ENSG00000087077

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000200457 ENSG00000087077 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIP6 protein_coding protein_coding 75.62568 143.8392 42.8108 8.022414 1.581524 -1.748173 53.165293 109.032620 24.993184 8.8896667 0.7041737 -2.1247084 0.66214583 0.75590000 0.58426667 -0.17163333 1.874290e-04 2.926752e-14 FALSE TRUE
ENST00000488670 ENSG00000087077 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIP6 protein_coding retained_intron 75.62568 143.8392 42.8108 8.022414 1.581524 -1.748173 4.629481 4.527412 4.086636 0.4425389 0.1800190 -0.1474301 0.08179583 0.03136667 0.09583333 0.06446667 2.926752e-14 2.926752e-14   FALSE
ENST00000619988 ENSG00000087077 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIP6 protein_coding protein_coding 75.62568 143.8392 42.8108 8.022414 1.581524 -1.748173 5.398720 14.433376 4.815179 3.7188622 0.8976710 -1.5817538 0.06974167 0.10363333 0.11163333 0.00800000 9.059240e-01 2.926752e-14 FALSE TRUE
MSTRG.30357.1 ENSG00000087077 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIP6 protein_coding   75.62568 143.8392 42.8108 8.022414 1.581524 -1.748173 4.727415 7.546317 3.610640 0.9782893 0.1444654 -1.0614385 0.06676250 0.05223333 0.08433333 0.03210000 6.476326e-03 2.926752e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000087077 E001 65.378605 0.0003951139 5.163786e-08 5.552638e-07 7 100867259 100867386 128 + 1.900 1.629 -0.916
ENSG00000087077 E002 36.278616 0.0005851376 1.472148e-04 7.351115e-04 7 100867387 100867388 2 + 1.636 1.384 -0.862
ENSG00000087077 E003 36.418489 0.0006030426 4.993348e-04 2.157410e-03 7 100867389 100867393 5 + 1.622 1.390 -0.796
ENSG00000087077 E004 428.274090 0.0035417627 7.671820e-01 8.494724e-01 7 100867394 100867497 104 + 2.500 2.498 -0.005
ENSG00000087077 E005 557.021471 0.0009589005 9.519267e-01 9.739101e-01 7 100867498 100867606 109 + 2.608 2.612 0.015
ENSG00000087077 E006 393.937459 0.0007728795 5.532901e-02 1.185590e-01 7 100867861 100867910 50 + 2.412 2.469 0.189
ENSG00000087077 E007 402.575041 0.0019736464 2.659589e-02 6.515070e-02 7 100867911 100867988 78 + 2.404 2.482 0.260
ENSG00000087077 E008 5.193785 0.0099102805 6.191719e-01 7.366487e-01 7 100867989 100868035 47 + 0.755 0.680 -0.312
ENSG00000087077 E009 7.688004 0.0032081679 2.480518e-02 6.147493e-02 7 100868036 100868107 72 + 1.044 0.759 -1.085
ENSG00000087077 E010 547.391596 0.0027983034 5.795861e-01 7.044569e-01 7 100868108 100868233 126 + 2.582 2.609 0.091
ENSG00000087077 E011 11.463152 0.0290541890 1.325842e-02 3.652047e-02 7 100868296 100868494 199 + 1.215 0.897 -1.164
ENSG00000087077 E012 1126.781372 0.0005381657 3.733266e-01 5.177705e-01 7 100868495 100868810 316 + 2.900 2.921 0.069
ENSG00000087077 E013 529.020390 0.0001198888 7.439197e-01 8.324082e-01 7 100868811 100868866 56 + 2.581 2.591 0.033
ENSG00000087077 E014 649.054526 0.0001148809 9.434051e-01 9.685087e-01 7 100870370 100870463 94 + 2.674 2.679 0.016
ENSG00000087077 E015 8.149009 0.0025854849 4.641262e-05 2.635395e-04 7 100870464 100870573 110 + 1.197 0.721 -1.790
ENSG00000087077 E016 1033.931009 0.0001227212 5.869904e-01 7.104010e-01 7 100870574 100870743 170 + 2.871 2.882 0.039
ENSG00000087077 E017 36.787434 0.0049321537 1.171724e-16 4.991671e-15 7 100870783 100871008 226 + 1.846 1.288 -1.907
ENSG00000087077 E018 25.224769 0.0007827260 1.567521e-10 2.675094e-09 7 100871061 100871177 117 + 1.636 1.169 -1.619
ENSG00000087077 E019 1229.657959 0.0006553447 9.033288e-01 9.424792e-01 7 100871543 100871721 179 + 2.951 2.959 0.026
ENSG00000087077 E020 916.401033 0.0012366083 5.749034e-01 7.006306e-01 7 100872624 100872744 121 + 2.815 2.833 0.060
ENSG00000087077 E021 18.749894 0.0009805444 1.129995e-04 5.816473e-04 7 100872745 100872833 89 + 1.423 1.087 -1.183
ENSG00000087077 E022 871.848654 0.0038654238 4.879808e-01 6.256064e-01 7 100873172 100873534 363 + 2.785 2.814 0.096