ENSG00000087274

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264758 ENSG00000087274 HEK293_OSMI2_2hA HEK293_TMG_2hB ADD1 protein_coding protein_coding 64.24335 78.74244 53.94655 3.644595 0.1298119 -0.5455266 6.722781 8.458951 7.438397 1.1160152 1.4289212 -0.1852532 0.10181250 0.10806667 0.1379667 0.0299000 7.003126e-01 3.169813e-13 FALSE TRUE
ENST00000398125 ENSG00000087274 HEK293_OSMI2_2hA HEK293_TMG_2hB ADD1 protein_coding protein_coding 64.24335 78.74244 53.94655 3.644595 0.1298119 -0.5455266 2.988563 6.348159 1.273572 1.2880546 0.6876792 -2.3084450 0.04362083 0.07950000 0.0236000 -0.0559000 4.384261e-01 3.169813e-13 FALSE TRUE
ENST00000398129 ENSG00000087274 HEK293_OSMI2_2hA HEK293_TMG_2hB ADD1 protein_coding protein_coding 64.24335 78.74244 53.94655 3.644595 0.1298119 -0.5455266 34.846815 55.939541 19.257659 1.5665095 0.4977749 -1.5379450 0.52360000 0.71246667 0.3569333 -0.3555333 3.169813e-13 3.169813e-13 FALSE TRUE
ENST00000510101 ENSG00000087274 HEK293_OSMI2_2hA HEK293_TMG_2hB ADD1 protein_coding nonsense_mediated_decay 64.24335 78.74244 53.94655 3.644595 0.1298119 -0.5455266 3.364058 1.371267 4.329957 0.8214547 0.5815450 1.6516887 0.05686667 0.01670000 0.0802000 0.0635000 3.076830e-01 3.169813e-13   FALSE
ENST00000513328 ENSG00000087274 HEK293_OSMI2_2hA HEK293_TMG_2hB ADD1 protein_coding protein_coding 64.24335 78.74244 53.94655 3.644595 0.1298119 -0.5455266 7.801261 1.167288 11.810432 0.7676803 0.6532199 3.3277437 0.13402083 0.01406667 0.2189333 0.2048667 2.541323e-04 3.169813e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000087274 E001 0.0000000       4 2843844 2843856 13 +      
ENSG00000087274 E002 0.0000000       4 2843857 2843871 15 +      
ENSG00000087274 E003 0.7353267 0.0956418833 5.766098e-02 1.226137e-01 4 2843872 2843889 18 + 0.433 0.096 -2.795
ENSG00000087274 E004 3.4300769 0.0045200373 4.351511e-02 9.749224e-02 4 2843890 2843898 9 + 0.788 0.509 -1.203
ENSG00000087274 E005 42.8366138 0.0139814076 1.693896e-02 4.479622e-02 4 2843899 2843944 46 + 1.711 1.551 -0.544
ENSG00000087274 E006 54.9944245 0.0217659575 2.255527e-02 5.683361e-02 4 2843945 2843952 8 + 1.819 1.656 -0.553
ENSG00000087274 E007 104.5848287 0.0170612593 3.315859e-04 1.507004e-03 4 2843953 2843972 20 + 2.132 1.904 -0.764
ENSG00000087274 E008 117.0239735 0.0151580392 2.994736e-04 1.377436e-03 4 2843973 2843978 6 + 2.174 1.959 -0.722
ENSG00000087274 E009 122.0883063 0.0157037775 4.419141e-04 1.935572e-03 4 2843979 2843981 3 + 2.190 1.979 -0.706
ENSG00000087274 E010 120.8285010 0.0164914021 1.155419e-03 4.489787e-03 4 2843982 2843986 5 + 2.178 1.981 -0.660
ENSG00000087274 E011 138.9310391 0.0099367524 2.420772e-05 1.473345e-04 4 2843987 2843988 2 + 2.246 2.034 -0.708
ENSG00000087274 E012 191.6397879 0.0109030568 2.154901e-05 1.325797e-04 4 2843989 2844024 36 + 2.385 2.174 -0.702
ENSG00000087274 E013 0.4751703 0.0205182010 9.816073e-01 9.925467e-01 4 2844150 2844400 251 + 0.155 0.175 0.211
ENSG00000087274 E014 0.6213751 0.0224708175 1.099826e-01 2.055160e-01 4 2844401 2844834 434 + 0.358 0.096 -2.372
ENSG00000087274 E015 0.3729606 0.0293162357 6.573930e-01 7.667467e-01 4 2853134 2853203 70 + 0.155 0.096 -0.785
ENSG00000087274 E016 0.7427016 0.0155762883 2.521997e-03 8.828247e-03 4 2853624 2853698 75 + 0.497 0.000 -14.277
ENSG00000087274 E017 0.1472490 0.0431201787 2.702094e-01   4 2854854 2855029 176 + 0.155 0.000 -11.352
ENSG00000087274 E018 0.0000000       4 2867875 2867971 97 +      
ENSG00000087274 E019 1.6532882 0.0177178609 6.197365e-02 1.299371e-01 4 2867972 2868129 158 + 0.601 0.298 -1.599
ENSG00000087274 E020 0.1472490 0.0431201787 2.702094e-01   4 2873015 2873135 121 + 0.155 0.000 -11.352
ENSG00000087274 E021 491.4487898 0.0028279655 1.247564e-08 1.511558e-07 4 2875896 2876110 215 + 2.753 2.612 -0.469
ENSG00000087274 E022 1.3662668 0.0097219643 9.060746e-04 3.635101e-03 4 2876111 2876405 295 + 0.646 0.096 -3.788
ENSG00000087274 E023 0.7427016 0.0155762883 2.521997e-03 8.828247e-03 4 2881600 2881897 298 + 0.497 0.000 -14.277
ENSG00000087274 E024 514.5149517 0.0033553617 1.037419e-04 5.392526e-04 4 2881898 2882060 163 + 2.744 2.650 -0.311
ENSG00000087274 E025 461.3904256 0.0030651265 2.454779e-04 1.156468e-03 4 2884515 2884666 152 + 2.692 2.607 -0.284
ENSG00000087274 E026 0.2903454 0.3466796379 1.397568e-01   4 2887504 2887720 217 + 0.268 0.000 -11.229
ENSG00000087274 E027 311.9151440 0.0056479436 1.815998e-02 4.747541e-02 4 2894013 2894093 81 + 2.513 2.443 -0.233
ENSG00000087274 E028 421.9087781 0.0027094333 2.968252e-02 7.133768e-02 4 2894582 2894731 150 + 2.623 2.587 -0.120
ENSG00000087274 E029 0.5212538 0.0214357667 9.775709e-01 9.900391e-01 4 2894732 2894733 2 + 0.155 0.175 0.212
ENSG00000087274 E030 443.0501251 0.0015090684 2.119653e-02 5.400746e-02 4 2898184 2898327 144 + 2.638 2.610 -0.095
ENSG00000087274 E031 0.9232601 0.0157674449 1.222003e-01 2.230855e-01 4 2898328 2898430 103 + 0.433 0.175 -1.789
ENSG00000087274 E032 0.9577154 0.0136462071 4.614771e-01 6.014285e-01 4 2898431 2898432 2 + 0.358 0.241 -0.789
ENSG00000087274 E033 387.0697834 0.0011111534 8.423786e-02 1.661974e-01 4 2898433 2898531 99 + 2.570 2.556 -0.044
ENSG00000087274 E034 3.0647186 0.1090480797 7.258235e-02 1.476485e-01 4 2898532 2899258 727 + 0.788 0.438 -1.559
ENSG00000087274 E035 571.0731986 0.0005011336 4.696188e-03 1.508534e-02 4 2899259 2899435 177 + 2.744 2.720 -0.079
ENSG00000087274 E036 20.8200806 0.0008908454 1.273606e-18 6.925395e-17 4 2899436 2902914 3479 + 1.628 0.985 -2.258
ENSG00000087274 E037 1.9398477 0.1126136015 2.398637e-03 8.456901e-03 4 2904664 2904763 100 + 0.757 0.173 -3.270
ENSG00000087274 E038 822.4028479 0.0001032772 4.636664e-06 3.326224e-05 4 2904764 2905015 252 + 2.908 2.876 -0.107
ENSG00000087274 E039 46.8432041 0.0021641469 4.198025e-02 9.468910e-02 4 2905016 2905108 93 + 1.712 1.626 -0.290
ENSG00000087274 E040 24.6858915 0.0057532547 5.087705e-15 1.748640e-13 4 2905109 2905721 613 + 1.682 1.102 -2.016
ENSG00000087274 E041 10.7818998 0.0030865205 1.187608e-03 4.599493e-03 4 2907204 2907376 173 + 1.226 0.926 -1.091
ENSG00000087274 E042 17.5600090 0.0011294263 2.488774e-08 2.847682e-07 4 2907377 2907742 366 + 1.478 1.057 -1.483
ENSG00000087274 E043 471.2756619 0.0001240995 1.142364e-02 3.217099e-02 4 2907743 2907829 87 + 2.656 2.640 -0.052
ENSG00000087274 E044 366.0843309 0.0001344678 4.795357e-02 1.055521e-01 4 2907830 2907844 15 + 2.543 2.532 -0.035
ENSG00000087274 E045 552.3999066 0.0001786794 4.173641e-01 5.607265e-01 4 2908515 2908604 90 + 2.704 2.719 0.050
ENSG00000087274 E046 5.1065473 0.0055176075 1.201310e-03 4.644869e-03 4 2908605 2909338 734 + 0.999 0.598 -1.598
ENSG00000087274 E047 20.1816075 0.0012239386 8.643021e-02 1.696922e-01 4 2909339 2909431 93 + 1.374 1.269 -0.367
ENSG00000087274 E048 4.3814721 0.0037851420 9.549560e-01 9.757608e-01 4 2914705 2914883 179 + 0.686 0.717 0.130
ENSG00000087274 E049 391.2295824 0.0001563093 4.236026e-01 5.666589e-01 4 2914884 2914941 58 + 2.534 2.578 0.148
ENSG00000087274 E050 555.9556597 0.0001509257 2.436291e-01 3.784328e-01 4 2914942 2915040 99 + 2.683 2.731 0.160
ENSG00000087274 E051 481.7884501 0.0001241831 5.620148e-03 1.760508e-02 4 2926014 2926112 99 + 2.600 2.678 0.259
ENSG00000087274 E052 3.5803221 0.0755014729 9.247453e-03 2.690350e-02 4 2926113 2926137 25 + 0.894 0.435 -1.987
ENSG00000087274 E053 2.5161663 0.0177458636 3.817571e-01 5.260567e-01 4 2926285 2926308 24 + 0.601 0.475 -0.594
ENSG00000087274 E054 2.5161663 0.0177458636 3.817571e-01 5.260567e-01 4 2926309 2926316 8 + 0.601 0.475 -0.594
ENSG00000087274 E055 8.9545185 0.0326014210 8.076758e-02 1.607430e-01 4 2926317 2926638 322 + 1.099 0.887 -0.784
ENSG00000087274 E056 3.8834772 0.0039955844 2.290001e-02 5.753306e-02 4 2926639 2926641 3 + 0.844 0.541 -1.273
ENSG00000087274 E057 34.5435924 0.0082851672 3.621495e-01 5.065387e-01 4 2926642 2926675 34 + 1.453 1.553 0.341
ENSG00000087274 E058 851.2086628 0.0009349807 3.269969e-04 1.488683e-03 4 2928171 2928602 432 + 2.833 2.931 0.324
ENSG00000087274 E059 234.1489729 0.0024755365 7.107647e-03 2.150430e-02 4 2928603 2928642 40 + 2.257 2.380 0.412
ENSG00000087274 E060 2391.6849958 0.0025994339 1.742935e-13 4.793059e-12 4 2928643 2929595 953 + 3.210 3.404 0.647
ENSG00000087274 E061 1020.8761651 0.0047097519 7.022323e-17 3.081673e-15 4 2929596 2930290 695 + 2.742 3.061 1.064