ENSG00000087263

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000561646 ENSG00000087263 HEK293_OSMI2_2hA HEK293_TMG_2hB OGFOD1 protein_coding protein_coding 38.94735 24.18715 54.49709 1.673089 2.798087 1.171607 7.126967 1.409677 11.139319 0.8677892 0.3873310 2.9733208 0.1708000 0.0598000 0.20580000 0.14600000 3.359371e-01 3.234104e-15 FALSE FALSE
ENST00000565682 ENSG00000087263 HEK293_OSMI2_2hA HEK293_TMG_2hB OGFOD1 protein_coding nonsense_mediated_decay 38.94735 24.18715 54.49709 1.673089 2.798087 1.171607 5.197552 3.575621 5.340135 0.1581422 0.7022845 0.5773521 0.1254708 0.1498333 0.09736667 -0.05246667 1.004095e-01 3.234104e-15 TRUE TRUE
ENST00000566157 ENSG00000087263 HEK293_OSMI2_2hA HEK293_TMG_2hB OGFOD1 protein_coding protein_coding 38.94735 24.18715 54.49709 1.673089 2.798087 1.171607 19.992721 17.942516 23.846258 2.2679082 1.0014123 0.4101817 0.5430833 0.7373000 0.43940000 -0.29790000 8.398052e-04 3.234104e-15 FALSE TRUE
ENST00000568172 ENSG00000087263 HEK293_OSMI2_2hA HEK293_TMG_2hB OGFOD1 protein_coding processed_transcript 38.94735 24.18715 54.49709 1.673089 2.798087 1.171607 2.849226 0.000000 8.126348 0.0000000 2.2308834 9.6682376 0.0604375 0.0000000 0.14596667 0.14596667 2.942652e-13 3.234104e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000087263 E001 1.4801046 0.0088993110 2.236696e-02 5.644160e-02 16 56451521 56451522 2 + 0.539 0.142 -2.665
ENSG00000087263 E002 1.4801046 0.0088993110 2.236696e-02 5.644160e-02 16 56451523 56451523 1 + 0.539 0.142 -2.665
ENSG00000087263 E003 3.7538124 0.0056318414 8.623457e-04 3.481710e-03 16 56451524 56451532 9 + 0.846 0.335 -2.369
ENSG00000087263 E004 10.8582134 0.0068790980 9.737447e-02 1.864645e-01 16 56451533 56451539 7 + 1.132 0.980 -0.556
ENSG00000087263 E005 28.8009482 0.0083312585 6.435519e-02 1.339622e-01 16 56451540 56451553 14 + 1.525 1.405 -0.411
ENSG00000087263 E006 28.9826526 0.0075706690 7.183162e-02 1.463902e-01 16 56451554 56451555 2 + 1.525 1.412 -0.388
ENSG00000087263 E007 36.4874550 0.0026138748 5.689497e-03 1.778937e-02 16 56451556 56451561 6 + 1.634 1.489 -0.494
ENSG00000087263 E008 43.0547912 0.0117218335 4.480173e-03 1.448561e-02 16 56451562 56451567 6 + 1.723 1.530 -0.657
ENSG00000087263 E009 218.9360160 0.0035435610 2.118633e-05 1.306156e-04 16 56451568 56451760 193 + 2.399 2.266 -0.446
ENSG00000087263 E010 122.9885282 0.0027810893 9.752728e-04 3.875134e-03 16 56451761 56451766 6 + 2.141 2.035 -0.355
ENSG00000087263 E011 244.6645150 0.0031830695 9.898673e-04 3.923742e-03 16 56453263 56453380 118 + 2.430 2.339 -0.302
ENSG00000087263 E012 113.5715293 0.0021336876 1.089536e-01 2.039901e-01 16 56453381 56453408 28 + 2.075 2.040 -0.117
ENSG00000087263 E013 8.1942464 0.0020127891 7.434046e-03 2.234673e-02 16 56453409 56453693 285 + 1.066 0.781 -1.079
ENSG00000087263 E014 9.8103361 0.0174061083 1.609301e-02 4.294410e-02 16 56454774 56454921 148 + 1.133 0.859 -1.014
ENSG00000087263 E015 12.6761990 0.0013736570 2.539340e-03 8.881682e-03 16 56458129 56458512 384 + 1.240 0.979 -0.942
ENSG00000087263 E016 3.1837282 0.0053233184 2.338801e-01 3.669937e-01 16 56458513 56458547 35 + 0.683 0.522 -0.717
ENSG00000087263 E017 154.2584067 0.0008103691 5.512425e-02 1.182111e-01 16 56458548 56458594 47 + 2.207 2.179 -0.093
ENSG00000087263 E018 0.4439371 0.0215758108 1.392348e-01 2.470092e-01 16 56458595 56458901 307 + 0.260 0.001 -9.359
ENSG00000087263 E019 222.3310559 0.0012350625 1.646590e-01 2.812388e-01 16 56462534 56462634 101 + 2.355 2.344 -0.035
ENSG00000087263 E020 255.8797187 0.0007545088 1.381699e-02 3.781147e-02 16 56466152 56466268 117 + 2.425 2.392 -0.108
ENSG00000087263 E021 265.9459637 0.0001717013 8.706061e-03 2.555171e-02 16 56466876 56466967 92 + 2.440 2.415 -0.085
ENSG00000087263 E022 284.3927858 0.0001800862 2.620029e-04 1.224725e-03 16 56467165 56467293 129 + 2.480 2.435 -0.150
ENSG00000087263 E023 305.0388627 0.0001439419 8.817797e-02 1.723414e-01 16 56467905 56468018 114 + 2.491 2.489 -0.007
ENSG00000087263 E024 273.1368300 0.0001487278 4.033373e-01 5.471107e-01 16 56470003 56470082 80 + 2.434 2.449 0.048
ENSG00000087263 E025 585.0686244 0.0001457383 7.932579e-01 8.678114e-01 16 56470487 56470791 305 + 2.758 2.786 0.093
ENSG00000087263 E026 349.0300810 0.0001800230 1.124802e-01 2.091602e-01 16 56474828 56474950 123 + 2.516 2.579 0.207
ENSG00000087263 E027 299.9510584 0.0001533335 6.605278e-03 2.020001e-02 16 56475507 56475565 59 + 2.440 2.527 0.292
ENSG00000087263 E028 1265.7393268 0.0037303393 8.040978e-09 1.008631e-07 16 56476044 56479104 3061 + 3.015 3.187 0.570