ENSG00000087191

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000310144 ENSG00000087191 HEK293_OSMI2_2hA HEK293_TMG_2hB PSMC5 protein_coding protein_coding 171.8869 230.515 145.7344 19.29809 0.6640305 -0.661483 152.4722 214.944 127.2466 19.22787 1.244025 -0.7562872 0.8782625 0.9316 0.8732 -0.0584 0.00122023 5.38574e-10 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000087191 E001 1.072798 0.1097868701 5.399145e-01 6.711229e-01 17 63827152 63827206 55 + 0.362 0.242 -0.808
ENSG00000087191 E002 20.728280 0.0013022956 8.225707e-02 1.630723e-01 17 63827418 63827430 13 + 1.388 1.263 -0.434
ENSG00000087191 E003 21.803055 0.0029905185 4.118193e-02 9.321807e-02 17 63827431 63827432 2 + 1.425 1.275 -0.522
ENSG00000087191 E004 52.021187 0.0147076065 1.930323e-02 4.999166e-02 17 63827433 63827445 13 + 1.808 1.627 -0.612
ENSG00000087191 E005 101.323035 0.0065607255 2.863831e-07 2.662009e-06 17 63827446 63827452 7 + 2.145 1.877 -0.899
ENSG00000087191 E006 111.290657 0.0040466823 3.394040e-10 5.469934e-09 17 63827453 63827454 2 + 2.192 1.911 -0.942
ENSG00000087191 E007 183.573337 0.0069511155 1.513228e-03 5.679010e-03 17 63827455 63827459 5 + 2.335 2.180 -0.518
ENSG00000087191 E008 298.352845 0.0028400791 8.785113e-05 4.649439e-04 17 63827460 63827471 12 + 2.529 2.401 -0.426
ENSG00000087191 E009 364.395412 0.0031020766 4.673115e-07 4.158147e-06 17 63827472 63827478 7 + 2.637 2.473 -0.546
ENSG00000087191 E010 416.739049 0.0023895478 2.558951e-07 2.402027e-06 17 63827479 63827489 11 + 2.687 2.537 -0.496
ENSG00000087191 E011 572.781726 0.0030122816 1.012892e-05 6.722107e-05 17 63827490 63827514 25 + 2.814 2.681 -0.442
ENSG00000087191 E012 8.171230 0.0042849127 2.100230e-08 2.438751e-07 17 63827515 63827523 9 + 1.253 0.621 -2.413
ENSG00000087191 E013 11.767447 0.0314421288 3.387305e-07 3.100671e-06 17 63827524 63827612 89 + 1.403 0.752 -2.386
ENSG00000087191 E014 6.985625 0.0023377656 6.760292e-08 7.096958e-07 17 63827613 63827619 7 + 1.197 0.566 -2.457
ENSG00000087191 E015 14.124848 0.0015000104 7.256267e-09 9.173082e-08 17 63827620 63827673 54 + 1.425 0.920 -1.805
ENSG00000087191 E016 12.506013 0.0209971814 2.969953e-04 1.367710e-03 17 63827674 63827683 10 + 1.331 0.922 -1.472
ENSG00000087191 E017 12.349199 0.0061299769 9.613515e-05 5.039156e-04 17 63827684 63827702 19 + 1.312 0.933 -1.365
ENSG00000087191 E018 36.557036 0.0006038723 7.217583e-05 3.907632e-04 17 63827703 63827828 126 + 1.684 1.463 -0.752
ENSG00000087191 E019 23.135912 0.0008354779 1.616656e-03 6.013795e-03 17 63827829 63827850 22 + 1.490 1.275 -0.748
ENSG00000087191 E020 23.264975 0.0008103672 5.879128e-03 1.829477e-02 17 63827851 63827877 27 + 1.478 1.291 -0.648
ENSG00000087191 E021 31.793918 0.0006684873 6.312719e-05 3.467658e-04 17 63827878 63827923 46 + 1.634 1.397 -0.814
ENSG00000087191 E022 18.159855 0.0191617513 4.354694e-07 3.897315e-06 17 63827924 63828118 195 + 1.532 1.013 -1.828
ENSG00000087191 E023 11.813032 0.0104401049 2.844885e-03 9.809060e-03 17 63828119 63828137 19 + 1.264 0.957 -1.107
ENSG00000087191 E024 979.515409 0.0029849420 1.207818e-01 2.210648e-01 17 63828138 63828209 72 + 2.990 2.947 -0.141
ENSG00000087191 E025 21.730598 0.0091865831 2.819796e-15 1.006599e-13 17 63828210 63828857 648 + 1.664 0.980 -2.401
ENSG00000087191 E026 23.864626 0.0008109404 1.042479e-15 3.925487e-14 17 63828858 63829493 636 + 1.664 1.113 -1.915
ENSG00000087191 E027 1088.029978 0.0016129759 1.465252e-01 2.569637e-01 17 63829494 63829563 70 + 3.027 2.998 -0.095
ENSG00000087191 E028 10.978954 0.0165149500 3.864230e-02 8.852383e-02 17 63829564 63829851 288 + 1.197 0.967 -0.833
ENSG00000087191 E029 1238.066356 0.0011506241 3.849004e-01 5.290463e-01 17 63829852 63829949 98 + 3.050 3.070 0.069
ENSG00000087191 E030 18.383663 0.0012499302 2.647837e-07 2.478138e-06 17 63829950 63830064 115 + 1.490 1.096 -1.384
ENSG00000087191 E031 18.415110 0.0019281145 1.597147e-06 1.269136e-05 17 63830065 63830132 68 + 1.478 1.104 -1.311
ENSG00000087191 E032 989.328734 0.0003370746 5.814874e-01 7.060158e-01 17 63830133 63830189 57 + 2.958 2.974 0.055
ENSG00000087191 E033 21.456228 0.0066522561 2.660719e-10 4.362691e-09 17 63830190 63830270 81 + 1.603 1.095 -1.772
ENSG00000087191 E034 1413.467697 0.0008576859 5.984473e-01 7.200364e-01 17 63830271 63830385 115 + 3.124 3.122 -0.006
ENSG00000087191 E035 1558.248269 0.0012875190 9.841857e-01 9.942040e-01 17 63830386 63830501 116 + 3.159 3.166 0.024
ENSG00000087191 E036 18.452210 0.0075170057 5.947111e-06 4.163417e-05 17 63830682 63830808 127 + 1.484 1.096 -1.364
ENSG00000087191 E037 1482.450688 0.0008761120 3.182633e-01 4.612351e-01 17 63830809 63830935 127 + 3.126 3.150 0.080
ENSG00000087191 E038 22.029789 0.0009473171 6.618113e-12 1.419108e-10 17 63830936 63831019 84 + 1.602 1.113 -1.706
ENSG00000087191 E039 14.152064 0.0050989120 2.328249e-04 1.103389e-03 17 63831020 63831035 16 + 1.347 1.012 -1.195
ENSG00000087191 E040 1753.713120 0.0002537332 1.426586e-06 1.146054e-05 17 63831036 63831226 191 + 3.173 3.236 0.208
ENSG00000087191 E041 724.680294 0.0001438184 2.926827e-04 1.350016e-03 17 63831327 63831338 12 + 2.790 2.854 0.213
ENSG00000087191 E042 1270.410803 0.0008120604 2.259166e-06 1.736981e-05 17 63831339 63831425 87 + 3.015 3.102 0.290
ENSG00000087191 E043 26.008192 0.0007197206 4.037407e-05 2.324564e-04 17 63831426 63831505 80 + 1.568 1.302 -0.919
ENSG00000087191 E044 1657.299927 0.0012831946 1.904521e-06 1.488780e-05 17 63831506 63831616 111 + 3.122 3.219 0.322
ENSG00000087191 E045 6.038807 0.0418852828 1.515977e-01 2.638369e-01 17 63831617 63831723 107 + 0.650 0.891 0.967
ENSG00000087191 E046 1162.650464 0.0021209944 1.169906e-05 7.653939e-05 17 63831724 63831810 87 + 2.954 3.071 0.386
ENSG00000087191 E047 595.076484 0.0017486139 1.448870e-11 2.939116e-10 17 63831916 63832026 111 + 2.614 2.799 0.617