ENSG00000087053

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000346299 ENSG00000087053 HEK293_OSMI2_2hA HEK293_TMG_2hB MTMR2 protein_coding protein_coding 15.61803 7.039907 23.90932 0.5338043 0.8210386 1.7625 2.2160070 1.1090585 3.0918113 0.6422706 0.9085069 1.4708254 0.17993333 0.14563333 0.13220000 -0.01343333 9.442417e-01 2.167617e-05 FALSE TRUE
ENST00000352297 ENSG00000087053 HEK293_OSMI2_2hA HEK293_TMG_2hB MTMR2 protein_coding protein_coding 15.61803 7.039907 23.90932 0.5338043 0.8210386 1.7625 8.0286065 0.9795081 12.9200583 0.5235240 1.2633706 3.7078735 0.44798333 0.14413333 0.53796667 0.39383333 2.059121e-01 2.167617e-05 FALSE TRUE
ENST00000409459 ENSG00000087053 HEK293_OSMI2_2hA HEK293_TMG_2hB MTMR2 protein_coding protein_coding 15.61803 7.039907 23.90932 0.5338043 0.8210386 1.7625 0.9929234 0.6835378 0.9747411 0.3944699 0.4874668 0.5057699 0.05960417 0.09436667 0.04196667 -0.05240000 9.011277e-01 2.167617e-05 FALSE TRUE
ENST00000444541 ENSG00000087053 HEK293_OSMI2_2hA HEK293_TMG_2hB MTMR2 protein_coding protein_coding 15.61803 7.039907 23.90932 0.5338043 0.8210386 1.7625 0.5776060 0.0000000 1.4219059 0.0000000 0.4444907 7.1617929 0.02233750 0.00000000 0.05966667 0.05966667 2.167617e-05 2.167617e-05 FALSE TRUE
ENST00000675022 ENSG00000087053 HEK293_OSMI2_2hA HEK293_TMG_2hB MTMR2 protein_coding protein_coding 15.61803 7.039907 23.90932 0.5338043 0.8210386 1.7625 0.1019037 0.7445660 0.0000000 0.3753414 0.0000000 -6.2375752 0.01450833 0.11360000 0.00000000 -0.11360000 9.298102e-02 2.167617e-05 FALSE TRUE
ENST00000675438 ENSG00000087053 HEK293_OSMI2_2hA HEK293_TMG_2hB MTMR2 protein_coding protein_coding 15.61803 7.039907 23.90932 0.5338043 0.8210386 1.7625 0.9708618 1.7640401 1.0662637 0.2713441 0.6311840 -0.7210071 0.08813333 0.25153333 0.04400000 -0.20753333 2.036911e-01 2.167617e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000087053 E001 10.4598892 0.0018790387 4.023364e-06 2.924395e-05 11 95821766 95823808 2043 - 0.818 1.323 1.846
ENSG00000087053 E002 1.1717752 0.1581291943 9.824535e-01 9.930790e-01 11 95823809 95824066 258 - 0.317 0.334 0.109
ENSG00000087053 E003 2.4841191 0.0209749950 2.333193e-01 3.663534e-01 11 95830548 95831161 614 - 0.546 0.339 -1.091
ENSG00000087053 E004 4.3160929 0.0525701786 2.521127e-01 3.884352e-01 11 95831162 95832879 1718 - 0.725 0.528 -0.863
ENSG00000087053 E005 0.4417471 0.7408718421 7.938057e-01 8.682083e-01 11 95832880 95832881 2 - 0.187 0.000 -11.900
ENSG00000087053 E006 121.2684579 0.0099347377 6.394845e-08 6.743580e-07 11 95832882 95834087 1206 - 1.913 2.266 1.182
ENSG00000087053 E007 10.3775542 0.0033516291 2.057795e-02 5.270501e-02 11 95834088 95834088 1 - 0.913 1.197 1.036
ENSG00000087053 E008 10.3775542 0.0033516291 2.057795e-02 5.270501e-02 11 95834089 95834091 3 - 0.913 1.197 1.036
ENSG00000087053 E009 10.9771594 0.0037088318 4.638686e-02 1.027362e-01 11 95834092 95834102 11 - 0.950 1.197 0.899
ENSG00000087053 E010 464.2206747 0.0040450241 6.142969e-10 9.480019e-09 11 95834103 95835289 1187 - 2.544 2.771 0.757
ENSG00000087053 E011 93.9522129 0.0003333067 2.951228e-03 1.012008e-02 11 95835290 95835320 31 - 1.880 2.037 0.525
ENSG00000087053 E012 158.8987000 0.0002621951 2.576788e-04 1.207283e-03 11 95835321 95835451 131 - 2.105 2.256 0.503
ENSG00000087053 E013 145.9623747 0.0002940839 3.020177e-01 4.438438e-01 11 95836148 95836324 177 - 2.094 2.168 0.246
ENSG00000087053 E014 121.4468753 0.0002431830 2.470947e-01 3.825144e-01 11 95838094 95838207 114 - 2.038 2.037 -0.004
ENSG00000087053 E015 95.9496406 0.0006154183 5.039561e-01 6.398864e-01 11 95841617 95841709 93 - 1.933 1.945 0.043
ENSG00000087053 E016 162.9145836 0.0009150052 1.163005e-01 2.146855e-01 11 95844953 95845159 207 - 2.166 2.154 -0.041
ENSG00000087053 E017 169.4229645 0.0002590726 1.446763e-04 7.239435e-04 11 95847714 95847899 186 - 2.200 2.120 -0.266
ENSG00000087053 E018 154.5136827 0.0006429170 8.928793e-07 7.492948e-06 11 95849674 95849862 189 - 2.172 2.039 -0.443
ENSG00000087053 E019 0.0000000       11 95850208 95850599 392 -      
ENSG00000087053 E020 115.8858627 0.0003301709 1.507045e-09 2.161514e-08 11 95850600 95850749 150 - 2.062 1.859 -0.682
ENSG00000087053 E021 41.9125314 0.0005061601 4.130200e-03 1.350665e-02 11 95857552 95857555 4 - 1.619 1.475 -0.492
ENSG00000087053 E022 63.3011730 0.0004005802 8.868770e-03 2.595303e-02 11 95857556 95857635 80 - 1.783 1.688 -0.321
ENSG00000087053 E023 5.8573393 0.1323545381 5.931701e-01 7.156186e-01 11 95857636 95858530 895 - 0.805 0.721 -0.335
ENSG00000087053 E024 83.5308868 0.0003595166 3.502525e-04 1.581069e-03 11 95858531 95858632 102 - 1.905 1.782 -0.416
ENSG00000087053 E025 94.0111633 0.0017517521 1.476788e-03 5.562087e-03 11 95861992 95862102 111 - 1.952 1.842 -0.373
ENSG00000087053 E026 88.4101522 0.0003708400 2.032916e-05 1.258512e-04 11 95862272 95862366 95 - 1.934 1.782 -0.513
ENSG00000087053 E027 2.7794578 0.0059832460 2.074338e-01 3.354250e-01 11 95862367 95865439 3073 - 0.474 0.709 1.060
ENSG00000087053 E028 1.3608665 0.0114803746 2.165085e-01 3.461983e-01 11 95865440 95865590 151 - 0.278 0.525 1.389
ENSG00000087053 E029 0.9169173 0.0673354340 6.640947e-01 7.719751e-01 11 95865591 95865600 10 - 0.235 0.338 0.711
ENSG00000087053 E030 71.6506613 0.0003433185 1.306499e-06 1.058333e-05 11 95865601 95865676 76 - 1.856 1.650 -0.699
ENSG00000087053 E031 0.2965864 0.0871210626 4.177398e-02   11 95866384 95866402 19 - 0.000 0.336 13.993
ENSG00000087053 E032 2.0639159 0.0075223988 3.262460e-01 4.696922e-01 11 95866403 95866486 84 - 0.499 0.338 -0.872
ENSG00000087053 E033 10.5443009 0.0755026307 7.535910e-01 8.394813e-01 11 95882374 95882496 123 - 1.006 1.006 -0.002
ENSG00000087053 E034 0.2903454 0.3200804962 8.696386e-01   11 95887326 95887373 48 - 0.133 0.000 -11.684
ENSG00000087053 E035 0.0000000       11 95887610 95887611 2 -      
ENSG00000087053 E036 13.6666623 0.0013138608 1.270328e-01 2.300104e-01 11 95887612 95887684 73 - 1.144 1.018 -0.456
ENSG00000087053 E037 0.1482932 0.0408452627 1.547784e-01   11 95887685 95887759 75 - 0.000 0.201 13.304
ENSG00000087053 E038 76.8972886 0.0006084403 6.058457e-05 3.343499e-04 11 95888156 95888261 106 - 1.875 1.719 -0.529
ENSG00000087053 E039 0.5149111 0.0200305741 1.324112e-01 2.374363e-01 11 95907862 95907923 62 - 0.072 0.338 2.714
ENSG00000087053 E040 0.0000000       11 95910610 95910843 234 -      
ENSG00000087053 E041 0.0000000       11 95912939 95913077 139 -      
ENSG00000087053 E042 35.7433830 0.0005870694 4.499315e-03 1.454080e-02 11 95914242 95914312 71 - 1.550 1.391 -0.549
ENSG00000087053 E043 1.3651209 0.0097799651 8.420055e-01 9.014837e-01 11 95914313 95914333 21 - 0.354 0.338 -0.094
ENSG00000087053 E044 0.0000000       11 95915815 95915963 149 -      
ENSG00000087053 E045 0.1515154 0.0433614445 1.000000e+00   11 95917377 95917486 110 - 0.072 0.000 -11.102
ENSG00000087053 E046 0.0000000       11 95923621 95923691 71 -      
ENSG00000087053 E047 1.9367392 0.1446447818 8.368927e-01 8.979973e-01 11 95923692 95923874 183 - 0.447 0.436 -0.059
ENSG00000087053 E048 60.4276049 0.0025686636 3.250366e-02 7.681138e-02 11 95923875 95924000 126 - 1.756 1.672 -0.285
ENSG00000087053 E049 42.6347473 0.0005524841 4.898774e-02 1.073594e-01 11 95924001 95924131 131 - 1.608 1.524 -0.286
ENSG00000087053 E050 0.0000000       11 95924479 95924776 298 -      
ENSG00000087053 E051 0.7427016 0.0157043411 1.896433e-01 3.132999e-01 11 95925081 95925315 235 - 0.278 0.000 -13.383