ENSG00000087111

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000268758 ENSG00000087111 HEK293_OSMI2_2hA HEK293_TMG_2hB PIGS protein_coding nonsense_mediated_decay 62.78834 91.80773 45.81774 2.88188 0.8305609 -1.002552 6.34177 22.26079 0.2608854 4.942025 0.2608854 -6.3613260 0.07785417 0.2460333 0.005566667 -0.24046667 0.003547291 0.003547291 FALSE TRUE
ENST00000308360 ENSG00000087111 HEK293_OSMI2_2hA HEK293_TMG_2hB PIGS protein_coding protein_coding 62.78834 91.80773 45.81774 2.88188 0.8305609 -1.002552 34.33229 40.92135 29.5137436 5.994915 0.5704175 -0.4713307 0.56452083 0.4429000 0.644200000 0.20130000 0.021164092 0.003547291 FALSE TRUE
ENST00000395346 ENSG00000087111 HEK293_OSMI2_2hA HEK293_TMG_2hB PIGS protein_coding protein_coding 62.78834 91.80773 45.81774 2.88188 0.8305609 -1.002552 17.49232 25.56382 10.7898677 2.279788 0.8094878 -1.2436543 0.27535417 0.2774333 0.235766667 -0.04166667 0.498832068 0.003547291 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000087111 E001 5.4161832 0.0124717866 5.659742e-06 3.979591e-05 17 28553383 28553386 4 - 0.000 0.903 14.138
ENSG00000087111 E002 2463.7657946 0.0026427130 6.639170e-10 1.018191e-08 17 28553387 28554495 1109 - 3.230 3.387 0.521
ENSG00000087111 E003 790.4707905 0.0006162476 2.665563e-02 6.527700e-02 17 28554851 28555061 211 - 2.804 2.872 0.224
ENSG00000087111 E004 24.9690387 0.0233545580 6.429171e-06 4.465581e-05 17 28555062 28556165 1104 - 1.631 1.198 -1.499
ENSG00000087111 E005 461.4973582 0.0001286680 1.758636e-01 2.958078e-01 17 28556166 28556266 101 - 2.581 2.633 0.175
ENSG00000087111 E006 9.3461325 0.0017801747 2.398733e-05 1.461527e-04 17 28556267 28556468 202 - 1.228 0.809 -1.549
ENSG00000087111 E007 15.6879389 0.0016770274 2.509902e-07 2.360237e-06 17 28556469 28556826 358 - 1.434 1.021 -1.462
ENSG00000087111 E008 540.1182386 0.0001068474 7.524327e-01 8.386102e-01 17 28556827 28556961 135 - 2.671 2.694 0.074
ENSG00000087111 E009 252.8685126 0.0002112159 8.236223e-01 8.888730e-01 17 28556962 28556972 11 - 2.344 2.366 0.073
ENSG00000087111 E010 13.7097784 0.0098524385 1.106291e-06 9.097692e-06 17 28556973 28557503 531 - 1.404 0.949 -1.624
ENSG00000087111 E011 308.2058074 0.0001986013 2.758899e-01 4.152849e-01 17 28558476 28558501 26 - 2.443 2.446 0.011
ENSG00000087111 E012 265.0273335 0.0009343168 8.714851e-02 1.708228e-01 17 28558502 28558521 20 - 2.394 2.376 -0.061
ENSG00000087111 E013 374.9511170 0.0001409948 4.182355e-01 5.615253e-01 17 28558522 28558590 69 - 2.522 2.533 0.037
ENSG00000087111 E014 496.2917087 0.0001368305 4.929696e-02 1.079185e-01 17 28560049 28560191 143 - 2.656 2.650 -0.023
ENSG00000087111 E015 3.5814164 0.0482748625 1.368597e-01 2.437105e-01 17 28560192 28560348 157 - 0.789 0.566 -0.942
ENSG00000087111 E016 603.7207697 0.0005902535 1.196719e-03 4.629195e-03 17 28561422 28561629 208 - 2.759 2.727 -0.107
ENSG00000087111 E017 6.7343479 0.0358066895 5.467210e-03 1.720138e-02 17 28561630 28561797 168 - 1.087 0.705 -1.462
ENSG00000087111 E018 275.2989456 0.0014625475 9.141666e-05 4.816077e-04 17 28563431 28563431 1 - 2.453 2.370 -0.279
ENSG00000087111 E019 477.6375551 0.0008773642 3.808798e-04 1.700762e-03 17 28563432 28563522 91 - 2.668 2.619 -0.163
ENSG00000087111 E020 1.7099820 0.3395439411 2.655899e-02 6.507147e-02 17 28563523 28563613 91 - 0.719 0.163 -3.215
ENSG00000087111 E021 0.8973375 0.0517642216 1.182309e-02 3.310985e-02 17 28563614 28563661 48 - 0.524 0.088 -3.374
ENSG00000087111 E022 1.1950698 0.1159916875 2.595184e-02 6.384979e-02 17 28563727 28563817 91 - 0.581 0.161 -2.653
ENSG00000087111 E023 268.2331614 0.0009848184 3.164569e-02 7.516094e-02 17 28563818 28563827 10 - 2.405 2.374 -0.102
ENSG00000087111 E024 434.5933714 0.0008517935 1.307244e-06 1.058846e-05 17 28563828 28563907 80 - 2.647 2.568 -0.264
ENSG00000087111 E025 420.9550692 0.0029809251 4.825831e-04 2.093518e-03 17 28570852 28570963 112 - 2.634 2.555 -0.263
ENSG00000087111 E026 9.0463464 0.0020945764 6.851172e-03 2.083947e-02 17 28570964 28571048 85 - 1.134 0.866 -0.994
ENSG00000087111 E027 363.6804748 0.0029759633 2.543831e-02 6.278611e-02 17 28571049 28571188 140 - 2.545 2.503 -0.141
ENSG00000087111 E028 179.2901765 0.0009489646 6.667456e-03 2.035773e-02 17 28571189 28571462 274 - 2.122 2.239 0.393
ENSG00000087111 E029 66.5963677 0.0058842758 7.031072e-02 1.438695e-01 17 28571463 28571540 78 - 1.835 1.758 -0.261
ENSG00000087111 E030 1.7253179 0.0325203275 4.464681e-01 5.879503e-01 17 28571550 28571794 245 - 0.287 0.449 0.954