ENSG00000088808

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000202556 ENSG00000088808 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP1R13B protein_coding protein_coding 11.50718 12.38738 8.710921 0.4606709 0.7228722 -0.5074827 1.9037313 2.06835195 1.5522451 0.41479049 0.26707790 -0.4118192 0.17200833 0.16540000 0.18616667 0.020766667 9.324265e-01 1.6439e-07 FALSE TRUE
ENST00000554432 ENSG00000088808 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP1R13B protein_coding retained_intron 11.50718 12.38738 8.710921 0.4606709 0.7228722 -0.5074827 0.7086563 0.73503682 0.5061211 0.06377716 0.16350907 -0.5296021 0.06013333 0.05933333 0.05883333 -0.000500000 9.529801e-01 1.6439e-07   FALSE
ENST00000555825 ENSG00000088808 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP1R13B protein_coding retained_intron 11.50718 12.38738 8.710921 0.4606709 0.7228722 -0.5074827 0.9307843 1.01238791 0.5456558 0.08497044 0.07237345 -0.8796793 0.07942083 0.08240000 0.06296667 -0.019433333 5.760597e-01 1.6439e-07 TRUE FALSE
ENST00000556597 ENSG00000088808 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP1R13B protein_coding nonsense_mediated_decay 11.50718 12.38738 8.710921 0.4606709 0.7228722 -0.5074827 2.2817925 4.21298269 1.4146289 0.04250036 0.04552794 -1.5676762 0.18996250 0.34133333 0.16460000 -0.176733333 9.255997e-06 1.6439e-07 TRUE TRUE
ENST00000557744 ENSG00000088808 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP1R13B protein_coding retained_intron 11.50718 12.38738 8.710921 0.4606709 0.7228722 -0.5074827 0.9278403 0.71686419 0.5998003 0.15336869 0.30206668 -0.2533490 0.07697917 0.05823333 0.06360000 0.005366667 9.298015e-01 1.6439e-07   FALSE
MSTRG.10233.6 ENSG00000088808 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP1R13B protein_coding   11.50718 12.38738 8.710921 0.4606709 0.7228722 -0.5074827 0.6310819 0.03857626 1.7395171 0.03857626 0.29924943 5.1705615 0.07041250 0.00300000 0.20850000 0.205500000 1.643900e-07 1.6439e-07 TRUE TRUE
MSTRG.10233.7 ENSG00000088808 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP1R13B protein_coding   11.50718 12.38738 8.710921 0.4606709 0.7228722 -0.5074827 2.3574669 2.56452320 1.1751021 0.17189591 0.59437045 -1.1192940 0.19651667 0.20656667 0.12453333 -0.082033333 6.983010e-01 1.6439e-07 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000088808 E001 3.1842268 0.0950295530 3.641200e-01 5.085141e-01 14 103733195 103733751 557 - 0.485 0.662 0.807
ENSG00000088808 E002 1.1749062 0.0108090048 1.649175e-01 2.815965e-01 14 103733752 103733752 1 - 0.150 0.406 1.909
ENSG00000088808 E003 12.5461630 0.0163050757 1.258664e-04 6.406333e-04 14 103733753 103733820 68 - 0.742 1.233 1.832
ENSG00000088808 E004 26.4954490 0.0163161098 1.664644e-04 8.200375e-04 14 103733821 103733895 75 - 1.138 1.516 1.319
ENSG00000088808 E005 26.7742690 0.0085704383 4.559788e-04 1.990319e-03 14 103733896 103733922 27 - 1.198 1.506 1.072
ENSG00000088808 E006 124.1653561 0.0075423783 1.305487e-07 1.296977e-06 14 103733923 103734366 444 - 1.863 2.154 0.978
ENSG00000088808 E007 132.5187658 0.0011046986 7.606714e-06 5.192106e-05 14 103734367 103734663 297 - 1.988 2.151 0.548
ENSG00000088808 E008 105.6047928 0.0003032599 7.123559e-07 6.107331e-06 14 103734664 103734891 228 - 1.865 2.055 0.635
ENSG00000088808 E009 30.3302704 0.0007065687 3.802852e-04 1.698468e-03 14 103734892 103734892 1 - 1.281 1.535 0.878
ENSG00000088808 E010 56.4636618 0.0021348690 7.329701e-05 3.960497e-04 14 103734893 103734999 107 - 1.566 1.791 0.766
ENSG00000088808 E011 51.1463147 0.0110024952 2.613873e-01 3.990318e-01 14 103735000 103735079 80 - 1.629 1.719 0.306
ENSG00000088808 E012 48.6980775 0.0053017845 7.015129e-02 1.436208e-01 14 103735080 103735113 34 - 1.589 1.710 0.410
ENSG00000088808 E013 71.4360523 0.0015959125 2.874388e-03 9.895586e-03 14 103735114 103735195 82 - 1.729 1.877 0.498
ENSG00000088808 E014 101.1011220 0.0002763775 1.817668e-01 3.034444e-01 14 103736003 103736202 200 - 1.947 2.000 0.176
ENSG00000088808 E015 27.4023654 0.0126187958 6.009041e-01 7.220981e-01 14 103736203 103737693 1491 - 1.402 1.453 0.174
ENSG00000088808 E016 77.9613436 0.0009930153 6.248569e-02 1.308258e-01 14 103737694 103737860 167 - 1.811 1.897 0.289
ENSG00000088808 E017 9.5298591 0.0185956877 6.693624e-01 7.761866e-01 14 103738389 103738678 290 - 1.036 0.988 -0.179
ENSG00000088808 E018 71.2639922 0.0057716147 6.372958e-01 7.512197e-01 14 103738679 103738812 134 - 1.809 1.841 0.109
ENSG00000088808 E019 80.0896675 0.0003749017 7.394818e-01 8.291611e-01 14 103738886 103739023 138 - 1.868 1.885 0.058
ENSG00000088808 E020 1.8810866 0.0074782121 4.457407e-01 5.872788e-01 14 103739024 103739272 249 - 0.349 0.486 0.740
ENSG00000088808 E021 92.3810505 0.0003317817 8.882985e-01 9.325827e-01 14 103739824 103740063 240 - 1.945 1.944 -0.006
ENSG00000088808 E022 115.2657174 0.0003401095 7.841986e-01 8.615631e-01 14 103740064 103740593 530 - 2.031 2.044 0.044
ENSG00000088808 E023 63.1499164 0.0004732692 8.216092e-01 8.874831e-01 14 103741790 103741991 202 - 1.788 1.782 -0.023
ENSG00000088808 E024 49.6133524 0.0006018220 2.168972e-01 3.466560e-01 14 103741992 103742088 97 - 1.716 1.656 -0.202
ENSG00000088808 E025 65.6453335 0.0092918615 7.439155e-01 8.324082e-01 14 103742089 103742291 203 - 1.808 1.795 -0.046
ENSG00000088808 E026 63.6693005 0.0043568169 5.038808e-01 6.398165e-01 14 103742654 103742823 170 - 1.808 1.777 -0.107
ENSG00000088808 E027 6.6845104 0.0122139678 6.875524e-01 7.898727e-01 14 103742824 103742898 75 - 0.830 0.886 0.216
ENSG00000088808 E028 4.0974338 0.0040634513 1.725483e-01 2.915125e-01 14 103743891 103744015 125 - 0.802 0.612 -0.790
ENSG00000088808 E029 25.4173690 0.0092177600 5.847559e-01 7.086035e-01 14 103746373 103746373 1 - 1.423 1.381 -0.145
ENSG00000088808 E030 57.9030662 0.0009358918 5.174240e-02 1.122589e-01 14 103746374 103746553 180 - 1.800 1.710 -0.304
ENSG00000088808 E031 2.3553040 0.0064890991 6.739872e-03 2.054826e-02 14 103746652 103746707 56 - 0.742 0.308 -2.134
ENSG00000088808 E032 1.6606631 0.0088433135 2.259954e-02 5.691933e-02 14 103746708 103746772 65 - 0.632 0.248 -2.091
ENSG00000088808 E033 2.2799473 0.0086643319 5.475380e-02 1.175644e-01 14 103746773 103746860 88 - 0.672 0.360 -1.521
ENSG00000088808 E034 5.2549288 0.0284914979 1.543720e-03 5.777081e-03 14 103746933 103747397 465 - 1.020 0.554 -1.874
ENSG00000088808 E035 63.6563980 0.0004301719 8.573012e-02 1.685588e-01 14 103749794 103749934 141 - 1.827 1.753 -0.250
ENSG00000088808 E036 75.8196707 0.0004435662 1.634262e-04 8.067277e-04 14 103753000 103753196 197 - 1.949 1.798 -0.508
ENSG00000088808 E037 51.9153754 0.0005553766 3.522707e-05 2.058121e-04 14 103754070 103754164 95 - 1.817 1.618 -0.674
ENSG00000088808 E038 40.9580037 0.0005506551 6.826631e-06 4.713480e-05 14 103754165 103754238 74 - 1.736 1.494 -0.826
ENSG00000088808 E039 22.0599821 0.0008962968 6.602320e-05 3.609262e-04 14 103754239 103754244 6 - 1.503 1.216 -0.996
ENSG00000088808 E040 0.6717251 0.0256889359 1.431781e-01 2.523459e-01 14 103757649 103757649 1 - 0.349 0.100 -2.258
ENSG00000088808 E041 44.3876924 0.0013544865 1.248132e-07 1.244827e-06 14 103757650 103757751 102 - 1.791 1.508 -0.962
ENSG00000088808 E042 0.1472490 0.0426530217 3.099242e-01   14 103759191 103759305 115 - 0.150 0.000 -10.849
ENSG00000088808 E043 7.0116811 0.0023692454 4.728932e-02 1.043495e-01 14 103763863 103764479 617 - 1.019 0.789 -0.876
ENSG00000088808 E044 0.1482932 0.0415266098 7.476477e-01   14 103778592 103778744 153 - 0.000 0.099 9.005
ENSG00000088808 E045 23.0421328 0.0008248139 2.626266e-03 9.147605e-03 14 103778745 103778754 10 - 1.480 1.268 -0.736
ENSG00000088808 E046 41.6601423 0.0063309417 6.154324e-04 2.589836e-03 14 103778755 103778821 67 - 1.729 1.512 -0.742
ENSG00000088808 E047 45.8957097 0.0048816526 2.197286e-06 1.693666e-05 14 103784795 103784914 120 - 1.806 1.524 -0.957
ENSG00000088808 E048 0.0000000       14 103794577 103794663 87 -      
ENSG00000088808 E049 38.4752315 0.0177192327 9.285323e-06 6.217576e-05 14 103797371 103797518 148 - 1.768 1.407 -1.231
ENSG00000088808 E050 0.1472490 0.0426530217 3.099242e-01   14 103840079 103840107 29 - 0.150 0.000 -10.849
ENSG00000088808 E051 1.0371971 0.0139905668 5.673887e-01 6.942145e-01 14 103844652 103844701 50 - 0.349 0.249 -0.673
ENSG00000088808 E052 0.0000000       14 103846775 103846885 111 -      
ENSG00000088808 E053 0.0000000       14 103847008 103847298 291 -      
ENSG00000088808 E054 16.1213875 0.0071931808 8.376176e-11 1.497727e-09 14 103847299 103847541 243 - 1.503 0.902 -2.144
ENSG00000088808 E055 3.1165307 0.0760675610 4.543834e-06 3.265861e-05 14 103847542 103847575 34 - 0.964 0.100 -4.991