ENSG00000088970

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000612654 ENSG00000088970 HEK293_OSMI2_2hA HEK293_TMG_2hB KIZ protein_coding nonsense_mediated_decay 8.557065 4.101268 12.39878 0.1288062 1.074846 1.593706 0.1948590 0.0000000 0.6169296 0.00000000 0.11303200 5.97023158 0.020979167 0.00000000 0.05096667 0.05096667 2.077036e-04 9.556635e-06 FALSE  
ENST00000616679 ENSG00000088970 HEK293_OSMI2_2hA HEK293_TMG_2hB KIZ protein_coding protein_coding 8.557065 4.101268 12.39878 0.1288062 1.074846 1.593706 0.7252469 0.5644393 0.4760183 0.02669043 0.04004988 -0.24114369 0.119058333 0.13763333 0.03903333 -0.09860000 9.556635e-06 9.556635e-06 FALSE  
ENST00000619189 ENSG00000088970 HEK293_OSMI2_2hA HEK293_TMG_2hB KIZ protein_coding protein_coding 8.557065 4.101268 12.39878 0.1288062 1.074846 1.593706 5.1081336 2.1057560 7.3027732 0.16778547 0.38712691 1.78924534 0.557083333 0.51643333 0.59280000 0.07636667 5.575266e-01 9.556635e-06 FALSE  
ENST00000620553 ENSG00000088970 HEK293_OSMI2_2hA HEK293_TMG_2hB KIZ protein_coding processed_transcript 8.557065 4.101268 12.39878 0.1288062 1.074846 1.593706 0.7137871 0.4209668 1.5381697 0.21178727 0.32250871 1.84491510 0.074666667 0.10146667 0.12186667 0.02040000 8.254458e-01 9.556635e-06 FALSE  
ENST00000620891 ENSG00000088970 HEK293_OSMI2_2hA HEK293_TMG_2hB KIZ protein_coding protein_coding 8.557065 4.101268 12.39878 0.1288062 1.074846 1.593706 0.7003351 0.3566476 0.6158338 0.18155147 0.10227275 0.77138550 0.078383333 0.08576667 0.05156667 -0.03420000 9.716282e-01 9.556635e-06 FALSE  
ENST00000621366 ENSG00000088970 HEK293_OSMI2_2hA HEK293_TMG_2hB KIZ protein_coding protein_coding 8.557065 4.101268 12.39878 0.1288062 1.074846 1.593706 0.6491127 0.5378949 0.5628679 0.05624378 0.05084891 0.06430347 0.097679167 0.13056667 0.04556667 -0.08500000 2.965979e-04 9.556635e-06 FALSE  
ENST00000622184 ENSG00000088970 HEK293_OSMI2_2hA HEK293_TMG_2hB KIZ protein_coding processed_transcript 8.557065 4.101268 12.39878 0.1288062 1.074846 1.593706 0.1010116 0.0000000 0.8080928 0.00000000 0.43528696 6.35419268 0.007466667 0.00000000 0.05973333 0.05973333 3.200924e-01 9.556635e-06 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000088970 E001 0.6256415 0.0176027503 8.114752e-01 8.803726e-01 20 21125983 21126006 24 + 0.218 0.173 -0.415
ENSG00000088970 E002 0.9922594 0.0121989077 8.903418e-01 9.339416e-01 20 21126007 21126013 7 + 0.271 0.296 0.171
ENSG00000088970 E003 1.6199773 0.0088939350 9.607253e-01 9.792615e-01 20 21126014 21126037 24 + 0.401 0.392 -0.051
ENSG00000088970 E004 1.6199773 0.0088939350 9.607253e-01 9.792615e-01 20 21126038 21126038 1 + 0.401 0.392 -0.051
ENSG00000088970 E005 3.4238385 0.0047443198 1.855903e-01 3.082358e-01 20 21126039 21126051 13 + 0.691 0.470 -0.999
ENSG00000088970 E006 4.7911494 0.0033395662 1.563185e-01 2.702211e-01 20 21126052 21126059 8 + 0.808 0.594 -0.889
ENSG00000088970 E007 13.5630043 0.0357208451 2.357117e-01 3.692179e-01 20 21126060 21126081 22 + 1.191 1.034 -0.565
ENSG00000088970 E008 33.5811596 0.0007050314 3.342887e-01 4.780167e-01 20 21126082 21126204 123 + 1.537 1.474 -0.214
ENSG00000088970 E009 0.2966881 0.0274424043 5.283439e-01   20 21131864 21131957 94 + 0.157 0.000 -10.961
ENSG00000088970 E010 37.0758104 0.0005871692 3.058774e-01 4.480227e-01 20 21132097 21132159 63 + 1.583 1.521 -0.212
ENSG00000088970 E011 0.0000000       20 21132960 21133179 220 +      
ENSG00000088970 E012 62.9318163 0.0004849023 4.535656e-03 1.464226e-02 20 21136390 21136552 163 + 1.831 1.697 -0.454
ENSG00000088970 E013 0.0000000       20 21144097 21144192 96 +      
ENSG00000088970 E014 27.0716987 0.0008261670 1.557691e-04 7.727759e-04 20 21145565 21145585 21 + 1.508 1.221 -1.000
ENSG00000088970 E015 21.8899834 0.0008555299 6.487405e-04 2.711528e-03 20 21145586 21145588 3 + 1.421 1.136 -1.000
ENSG00000088970 E016 36.7818183 0.0005528150 1.088587e-05 7.171707e-05 20 21145589 21145654 66 + 1.639 1.352 -0.986
ENSG00000088970 E017 0.0000000       20 21145655 21145655 1 +      
ENSG00000088970 E018 63.0430964 0.0005677960 1.182090e-03 4.580652e-03 20 21161871 21162082 212 + 1.835 1.680 -0.526
ENSG00000088970 E019 82.5061515 0.0030656100 3.073671e-02 7.339732e-02 20 21162083 21162507 425 + 1.930 1.827 -0.346
ENSG00000088970 E020 66.5481465 0.0004890479 8.505324e-01 9.072681e-01 20 21162850 21163159 310 + 1.809 1.799 -0.031
ENSG00000088970 E021 29.8565561 0.0010260182 8.640130e-01 9.163327e-01 20 21205491 21205530 40 + 1.472 1.460 -0.042
ENSG00000088970 E022 24.1653724 0.0007708434 3.581909e-01 5.025602e-01 20 21205531 21205584 54 + 1.356 1.421 0.227
ENSG00000088970 E023 54.4645261 0.0014659773 2.413183e-01 3.757338e-01 20 21214535 21214700 166 + 1.705 1.764 0.200
ENSG00000088970 E024 37.5473169 0.0007411224 1.116888e-01 2.080440e-01 20 21215583 21215648 66 + 1.531 1.623 0.314
ENSG00000088970 E025 0.0000000       20 21218459 21218463 5 +      
ENSG00000088970 E026 0.0000000       20 21218464 21218592 129 +      
ENSG00000088970 E027 0.2214452 0.0390366214 2.148627e-01   20 21226109 21226139 31 + 0.000 0.173 12.030
ENSG00000088970 E028 0.2214452 0.0390366214 2.148627e-01   20 21226140 21226295 156 + 0.000 0.173 12.030
ENSG00000088970 E029 45.0973733 0.0023861691 2.529780e-03 8.852057e-03 20 21229011 21229115 105 + 1.573 1.742 0.573
ENSG00000088970 E030 41.9804529 0.0007455605 4.360367e-04 1.913014e-03 20 21232734 21232830 97 + 1.531 1.722 0.651
ENSG00000088970 E031 1.1929815 0.0183639166 3.131421e-02 7.451150e-02 20 21232831 21232914 84 + 0.437 0.000 -12.962
ENSG00000088970 E032 24.0815040 0.0008432850 2.219989e-02 5.608575e-02 20 21244245 21244288 44 + 1.312 1.474 0.561
ENSG00000088970 E033 4.6718055 0.0035409069 1.332051e-02 3.666644e-02 20 21244289 21244470 182 + 0.582 0.920 1.377
ENSG00000088970 E034 2.0648568 0.0071852811 2.519116e-01 3.882170e-01 20 21244471 21244520 50 + 0.401 0.594 0.947
ENSG00000088970 E035 35.3067407 0.0014028759 9.568974e-17 4.127535e-15 20 21244521 21246478 1958 + 1.303 1.796 1.686
ENSG00000088970 E036 20.8758133 0.0009377030 1.905029e-04 9.233301e-04 20 21246479 21246622 144 + 1.203 1.481 0.968