ENSG00000086712

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000380122 ENSG00000086712 HEK293_OSMI2_2hA HEK293_TMG_2hB TXLNG protein_coding protein_coding 23.33737 9.297182 38.55408 0.2795295 1.13412 2.050841 19.581343 6.626642 33.775795 0.3464258 0.8359336 2.347891 0.81218333 0.7159333 0.876766667 0.1608333 4.324624e-02 7.138591e-09 FALSE TRUE
ENST00000485153 ENSG00000086712 HEK293_OSMI2_2hA HEK293_TMG_2hB TXLNG protein_coding processed_transcript 23.33737 9.297182 38.55408 0.2795295 1.13412 2.050841 1.051255 2.075601 0.345434 0.6225134 0.1061010 -2.552809 0.09226667 0.2201333 0.008966667 -0.2111667 7.138591e-09 7.138591e-09   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000086712 E001 3.0142193 0.0613977935 2.713839e-01 4.101349e-01 X 16786432 16786465 34 + 0.570 0.380 -0.957
ENSG00000086712 E002 3.0142193 0.0613977935 2.713839e-01 4.101349e-01 X 16786466 16786471 6 + 0.570 0.380 -0.957
ENSG00000086712 E003 6.2669494 0.0056284436 1.769053e-01 2.972275e-01 X 16786472 16786474 3 + 0.809 0.653 -0.638
ENSG00000086712 E004 98.4707282 0.0003421098 1.641289e-07 1.599636e-06 X 16786475 16786589 115 + 1.939 1.761 -0.598
ENSG00000086712 E005 0.1515154 0.0423205016 1.000000e+00   X 16789118 16789151 34 + 0.061 0.000 -8.050
ENSG00000086712 E006 3.2685611 0.0538461908 4.175402e-01 5.608739e-01 X 16790386 16790549 164 + 0.515 0.714 0.879
ENSG00000086712 E007 4.6315686 0.0045227715 3.197988e-01 4.628867e-01 X 16793677 16793786 110 + 0.693 0.580 -0.491
ENSG00000086712 E008 0.3729606 0.0259256416 3.185936e-01 4.615584e-01 X 16802933 16802962 30 + 0.061 0.231 2.211
ENSG00000086712 E009 260.9032354 0.0001734908 3.494473e-08 3.883483e-07 X 16818574 16818877 304 + 2.344 2.264 -0.266
ENSG00000086712 E010 147.0862693 0.0002229633 4.958018e-04 2.143940e-03 X 16820164 16820255 92 + 2.091 2.036 -0.184
ENSG00000086712 E011 181.0772312 0.0007220386 7.408040e-05 3.997012e-04 X 16828094 16828264 171 + 2.182 2.116 -0.222
ENSG00000086712 E012 216.5420063 0.0002231937 4.865906e-08 5.259492e-07 X 16829576 16829770 195 + 2.264 2.168 -0.321
ENSG00000086712 E013 148.4245055 0.0007108895 1.981386e-04 9.558877e-04 X 16832623 16832742 120 + 2.096 2.025 -0.237
ENSG00000086712 E014 136.6765719 0.0002494856 2.181159e-03 7.783860e-03 X 16834283 16834357 75 + 2.057 2.014 -0.146
ENSG00000086712 E015 144.9618081 0.0002748228 2.924317e-03 1.004284e-02 X 16837593 16837685 93 + 2.082 2.045 -0.124
ENSG00000086712 E016 103.0174242 0.0058915322 4.914181e-02 1.076249e-01 X 16839821 16839836 16 + 1.935 1.890 -0.151
ENSG00000086712 E017 149.6564588 0.0045359980 6.667508e-02 1.378642e-01 X 16839837 16839916 80 + 2.091 2.072 -0.065
ENSG00000086712 E018 2.7175668 0.0061285209 5.447621e-02 1.170865e-01 X 16839917 16839975 59 + 0.400 0.771 1.694
ENSG00000086712 E019 261.8953936 0.0012706190 1.053906e-01 1.986918e-01 X 16841428 16841772 345 + 2.324 2.346 0.072
ENSG00000086712 E020 49.2991549 0.0027616544 3.633948e-01 5.078006e-01 X 16841773 16841774 2 + 1.609 1.619 0.035
ENSG00000086712 E021 1472.0767346 0.0027992401 8.371533e-10 1.258500e-08 X 16841775 16844372 2598 + 3.035 3.210 0.581
ENSG00000086712 E022 86.4573565 0.0129763636 1.175789e-13 3.308328e-12 X 16844373 16844519 147 + 1.660 2.236 1.937
ENSG00000086712 E023 1.5155921 0.0089389687 3.829120e-01 5.270802e-01 X 16845522 16845526 5 + 0.373 0.230 -0.961
ENSG00000086712 E024 3.9608110 0.0061142785 2.237258e-01 3.548576e-01 X 16845527 16845800 274 + 0.571 0.819 1.036