ENSG00000087470

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000266481 ENSG00000087470 HEK293_OSMI2_2hA HEK293_TMG_2hB DNM1L protein_coding protein_coding 33.51592 10.31031 56.13502 0.271036 2.230399 2.443672 10.46558865 3.6929637 15.396807 0.29661498 0.7522743 2.056816 0.328870833 0.35913333 0.27433333 -0.08480000 0.14241113 0.01004517 FALSE TRUE
ENST00000434676 ENSG00000087470 HEK293_OSMI2_2hA HEK293_TMG_2hB DNM1L protein_coding nonsense_mediated_decay 33.51592 10.31031 56.13502 0.271036 2.230399 2.443672 2.82628322 0.1093351 7.010191 0.10933506 0.3601721 5.878420 0.050983333 0.01050000 0.12476667 0.11426667 0.01724184 0.01004517 TRUE FALSE
ENST00000452533 ENSG00000087470 HEK293_OSMI2_2hA HEK293_TMG_2hB DNM1L protein_coding protein_coding 33.51592 10.31031 56.13502 0.271036 2.230399 2.443672 6.42795751 2.1573161 10.227836 0.74739115 0.3132014 2.239929 0.206137500 0.21203333 0.18290000 -0.02913333 1.00000000 0.01004517 FALSE TRUE
ENST00000546757 ENSG00000087470 HEK293_OSMI2_2hA HEK293_TMG_2hB DNM1L protein_coding nonsense_mediated_decay 33.51592 10.31031 56.13502 0.271036 2.230399 2.443672 0.09515969 0.7193179 0.000000 0.71931792 0.0000000 -6.188476 0.008483333 0.06710000 0.00000000 -0.06710000 0.53756213 0.01004517 FALSE TRUE
ENST00000547312 ENSG00000087470 HEK293_OSMI2_2hA HEK293_TMG_2hB DNM1L protein_coding protein_coding 33.51592 10.31031 56.13502 0.271036 2.230399 2.443672 2.19131266 0.6890551 4.199999 0.15447276 0.5455358 2.590342 0.069033333 0.06643333 0.07573333 0.00930000 0.87822495 0.01004517 FALSE TRUE
ENST00000547640 ENSG00000087470 HEK293_OSMI2_2hA HEK293_TMG_2hB DNM1L protein_coding retained_intron 33.51592 10.31031 56.13502 0.271036 2.230399 2.443672 3.72586253 0.7127846 5.419264 0.08241710 0.2401314 2.909119 0.116466667 0.06880000 0.09663333 0.02783333 0.18380788 0.01004517 FALSE FALSE
ENST00000549701 ENSG00000087470 HEK293_OSMI2_2hA HEK293_TMG_2hB DNM1L protein_coding protein_coding 33.51592 10.31031 56.13502 0.271036 2.230399 2.443672 2.21876620 1.2272301 3.912344 0.03325887 0.3804707 1.664602 0.078216667 0.11910000 0.06960000 -0.04950000 0.01004517 0.01004517 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000087470 E001 8.6959030 0.0019451332 9.611590e-04 3.825553e-03 12 32679200 32679291 92 + 1.000 0.469 -2.213
ENSG00000087470 E002 13.8747643 0.0012587357 7.321824e-04 3.015036e-03 12 32679292 32679300 9 + 1.174 0.743 -1.619
ENSG00000087470 E003 14.2079841 0.0013174662 1.706052e-03 6.301305e-03 12 32679301 32679302 2 + 1.178 0.791 -1.443
ENSG00000087470 E004 29.6768743 0.0006728410 1.360998e-04 6.862109e-04 12 32679303 32679315 13 + 1.474 1.144 -1.154
ENSG00000087470 E005 31.1819710 0.0006687993 9.106325e-05 4.800662e-04 12 32679316 32679319 4 + 1.495 1.164 -1.156
ENSG00000087470 E006 32.2827577 0.0006589782 8.839989e-05 4.674956e-04 12 32679320 32679322 3 + 1.509 1.183 -1.135
ENSG00000087470 E007 79.7140268 0.0010570470 7.231050e-06 4.961611e-05 12 32679323 32679335 13 + 1.880 1.641 -0.807
ENSG00000087470 E008 161.6855050 0.0094820507 1.597223e-05 1.013156e-04 12 32679336 32679465 130 + 2.186 1.928 -0.865
ENSG00000087470 E009 0.2903454 0.3116583663 1.000000e+00   12 32679708 32679987 280 + 0.123 0.000 -9.609
ENSG00000087470 E010 141.7296184 0.0062216739 1.405866e-04 7.060526e-04 12 32701415 32701472 58 + 2.121 1.917 -0.684
ENSG00000087470 E011 160.3924741 0.0002371659 1.916179e-08 2.242629e-07 12 32701473 32701562 90 + 2.174 1.974 -0.670
ENSG00000087470 E012 1.0393897 0.0120023337 1.517632e-01 2.640621e-01 12 32705825 32705863 39 + 0.332 0.000 -12.603
ENSG00000087470 E013 0.2987644 0.0273529612 1.000000e+00   12 32705864 32706102 239 + 0.123 0.000 -10.609
ENSG00000087470 E014 1.1115096 0.0739687455 7.084649e-01 8.061054e-01 12 32706690 32706814 125 + 0.297 0.218 -0.595
ENSG00000087470 E015 0.3666179 0.0305166917 3.208090e-01 4.639696e-01 12 32706867 32707366 500 + 0.066 0.217 1.986
ENSG00000087470 E016 130.2365061 0.0146042126 2.898500e-03 9.965377e-03 12 32707367 32707413 47 + 2.085 1.878 -0.694
ENSG00000087470 E017 131.1956256 0.0002980367 7.687012e-04 3.145656e-03 12 32708153 32708224 72 + 2.075 1.949 -0.421
ENSG00000087470 E018 1.7974047 0.0586057005 2.886586e-01 4.292730e-01 12 32709544 32709607 64 + 0.447 0.217 -1.474
ENSG00000087470 E019 150.1360574 0.0002306994 3.553834e-03 1.188021e-02 12 32710929 32711015 87 + 2.128 2.030 -0.330
ENSG00000087470 E020 0.8136755 0.0145546374 3.237780e-01 4.671052e-01 12 32711180 32711272 93 + 0.173 0.361 1.398
ENSG00000087470 E021 107.5061870 0.0003626996 2.815236e-01 4.214212e-01 12 32713209 32713246 38 + 1.971 1.933 -0.128
ENSG00000087470 E022 190.0137813 0.0002203169 1.994528e-02 5.137491e-02 12 32713247 32713371 125 + 2.223 2.156 -0.224
ENSG00000087470 E023 203.6416925 0.0002265984 4.578521e-02 1.016437e-01 12 32718643 32718763 121 + 2.251 2.198 -0.180
ENSG00000087470 E024 202.5476548 0.0001774746 3.474683e-02 8.116248e-02 12 32720664 32720795 132 + 2.249 2.192 -0.192
ENSG00000087470 E025 238.6914123 0.0002159552 7.043917e-02 1.440747e-01 12 32722427 32722633 207 + 2.317 2.273 -0.147
ENSG00000087470 E026 1.6062727 0.3842881542 4.617126e-01 6.016237e-01 12 32722634 32722772 139 + 0.296 0.558 1.420
ENSG00000087470 E027 216.6425604 0.0002012994 1.918675e-01 3.161115e-01 12 32731014 32731134 121 + 2.273 2.242 -0.104
ENSG00000087470 E028 206.4766339 0.0001779170 2.859928e-01 4.263595e-01 12 32731356 32731468 113 + 2.236 2.274 0.127
ENSG00000087470 E029 120.2115252 0.0002325616 1.767459e-01 2.970147e-01 12 32731469 32731485 17 + 1.997 2.055 0.195
ENSG00000087470 E030 117.4428959 0.0002508685 2.784737e-02 6.771317e-02 12 32731486 32731511 26 + 1.980 2.070 0.302
ENSG00000087470 E031 188.1101357 0.0002088655 7.002022e-01 7.997203e-01 12 32731854 32731943 90 + 2.207 2.203 -0.016
ENSG00000087470 E032 0.7342825 0.0159628325 2.839972e-01 4.242089e-01 12 32732538 32732610 73 + 0.260 0.000 -12.071
ENSG00000087470 E033 0.2998086 0.0292994145 3.234602e-01   12 32733453 32733565 113 + 0.066 0.216 1.980
ENSG00000087470 E034 0.6287620 0.0181057693 1.936595e-01 3.183856e-01 12 32733566 32733714 149 + 0.123 0.360 1.982
ENSG00000087470 E035 212.1145631 0.0002061591 2.099764e-01 3.385107e-01 12 32733715 32733807 93 + 2.247 2.290 0.144
ENSG00000087470 E036 170.0699225 0.0027095811 3.833058e-02 8.796944e-02 12 32737105 32737161 57 + 2.140 2.232 0.306
ENSG00000087470 E037 14.9275399 0.0267644994 4.935857e-02 1.080197e-01 12 32737162 32737431 270 + 1.183 0.910 -0.999
ENSG00000087470 E038 46.4071509 0.0013214343 8.811767e-01 9.278259e-01 12 32737865 32737942 78 + 1.603 1.620 0.058
ENSG00000087470 E039 6.6525083 0.0024241346 4.436423e-01 5.852263e-01 12 32737943 32737976 34 + 0.849 0.743 -0.420
ENSG00000087470 E040 14.4700123 0.0013418422 8.021161e-02 1.598806e-01 12 32737977 32738263 287 + 1.164 0.973 -0.692
ENSG00000087470 E041 60.7656529 0.0003955885 1.156529e-03 4.493642e-03 12 32738264 32738296 33 + 1.675 1.846 0.579
ENSG00000087470 E042 16.1018463 0.0011832694 2.787453e-02 6.776615e-02 12 32739845 32740063 219 + 1.210 0.974 -0.856
ENSG00000087470 E043 192.6288078 0.0010037715 2.809762e-03 9.703607e-03 12 32740064 32740153 90 + 2.190 2.294 0.348
ENSG00000087470 E044 187.4691177 0.0012574935 2.464556e-06 1.880019e-05 12 32740154 32740240 87 + 2.161 2.324 0.544
ENSG00000087470 E045 6.5895272 0.1237050967 3.342432e-01 4.779840e-01 12 32740241 32740408 168 + 0.861 0.629 -0.944
ENSG00000087470 E046 214.9932123 0.0007513501 2.513086e-05 1.522876e-04 12 32740409 32740518 110 + 2.230 2.362 0.442
ENSG00000087470 E047 283.7960925 0.0022924026 2.055761e-03 7.398039e-03 12 32742589 32742748 160 + 2.357 2.466 0.364
ENSG00000087470 E048 980.5403124 0.0010484700 2.779629e-09 3.797998e-08 12 32743354 32745650 2297 + 2.892 3.003 0.371