ENSG00000087088

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000293288 ENSG00000087088 HEK293_OSMI2_2hA HEK293_TMG_2hB BAX protein_coding protein_coding 206.3528 381.1026 116.453 16.67518 7.01375 -1.710345 50.48745 107.39900 20.121325 4.9269890 0.9045365 -2.415601 0.22377083 0.2822667 0.1749 -0.1073667 0.004138489 2.998042e-07 FALSE TRUE
ENST00000345358 ENSG00000087088 HEK293_OSMI2_2hA HEK293_TMG_2hB BAX protein_coding protein_coding 206.3528 381.1026 116.453 16.67518 7.01375 -1.710345 102.40672 183.19683 65.370219 12.6686671 4.2886691 -1.486547 0.50318333 0.4796000 0.5612 0.0816000 0.013240637 2.998042e-07 FALSE TRUE
MSTRG.17463.4 ENSG00000087088 HEK293_OSMI2_2hA HEK293_TMG_2hB BAX protein_coding   206.3528 381.1026 116.453 16.67518 7.01375 -1.710345 11.63647 20.33928 7.660499 0.3981787 0.8207142 -1.407585 0.05945833 0.0536000 0.0654 0.0118000 0.235991359 2.998042e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000087088 E001 32.81190 0.0147136793 3.027855e-01 4.446996e-01 19 48954815 48954874 60 + 1.477 1.398 -0.275
ENSG00000087088 E002 98.68116 0.0113775624 1.961846e-01 3.214547e-01 19 48954875 48954896 22 + 1.932 1.868 -0.215
ENSG00000087088 E003 413.56866 0.0035399685 1.687995e-02 4.466841e-02 19 48954897 48954928 32 + 2.553 2.488 -0.216
ENSG00000087088 E004 609.74563 0.0024191594 4.298347e-02 9.651412e-02 19 48954929 48954962 34 + 2.702 2.662 -0.134
ENSG00000087088 E005 77.74492 0.0064415482 2.344806e-15 8.446788e-14 19 48954963 48955507 545 + 2.098 1.663 -1.465
ENSG00000087088 E006 36.28300 0.0124240507 6.565402e-07 5.672181e-06 19 48955508 48955547 40 + 1.743 1.356 -1.325
ENSG00000087088 E007 792.36039 0.0015277067 3.587396e-03 1.197507e-02 19 48955548 48955599 52 + 2.824 2.773 -0.169
ENSG00000087088 E008 77.57908 0.0003318775 3.635111e-09 4.855879e-08 19 48955600 48955686 87 + 1.975 1.722 -0.852
ENSG00000087088 E009 1811.04620 0.0002083739 1.308829e-04 6.626413e-04 19 48955687 48955833 147 + 3.164 3.136 -0.092
ENSG00000087088 E010 30.94895 0.0136179270 3.116620e-08 3.494315e-07 19 48955853 48956197 345 + 1.722 1.262 -1.581
ENSG00000087088 E011 2358.44956 0.0003261903 5.833570e-01 7.074832e-01 19 48956198 48956333 136 + 3.249 3.259 0.034
ENSG00000087088 E012 20.93722 0.0009078708 6.918941e-01 7.932617e-01 19 48960239 48960336 98 + 1.191 1.242 0.181
ENSG00000087088 E013 1914.74640 0.0006535235 2.685495e-01 4.070235e-01 19 48960810 48960914 105 + 3.167 3.167 0.003
ENSG00000087088 E014 1620.19826 0.0039882679 5.050337e-11 9.379190e-10 19 48960915 48961482 568 + 2.906 3.128 0.740
ENSG00000087088 E015 656.51779 0.0020470068 8.021464e-07 6.798990e-06 19 48961483 48961531 49 + 2.568 2.728 0.533
ENSG00000087088 E016 1319.06505 0.0004741038 5.694055e-01 6.959655e-01 19 48961532 48961570 39 + 2.984 3.010 0.086
ENSG00000087088 E017 1330.50239 0.0002384237 7.461853e-01 8.340220e-01 19 48961571 48961798 228 + 2.992 3.012 0.068