ENSG00000087116

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000251582 ENSG00000087116 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAMTS2 protein_coding protein_coding 3.260161 4.568319 2.647168 0.3423198 0.06534788 -0.7849286 0.9585404 1.0512397 1.16068191 0.08085361 0.08252392 0.14159859 0.31545000 0.23063333 0.44026667 0.20963333 0.003220363 0.001395491 FALSE TRUE
ENST00000274609 ENSG00000087116 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAMTS2 protein_coding protein_coding 3.260161 4.568319 2.647168 0.3423198 0.06534788 -0.7849286 1.6746316 3.0010955 0.97030754 0.28154410 0.12582279 -1.61898213 0.46677083 0.65733333 0.36520000 -0.29213333 0.001395491 0.001395491 FALSE TRUE
ENST00000518335 ENSG00000087116 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAMTS2 protein_coding protein_coding 3.260161 4.568319 2.647168 0.3423198 0.06534788 -0.7849286 0.3166607 0.4110252 0.35631047 0.03982784 0.06857498 -0.20083979 0.09717500 0.09046667 0.13590000 0.04543333 0.542859770 0.001395491 FALSE TRUE
ENST00000523450 ENSG00000087116 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAMTS2 protein_coding retained_intron 3.260161 4.568319 2.647168 0.3423198 0.06534788 -0.7849286 0.1483368 0.1049589 0.11037469 0.10495885 0.11037469 0.06641454 0.05069583 0.02153333 0.03993333 0.01840000 0.963436919 0.001395491 FALSE FALSE
MSTRG.27431.3 ENSG00000087116 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAMTS2 protein_coding   3.260161 4.568319 2.647168 0.3423198 0.06534788 -0.7849286 0.1250371 0.0000000 0.04949338 0.00000000 0.04949338 2.57272904 0.05475000 0.00000000 0.01876667 0.01876667 0.679158936 0.001395491 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000087116 E001 104.0477460 0.0003249389 6.616209e-09 8.437136e-08 5 179110853 179114063 3211 - 2.110 1.922 -0.632
ENSG00000087116 E002 18.3316292 0.0010800033 1.593067e-02 4.257686e-02 5 179114064 179114288 225 - 1.373 1.181 -0.673
ENSG00000087116 E003 6.4527086 0.0282300528 1.419154e-01 2.506545e-01 5 179114289 179114324 36 - 0.965 0.755 -0.809
ENSG00000087116 E004 19.3472010 0.0010083614 3.260725e-01 4.695066e-01 5 179120172 179121660 1489 - 1.333 1.256 -0.273
ENSG00000087116 E005 9.6848838 0.0189898720 1.734075e-01 2.926223e-01 5 179121661 179121750 90 - 1.111 0.941 -0.623
ENSG00000087116 E006 0.0000000       5 179121751 179121854 104 -      
ENSG00000087116 E007 9.0511259 0.0049479376 5.842018e-02 1.239215e-01 5 179122644 179122773 130 - 1.097 0.887 -0.777
ENSG00000087116 E008 0.6653823 0.0170688164 1.440442e-01 2.535211e-01 5 179122774 179122839 66 - 0.349 0.100 -2.257
ENSG00000087116 E009 13.7837993 0.0013327613 4.027320e-01 5.465200e-01 5 179124973 179125180 208 - 1.187 1.109 -0.278
ENSG00000087116 E010 16.2693343 0.0011647271 6.884264e-01 7.905604e-01 5 179125998 179126130 133 - 1.231 1.196 -0.125
ENSG00000087116 E011 15.6024171 0.0018064260 5.468990e-01 6.769975e-01 5 179127959 179128118 160 - 1.221 1.167 -0.192
ENSG00000087116 E012 15.6795055 0.0134703317 7.981333e-01 8.711662e-01 5 179129932 179130098 167 - 1.175 1.204 0.103
ENSG00000087116 E013 11.7992819 0.0014862440 6.322896e-01 7.471601e-01 5 179132230 179132310 81 - 1.111 1.063 -0.174
ENSG00000087116 E014 13.6312856 0.0216747759 1.256042e-02 3.487467e-02 5 179132777 179132900 124 - 1.308 1.031 -0.988
ENSG00000087116 E015 10.6682652 0.0016563433 8.069059e-05 4.311912e-04 5 179135909 179136042 134 - 1.262 0.872 -1.422
ENSG00000087116 E016 13.0473307 0.0013603074 1.789816e-01 2.998650e-01 5 179137769 179137944 176 - 1.199 1.073 -0.451
ENSG00000087116 E017 10.7122644 0.0209047189 2.322928e-01 3.651654e-01 5 179139890 179140035 146 - 1.125 0.982 -0.522
ENSG00000087116 E018 35.2841182 0.0006651143 5.786032e-10 8.970102e-09 5 179150888 179151200 313 - 1.210 1.634 1.467
ENSG00000087116 E019 33.5715305 0.0009122043 4.272923e-04 1.879306e-03 5 179152142 179152255 114 - 1.342 1.573 0.795
ENSG00000087116 E020 35.2641429 0.0009305133 3.694326e-04 1.655852e-03 5 179153491 179153623 133 - 1.365 1.593 0.783
ENSG00000087116 E021 29.9596121 0.0008494005 5.861919e-05 3.245815e-04 5 179154049 179154192 144 - 1.252 1.535 0.982
ENSG00000087116 E022 27.8230249 0.0026904595 1.410367e-02 3.846119e-02 5 179154814 179154919 106 - 1.317 1.493 0.611
ENSG00000087116 E023 43.9703082 0.0052175467 1.414229e-01 2.499743e-01 5 179158723 179158879 157 - 1.570 1.663 0.314
ENSG00000087116 E024 29.2681386 0.0107656319 5.417467e-01 6.726840e-01 5 179181072 179181155 84 - 1.430 1.480 0.172
ENSG00000087116 E025 46.4331315 0.0056095313 7.210630e-01 8.155525e-01 5 179207513 179207715 203 - 1.641 1.663 0.075
ENSG00000087116 E026 38.6194651 0.0008187221 2.137771e-01 3.429742e-01 5 179272911 179273064 154 - 1.525 1.596 0.242
ENSG00000087116 E027 36.5211157 0.0143187876 5.534983e-01 6.826192e-01 5 179343767 179344161 395 - 1.514 1.566 0.178
ENSG00000087116 E028 7.0129550 0.1025613203 6.342484e-02 1.323995e-01 5 179345190 179345461 272 - 1.069 0.736 -1.268