ENSG00000088448

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000267339 ENSG00000088448 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD10 protein_coding protein_coding 19.75645 12.03989 24.39594 1.264687 1.09356 1.018213 6.680458 4.40298214 8.052930 1.13076809 0.28585909 0.8695503 0.33960417 0.35466667 0.33060000 -0.02406667 8.993724e-01 1.410587e-29 FALSE TRUE
ENST00000310847 ENSG00000088448 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD10 protein_coding protein_coding 19.75645 12.03989 24.39594 1.264687 1.09356 1.018213 3.723874 4.74319266 3.059959 0.47965081 0.08689176 -0.6306774 0.21980417 0.39433333 0.12566667 -0.26866667 1.410587e-29 1.410587e-29 FALSE TRUE
ENST00000463156 ENSG00000088448 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD10 protein_coding processed_transcript 19.75645 12.03989 24.39594 1.264687 1.09356 1.018213 1.912816 0.73064390 2.708339 0.14470293 0.57777754 1.8758732 0.08738333 0.06426667 0.11070000 0.04643333 3.984500e-01 1.410587e-29   FALSE
ENST00000475809 ENSG00000088448 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD10 protein_coding processed_transcript 19.75645 12.03989 24.39594 1.264687 1.09356 1.018213 2.678198 0.70674147 4.521592 0.09990775 0.71234713 2.6604934 0.12087500 0.06150000 0.18336667 0.12186667 1.964394e-03 1.410587e-29   FALSE
MSTRG.9072.4 ENSG00000088448 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD10 protein_coding   19.75645 12.03989 24.39594 1.264687 1.09356 1.018213 1.250726 0.06257715 2.208505 0.06257715 0.07689123 4.9339286 0.05380000 0.00430000 0.09063333 0.08633333 1.605845e-10 1.410587e-29 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000088448 E001 165.8604530 0.0126692347 1.786948e-02 4.685628e-02 13 110878540 110879357 818 - 2.147 2.303 0.522
ENSG00000088448 E002 63.6398777 0.0274518351 5.435407e-01 6.741221e-01 13 110879358 110879537 180 - 1.768 1.857 0.299
ENSG00000088448 E003 70.9379335 0.0012252946 6.673118e-01 7.746005e-01 13 110879538 110879726 189 - 1.861 1.863 0.006
ENSG00000088448 E004 42.2963497 0.0036018492 2.431211e-02 6.045859e-02 13 110879727 110879767 41 - 1.688 1.570 -0.403
ENSG00000088448 E005 46.0211050 0.0080172950 2.672908e-02 6.542897e-02 13 110879768 110879817 50 - 1.728 1.599 -0.439
ENSG00000088448 E006 38.7321847 0.0007442761 4.433208e-02 9.899199e-02 13 110879818 110879841 24 - 1.642 1.547 -0.324
ENSG00000088448 E007 103.5915801 0.0004085580 5.712832e-08 6.078853e-07 13 110879842 110880112 271 - 2.090 1.918 -0.576
ENSG00000088448 E008 12.8921650 0.0081979650 3.704512e-07 3.363569e-06 13 110883195 110883552 358 - 1.311 0.739 -2.119
ENSG00000088448 E009 8.4300046 0.0336022171 9.651600e-03 2.790669e-02 13 110883553 110883697 145 - 1.103 0.736 -1.391
ENSG00000088448 E010 21.2728133 0.0017261474 1.473419e-02 3.989086e-02 13 110883698 110883708 11 - 1.418 1.248 -0.592
ENSG00000088448 E011 48.3757322 0.0004755759 2.268404e-08 2.617986e-07 13 110883709 110883793 85 - 1.796 1.521 -0.934
ENSG00000088448 E012 60.8598090 0.0022677534 6.454178e-22 5.094686e-20 13 110892692 110892956 265 - 1.507 2.006 1.687
ENSG00000088448 E013 51.3304671 0.0005224909 1.577189e-25 1.823025e-23 13 110892957 110893027 71 - 1.409 1.949 1.835
ENSG00000088448 E014 122.0826737 0.0002913072 3.223789e-03 1.092651e-02 13 110893028 110893196 169 - 2.043 2.152 0.367
ENSG00000088448 E015 75.8702617 0.0008898477 9.690809e-01 9.846579e-01 13 110893197 110893263 67 - 1.878 1.897 0.062
ENSG00000088448 E016 35.6359915 0.0031584302 6.700858e-01 7.766557e-01 13 110894109 110894202 94 - 1.544 1.585 0.140
ENSG00000088448 E017 14.5951009 0.0191616749 4.561942e-02 1.013327e-01 13 110894285 110894393 109 - 1.265 1.051 -0.763
ENSG00000088448 E018 19.7904754 0.0200943271 1.974726e-03 7.148292e-03 13 110900530 110900661 132 - 1.427 1.096 -1.164
ENSG00000088448 E019 10.9891220 0.0016426469 2.207614e-03 7.865972e-03 13 110900662 110900694 33 - 1.184 0.877 -1.129
ENSG00000088448 E020 10.2296144 0.0170097787 1.036526e-04 5.388477e-04 13 110900695 110900739 45 - 1.199 0.705 -1.862
ENSG00000088448 E021 4.0808163 0.0537961942 2.009967e-02 5.169648e-02 13 110903475 110903475 1 - 0.843 0.420 -1.871
ENSG00000088448 E022 8.6847552 0.0214030371 4.049409e-01 5.486164e-01 13 110903476 110903539 64 - 1.025 0.922 -0.386
ENSG00000088448 E023 12.0969620 0.0026526217 3.047208e-06 2.276448e-05 13 110904031 110904342 312 - 1.265 0.771 -1.829
ENSG00000088448 E024 8.6433684 0.0024987676 5.218235e-03 1.652451e-02 13 110905023 110905233 211 - 1.085 0.771 -1.189
ENSG00000088448 E025 64.7624923 0.0024852803 4.755876e-01 6.143033e-01 13 110906033 110906124 92 - 1.827 1.806 -0.071
ENSG00000088448 E026 71.4446777 0.0004356320 3.653279e-01 5.096561e-01 13 110910618 110910770 153 - 1.869 1.849 -0.066
ENSG00000088448 E027 2.6376065 0.0832974031 7.453713e-01 8.334235e-01 13 110911654 110911771 118 - 0.524 0.587 0.291
ENSG00000088448 E028 0.9223296 0.0134091579 2.268357e-01 3.586108e-01 13 110914508 110914724 217 - 0.361 0.149 -1.666
ENSG00000088448 E029 50.6395070 0.0053395608 3.604071e-01 5.047202e-01 13 110914725 110915071 347 - 1.683 1.745 0.208