ENSG00000087152

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000389384 ENSG00000087152 HEK293_OSMI2_2hA HEK293_TMG_2hB ATXN7L3 protein_coding protein_coding 42.85829 56.56361 37.07706 1.636547 2.458688 -0.6092133 10.838563 15.328127 5.7499302 0.7320212 0.90906592 -1.4129991 0.26237917 0.27133333 0.155333333 -0.1160000 2.613273e-02 1.029293e-13 FALSE TRUE
ENST00000454077 ENSG00000087152 HEK293_OSMI2_2hA HEK293_TMG_2hB ATXN7L3 protein_coding protein_coding 42.85829 56.56361 37.07706 1.636547 2.458688 -0.6092133 10.801585 15.631483 8.3802487 0.9073667 0.63979274 -0.8985918 0.24545000 0.27620000 0.226900000 -0.0493000 3.022109e-01 1.029293e-13 FALSE TRUE
ENST00000587097 ENSG00000087152 HEK293_OSMI2_2hA HEK293_TMG_2hB ATXN7L3 protein_coding protein_coding 42.85829 56.56361 37.07706 1.636547 2.458688 -0.6092133 10.521395 9.005783 14.0989190 2.6366800 0.80202826 0.6460827 0.24822500 0.15676667 0.384633333 0.2278667 2.664733e-02 1.029293e-13 FALSE TRUE
ENST00000590169 ENSG00000087152 HEK293_OSMI2_2hA HEK293_TMG_2hB ATXN7L3 protein_coding protein_coding 42.85829 56.56361 37.07706 1.636547 2.458688 -0.6092133 1.516721 0.995583 3.3039198 0.4499059 0.90247465 1.7205065 0.03920417 0.01806667 0.087166667 0.0691000 3.269227e-02 1.029293e-13 FALSE FALSE
ENST00000591295 ENSG00000087152 HEK293_OSMI2_2hA HEK293_TMG_2hB ATXN7L3 protein_coding protein_coding 42.85829 56.56361 37.07706 1.636547 2.458688 -0.6092133 4.114462 11.622395 0.3456889 1.9789950 0.08699167 -5.0313883 0.07936250 0.20733333 0.009166667 -0.1981667 1.029293e-13 1.029293e-13 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000087152 E001 2929.886780 0.0023557119 9.051818e-16 3.442071e-14 17 44191805 44194239 2435 - 3.316 3.508 0.638
ENSG00000087152 E002 404.516175 0.0001409903 7.000360e-02 1.433758e-01 17 44194240 44194370 131 - 2.528 2.615 0.291
ENSG00000087152 E003 262.151265 0.0001639368 9.478702e-01 9.712412e-01 17 44194371 44194411 41 - 2.365 2.417 0.172
ENSG00000087152 E004 204.568422 0.0001796444 1.086865e-01 2.035928e-01 17 44194517 44194539 23 - 2.284 2.295 0.038
ENSG00000087152 E005 326.945030 0.0009229484 1.146485e-01 2.123211e-01 17 44194540 44194650 111 - 2.486 2.501 0.051
ENSG00000087152 E006 157.185335 0.0026982611 2.401194e-01 3.742885e-01 17 44194651 44194656 6 - 2.172 2.181 0.029
ENSG00000087152 E007 169.253252 0.0050958197 3.748635e-01 5.193144e-01 17 44194657 44194674 18 - 2.202 2.216 0.044
ENSG00000087152 E008 1.696234 0.1835927639 4.669914e-01 6.065111e-01 17 44194675 44194767 93 - 0.253 0.468 1.291
ENSG00000087152 E009 295.813135 0.0003717366 2.556207e-03 8.931004e-03 17 44194768 44194839 72 - 2.459 2.445 -0.050
ENSG00000087152 E010 12.308449 0.0049144755 2.695042e-02 6.588914e-02 17 44194840 44195096 257 - 1.205 1.037 -0.605
ENSG00000087152 E011 221.388089 0.0001703935 3.217289e-04 1.467734e-03 17 44195097 44195120 24 - 2.348 2.312 -0.119
ENSG00000087152 E012 203.934335 0.0007276640 1.264686e-02 3.507973e-02 17 44195121 44195140 20 - 2.299 2.282 -0.056
ENSG00000087152 E013 6.159093 0.0026460916 3.619036e-01 5.063145e-01 17 44195141 44195158 18 - 0.888 0.820 -0.262
ENSG00000087152 E014 6.252117 0.0029335000 1.213354e-02 3.385165e-02 17 44195159 44195293 135 - 0.987 0.723 -1.024
ENSG00000087152 E015 192.455813 0.0015497133 1.934191e-01 3.180732e-01 17 44195419 44195442 24 - 2.255 2.268 0.042
ENSG00000087152 E016 221.635671 0.0008291038 2.004085e-01 3.267282e-01 17 44195443 44195487 45 - 2.312 2.331 0.061
ENSG00000087152 E017 181.108596 0.0002356846 2.174391e-01 3.473083e-01 17 44195800 44195828 29 - 2.226 2.244 0.063
ENSG00000087152 E018 21.738971 0.0008660808 5.496113e-01 6.793163e-01 17 44195829 44195885 57 - 1.334 1.340 0.019
ENSG00000087152 E019 3.432168 0.0046517583 1.431385e-02 3.894409e-02 17 44195886 44196033 148 - 0.816 0.497 -1.374
ENSG00000087152 E020 237.552248 0.0032518611 1.440456e-01 2.535211e-01 17 44196034 44196079 46 - 2.354 2.357 0.012
ENSG00000087152 E021 24.476422 0.0038596549 1.354094e-01 2.416849e-01 17 44196080 44196100 21 - 1.427 1.366 -0.213
ENSG00000087152 E022 3.834259 0.0043384006 6.814617e-02 1.402904e-01 17 44196101 44196213 113 - 0.789 0.566 -0.943
ENSG00000087152 E023 195.904418 0.0025594512 1.521673e-02 4.097839e-02 17 44196396 44196418 23 - 2.292 2.261 -0.102
ENSG00000087152 E024 179.215934 0.0034907267 8.063886e-03 2.394208e-02 17 44196929 44196940 12 - 2.264 2.216 -0.159
ENSG00000087152 E025 184.220415 0.0022211415 9.363529e-04 3.741284e-03 17 44196941 44196963 23 - 2.284 2.224 -0.200
ENSG00000087152 E026 246.002527 0.0002492971 5.218182e-08 5.606039e-07 17 44196964 44197026 63 - 2.419 2.343 -0.252
ENSG00000087152 E027 388.591475 0.0006148159 2.428215e-07 2.290014e-06 17 44197228 44197399 172 - 2.606 2.550 -0.186
ENSG00000087152 E028 299.694750 0.0002987834 4.104413e-11 7.721637e-10 17 44197598 44197730 133 - 2.513 2.423 -0.302
ENSG00000087152 E029 175.591345 0.0002673082 2.702172e-10 4.428360e-09 17 44198020 44198130 111 - 2.298 2.176 -0.406
ENSG00000087152 E030 12.327838 0.0137911724 2.780966e-01 4.177203e-01 17 44198131 44198379 249 - 1.148 1.079 -0.251
ENSG00000087152 E031 10.233917 0.0017591564 1.830302e-03 6.696303e-03 17 44198421 44198511 91 - 1.183 0.915 -0.981
ENSG00000087152 E032 5.134202 0.0293360619 8.886132e-01 9.327943e-01 17 44199064 44199206 143 - 0.760 0.784 0.097
ENSG00000087152 E033 58.260757 0.0290200319 1.573354e-05 9.992196e-05 17 44199496 44199884 389 - 1.935 1.596 -1.148
ENSG00000087152 E034 5.967927 0.0032405707 4.399976e-02 9.838305e-02 17 44200057 44200113 57 - 0.950 0.744 -0.801