ENSG00000088038

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000221232 ENSG00000088038 HEK293_OSMI2_2hA HEK293_TMG_2hB CNOT3 protein_coding protein_coding 69.69363 85.35596 66.98552 7.690699 1.131967 -0.3495963 31.947324 52.018962 23.410616 3.6319392 1.3980084 -1.1515359 0.44495000 0.61176667 0.3497000 -0.26206667 4.502711e-10 4.502711e-10 FALSE TRUE
ENST00000644245 ENSG00000088038 HEK293_OSMI2_2hA HEK293_TMG_2hB CNOT3 protein_coding protein_coding 69.69363 85.35596 66.98552 7.690699 1.131967 -0.3495963 14.636243 8.580426 22.370956 2.0412883 0.7293757 1.3814701 0.21893750 0.10020000 0.3338333 0.23363333 8.592531e-07 4.502711e-10 FALSE FALSE
ENST00000644707 ENSG00000088038 HEK293_OSMI2_2hA HEK293_TMG_2hB CNOT3 protein_coding retained_intron 69.69363 85.35596 66.98552 7.690699 1.131967 -0.3495963 6.037859 4.391994 7.896809 4.3919943 0.9148415 0.8449383 0.08672917 0.04456667 0.1179667 0.07340000 1.218120e-01 4.502711e-10   FALSE
MSTRG.17671.1 ENSG00000088038 HEK293_OSMI2_2hA HEK293_TMG_2hB CNOT3 protein_coding   69.69363 85.35596 66.98552 7.690699 1.131967 -0.3495963 6.553775 9.363629 5.766810 0.9204215 1.2101297 -0.6983346 0.08980417 0.11036667 0.0860000 -0.02436667 5.976655e-01 4.502711e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000088038 E001 0.0000000       19 54137594 54137642 49 +      
ENSG00000088038 E002 0.6558305 0.0666735311 5.405888e-01 6.717152e-01 19 54137643 54137724 82 + 0.274 0.171 -0.867
ENSG00000088038 E003 11.2321626 0.0015091444 1.008517e-02 2.897095e-02 19 54137725 54137748 24 + 1.203 0.963 -0.870
ENSG00000088038 E004 14.2539036 0.0016986375 4.061796e-03 1.331537e-02 19 54137749 54137761 13 + 1.299 1.055 -0.869
ENSG00000088038 E005 14.7290738 0.0023552878 5.251703e-03 1.661661e-02 19 54137762 54137762 1 + 1.309 1.073 -0.837
ENSG00000088038 E006 29.9338806 0.0068235810 2.186669e-02 5.540059e-02 19 54137763 54137768 6 + 1.559 1.404 -0.533
ENSG00000088038 E007 38.4914446 0.0067183871 4.009853e-04 1.778218e-03 19 54137769 54137773 5 + 1.705 1.480 -0.769
ENSG00000088038 E008 77.5913145 0.0087039320 4.974822e-02 1.087142e-01 19 54137774 54137781 8 + 1.927 1.828 -0.335
ENSG00000088038 E009 262.8157900 0.0035423190 9.704150e-04 3.857207e-03 19 54137782 54137993 212 + 2.452 2.352 -0.334
ENSG00000088038 E010 12.7110260 0.0014185968 3.335794e-01 4.773183e-01 19 54139276 54139513 238 + 1.152 1.073 -0.285
ENSG00000088038 E011 26.1521409 0.0007227549 7.478906e-06 5.112974e-05 19 54141396 54142925 1530 + 1.574 1.286 -0.997
ENSG00000088038 E012 27.4601272 0.0167567902 4.870958e-01 6.247975e-01 19 54142926 54142928 3 + 1.452 1.405 -0.160
ENSG00000088038 E013 286.9068448 0.0015147634 3.308382e-06 2.454429e-05 19 54142929 54143003 75 + 2.497 2.383 -0.380
ENSG00000088038 E014 349.9352983 0.0007936201 4.001843e-07 3.608115e-06 19 54143119 54143186 68 + 2.576 2.473 -0.340
ENSG00000088038 E015 0.0000000       19 54143187 54143339 153 +      
ENSG00000088038 E016 440.1439982 0.0006190145 1.321388e-08 1.592651e-07 19 54143442 54143516 75 + 2.674 2.573 -0.337
ENSG00000088038 E017 560.8688051 0.0007690268 4.336267e-12 9.573393e-11 19 54143660 54143736 77 + 2.792 2.671 -0.400
ENSG00000088038 E018 397.1688999 0.0006263403 1.106179e-12 2.692911e-11 19 54143737 54143749 13 + 2.652 2.516 -0.454
ENSG00000088038 E019 3.3162140 0.0067606728 6.749549e-03 2.057346e-02 19 54143750 54144004 255 + 0.827 0.429 -1.761
ENSG00000088038 E020 1.4393301 0.1185432947 8.699962e-02 1.705927e-01 19 54144005 54144005 1 + 0.562 0.237 -1.866
ENSG00000088038 E021 772.6985483 0.0006087873 8.540794e-16 3.255589e-14 19 54144006 54144134 129 + 2.931 2.812 -0.398
ENSG00000088038 E022 448.1500213 0.0002484125 7.216276e-13 1.809772e-11 19 54144237 54144263 27 + 2.693 2.577 -0.386
ENSG00000088038 E023 596.7682523 0.0002861420 6.600719e-11 1.199853e-09 19 54144264 54144332 69 + 2.802 2.710 -0.306
ENSG00000088038 E024 8.5927385 0.0020610124 5.011108e-01 6.372860e-01 19 54145542 54145594 53 + 0.881 0.974 0.353
ENSG00000088038 E025 74.4916684 0.0020910153 2.644118e-01 4.023778e-01 19 54145595 54145597 3 + 1.869 1.832 -0.125
ENSG00000088038 E026 748.1805069 0.0002141613 8.912108e-13 2.207022e-11 19 54145598 54145817 220 + 2.897 2.809 -0.293
ENSG00000088038 E027 350.4135080 0.0001592678 3.777286e-01 5.220342e-01 19 54145910 54146043 134 + 2.510 2.508 -0.007
ENSG00000088038 E028 210.2791556 0.0002318154 4.783642e-04 2.077213e-03 19 54146601 54146657 57 + 2.206 2.318 0.374
ENSG00000088038 E029 632.1319787 0.0013366333 3.955792e-09 5.251667e-08 19 54148148 54148535 388 + 2.651 2.808 0.520
ENSG00000088038 E030 442.3621245 0.0005868428 2.130575e-15 7.710240e-14 19 54148620 54148743 124 + 2.467 2.660 0.643
ENSG00000088038 E031 246.8989471 0.0002136762 2.051682e-07 1.962362e-06 19 54149560 54149569 10 + 2.249 2.399 0.499
ENSG00000088038 E032 667.7229561 0.0009156520 3.083756e-06 2.300758e-05 19 54149570 54149729 160 + 2.707 2.822 0.380
ENSG00000088038 E033 416.2728836 0.0030240527 4.340944e-02 9.731258e-02 19 54149730 54149758 29 + 2.524 2.610 0.286
ENSG00000088038 E034 559.8855648 0.0012527764 1.839097e-02 4.799215e-02 19 54152226 54152325 100 + 2.661 2.734 0.245
ENSG00000088038 E035 1.7349610 0.0080051969 1.472775e-03 5.548407e-03 19 54152326 54152335 10 + 0.695 0.171 -3.039
ENSG00000088038 E036 744.7331325 0.0007708169 6.003362e-05 3.316185e-04 19 54152428 54152626 199 + 2.770 2.864 0.314
ENSG00000088038 E037 233.7991444 0.0011745034 2.465822e-03 8.661535e-03 19 54152867 54152870 4 + 2.258 2.366 0.362
ENSG00000088038 E038 595.7306037 0.0017330480 1.508908e-06 1.205898e-05 19 54152871 54152999 129 + 2.640 2.781 0.468
ENSG00000088038 E039 17.8838163 0.0010608374 3.114470e-01 4.539019e-01 19 54153000 54153082 83 + 1.166 1.269 0.366
ENSG00000088038 E040 2.2497849 0.0349347034 1.853681e-02 4.831184e-02 19 54153181 54153393 213 + 0.732 0.341 -1.881
ENSG00000088038 E041 5.2820067 0.0031508190 3.440630e-02 8.053687e-02 19 54153497 54153714 218 + 0.928 0.664 -1.050
ENSG00000088038 E042 302.2433591 0.0035041467 6.419962e-04 2.687352e-03 19 54153715 54153723 9 + 2.345 2.488 0.476
ENSG00000088038 E043 622.8627352 0.0033008815 1.034436e-06 8.553942e-06 19 54153724 54153840 117 + 2.635 2.809 0.578
ENSG00000088038 E044 39.7867729 0.0046865034 9.678637e-01 9.839119e-01 19 54153841 54153943 103 + 1.569 1.583 0.047
ENSG00000088038 E045 168.6901457 0.0036503863 4.516611e-01 5.925899e-01 19 54153944 54155257 1314 + 2.205 2.193 -0.041
ENSG00000088038 E046 40.6410683 0.0080401773 8.612091e-02 1.691884e-01 19 54155258 54155308 51 + 1.478 1.624 0.501
ENSG00000088038 E047 499.8787988 0.0044914112 1.055348e-12 2.579110e-11 19 54155309 54155681 373 + 2.451 2.737 0.952