ENSG00000088756

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000314319 ENSG00000088756 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP28 protein_coding protein_coding 0.7091358 0.2758602 1.123271 0.07994771 0.0420257 1.987111 0.08854502 0.15402694 0.1609897 0.07706407 0.16098969 0.0599766 0.24757500 0.4935667 0.1333333 -0.36023333 0.3889711 0.0263072 FALSE TRUE
ENST00000383472 ENSG00000088756 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP28 protein_coding protein_coding 0.7091358 0.2758602 1.123271 0.07994771 0.0420257 1.987111 0.43424284 0.02121612 0.8225945 0.02121612 0.18671080 4.7372508 0.47559583 0.0496000 0.7461000 0.69650000 0.0263072 0.0263072 FALSE TRUE
ENST00000531294 ENSG00000088756 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP28 protein_coding protein_coding 0.7091358 0.2758602 1.123271 0.07994771 0.0420257 1.987111 0.00920886 0.04937325 0.0000000 0.04937325 0.00000000 -2.5698132 0.06963750 0.3155667 0.0000000 -0.31556667 0.7781685 0.0263072 FALSE TRUE
ENST00000579689 ENSG00000088756 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP28 protein_coding protein_coding 0.7091358 0.2758602 1.123271 0.07994771 0.0420257 1.987111 0.09325395 0.03515292 0.1249897 0.03515292 0.07532827 1.5799577 0.07822917 0.0822000 0.1072667 0.02506667 0.9932878 0.0263072 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000088756 E001 1.728618 0.0081447821 9.136127e-01 9.492847e-01 18 6729716 6729943 228 + 0.367 0.387 0.111
ENSG00000088756 E002 0.000000       18 6729946 6730042 97 +      
ENSG00000088756 E003 0.000000       18 6730043 6730076 34 +      
ENSG00000088756 E004 0.000000       18 6730077 6730113 37 +      
ENSG00000088756 E005 0.000000       18 6754688 6754815 128 +      
ENSG00000088756 E006 0.000000       18 6774002 6774234 233 +      
ENSG00000088756 E007 0.000000       18 6778946 6779036 91 +      
ENSG00000088756 E008 0.147249 0.0442676868 1.000000e+00   18 6788494 6791670 3177 + 0.060 0.001 -5.995
ENSG00000088756 E009 2.569352 0.0367875047 1.910842e-01 3.151130e-01 18 6824762 6824898 137 + 0.526 0.235 -1.714
ENSG00000088756 E010 3.089576 0.0216102775 9.485113e-02 1.826627e-01 18 6824899 6824964 66 + 0.597 0.235 -2.043
ENSG00000088756 E011 0.000000       18 6834475 6834479 5 +      
ENSG00000088756 E012 0.000000       18 6834480 6834539 60 +      
ENSG00000088756 E013 0.000000       18 6836098 6836175 78 +      
ENSG00000088756 E014 0.000000       18 6837193 6837196 4 +      
ENSG00000088756 E015 3.537779 0.0142253059 5.524576e-02 1.184114e-01 18 6837197 6837253 57 + 0.643 0.235 -2.244
ENSG00000088756 E016 4.794360 0.0448286497 5.132668e-01 6.480944e-01 18 6837254 6837414 161 + 0.710 0.586 -0.533
ENSG00000088756 E017 0.000000       18 6850791 6850876 86 +      
ENSG00000088756 E018 3.357946 0.0051176390 4.875448e-01 6.252126e-01 18 6851034 6851115 82 + 0.545 0.661 0.514
ENSG00000088756 E019 1.770336 0.0091780449 3.941291e-01 5.380212e-01 18 6851116 6851126 11 + 0.419 0.235 -1.180
ENSG00000088756 E020 1.623087 0.0084680985 4.622124e-01 6.020679e-01 18 6859808 6859811 4 + 0.394 0.235 -1.043
ENSG00000088756 E021 2.359344 0.0428053053 8.629741e-01 9.156411e-01 18 6859812 6859830 19 + 0.465 0.496 0.155
ENSG00000088756 E022 3.470740 0.0087805667 9.573669e-01 9.772690e-01 18 6859831 6859897 67 + 0.580 0.587 0.031
ENSG00000088756 E023 3.887721 0.0043511856 6.908698e-01 7.924436e-01 18 6868150 6868231 82 + 0.597 0.661 0.280
ENSG00000088756 E024 1.588642 0.0095951872 3.105429e-01 4.529501e-01 18 6868232 6868234 3 + 0.308 0.499 1.058
ENSG00000088756 E025 4.541564 0.0036276412 9.682579e-01 9.841797e-01 18 6870590 6870732 143 + 0.657 0.662 0.018
ENSG00000088756 E026 3.260105 0.0051176390 3.279432e-01 4.714192e-01 18 6873409 6873465 57 + 0.580 0.387 -0.967
ENSG00000088756 E027 2.306567 0.0147568990 2.427996e-01 3.774662e-01 18 6873466 6873480 15 + 0.487 0.235 -1.527
ENSG00000088756 E028 4.447687 0.0491173912 3.955838e-01 5.393851e-01 18 6873481 6873574 94 + 0.685 0.500 -0.831
ENSG00000088756 E029 4.878939 0.0038783647 2.184640e-01 3.485603e-01 18 6873684 6873775 92 + 0.723 0.499 -0.993
ENSG00000088756 E030 2.531687 0.0218956540 1.857385e-01 3.084251e-01 18 6876131 6876208 78 + 0.526 0.235 -1.719
ENSG00000088756 E031 5.034708 0.0033703174 1.898863e-01 3.136158e-01 18 6882137 6882299 163 + 0.735 0.499 -1.042
ENSG00000088756 E032 0.000000       18 6882300 6882361 62 +      
ENSG00000088756 E033 4.442376 0.0040594697 6.374018e-01 7.512979e-01 18 6887157 6887239 83 + 0.671 0.588 -0.364
ENSG00000088756 E034 7.125576 0.0024640159 9.383069e-01 9.652473e-01 18 6889888 6890085 198 + 0.820 0.829 0.032
ENSG00000088756 E035 4.844595 0.0034680016 8.993971e-01 9.398077e-01 18 6890430 6890543 114 + 0.685 0.662 -0.098
ENSG00000088756 E036 4.109283 0.0040455646 3.909050e-01 5.348522e-01 18 6894835 6894891 57 + 0.657 0.499 -0.720
ENSG00000088756 E037 4.991960 0.0033788770 5.868352e-02 1.243768e-01 18 6896502 6896626 125 + 0.746 0.386 -1.674
ENSG00000088756 E038 0.000000       18 6896760 6898435 1676 +      
ENSG00000088756 E039 0.000000       18 6898436 6898721 286 +      
ENSG00000088756 E040 3.776162 0.0049765311 5.412200e-01 6.722473e-01 18 6908960 6909024 65 + 0.613 0.499 -0.526
ENSG00000088756 E041 54.071561 0.0007209509 4.467129e-06 3.216955e-05 18 6912060 6915716 3657 + 1.597 1.792 0.662