ENSG00000087903

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000303657 ENSG00000087903 HEK293_OSMI2_2hA HEK293_TMG_2hB RFX2 protein_coding protein_coding 6.46859 7.445039 6.015518 0.4433687 0.3267742 -0.3071308 1.2973674 2.22108808 0.5567922 0.25098709 0.10279779 -1.9768556 0.19769167 0.30460000 0.09316667 -0.21143333 0.002271271 9.414764e-05 FALSE TRUE
ENST00000359161 ENSG00000087903 HEK293_OSMI2_2hA HEK293_TMG_2hB RFX2 protein_coding protein_coding 6.46859 7.445039 6.015518 0.4433687 0.3267742 -0.3071308 0.8831807 0.34888498 0.8456023 0.34888498 0.19477823 1.2534188 0.13792917 0.04400000 0.14253333 0.09853333 0.198656336 9.414764e-05 FALSE TRUE
ENST00000587700 ENSG00000087903 HEK293_OSMI2_2hA HEK293_TMG_2hB RFX2 protein_coding processed_transcript 6.46859 7.445039 6.015518 0.4433687 0.3267742 -0.3071308 1.0039259 0.56402414 1.0670764 0.09112899 0.01549240 0.9079373 0.16189167 0.07480000 0.17860000 0.10380000 0.001283608 9.414764e-05   FALSE
ENST00000589641 ENSG00000087903 HEK293_OSMI2_2hA HEK293_TMG_2hB RFX2 protein_coding processed_transcript 6.46859 7.445039 6.015518 0.4433687 0.3267742 -0.3071308 0.2216570 0.09235246 0.7538688 0.04855279 0.23209149 2.8997791 0.03670833 0.01273333 0.12273333 0.11000000 0.001512132 9.414764e-05   FALSE
ENST00000590778 ENSG00000087903 HEK293_OSMI2_2hA HEK293_TMG_2hB RFX2 protein_coding retained_intron 6.46859 7.445039 6.015518 0.4433687 0.3267742 -0.3071308 0.4155115 0.67984652 0.2765796 0.37141779 0.02299222 -1.2673396 0.06602500 0.09823333 0.04660000 -0.05163333 0.780923535 9.414764e-05 FALSE TRUE
ENST00000590822 ENSG00000087903 HEK293_OSMI2_2hA HEK293_TMG_2hB RFX2 protein_coding processed_transcript 6.46859 7.445039 6.015518 0.4433687 0.3267742 -0.3071308 0.9376726 1.35973759 0.6901766 0.36751946 0.26590335 -0.9681088 0.13913333 0.17810000 0.11063333 -0.06746667 0.637772363 9.414764e-05   FALSE
MSTRG.16272.26 ENSG00000087903 HEK293_OSMI2_2hA HEK293_TMG_2hB RFX2 protein_coding   6.46859 7.445039 6.015518 0.4433687 0.3267742 -0.3071308 0.2147219 0.00000000 0.2773288 0.00000000 0.27732875 4.8446305 0.03623750 0.00000000 0.05116667 0.05116667 0.809179218 9.414764e-05   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000087903 E001 10.6208838 0.0018203115 2.257024e-02 5.686312e-02 19 5993164 5993516 353 - 0.863 1.109 0.912
ENSG00000087903 E002 84.2553179 0.0058770306 4.906057e-05 2.770059e-04 19 5993517 5994501 985 - 1.758 1.963 0.693
ENSG00000087903 E003 32.4937967 0.0006943687 1.034814e-01 1.957977e-01 19 5994502 5994815 314 - 1.425 1.522 0.335
ENSG00000087903 E004 19.7775972 0.0013859849 5.438592e-01 6.744067e-01 19 5994816 5994950 135 - 1.325 1.271 -0.191
ENSG00000087903 E005 11.1868292 0.0836188600 9.970011e-01 1.000000e+00 19 5995601 5995643 43 - 1.061 1.059 -0.007
ENSG00000087903 E006 20.2987307 0.0083959609 3.216765e-01 4.649296e-01 19 5997060 5997213 154 - 1.240 1.323 0.289
ENSG00000087903 E007 3.8516855 0.0048903199 7.566780e-01 8.417273e-01 19 5997214 5997373 160 - 0.639 0.680 0.172
ENSG00000087903 E008 23.3687100 0.0008425143 7.714586e-01 8.524679e-01 19 6001815 6002023 209 - 1.374 1.346 -0.098
ENSG00000087903 E009 12.1293932 0.0014789358 6.836215e-01 7.867757e-01 19 6002721 6002721 1 - 1.120 1.074 -0.167
ENSG00000087903 E010 22.8786814 0.0008163464 2.186671e-01 3.488139e-01 19 6002722 6002870 149 - 1.411 1.315 -0.332
ENSG00000087903 E011 20.6035070 0.0011441044 4.307607e-01 5.733680e-01 19 6004201 6004298 98 - 1.260 1.316 0.194
ENSG00000087903 E012 22.2711336 0.0009006728 8.133824e-01 8.816743e-01 19 6007012 6007166 155 - 1.351 1.326 -0.085
ENSG00000087903 E013 17.8299883 0.0011902483 5.277818e-01 6.607753e-01 19 6007690 6007774 85 - 1.280 1.221 -0.207
ENSG00000087903 E014 9.7270538 0.0018298836 1.854995e-01 3.081282e-01 19 6007775 6007802 28 - 1.091 0.946 -0.535
ENSG00000087903 E015 1.4821784 0.0098554627 2.908182e-01 4.316070e-01 19 6007866 6008105 240 - 0.491 0.303 -1.057
ENSG00000087903 E016 11.2547796 0.0016374499 8.427172e-02 1.662538e-01 19 6008106 6008188 83 - 0.932 1.109 0.650
ENSG00000087903 E017 11.6183366 0.0116623560 1.111108e-01 2.071731e-01 19 6008189 6008224 36 - 0.932 1.113 0.664
ENSG00000087903 E018 0.0000000       19 6008225 6008226 2 -      
ENSG00000087903 E019 13.3823421 0.0050673946 6.126350e-01 7.315201e-01 19 6010136 6010181 46 - 1.091 1.135 0.159
ENSG00000087903 E020 14.5519483 0.0046269073 1.508777e-01 2.628642e-01 19 6010182 6010251 70 - 1.061 1.195 0.484
ENSG00000087903 E021 11.6021459 0.0161013921 7.728514e-01 8.533898e-01 19 6012986 6013038 53 - 1.060 1.083 0.084
ENSG00000087903 E022 13.9175651 0.0922578890 6.960034e-01 7.964565e-01 19 6013039 6013105 67 - 1.132 1.155 0.085
ENSG00000087903 E023 24.3019256 0.0055811902 2.442396e-01 3.791881e-01 19 6016090 6016271 182 - 1.308 1.395 0.304
ENSG00000087903 E024 0.0000000       19 6023096 6023205 110 -      
ENSG00000087903 E025 8.0191337 0.0024499724 6.587766e-01 7.677885e-01 19 6026163 6026195 33 - 0.888 0.933 0.173
ENSG00000087903 E026 8.4256429 0.0361170459 2.323124e-01 3.651887e-01 19 6026196 6026237 42 - 0.810 0.989 0.680
ENSG00000087903 E027 2.6162970 0.0059381413 1.378955e-01 2.451520e-01 19 6026238 6026699 462 - 0.354 0.605 1.265
ENSG00000087903 E028 0.8867258 0.0177764484 3.938306e-01 5.377260e-01 19 6027164 6027334 171 - 0.152 0.303 1.265
ENSG00000087903 E029 15.4244034 0.0018450481 4.427934e-02 9.889696e-02 19 6039980 6040034 55 - 1.044 1.228 0.659
ENSG00000087903 E030 12.5906870 0.0228436996 2.077500e-01 3.357786e-01 19 6040035 6040073 39 - 0.992 1.140 0.539
ENSG00000087903 E031 7.6418311 0.0531124748 3.311075e-01 4.746970e-01 19 6040074 6040085 12 - 0.810 0.950 0.536
ENSG00000087903 E032 17.0881259 0.0011753022 1.709409e-01 2.894045e-01 19 6040086 6040185 100 - 1.147 1.259 0.399
ENSG00000087903 E033 13.6114934 0.0014795577 5.915169e-01 7.142791e-01 19 6040186 6040202 17 - 1.106 1.150 0.158
ENSG00000087903 E034 14.6619250 0.0012330543 1.587951e-01 2.735338e-01 19 6040203 6040241 39 - 1.076 1.201 0.447
ENSG00000087903 E035 15.5099422 0.0011672006 1.780441e-01 2.986912e-01 19 6042044 6042123 80 - 1.106 1.221 0.412
ENSG00000087903 E036 13.2672470 0.0081070193 1.312879e-01 2.359379e-01 19 6044193 6044282 90 - 1.028 1.179 0.545
ENSG00000087903 E037 8.6360996 0.0020967045 2.759275e-04 1.281688e-03 19 6047407 6047504 98 - 0.595 1.064 1.850
ENSG00000087903 E038 0.0000000       19 6049136 6049232 97 -      
ENSG00000087903 E039 0.0000000       19 6057162 6057283 122 -      
ENSG00000087903 E040 0.2214452 0.0371822263 7.610396e-01   19 6072005 6072147 143 - 0.000 0.098 7.973
ENSG00000087903 E041 6.8747203 0.1010189100 4.912675e-01 6.285627e-01 19 6078101 6078334 234 - 0.781 0.916 0.520
ENSG00000087903 E042 17.4751726 0.0012638345 1.601282e-05 1.015398e-04 19 6110393 6110601 209 - 0.932 1.336 1.452
ENSG00000087903 E043 0.0000000       19 6113562 6113761 200 -      
ENSG00000087903 E044 1.4789707 0.2328873693 2.244237e-01 3.557173e-01 19 6148231 6148329 99 - 0.546 0.294 -1.380
ENSG00000087903 E045 0.0000000       19 6175873 6176255 383 -      
ENSG00000087903 E046 0.0000000       19 6176256 6176274 19 -      
ENSG00000087903 E047 1.4382849 0.0143206159 2.930428e-01 4.340721e-01 19 6176275 6176443 169 - 0.491 0.303 -1.058
ENSG00000087903 E048 38.4480692 0.0223892793 3.310979e-05 1.948784e-04 19 6189728 6191325 1598 - 1.779 1.418 -1.233
ENSG00000087903 E049 7.3739229 0.0024160763 3.915896e-04 1.742343e-03 19 6191326 6191438 113 - 1.133 0.723 -1.556
ENSG00000087903 E050 4.9382941 0.0033127419 3.135065e-03 1.066199e-02 19 6191439 6191452 14 - 0.973 0.577 -1.598
ENSG00000087903 E051 7.5286366 0.0023853529 2.502654e-07 2.353889e-06 19 6191453 6191569 117 - 1.207 0.605 -2.320
ENSG00000087903 E052 3.9794234 0.0039685034 1.237952e-06 1.007935e-05 19 6191570 6191594 25 - 1.010 0.303 -3.195
ENSG00000087903 E053 3.9459104 0.0078058004 8.341135e-05 4.441392e-04 19 6191595 6191610 16 - 0.973 0.400 -2.474
ENSG00000087903 E054 9.3118607 0.0018534910 5.762512e-12 1.246649e-10 19 6191611 6191864 254 - 1.334 0.577 -2.890
ENSG00000087903 E055 6.8686680 0.0024478294 1.125947e-08 1.374845e-07 19 6191865 6192029 165 - 1.207 0.514 -2.736
ENSG00000087903 E056 0.8211642 0.1811357861 9.634327e-02 1.848867e-01 19 6192030 6192053 24 - 0.429 0.099 -2.721
ENSG00000087903 E057 4.3889146 0.0035859961 3.883772e-04 1.729837e-03 19 6199476 6199479 4 - 0.973 0.480 -2.057
ENSG00000087903 E058 5.1252734 0.0031514330 1.259100e-05 8.176210e-05 19 6199480 6199572 93 - 1.061 0.480 -2.379