 18.9872 16.65149 0.9313223 0.2492049 -0.1892694 1.003382 0.6972129 0.9204893 0.3896817 0.1033813 0.3958450 0.0572500 0.03876667 0.05513333 0.01636667 0.727210411 0.0002114047 FALSE TRUE
ENST00000377071 ENSG00000089094 HEK293_OSMI2_2hA HEK293_TMG_2hB KDM2B protein_coding protein_coding 17.54518 18.9872 16.65149 0.9313223 0.2492049 -0.1892694 7.553263 10.6173071 6.7032579 0.5345955 0.3559291 -0.6626911 0.4263917 0.55920000 0.40336667 -0.15583333 0.002312852 0.0002114047 FALSE TRUE
ENST00000542973 ENSG00000089094 HEK293_OSMI2_2hA HEK293_TMG_2hB KDM2B protein_coding protein_coding 17.54518 18.9872 16.65149 0.9313223 0.2492049 -0.1892694 6.477137 5.3029065 6.8052564 0.8339046 0.4974661 0.3592666 0.3728458 0.27643333 0.40796667 0.13153333 0.047368810 0.0002114047 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000089094 E001 1.4704484 0.0091030534 2.015786e-01 3.281557e-01 12 121424735 121424735 1 - 0.241 0.477 1.433
ENSG00000089094 E002 15.8282917 0.0057598145 8.608898e-03 2.531006e-02 12 121424736 121425873 1138 - 1.344 1.123 -0.783
ENSG00000089094 E003 13.4634759 0.0161996604 1.346465e-01 2.406123e-01 12 121425874 121426901 1028 - 1.238 1.092 -0.521
ENSG00000089094 E004 10.5711877 0.0033665139 1.048083e-01 1.978143e-01 12 121426902 121427385 484 - 1.145 0.994 -0.550
ENSG00000089094 E005 0.8836053 0.0206218930 8.970299e-01 9.382399e-01 12 121427386 121427394 9 - 0.241 0.269 0.215
ENSG00000089094 E006 58.4418533 0.0006403403 4.745177e-01 6.133480e-01 12 121427395 121429095 1701 - 1.738 1.785 0.161
ENSG00000089094 E007 4.5233974 0.0036985357 8.289896e-01 8.925909e-01 12 121429096 121429096 1 - 0.705 0.746 0.168
ENSG00000089094 E008 4.5233974 0.0036985357 8.289896e-01 8.925909e-01 12 121429097 121429098 2 - 0.705 0.746 0.168
ENSG00000089094 E009 27.1776967 0.0008767534 1.047355e-01 1.977163e-01 12 121429099 121429199 101 - 1.359 1.484 0.431
ENSG00000089094 E010 25.1839019 0.0180211725 2.767880e-02 6.737333e-02 12 121429200 121429225 26 - 1.257 1.485 0.793
ENSG00000089094 E011 289.6742713 0.0044067754 2.425917e-10 4.004380e-09 12 121429226 121429508 283 - 2.279 2.537 0.859
ENSG00000089094 E012 431.2176730 0.0053398088 5.536559e-05 3.084955e-04 12 121429509 121429870 362 - 2.518 2.682 0.547
ENSG00000089094 E013 445.8295064 0.0002267334 7.554230e-04 3.099017e-03 12 121429871 121430163 293 - 2.596 2.669 0.244
ENSG00000089094 E014 174.0895294 0.0002632836 4.815826e-01 6.197861e-01 12 121430164 121430272 109 - 2.214 2.247 0.111
ENSG00000089094 E015 19.8370245 0.0024928902 8.469018e-01 9.048626e-01 12 121430273 121430276 4 - 1.299 1.328 0.102
ENSG00000089094 E016 112.6692441 0.0127166921 7.712344e-01 8.522998e-01 12 121430277 121430292 16 - 2.047 2.050 0.011
ENSG00000089094 E017 150.6439614 0.0047783900 9.405056e-01 9.666297e-01 12 121430293 121430341 49 - 2.166 2.179 0.045
ENSG00000089094 E018 300.0056565 0.0016910908 4.601320e-01 6.001858e-01 12 121430342 121430469 128 - 2.474 2.469 -0.018
ENSG00000089094 E019 229.7945701 0.0001959769 9.433172e-02 1.818788e-01 12 121439857 121439912 56 - 2.370 2.345 -0.086
ENSG00000089094 E020 257.9038550 0.0005114463 3.206338e-01 4.637870e-01 12 121439913 121440075 163 - 2.412 2.402 -0.033
ENSG00000089094 E021 1.4757470 0.0090422258 5.674834e-01 6.942676e-01 12 121440076 121440815 740 - 0.324 0.434 0.626
ENSG00000089094 E022 179.3233811 0.0012273006 4.076732e-01 5.512588e-01 12 121440816 121440977 162 - 2.223 2.263 0.132
ENSG00000089094 E023 162.2593316 0.0004905630 7.352482e-02 1.491605e-01 12 121441070 121441233 164 - 2.160 2.227 0.222
ENSG00000089094 E024 0.3332198 0.0300879255 8.330996e-01   12 121441234 121441244 11 - 0.137 0.109 -0.373
ENSG00000089094 E025 297.6122188 0.0020439011 9.801323e-01 9.916004e-01 12 121442157 121442770 614 - 2.456 2.468 0.042
ENSG00000089094 E026 94.1915454 0.0093028483 1.946583e-01 3.195701e-01 12 121442771 121442836 66 - 2.007 1.939 -0.226
ENSG00000089094 E027 2.6110777 0.0150950029 1.304528e-01 2.347882e-01 12 121442837 121442991 155 - 0.672 0.434 -1.107
ENSG00000089094 E028 82.6052932 0.0007880970 2.167614e-02 5.500183e-02 12 121442992 121443030 39 - 1.957 1.877 -0.268
ENSG00000089094 E029 21.0776839 0.0008890794 2.192341e-04 1.046283e-03 12 121443031 121443679 649 - 1.475 1.216 -0.904
ENSG00000089094 E030 132.0995327 0.0002413678 3.421422e-01 4.861400e-01 12 121443680 121443793 114 - 2.123 2.107 -0.054
ENSG00000089094 E031 77.1224527 0.0003215219 1.740988e-01 2.934958e-01 12 121444012 121444014 3 - 1.908 1.867 -0.139
ENSG00000089094 E032 244.3180828 0.0002605042 2.233353e-03 7.946472e-03 12 121444015 121444272 258 - 2.412 2.354 -0.193
ENSG00000089094 E033 130.1043293 0.0005860627 2.614830e-02 6.424638e-02 12 121444450 121444536 87 - 2.140 2.080 -0.199
ENSG00000089094 E034 0.8942144 0.2185971741 8.827726e-01 9.289693e-01 12 121444537 121445274 738 - 0.241 0.272 0.231
ENSG00000089094 E035 148.2935815 0.0006026002 2.693755e-04 1.255008e-03 12 121445275 121445418 144 - 2.220 2.121 -0.330
ENSG00000089094 E036 143.1759534 0.0139623049 2.117842e-02 5.397297e-02 12 121453120 121453344 225 - 2.222 2.089 -0.446
ENSG00000089094 E037 62.2087832 0.0069696198 1.203077e-06 9.822415e-06 12 121467158 121470553 3396 - 1.934 1.655 -0.942
ENSG00000089094 E038 0.0000000       12 121493846 121494578 733 -      
ENSG00000089094 E039 24.3214504 0.0025692658 2.448684e-01 3.798844e-01 12 121494579 121494665 87 - 1.430 1.357 -0.252
ENSG00000089094 E040 15.2678927 0.0011907802 8.981193e-01 9.389852e-01 12 121509567 121509571 5 - 1.199 1.201 0.006
ENSG00000089094 E041 55.0686585 0.0008689420 2.588661e-02 6.371000e-02 12 121509572 121509942 371 - 1.793 1.698 -0.321
ENSG00000089094 E042 21.2883095 0.0013284768 1.307769e-01 2.352361e-01 12 121509943 121510006 64 - 1.393 1.292 -0.350
ENSG00000089094 E043 18.3389951 0.0009893665 8.802132e-03 2.578892e-02 12 121510007 121510039 33 - 1.379 1.185 -0.683
ENSG00000089094 E044 15.7914834 0.0011533134 6.776361e-04 2.817243e-03 12 121513276 121513292 17 - 1.359 1.085 -0.970
ENSG00000089094 E045 20.6332367 0.0011516822 8.531214e-03 2.511636e-02 12 121513293 121513327 35 - 1.424 1.238 -0.648
ENSG00000089094 E046 25.2766605 0.0131522929 1.512468e-01 2.633716e-01 12 121513328 121513402 75 - 1.470 1.355 -0.396
ENSG00000089094 E047 0.4448795 0.4589720252 3.131625e-01 4.556973e-01 12 121516347 121516468 122 - 0.000 0.258 10.253
ENSG00000089094 E048 1.9790299 0.0077381096 2.060183e-01 3.337056e-01 12 121516469 121516520 52 - 0.324 0.553 1.211
ENSG00000089094 E049 5.4507283 0.0031394011 5.570915e-05 3.101908e-04 12 121516521 121516863 343 - 0.324 0.955 2.849
ENSG00000089094 E050 26.7681438 0.0474611549 7.808064e-01 8.591719e-01 12 121520985 121521045 61 - 1.435 1.422 -0.045
ENSG00000089094 E051 23.1159698 0.0206118539 8.766397e-01 9.248117e-01 12 121521046 121521100 55 - 1.366 1.364 -0.007
ENSG00000089094 E052 0.0000000       12 121524676 121524795 120 -      
ENSG00000089094 E053 21.0132501 0.0115444968 6.351360e-01 7.494852e-01 12 121532806 121532845 40 - 1.344 1.314 -0.107
ENSG00000089094 E054 35.6330847 0.0216234238 9.952795e-01 1.000000e+00 12 121532846 121532959 114 - 1.540 1.555 0.051
ENSG00000089094 E055 30.1257230 0.0079172301 7.575465e-01 8.423373e-01 12 121534497 121534590 94 - 1.486 1.473 -0.042
ENSG00000089094 E056 0.2214452 0.0420057898 6.245956e-01   12 121534591 121534660 70 - 0.000 0.110 9.731
ENSG00000089094 E057 0.5944058 0.4017131445 8.099560e-01 8.793867e-01 12 121536011 121536019 9 - 0.137 0.204 0.692
ENSG00000089094 E058 0.0000000       12 121536020 121536235 216 -      
ENSG00000089094 E059 2.1862825 0.0127613944 4.393529e-01 5.811055e-01 12 121537310 121537616 307 - 0.555 0.434 -0.594
ENSG00000089094 E060 28.8894745 0.0073226876 7.122451e-01 8.090557e-01 12 121548877 121548983 107 - 1.476 1.462 -0.046
ENSG00000089094 E061 36.9608254 0.0047284227 2.600935e-01 3.975659e-01 12 121549460 121549638 179 - 1.601 1.539 -0.212
ENSG00000089094 E062 0.0000000       12 121549639 121549639 1 -      
ENSG00000089094 E063 0.0000000       12 121574365 121574546 182 -      
ENSG00000089094 E064 20.3194684 0.0149453172 2.622124e-01 3.999710e-01 12 121574547 121574593 47 - 1.366 1.270 -0.334
ENSG00000089094 E065 22.9362299 0.0086262951 6.639633e-01 7.718914e-01 12 121575781 121575859 79 - 1.379 1.353 -0.091
ENSG00000089094 E066 24.5030268 0.0008007361 4.099561e-01 5.535788e-01 12 121578802 121578946 145 - 1.418 1.373 -0.156
ENSG00000089094 E067 0.8867258 0.0252485134 2.905640e-01 4.313852e-01 12 121579612 121579665 54 - 0.137 0.331 1.628
ENSG00000089094 E068 12.2724551 0.0014529532 1.476065e-01 2.584342e-01 12 121580020 121580201 182 - 1.178 1.053 -0.450
ENSG00000089094 E069 5.1833951 0.0031135084 6.469677e-01 7.587540e-01 12 121580202 121580569 368 - 0.817 0.768 -0.193
ENSG00000089094 E070 2.0585246 0.0072801449 2.045524e-01 3.318533e-01 12 121580786 121580962 177 - 0.324 0.553 1.212
ENSG00000089094 E071 1.8466313 0.0077697303 6.680435e-01 7.751361e-01 12 121580963 121581023 61 - 0.395 0.477 0.434