ENSG00000088305

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000348286 ENSG00000088305 HEK293_OSMI2_2hA HEK293_TMG_2hB DNMT3B protein_coding protein_coding 14.66906 17.66235 13.6734 0.1262034 0.1831989 -0.3690668 6.1847929 5.4811011 7.0266603 0.4984502 0.4063576 0.3577954 0.43365000 0.310633333 0.51453333 0.2039000 0.004697153 0.0002605511 FALSE TRUE
ENST00000443239 ENSG00000088305 HEK293_OSMI2_2hA HEK293_TMG_2hB DNMT3B protein_coding protein_coding 14.66906 17.66235 13.6734 0.1262034 0.1831989 -0.3690668 3.0919348 5.0240954 2.3396644 1.3640274 0.3477907 -1.0992778 0.21110417 0.285000000 0.17053333 -0.1144667 0.477547896 0.0002605511 FALSE TRUE
ENST00000696232 ENSG00000088305 HEK293_OSMI2_2hA HEK293_TMG_2hB DNMT3B protein_coding protein_coding 14.66906 17.66235 13.6734 0.1262034 0.1831989 -0.3690668 0.2615792 0.1511916 0.8755686 0.1511916 0.4801403 2.4578276 0.01696667 0.008566667 0.06456667 0.0560000 0.488998861 0.0002605511 FALSE TRUE
ENST00000696245 ENSG00000088305 HEK293_OSMI2_2hA HEK293_TMG_2hB DNMT3B protein_coding processed_transcript 14.66906 17.66235 13.6734 0.1262034 0.1831989 -0.3690668 2.3896011 4.7524590 0.4410679 1.0066621 0.1796498 -3.4002901 0.14559583 0.269000000 0.03196667 -0.2370333 0.002703679 0.0002605511 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000088305 E001 1.0759214 0.0120327826 2.168671e-02 5.502406e-02 20 32762385 32762399 15 + 0.498 0.113 -2.858
ENSG00000088305 E002 5.2725366 0.0584968293 2.257328e-04 1.073565e-03 20 32762400 32762423 24 + 1.042 0.445 -2.485
ENSG00000088305 E003 5.6842085 0.0037809556 8.862271e-08 9.086106e-07 20 32762424 32762445 22 + 1.095 0.395 -2.950
ENSG00000088305 E004 16.0692775 0.0047963928 8.476787e-08 8.727253e-07 20 32762446 32762595 150 + 1.433 0.982 -1.603
ENSG00000088305 E005 10.8516945 0.0209995187 3.685094e-03 1.225327e-02 20 32762596 32762617 22 + 1.223 0.910 -1.142
ENSG00000088305 E006 13.9944068 0.0563748541 5.695570e-02 1.213842e-01 20 32762618 32762641 24 + 1.284 1.062 -0.791
ENSG00000088305 E007 13.3289358 0.0672062580 1.269691e-01 2.299323e-01 20 32762642 32762645 4 + 1.241 1.071 -0.610
ENSG00000088305 E008 24.1061073 0.0355979327 1.423402e-02 3.875806e-02 20 32762646 32762699 54 + 1.512 1.284 -0.788
ENSG00000088305 E009 0.1451727 0.0432938925 3.838433e-01   20 32762700 32762761 62 + 0.133 0.000 -12.305
ENSG00000088305 E010 0.5996172 0.3753119121 8.116566e-01 8.804686e-01 20 32762762 32762861 100 + 0.235 0.196 -0.331
ENSG00000088305 E011 0.1515154 0.0432129082 3.833092e-01   20 32779852 32780145 294 + 0.133 0.000 -12.307
ENSG00000088305 E012 0.1451727 0.0432938925 3.838433e-01   20 32780315 32780317 3 + 0.133 0.000 -12.305
ENSG00000088305 E013 20.0006296 0.0279167082 4.555069e-02 1.012037e-01 20 32780318 32780323 6 + 1.410 1.233 -0.619
ENSG00000088305 E014 61.4177955 0.0099436428 2.527770e-03 8.846005e-03 20 32780324 32780465 142 + 1.876 1.717 -0.535
ENSG00000088305 E015 57.3752383 0.0038602703 2.521580e-04 1.184258e-03 20 32781353 32781414 62 + 1.848 1.682 -0.559
ENSG00000088305 E016 79.0621131 0.0048576483 2.320017e-03 8.213796e-03 20 32784758 32784859 102 + 1.962 1.838 -0.416
ENSG00000088305 E017 71.1528001 0.0003965705 4.699756e-07 4.179284e-06 20 32786502 32786627 126 + 1.944 1.767 -0.597
ENSG00000088305 E018 115.6289954 0.0008915692 2.613786e-04 1.222169e-03 20 32787230 32787451 222 + 2.111 2.016 -0.316
ENSG00000088305 E019 0.4751703 0.0204760141 7.308197e-01 8.226330e-01 20 32787452 32787457 6 + 0.133 0.202 0.726
ENSG00000088305 E020 90.3657662 0.0063917310 6.367806e-03 1.957839e-02 20 32788854 32789012 159 + 2.015 1.907 -0.362
ENSG00000088305 E021 1.9178128 0.0964706362 1.499122e-03 5.632768e-03 20 32791486 32791600 115 + 0.723 0.112 -3.865
ENSG00000088305 E022 80.3696676 0.0013876067 3.368932e-03 1.134800e-02 20 32791601 32791708 108 + 1.956 1.866 -0.303
ENSG00000088305 E023 1.5113377 0.0090573832 9.378367e-02 1.810358e-01 20 32792416 32792625 210 + 0.545 0.276 -1.497
ENSG00000088305 E024 93.2721067 0.0044665527 2.224456e-01 3.533180e-01 20 32792626 32792770 145 + 1.983 1.959 -0.079
ENSG00000088305 E025 4.3617443 0.0401467257 5.351554e-02 1.154014e-01 20 32792771 32793262 492 + 0.871 0.595 -1.131
ENSG00000088305 E026 0.8845503 0.2392264267 7.182778e-01 8.134307e-01 20 32793536 32793595 60 + 0.316 0.269 -0.319
ENSG00000088305 E027 1.6167565 0.1653529440 1.136159e-01 2.108046e-01 20 32793596 32793755 160 + 0.586 0.271 -1.720
ENSG00000088305 E028 3.2922780 0.0060651101 5.624251e-01 6.900220e-01 20 32795141 32795314 174 + 0.661 0.598 -0.273
ENSG00000088305 E029 1.8434977 0.0505315835 9.081144e-01 9.456601e-01 20 32795315 32795408 94 + 0.445 0.444 -0.006
ENSG00000088305 E030 50.1066276 0.0041775282 9.495852e-01 9.724269e-01 20 32795409 32795418 10 + 1.683 1.713 0.100
ENSG00000088305 E031 106.8097885 0.0003429775 9.132279e-01 9.490193e-01 20 32795419 32795534 116 + 2.010 2.039 0.098
ENSG00000088305 E032 68.6632780 0.0018248106 5.860629e-01 7.097016e-01 20 32795650 32795694 45 + 1.834 1.842 0.028
ENSG00000088305 E033 61.2064901 0.0004869340 8.521957e-01 9.083877e-01 20 32796790 32796811 22 + 1.765 1.806 0.139
ENSG00000088305 E034 75.7821409 0.0011703260 4.863240e-01 6.240846e-01 20 32796812 32796869 58 + 1.879 1.883 0.012
ENSG00000088305 E035 1.0747875 0.0431639124 9.924916e-01 9.993917e-01 20 32796870 32796940 71 + 0.317 0.338 0.132
ENSG00000088305 E036 1.3337860 0.0301292187 4.306231e-02 9.666299e-02 20 32796941 32797186 246 + 0.545 0.201 -2.086
ENSG00000088305 E037 63.9737781 0.0025491092 7.410428e-01 8.303415e-01 20 32797187 32797229 43 + 1.799 1.815 0.057
ENSG00000088305 E038 60.6979183 0.0004191161 9.755277e-01 9.887266e-01 20 32797230 32797299 70 + 1.762 1.796 0.115
ENSG00000088305 E039 97.1843368 0.0023698333 3.152144e-01 4.579607e-01 20 32798460 32798643 184 + 1.937 2.012 0.251
ENSG00000088305 E040 3.0967579 0.0049834529 5.573408e-02 1.192395e-01 20 32798644 32799215 572 + 0.752 0.487 -1.167
ENSG00000088305 E041 84.0935451 0.0060113662 9.421582e-01 9.676930e-01 20 32799244 32799328 85 + 1.905 1.932 0.090
ENSG00000088305 E042 120.4169788 0.0002817402 3.426312e-01 4.866435e-01 20 32800153 32800298 146 + 2.038 2.101 0.213
ENSG00000088305 E043 115.0130204 0.0003215584 6.724705e-04 2.797670e-03 20 32800835 32800925 91 + 1.960 2.108 0.499
ENSG00000088305 E044 138.2078400 0.0014957512 1.414142e-03 5.353939e-03 20 32801278 32801426 149 + 2.042 2.186 0.484
ENSG00000088305 E045 98.2041737 0.0003401038 7.579481e-02 1.527710e-01 20 32802385 32802470 86 + 1.926 2.023 0.327
ENSG00000088305 E046 6.9409641 0.0103062446 2.114771e-01 3.402322e-01 20 32805338 32805407 70 + 0.779 0.967 0.725
ENSG00000088305 E047 12.6224512 0.0128544254 5.193723e-01 6.534823e-01 20 32806209 32806327 119 + 1.153 1.117 -0.131
ENSG00000088305 E048 707.4391123 0.0069567019 1.218745e-06 9.936207e-06 20 32807762 32809359 1598 + 2.717 2.911 0.646