ENSG00000087502

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360150 ENSG00000087502 HEK293_OSMI2_2hA HEK293_TMG_2hB ERGIC2 protein_coding protein_coding 29.53483 8.089092 41.92708 0.6204769 2.046734 2.372394 1.9739285 0.5753987 3.323597 0.09243721 0.3288753 2.509588 0.06987500 0.07076667 0.07900000 0.008233333 8.389760e-01 3.375113e-55 FALSE TRUE
ENST00000548098 ENSG00000087502 HEK293_OSMI2_2hA HEK293_TMG_2hB ERGIC2 protein_coding retained_intron 29.53483 8.089092 41.92708 0.6204769 2.046734 2.372394 0.2253404 0.5636224 0.226318 0.34059215 0.2263180 -1.279372 0.01218750 0.07456667 0.00590000 -0.068666667 3.319312e-01 3.375113e-55   FALSE
ENST00000548909 ENSG00000087502 HEK293_OSMI2_2hA HEK293_TMG_2hB ERGIC2 protein_coding protein_coding 29.53483 8.089092 41.92708 0.6204769 2.046734 2.372394 0.4239310 2.0711941 0.000000 0.29656245 0.0000000 -7.701268 0.05657083 0.25376667 0.00000000 -0.253766667 3.375113e-55 3.375113e-55 FALSE TRUE
ENST00000551467 ENSG00000087502 HEK293_OSMI2_2hA HEK293_TMG_2hB ERGIC2 protein_coding protein_coding 29.53483 8.089092 41.92708 0.6204769 2.046734 2.372394 5.5404646 0.5070726 6.929966 0.50707257 0.8526352 3.746490 0.15690833 0.06980000 0.16423333 0.094433333 2.051690e-01 3.375113e-55 FALSE TRUE
ENST00000552155 ENSG00000087502 HEK293_OSMI2_2hA HEK293_TMG_2hB ERGIC2 protein_coding protein_coding 29.53483 8.089092 41.92708 0.6204769 2.046734 2.372394 9.2427783 0.9496983 14.232464 0.51052289 0.7051837 3.891474 0.24625417 0.11030000 0.33946667 0.229166667 3.723107e-01 3.375113e-55 FALSE FALSE
MSTRG.7044.3 ENSG00000087502 HEK293_OSMI2_2hA HEK293_TMG_2hB ERGIC2 protein_coding   29.53483 8.089092 41.92708 0.6204769 2.046734 2.372394 8.6260515 2.5982804 12.807113 0.13784470 0.5515452 2.296900 0.33429583 0.32603333 0.30576667 -0.020266667 8.609800e-01 3.375113e-55 TRUE TRUE
MSTRG.7044.5 ENSG00000087502 HEK293_OSMI2_2hA HEK293_TMG_2hB ERGIC2 protein_coding   29.53483 8.089092 41.92708 0.6204769 2.046734 2.372394 2.8864060 0.0000000 4.148533 0.00000000 0.2137830 8.699931 0.06972083 0.00000000 0.09936667 0.099366667 5.737968e-17 3.375113e-55 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000087502 E001 12.2230499 0.0222798384 8.866704e-02 1.730875e-01 12 29337352 29337587 236 - 1.078 0.822 -0.964
ENSG00000087502 E002 40.6322436 0.0025297488 7.849910e-01 8.621363e-01 12 29337588 29338642 1055 - 1.530 1.515 -0.050
ENSG00000087502 E003 17.1633719 0.0288382367 7.400760e-02 1.499308e-01 12 29338643 29338869 227 - 1.110 1.335 0.796
ENSG00000087502 E004 18.0589780 0.0319987940 3.503300e-01 4.945159e-01 12 29338870 29338977 108 - 1.163 1.274 0.394
ENSG00000087502 E005 66.3849886 0.0003542026 1.200028e-01 2.199939e-01 12 29338978 29339850 873 - 1.752 1.671 -0.276
ENSG00000087502 E006 174.7230455 0.0002111425 8.136693e-03 2.413147e-02 12 29339851 29340856 1006 - 2.168 2.083 -0.287
ENSG00000087502 E007 130.6865461 0.0017202857 1.411183e-01 2.495770e-01 12 29340857 29341017 161 - 2.014 2.082 0.229
ENSG00000087502 E008 41.5621772 0.0069857012 8.704630e-04 3.510892e-03 12 29341018 29341019 2 - 1.479 1.724 0.838
ENSG00000087502 E009 42.4594129 0.0062750654 3.850255e-04 1.716927e-03 12 29341020 29341032 13 - 1.485 1.741 0.872
ENSG00000087502 E010 140.0936881 0.0002850617 9.939560e-06 6.610334e-05 12 29341033 29341218 186 - 2.020 2.180 0.535
ENSG00000087502 E011 83.3674979 0.0003310412 2.502838e-02 6.193169e-02 12 29341734 29341761 28 - 1.810 1.918 0.366
ENSG00000087502 E012 90.0725790 0.0003379221 1.990680e-01 3.250575e-01 12 29341762 29341816 55 - 1.855 1.918 0.214
ENSG00000087502 E013 1.0276452 0.0427352381 1.049897e-02 2.997647e-02 12 29341817 29341865 49 - 0.114 0.583 3.236
ENSG00000087502 E014 88.7734385 0.0003758618 4.245496e-01 5.675090e-01 12 29343120 29343162 43 - 1.853 1.895 0.144
ENSG00000087502 E015 122.9574118 0.0007320074 2.008819e-01 3.272887e-01 12 29343163 29343244 82 - 1.990 2.048 0.193
ENSG00000087502 E016 97.5902403 0.0079737595 3.249434e-01 4.683650e-01 12 29343245 29343282 38 - 1.888 1.958 0.236
ENSG00000087502 E017 139.2797571 0.0009033590 1.862213e-02 4.850223e-02 12 29345443 29345540 98 - 2.034 2.128 0.315
ENSG00000087502 E018 0.7331471 0.0163562304 3.976527e-04 1.765216e-03 12 29345541 29345557 17 - 0.000 0.583 13.455
ENSG00000087502 E019 81.5417719 0.0058224355 6.935639e-02 1.422948e-01 12 29349079 29349100 22 - 1.801 1.907 0.357
ENSG00000087502 E020 88.5057952 0.0003688049 4.438584e-02 9.908049e-02 12 29349101 29349144 44 - 1.837 1.933 0.323
ENSG00000087502 E021 62.3016292 0.0004457138 5.710353e-01 6.974105e-01 12 29349145 29349158 14 - 1.701 1.737 0.124
ENSG00000087502 E022 59.0964281 0.0004132085 1.397230e-01 2.476433e-01 12 29349159 29349177 19 - 1.667 1.754 0.294
ENSG00000087502 E023 86.9296469 0.0003150525 4.425966e-01 5.841927e-01 12 29350013 29350068 56 - 1.843 1.884 0.138
ENSG00000087502 E024 86.5243299 0.0002913858 1.335366e-01 2.390515e-01 12 29356382 29356427 46 - 1.863 1.795 -0.228
ENSG00000087502 E025 83.7283503 0.0003152367 8.340261e-02 1.648930e-01 12 29356428 29356477 50 - 1.851 1.770 -0.274
ENSG00000087502 E026 114.6629288 0.0002687185 8.307841e-04 3.368928e-03 12 29357623 29357724 102 - 1.996 1.855 -0.476
ENSG00000087502 E027 93.8225192 0.0003545180 1.572708e-03 5.870026e-03 12 29361645 29361685 41 - 1.909 1.759 -0.505
ENSG00000087502 E028 111.4080835 0.0015272776 6.155682e-04 2.590350e-03 12 29366877 29366947 71 - 1.986 1.824 -0.544
ENSG00000087502 E029 84.4433187 0.0004109216 3.671229e-02 8.492416e-02 12 29368241 29368287 47 - 1.859 1.759 -0.337
ENSG00000087502 E030 107.6706541 0.0002751547 2.170259e-01 3.468064e-01 12 29370114 29370168 55 - 1.951 1.903 -0.162
ENSG00000087502 E031 113.7475243 0.0007987399 1.405624e-01 2.488121e-01 12 29370169 29370222 54 - 1.978 1.918 -0.199
ENSG00000087502 E032 165.2999790 0.0002854406 3.347154e-04 1.519332e-03 12 29371528 29371670 143 - 2.149 2.023 -0.421
ENSG00000087502 E033 0.2214452 0.0389375089 8.660947e-02   12 29372464 29372520 57 - 0.000 0.232 11.458
ENSG00000087502 E034 0.3332198 0.0324382030 2.625581e-01   12 29372855 29372967 113 - 0.061 0.232 2.233
ENSG00000087502 E035 1.1113958 0.0122093257 8.221889e-01 8.878774e-01 12 29380575 29381114 540 - 0.279 0.232 -0.351
ENSG00000087502 E036 88.7165810 0.0003075267 1.847302e-05 1.155232e-04 12 29381115 29381228 114 - 1.895 1.677 -0.736