ENSG00000087085

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000411582 ENSG00000087085 HEK293_OSMI2_2hA HEK293_TMG_2hB ACHE protein_coding protein_coding 3.374457 4.947561 2.541551 0.4140943 0.1305669 -0.9582562 0.50743283 0.7171894 0.39917180 0.4292659 0.20237804 -0.82962449 0.14619167 0.13596667 0.15263333 0.01666667 0.99160246 0.01732605 FALSE TRUE
ENST00000419336 ENSG00000087085 HEK293_OSMI2_2hA HEK293_TMG_2hB ACHE protein_coding protein_coding 3.374457 4.947561 2.541551 0.4140943 0.1305669 -0.9582562 0.09288457 0.0000000 0.14387295 0.0000000 0.14387295 3.94366776 0.03492917 0.00000000 0.06126667 0.06126667 0.71808601 0.01732605 FALSE TRUE
ENST00000440755 ENSG00000087085 HEK293_OSMI2_2hA HEK293_TMG_2hB ACHE protein_coding nonsense_mediated_decay 3.374457 4.947561 2.541551 0.4140943 0.1305669 -0.9582562 0.41615878 0.8139005 0.28693042 0.1563414 0.14902091 -1.47234525 0.11871250 0.16433333 0.11096667 -0.05336667 0.72374944 0.01732605 TRUE TRUE
ENST00000651875 ENSG00000087085 HEK293_OSMI2_2hA HEK293_TMG_2hB ACHE protein_coding retained_intron 3.374457 4.947561 2.541551 0.4140943 0.1305669 -0.9582562 0.87582909 0.8490064 0.81727485 0.1491041 0.05881026 -0.05430224 0.27843750 0.17040000 0.32100000 0.15060000 0.01732605 0.01732605 TRUE TRUE
MSTRG.30358.17 ENSG00000087085 HEK293_OSMI2_2hA HEK293_TMG_2hB ACHE protein_coding   3.374457 4.947561 2.541551 0.4140943 0.1305669 -0.9582562 0.09653339 0.2710115 0.00000000 0.2710115 0.00000000 -4.81255729 0.02681250 0.06113333 0.00000000 -0.06113333 0.87300982 0.01732605 FALSE TRUE
MSTRG.30358.18 ENSG00000087085 HEK293_OSMI2_2hA HEK293_TMG_2hB ACHE protein_coding   3.374457 4.947561 2.541551 0.4140943 0.1305669 -0.9582562 0.18667143 0.5579044 0.00000000 0.3049163 0.00000000 -5.82757610 0.03796667 0.11143333 0.00000000 -0.11143333 0.26984699 0.01732605 FALSE TRUE
MSTRG.30358.8 ENSG00000087085 HEK293_OSMI2_2hA HEK293_TMG_2hB ACHE protein_coding   3.374457 4.947561 2.541551 0.4140943 0.1305669 -0.9582562 0.18871341 0.1967499 0.06770102 0.1967499 0.06770102 -1.41188100 0.05869167 0.03413333 0.02723333 -0.00690000 0.97629901 0.01732605 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000087085 E001 0.0000000       7 100889994 100889994 1 -      
ENSG00000087085 E002 0.0000000       7 100889995 100889996 2 -      
ENSG00000087085 E003 1.6355812 0.6985757957 0.52097520 0.65489452 7 100889997 100890103 107 - 0.460 0.384 -0.409
ENSG00000087085 E004 5.1334097 0.0386799779 0.37484583 0.51929753 7 100890104 100890210 107 - 0.851 0.720 -0.521
ENSG00000087085 E005 13.3770470 0.0020833331 0.99165411 0.99887757 7 100890211 100890335 125 - 1.120 1.121 0.002
ENSG00000087085 E006 3.3183128 0.0050513105 0.69713921 0.79733238 7 100890336 100890439 104 - 0.631 0.570 -0.272
ENSG00000087085 E007 9.3637286 0.0019480983 0.33013114 0.47371958 7 100890440 100890747 308 - 1.035 0.928 -0.398
ENSG00000087085 E008 7.0093868 0.0024707424 0.28493868 0.42523970 7 100890748 100890780 33 - 0.953 0.823 -0.495
ENSG00000087085 E009 9.1870467 0.0025074282 0.55208324 0.68144775 7 100890781 100890831 51 - 1.016 0.950 -0.245
ENSG00000087085 E010 23.6803735 0.0009024795 0.29506376 0.43617891 7 100890832 100891088 257 - 1.285 1.365 0.278
ENSG00000087085 E011 23.3565802 0.0009395012 0.38006186 0.52433044 7 100891169 100891254 86 - 1.285 1.352 0.234
ENSG00000087085 E012 26.7968606 0.0007937947 0.30785856 0.45009168 7 100891255 100891338 84 - 1.344 1.417 0.251
ENSG00000087085 E013 34.4228430 0.0032768183 0.76595047 0.84859576 7 100892334 100892554 221 - 1.491 1.511 0.067
ENSG00000087085 E014 14.8899008 0.0013011226 0.69513290 0.79579200 7 100892555 100892643 89 - 1.120 1.157 0.132
ENSG00000087085 E015 11.1130791 0.0235465688 0.97174032 0.98635496 7 100892644 100892686 43 - 1.016 1.029 0.049
ENSG00000087085 E016 8.7222318 0.0271924484 0.85949272 0.91336499 7 100892687 100892707 21 - 0.953 0.932 -0.078
ENSG00000087085 E017 15.9766324 0.0022414016 0.72005093 0.81472284 7 100892708 100892818 111 - 1.164 1.196 0.113
ENSG00000087085 E018 14.2211800 0.0018176397 0.02531055 0.06251476 7 100892819 100893164 346 - 1.274 1.074 -0.715
ENSG00000087085 E019 86.6652185 0.0020394169 0.36133764 0.50573548 7 100893165 100893756 592 - 1.870 1.907 0.125
ENSG00000087085 E020 37.2813240 0.0006215089 0.55238373 0.68166679 7 100893757 100893904 148 - 1.558 1.523 -0.120
ENSG00000087085 E021 28.3370717 0.0006988841 0.24595684 0.38121446 7 100893905 100894106 202 - 1.471 1.394 -0.267
ENSG00000087085 E022 10.0625025 0.0282833197 0.35801485 0.50240994 7 100894107 100894148 42 - 0.879 1.021 0.532
ENSG00000087085 E023 14.4668492 0.0410438424 0.43489229 0.57714708 7 100894149 100894252 104 - 1.035 1.166 0.473
ENSG00000087085 E024 3.9053041 0.1359890519 0.85265197 0.90868830 7 100894253 100894255 3 - 0.631 0.638 0.029
ENSG00000087085 E025 1.3254792 0.0103915044 0.08733396 0.17109519 7 100894256 100894388 133 - 0.524 0.225 -1.787
ENSG00000087085 E026 9.1327144 0.0024124112 0.43175426 0.57427490 7 100895802 100895920 119 - 0.878 0.972 0.353
ENSG00000087085 E027 0.8856816 0.0681101775 0.73653449 0.82699547 7 100896059 100896129 71 - 0.287 0.226 -0.458
ENSG00000087085 E028 1.8529489 0.1405849588 0.22160866 0.35232541 7 100896140 100896281 142 - 0.581 0.331 -1.299
ENSG00000087085 E029 2.7991102 0.1639446996 0.32863000 0.47212051 7 100896553 100896974 422 - 0.676 0.459 -0.995