ENSG00000088538

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
MSTRG.23009.1 ENSG00000088538 HEK293_OSMI2_2hA HEK293_TMG_2hB DOCK3 protein_coding   4.52084 4.010055 5.306122 0.2274619 0.3814063 0.4031592 0.3921791 0.4115941 0.4065161 0.05299822 0.06907584 -0.01748252 0.08090833 0.10180000 0.07616667 -0.025633333 0.665907396 0.000472263 FALSE TRUE
MSTRG.23009.10 ENSG00000088538 HEK293_OSMI2_2hA HEK293_TMG_2hB DOCK3 protein_coding   4.52084 4.010055 5.306122 0.2274619 0.3814063 0.4031592 0.3338708 0.1889947 0.3855289 0.05775059 0.10048415 0.99105309 0.07400000 0.04876667 0.07356667 0.024800000 0.723576287 0.000472263 FALSE TRUE
MSTRG.23009.11 ENSG00000088538 HEK293_OSMI2_2hA HEK293_TMG_2hB DOCK3 protein_coding   4.52084 4.010055 5.306122 0.2274619 0.3814063 0.4031592 0.1791382 0.0000000 0.4405584 0.00000000 0.24386980 5.49364208 0.03796667 0.00000000 0.07730000 0.077300000 0.210723042 0.000472263 FALSE TRUE
MSTRG.23009.13 ENSG00000088538 HEK293_OSMI2_2hA HEK293_TMG_2hB DOCK3 protein_coding   4.52084 4.010055 5.306122 0.2274619 0.3814063 0.4031592 0.4367856 0.2889425 0.4466923 0.14447550 0.12963476 0.61135427 0.09382083 0.07383333 0.08150000 0.007666667 0.878785634 0.000472263 FALSE TRUE
MSTRG.23009.14 ENSG00000088538 HEK293_OSMI2_2hA HEK293_TMG_2hB DOCK3 protein_coding   4.52084 4.010055 5.306122 0.2274619 0.3814063 0.4031592 1.3419425 1.8217902 0.6110698 0.26807274 0.18844890 -1.56042705 0.28227083 0.44993333 0.11093333 -0.339000000 0.000472263 0.000472263 FALSE TRUE
MSTRG.23009.3 ENSG00000088538 HEK293_OSMI2_2hA HEK293_TMG_2hB DOCK3 protein_coding   4.52084 4.010055 5.306122 0.2274619 0.3814063 0.4031592 0.9382491 0.9901227 1.8066687 0.14763178 0.10919613 0.86111838 0.21814167 0.25213333 0.34253333 0.090400000 0.475474605 0.000472263 FALSE TRUE
MSTRG.23009.5 ENSG00000088538 HEK293_OSMI2_2hA HEK293_TMG_2hB DOCK3 protein_coding   4.52084 4.010055 5.306122 0.2274619 0.3814063 0.4031592 0.1110853 0.0000000 0.2958054 0.00000000 0.14806074 4.93454197 0.02682500 0.00000000 0.05863333 0.058633333 0.237575692 0.000472263 FALSE TRUE
MSTRG.23009.7 ENSG00000088538 HEK293_OSMI2_2hA HEK293_TMG_2hB DOCK3 protein_coding   4.52084 4.010055 5.306122 0.2274619 0.3814063 0.4031592 0.2662696 0.1529902 0.4980625 0.15299016 0.35188688 1.64022119 0.06466250 0.03703333 0.10510000 0.068066667 0.697362769 0.000472263 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000088538 E001 0.4804688 0.0210352377 7.510530e-01 8.375898e-01 3 50674922 50674926 5 + 0.181 0.149 -0.328
ENSG00000088538 E002 1.2168277 0.0106526525 6.653593e-02 1.376163e-01 3 50674927 50674949 23 + 0.448 0.149 -2.136
ENSG00000088538 E003 2.8357728 0.0054767027 1.991158e-01 3.251130e-01 3 50674950 50674992 43 + 0.639 0.485 -0.707
ENSG00000088538 E004 3.4290353 0.0047103875 5.386135e-02 1.160085e-01 3 50674993 50675042 50 + 0.731 0.485 -1.094
ENSG00000088538 E005 2.2100175 0.0167190026 2.958562e-01 4.370026e-01 3 50675043 50675051 9 + 0.554 0.422 -0.649
ENSG00000088538 E006 3.1344235 0.0150225070 1.162726e-01 2.146428e-01 3 50675052 50675079 28 + 0.687 0.485 -0.912
ENSG00000088538 E007 3.6494509 0.0041404849 7.224613e-03 2.180748e-02 3 50675080 50675167 88 + 0.789 0.422 -1.651
ENSG00000088538 E008 6.0360792 0.0070782249 6.085832e-05 3.357042e-04 3 50675168 50675276 109 + 1.001 0.485 -2.136
ENSG00000088538 E009 7.2871322 0.0194625933 6.179062e-03 1.908543e-02 3 50675277 50675300 24 + 1.023 0.709 -1.212
ENSG00000088538 E010 17.1221052 0.0245409524 8.952400e-03 2.616041e-02 3 50778675 50778758 84 + 1.330 1.115 -0.757
ENSG00000088538 E011 16.3357861 0.0011296717 2.969609e-02 7.136214e-02 3 50841675 50841715 41 + 1.280 1.163 -0.413
ENSG00000088538 E012 17.2039893 0.0010742016 7.989125e-02 1.593929e-01 3 50890026 50890081 56 + 1.286 1.209 -0.269
ENSG00000088538 E013 22.9639679 0.0009920038 4.526448e-01 5.934862e-01 3 50933981 50934077 97 + 1.365 1.380 0.053
ENSG00000088538 E014 30.2402075 0.0017966152 8.664020e-01 9.179889e-01 3 51064448 51064596 149 + 1.460 1.519 0.203
ENSG00000088538 E015 24.0338105 0.0009127183 4.653267e-01 6.050512e-01 3 51075356 51075440 85 + 1.384 1.402 0.063
ENSG00000088538 E016 12.8188233 0.0621902088 8.946894e-01 9.367072e-01 3 51081175 51081398 224 + 1.118 1.176 0.205
ENSG00000088538 E017 7.3656783 0.0045501120 2.170358e-01 3.468152e-01 3 51089243 51089284 42 + 0.941 0.856 -0.325
ENSG00000088538 E018 7.9076724 0.0134346821 1.962448e-01 3.215282e-01 3 51090230 51090280 51 + 0.978 0.881 -0.366
ENSG00000088538 E019 11.8475054 0.0334033784 1.086954e-01 2.036053e-01 3 51090281 51090384 104 + 1.151 1.024 -0.460
ENSG00000088538 E020 9.6971622 0.0018978236 4.729499e-02 1.043583e-01 3 51146549 51146630 82 + 1.073 0.924 -0.550
ENSG00000088538 E021 10.0386888 0.0017635741 2.315660e-02 5.807450e-02 3 51159244 51159304 61 + 1.101 0.924 -0.650
ENSG00000088538 E022 14.0118116 0.0042427569 7.974054e-05 4.266318e-04 3 51160555 51160702 148 + 1.286 0.964 -1.157
ENSG00000088538 E023 0.2965864 0.4108028818 2.163184e-01   3 51170656 51170668 13 + 0.000 0.253 11.191
ENSG00000088538 E024 2.9560671 0.0070430415 1.481771e-01 2.592032e-01 3 51174636 51174756 121 + 0.664 0.485 -0.814
ENSG00000088538 E025 6.5429736 0.0247430627 2.462460e-02 6.110655e-02 3 51208774 51208787 14 + 0.967 0.709 -1.006
ENSG00000088538 E026 8.8273156 0.0443576995 2.805067e-02 6.811745e-02 3 51208788 51208862 75 + 1.083 0.829 -0.952
ENSG00000088538 E027 5.4972426 0.0170016114 4.227870e-02 9.523415e-02 3 51214122 51214141 20 + 0.901 0.671 -0.918
ENSG00000088538 E028 10.4709131 0.0066255975 4.273395e-03 1.390915e-02 3 51214142 51214247 106 + 1.151 0.902 -0.915
ENSG00000088538 E029 14.3194424 0.0128187000 1.392463e-02 3.805510e-02 3 51225649 51225773 125 + 1.255 1.067 -0.673
ENSG00000088538 E030 13.5582938 0.0013935858 4.203764e-03 1.371314e-02 3 51227283 51227445 163 + 1.237 1.036 -0.721
ENSG00000088538 E031 9.3972599 0.0025726697 4.219313e-05 2.418713e-04 3 51227982 51228088 107 + 1.151 0.742 -1.542
ENSG00000088538 E032 10.8799319 0.0017722985 1.742323e-05 1.095476e-04 3 51228661 51228832 172 + 1.203 0.802 -1.486
ENSG00000088538 E033 10.1622093 0.0016706745 9.918982e-05 5.180496e-04 3 51229512 51229609 98 + 1.166 0.802 -1.356
ENSG00000088538 E034 9.0646344 0.0019895380 1.169758e-06 9.575974e-06 3 51236345 51236428 84 + 1.159 0.632 -2.029
ENSG00000088538 E035 11.5194168 0.0163639978 3.613985e-04 1.624416e-03 3 51237490 51237590 101 + 1.217 0.854 -1.333
ENSG00000088538 E036 13.7331275 0.0019687822 2.970607e-02 7.138252e-02 3 51246726 51246807 82 + 1.217 1.082 -0.480
ENSG00000088538 E037 20.8400333 0.0211095963 6.298621e-02 1.316840e-01 3 51260156 51260326 171 + 1.379 1.264 -0.401
ENSG00000088538 E038 16.6668720 0.0960532337 4.444699e-01 5.860325e-01 3 51270815 51271007 193 + 1.254 1.221 -0.116
ENSG00000088538 E039 11.0884054 0.0050167322 9.793754e-02 1.873741e-01 3 51275079 51275206 128 + 1.109 1.003 -0.388
ENSG00000088538 E040 2.1195775 0.0186061173 3.824554e-03 1.264927e-02 3 51275207 51275220 14 + 0.639 0.149 -3.029
ENSG00000088538 E041 3.9481997 0.0041570908 1.369292e-01 2.438070e-01 3 51275282 51275373 92 + 0.751 0.588 -0.691
ENSG00000088538 E042 9.1799676 0.0018848194 7.584665e-01 8.430642e-01 3 51277608 51277712 105 + 0.954 1.052 0.362
ENSG00000088538 E043 1.7466274 0.3514005590 4.848048e-01 6.227485e-01 3 51277713 51277754 42 + 0.488 0.351 -0.741
ENSG00000088538 E044 1.6221542 0.0180826811 4.258393e-01 5.687217e-01 3 51278401 51278436 36 + 0.448 0.349 -0.548
ENSG00000088538 E045 3.3203906 0.0050076891 2.716134e-01 4.103868e-01 3 51278437 51278528 92 + 0.521 0.742 0.961
ENSG00000088538 E046 11.2331831 0.0031343284 5.361289e-01 6.678810e-01 3 51280106 51280204 99 + 1.023 1.151 0.463
ENSG00000088538 E047 11.2135793 0.0015296430 5.652381e-01 6.923673e-01 3 51310232 51310326 95 + 1.073 1.083 0.035
ENSG00000088538 E048 12.0765356 0.0053139163 2.162258e-01 3.458659e-01 3 51312004 51312079 76 + 1.126 1.068 -0.209
ENSG00000088538 E049 15.7256452 0.0246939762 2.085485e-01 3.367387e-01 3 51312476 51312576 101 + 1.237 1.169 -0.241
ENSG00000088538 E050 14.7185338 0.0136744405 4.757480e-01 6.144339e-01 3 51312844 51312902 59 + 1.182 1.179 -0.010
ENSG00000088538 E051 21.5458568 0.0009247692 2.759753e-01 4.153771e-01 3 51314980 51315128 149 + 1.345 1.333 -0.041
ENSG00000088538 E052 16.6764999 0.0012628634 7.750829e-01 8.550774e-01 3 51330138 51330223 86 + 1.217 1.262 0.158
ENSG00000088538 E053 0.4772466 0.0209936472 4.076242e-01 5.512162e-01 3 51333001 51333027 27 + 0.100 0.260 1.670
ENSG00000088538 E054 15.7682255 0.0011386868 8.884761e-01 9.326865e-01 3 51333158 51333253 96 + 1.181 1.261 0.283
ENSG00000088538 E055 13.0959110 0.0013414172 7.602524e-01 8.444194e-01 3 51338359 51338419 61 + 1.092 1.187 0.342
ENSG00000088538 E056 14.5903045 0.0020790852 1.771143e-01 2.974757e-01 3 51338935 51339028 94 + 1.082 1.272 0.674
ENSG00000088538 E057 20.7885875 0.0014309986 5.747765e-02 1.223095e-01 3 51341237 51341385 149 + 1.224 1.436 0.742
ENSG00000088538 E058 13.3891019 0.0013969629 5.618667e-01 6.895880e-01 3 51348852 51348938 87 + 1.101 1.220 0.427
ENSG00000088538 E059 17.1545490 0.0010411036 6.555784e-01 7.654314e-01 3 51350288 51350392 105 + 1.203 1.308 0.368
ENSG00000088538 E060 20.1585316 0.0013511277 3.260971e-01 4.695349e-01 3 51354882 51355023 142 + 1.243 1.388 0.506
ENSG00000088538 E061 27.6313994 0.0010092220 3.319183e-01 4.755528e-01 3 51356089 51356255 167 + 1.379 1.514 0.464
ENSG00000088538 E062 22.0456586 0.0009974733 5.603543e-01 6.883507e-01 3 51356407 51356493 87 + 1.297 1.409 0.390
ENSG00000088538 E063 23.9674718 0.0007851286 4.244964e-01 5.674579e-01 3 51356962 51357141 180 + 1.330 1.455 0.434
ENSG00000088538 E064 15.1521897 0.0017011148 8.305483e-01 8.937003e-01 3 51357758 51357841 84 + 1.181 1.231 0.176
ENSG00000088538 E065 16.6785552 0.0010627614 1.000714e-01 1.905924e-01 3 51357961 51358077 117 + 1.268 1.198 -0.246
ENSG00000088538 E066 16.6918915 0.0011337738 2.445411e-01 3.795195e-01 3 51360511 51360632 122 + 1.249 1.221 -0.102
ENSG00000088538 E067 14.0590126 0.0035216450 8.635814e-01 9.160143e-01 3 51361859 51361921 63 + 1.126 1.210 0.299
ENSG00000088538 E068 18.6123256 0.0123937311 8.656167e-01 9.174432e-01 3 51361922 51361997 76 + 1.255 1.311 0.196
ENSG00000088538 E069 24.2482408 0.0146900535 6.359572e-01 7.500992e-01 3 51362527 51362674 148 + 1.374 1.408 0.118
ENSG00000088538 E070 10.1514613 0.0741049706 9.114592e-01 9.477905e-01 3 51374469 51374486 18 + 1.002 1.068 0.243
ENSG00000088538 E071 25.0930809 0.0011087838 1.861832e-01 3.089524e-01 3 51374487 51374587 101 + 1.411 1.388 -0.079
ENSG00000088538 E072 17.0205513 0.0010654912 7.383142e-01 8.282149e-01 3 51375748 51375835 88 + 1.203 1.299 0.338
ENSG00000088538 E073 9.4617177 0.0018646617 5.491327e-01 6.788975e-01 3 51379449 51379571 123 + 0.954 1.082 0.473
ENSG00000088538 E074 12.5084888 0.0016056166 3.410701e-01 4.849841e-01 3 51380125 51380207 83 + 1.054 1.209 0.559
ENSG00000088538 E075 325.9482536 0.0120305523 4.369477e-12 9.638848e-11 3 51381050 51384198 3149 + 2.301 2.685 1.280