ENSG00000087884

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000393427 ENSG00000087884 HEK293_OSMI2_2hA HEK293_TMG_2hB AAMDC protein_coding protein_coding 64.19941 109.0468 37.70421 4.017938 0.3833663 -1.531899 41.21489 72.00891 19.17527 2.396401 0.3002348 -1.9083767 0.6264583 0.6605667 0.5088 -0.1517667 2.479640e-09 2.47964e-09 FALSE TRUE
ENST00000526415 ENSG00000087884 HEK293_OSMI2_2hA HEK293_TMG_2hB AAMDC protein_coding protein_coding 64.19941 109.0468 37.70421 4.017938 0.3833663 -1.531899 14.49240 20.37407 12.97919 1.948164 0.5698265 -0.6501299 0.2411125 0.1861333 0.3440 0.1578667 5.316473e-08 2.47964e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000087884 E001 0.1482932 0.0411059639 1.000000e+00   11 77821109 77821112 4 + 0.000 0.072 8.264
ENSG00000087884 E002 0.3697384 0.0246578076 7.824233e-01 8.603028e-01 11 77821113 77821113 1 + 0.000 0.135 11.012
ENSG00000087884 E003 1.6294394 0.0371249697 2.656559e-01 4.037136e-01 11 77821114 77821128 15 + 0.523 0.319 -1.104
ENSG00000087884 E004 1.6294394 0.0371249697 2.656559e-01 4.037136e-01 11 77821129 77821134 6 + 0.523 0.319 -1.104
ENSG00000087884 E005 1.9594369 0.0096353709 4.490605e-01 5.902667e-01 11 77821135 77821135 1 + 0.523 0.389 -0.687
ENSG00000087884 E006 3.5501651 0.0193994512 9.688314e-01 9.844889e-01 11 77821136 77821141 6 + 0.593 0.591 -0.011
ENSG00000087884 E007 4.1005637 0.0042112118 8.737042e-01 9.228300e-01 11 77821142 77821143 2 + 0.653 0.630 -0.100
ENSG00000087884 E008 4.2488569 0.0043498116 9.613230e-01 9.796402e-01 11 77821144 77821144 1 + 0.653 0.648 -0.022
ENSG00000087884 E009 14.4832499 0.0013854216 8.712221e-01 9.212053e-01 11 77821145 77821153 9 + 1.082 1.101 0.068
ENSG00000087884 E010 33.0663780 0.0009149783 1.314205e-01 2.361256e-01 11 77821154 77821154 1 + 1.343 1.459 0.404
ENSG00000087884 E011 105.8725720 0.0003320865 4.970843e-01 6.336327e-01 11 77821155 77821161 7 + 1.958 1.933 -0.085
ENSG00000087884 E012 161.5874683 0.0002232329 6.825916e-01 7.860182e-01 11 77821162 77821180 19 + 2.129 2.118 -0.037
ENSG00000087884 E013 170.2299611 0.0002360017 7.250500e-01 8.183856e-01 11 77821181 77821186 6 + 2.149 2.140 -0.030
ENSG00000087884 E014 270.2504694 0.0007088599 5.431987e-01 6.738259e-01 11 77821187 77821237 51 + 2.352 2.337 -0.051
ENSG00000087884 E015 187.4109911 0.0035537416 4.581357e-01 5.984612e-01 11 77821238 77821241 4 + 2.205 2.174 -0.103
ENSG00000087884 E016 5.8613455 0.0028989768 1.593612e-01 2.742609e-01 11 77831892 77832012 121 + 0.903 0.714 -0.746
ENSG00000087884 E017 90.8740881 0.0003570726 6.083705e-07 5.293679e-06 11 77841019 77841060 42 + 2.025 1.826 -0.670
ENSG00000087884 E018 8.0410829 0.0022657513 6.987291e-02 1.431638e-01 11 77841061 77841137 77 + 1.038 0.821 -0.818
ENSG00000087884 E019 9.4804119 0.0018020629 2.719798e-02 6.639403e-02 11 77841138 77841224 87 + 1.122 0.877 -0.907
ENSG00000087884 E020 0.0000000       11 77841225 77841255 31 +      
ENSG00000087884 E021 563.4681802 0.0004898491 1.481218e-01 2.591233e-01 11 77842479 77842628 150 + 2.639 2.667 0.093
ENSG00000087884 E022 37.1391064 0.0156961563 6.471807e-01 7.589193e-01 11 77855345 77855482 138 + 1.454 1.493 0.135
ENSG00000087884 E023 436.0626055 0.0011334983 1.283891e-01 2.319098e-01 11 77869722 77869817 96 + 2.520 2.558 0.126
ENSG00000087884 E024 318.9762219 0.0003549612 7.332650e-03 2.208328e-02 11 77872175 77872354 180 + 2.361 2.428 0.223
ENSG00000087884 E025 0.1472490 0.0433364544 1.428577e-01   11 77876948 77876949 2 + 0.200 0.000 -12.707
ENSG00000087884 E026 1.5510785 0.0091320969 2.211297e-03 7.878056e-03 11 77876950 77877049 100 + 0.706 0.189 -2.908
ENSG00000087884 E027 0.6632043 0.0179376923 9.564896e-01 9.767309e-01 11 77878702 77878756 55 + 0.200 0.189 -0.101
ENSG00000087884 E028 2.9901049 0.2239726834 7.917705e-02 1.581946e-01 11 77884780 77884916 137 + 0.795 0.456 -1.494
ENSG00000087884 E029 3.7361134 0.0046755693 1.265543e-02 3.510042e-02 11 77900571 77900785 215 + 0.870 0.502 -1.560
ENSG00000087884 E030 5.1250154 0.0270213002 1.826269e-01 3.044912e-01 11 77918061 77918432 372 + 0.871 0.664 -0.828