ENSG00000089053

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261819 ENSG00000089053 HEK293_OSMI2_2hA HEK293_TMG_2hB ANAPC5 protein_coding protein_coding 126.9802 129.0138 128.0611 23.56879 2.721173 -0.01069169 60.694214 59.949041 57.681442 9.237028 2.3743784 -0.05561999 0.48199167 0.46980000 0.45086667 -0.01893333 8.946343e-01 7.005301e-80 FALSE TRUE
ENST00000441917 ENSG00000089053 HEK293_OSMI2_2hA HEK293_TMG_2hB ANAPC5 protein_coding protein_coding 126.9802 129.0138 128.0611 23.56879 2.721173 -0.01069169 20.735972 30.855164 9.523131 7.169081 1.2435388 -1.69495747 0.15873750 0.23606667 0.07456667 -0.16150000 1.503959e-08 7.005301e-80 FALSE TRUE
ENST00000541652 ENSG00000089053 HEK293_OSMI2_2hA HEK293_TMG_2hB ANAPC5 protein_coding retained_intron 126.9802 129.0138 128.0611 23.56879 2.721173 -0.01069169 4.090868 0.000000 10.838264 0.000000 0.6022875 10.08324852 0.03081250 0.00000000 0.08453333 0.08453333 7.005301e-80 7.005301e-80 FALSE TRUE
ENST00000541887 ENSG00000089053 HEK293_OSMI2_2hA HEK293_TMG_2hB ANAPC5 protein_coding protein_coding 126.9802 129.0138 128.0611 23.56879 2.721173 -0.01069169 10.244355 3.913110 24.995725 3.913110 1.5768644 2.67218890 0.08313333 0.03293333 0.19530000 0.16236667 6.604882e-02 7.005301e-80 FALSE TRUE
ENST00000544314 ENSG00000089053 HEK293_OSMI2_2hA HEK293_TMG_2hB ANAPC5 protein_coding processed_transcript 126.9802 129.0138 128.0611 23.56879 2.721173 -0.01069169 6.977114 21.347154 0.000000 9.432947 0.0000000 -11.06050366 0.05295833 0.15570000 0.00000000 -0.15570000 2.055376e-18 7.005301e-80 FALSE TRUE
MSTRG.8186.17 ENSG00000089053 HEK293_OSMI2_2hA HEK293_TMG_2hB ANAPC5 protein_coding   126.9802 129.0138 128.0611 23.56879 2.721173 -0.01069169 6.214507 1.342869 9.214083 1.342869 2.5211111 2.76938332 0.04984167 0.01423333 0.07143333 0.05720000 9.624704e-02 7.005301e-80 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000089053 E001 4.1725869 0.0039314386 7.291357e-01 8.213873e-01 12 121308245 121308331 87 - 0.688 0.740 0.214
ENSG00000089053 E002 5.3173173 0.0029829449 4.683113e-01 6.077307e-01 12 121308332 121308346 15 - 0.747 0.845 0.388
ENSG00000089053 E003 6.3136396 0.0025749224 1.216183e-01 2.222436e-01 12 121308347 121308356 10 - 0.747 0.944 0.766
ENSG00000089053 E004 12.5798567 0.0017780592 2.470750e-05 1.501014e-04 12 121308357 121308357 1 - 0.845 1.278 1.584
ENSG00000089053 E005 12.8796653 0.0034136158 5.497299e-05 3.065513e-04 12 121308358 121308360 3 - 0.866 1.284 1.522
ENSG00000089053 E006 13.1011106 0.0018452358 2.552214e-05 1.544067e-04 12 121308361 121308365 5 - 0.866 1.292 1.549
ENSG00000089053 E007 14.3523805 0.0012695467 4.781754e-04 2.076536e-03 12 121308366 121308366 1 - 0.976 1.305 1.181
ENSG00000089053 E008 1430.8949398 0.0013008007 1.338506e-18 7.255390e-17 12 121308367 121308691 325 - 3.048 3.215 0.555
ENSG00000089053 E009 1493.0847894 0.0020895500 2.887460e-08 3.260734e-07 12 121309701 121309863 163 - 3.094 3.217 0.408
ENSG00000089053 E010 12.6706741 0.0611514068 9.513239e-01 9.735445e-01 12 121309864 121309969 106 - 1.126 1.142 0.056
ENSG00000089053 E011 7.1643183 0.0912052190 5.787568e-01 7.037828e-01 12 121309970 121310011 42 - 0.961 0.883 -0.295
ENSG00000089053 E012 12.2733838 0.0278882303 3.324736e-01 4.761324e-01 12 121310012 121310394 383 - 1.051 1.166 0.417
ENSG00000089053 E013 4.6145521 0.0035436258 2.357551e-02 5.893784e-02 12 121317890 121318154 265 - 0.906 0.602 -1.233
ENSG00000089053 E014 898.2052042 0.0007675876 4.375094e-15 1.518315e-13 12 121318277 121318351 75 - 2.868 3.006 0.460
ENSG00000089053 E015 740.8299249 0.0016730301 1.541600e-08 1.834840e-07 12 121318352 121318404 53 - 2.786 2.920 0.447
ENSG00000089053 E016 561.3641905 0.0023940446 3.876750e-07 3.503667e-06 12 121318405 121318424 20 - 2.658 2.803 0.482
ENSG00000089053 E017 34.3529134 0.0337288024 3.222778e-01 4.655927e-01 12 121318425 121318500 76 - 1.608 1.488 -0.411
ENSG00000089053 E018 699.7576587 0.0028267831 1.665097e-04 8.202180e-04 12 121318501 121318534 34 - 2.776 2.885 0.364
ENSG00000089053 E019 837.7250161 0.0004584179 7.328058e-08 7.640078e-07 12 121318535 121318608 74 - 2.873 2.959 0.287
ENSG00000089053 E020 588.7655222 0.0001907763 5.068403e-04 2.185935e-03 12 121319697 121319733 37 - 2.739 2.796 0.189
ENSG00000089053 E021 743.9904739 0.0002168153 2.264527e-07 2.149123e-06 12 121319734 121319818 85 - 2.829 2.906 0.257
ENSG00000089053 E022 603.8161668 0.0005815210 9.787704e-05 5.120968e-04 12 121320385 121320459 75 - 2.740 2.812 0.237
ENSG00000089053 E023 2.1722752 0.0090572324 2.025377e-01 3.293831e-01 12 121320460 121321111 652 - 0.382 0.601 1.085
ENSG00000089053 E024 0.5901540 0.0194557489 2.439359e-01 3.788194e-01 12 121326353 121326485 133 - 0.313 0.114 -1.819
ENSG00000089053 E025 1.2543904 0.0106948039 3.494544e-01 4.936681e-01 12 121326486 121326642 157 - 0.441 0.279 -0.970
ENSG00000089053 E026 917.4840641 0.0003122186 1.136783e-03 4.426726e-03 12 121327096 121327231 136 - 2.937 2.984 0.155
ENSG00000089053 E027 32.9257822 0.0006430715 4.190406e-13 1.091516e-11 12 121327232 121328256 1025 - 1.734 1.292 -1.517
ENSG00000089053 E028 4.3556077 0.0036558422 8.764847e-07 7.367115e-06 12 121328257 121328315 59 - 1.007 0.279 -3.348
ENSG00000089053 E029 1077.6800983 0.0001094079 6.245694e-01 7.408511e-01 12 121328316 121328458 143 - 3.038 3.034 -0.013
ENSG00000089053 E030 536.6237853 0.0001437332 6.965631e-01 7.968707e-01 12 121328459 121328497 39 - 2.736 2.732 -0.013
ENSG00000089053 E031 7.7036741 0.0177843117 2.528871e-04 1.187358e-03 12 121328773 121328835 63 - 1.148 0.664 -1.855
ENSG00000089053 E032 5.5936656 0.0037411792 2.721222e-06 2.056680e-05 12 121328999 121329185 187 - 1.077 0.447 -2.602
ENSG00000089053 E033 831.1767450 0.0001795053 1.966599e-02 5.077425e-02 12 121330583 121330672 90 - 2.940 2.910 -0.101
ENSG00000089053 E034 43.3667250 0.0164425514 5.276271e-11 9.757650e-10 12 121330673 121331226 554 - 1.884 1.308 -1.968
ENSG00000089053 E035 18.1110251 0.0019001962 2.369114e-03 8.365265e-03 12 121331227 121331346 120 - 1.410 1.170 -0.840
ENSG00000089053 E036 801.1069531 0.0001751959 1.526030e-01 2.652187e-01 12 121331347 121331428 82 - 2.917 2.899 -0.063
ENSG00000089053 E037 97.5558903 0.0139586579 1.195307e-26 1.495689e-24 12 121331429 121335172 3744 - 2.282 1.483 -2.696
ENSG00000089053 E038 4.5436679 0.0034828673 4.129081e-06 2.992853e-05 12 121335517 121335532 16 - 1.007 0.343 -2.933
ENSG00000089053 E039 1140.8212267 0.0004066030 3.631275e-02 8.417568e-02 12 121335533 121335723 191 - 3.076 3.043 -0.111
ENSG00000089053 E040 723.9896827 0.0009456408 1.998331e-01 3.260313e-01 12 121337291 121337392 102 - 2.878 2.844 -0.111
ENSG00000089053 E041 0.6028395 0.4456851755 4.431610e-01 5.847299e-01 12 121337393 121337395 3 - 0.315 0.112 -1.861
ENSG00000089053 E042 688.2579326 0.0022470798 8.262160e-03 2.444811e-02 12 121342003 121342069 67 - 2.882 2.798 -0.278
ENSG00000089053 E043 0.5546650 0.0221447828 6.610072e-01 7.695622e-01 12 121342070 121342071 2 - 0.131 0.205 0.770
ENSG00000089053 E044 417.3978549 0.0023188240 4.923924e-04 2.131143e-03 12 121345839 121345839 1 - 2.681 2.569 -0.372
ENSG00000089053 E045 812.8912270 0.0031505355 1.783437e-04 8.708132e-04 12 121345840 121345923 84 - 2.976 2.849 -0.420
ENSG00000089053 E046 576.6364550 0.0032543463 6.138696e-07 5.336942e-06 12 121345924 121345951 28 - 2.849 2.679 -0.566
ENSG00000089053 E047 619.3576774 0.0033204151 6.803372e-07 5.856142e-06 12 121345952 121345998 47 - 2.880 2.709 -0.569
ENSG00000089053 E048 534.2301474 0.0009335433 5.970360e-14 1.752035e-12 12 121345999 121346031 33 - 2.816 2.651 -0.550
ENSG00000089053 E049 20.1660037 0.0126720673 3.524377e-08 3.912814e-07 12 121346032 121346035 4 - 1.551 1.014 -1.892
ENSG00000089053 E050 30.5726431 0.0592393618 5.179947e-04 2.227298e-03 12 121346036 121346126 91 - 1.712 1.214 -1.716
ENSG00000089053 E051 54.1522235 0.0345580009 1.710716e-04 8.396765e-04 12 121346127 121346565 439 - 1.927 1.514 -1.401
ENSG00000089053 E052 37.7940039 0.0066075609 6.435726e-16 2.493821e-14 12 121346566 121346794 229 - 1.830 1.243 -2.014
ENSG00000089053 E053 25.2935199 0.0526838923 3.128766e-06 2.330942e-05 12 121346795 121346895 101 - 1.674 1.021 -2.283
ENSG00000089053 E054 632.7555686 0.0021845975 1.435059e-12 3.425319e-11 12 121346896 121347005 110 - 2.904 2.705 -0.663
ENSG00000089053 E055 1.8842983 0.0075001214 1.522024e-01 2.646825e-01 12 121347006 121347801 796 - 0.582 0.343 -1.232
ENSG00000089053 E056 480.7149849 0.0020399733 3.853473e-05 2.230049e-04 12 121347802 121347881 80 - 2.747 2.626 -0.402
ENSG00000089053 E057 1.6263200 0.0273045481 1.467805e-01 2.572929e-01 12 121347882 121347883 2 - 0.540 0.279 -1.451
ENSG00000089053 E058 0.5911862 0.0184618525 2.646091e-02 6.487060e-02 12 121351060 121351203 144 - 0.382 0.000 -11.047
ENSG00000089053 E059 683.5360731 0.0045887717 7.781011e-05 4.177073e-04 12 121352134 121352446 313 - 2.915 2.759 -0.519
ENSG00000089053 E060 3.2754369 0.2131761282 4.080086e-01 5.516021e-01 12 121399611 121399896 286 - 0.494 0.681 0.840