ENSG00000086300

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000338523 ENSG00000086300 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX10 protein_coding protein_coding 2.91267 1.021697 5.404869 0.1639215 0.5055359 2.391908 2.05258977 0.12827277 4.3171498 0.08249443 0.1952987 4.967828 0.62042917 0.1141667 0.8058667 0.69170000 4.844841e-06 4.844841e-06 FALSE TRUE
ENST00000396376 ENSG00000086300 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX10 protein_coding protein_coding 2.91267 1.021697 5.404869 0.1639215 0.5055359 2.391908 0.06071442 0.27251325 0.0000000 0.27251325 0.0000000 -4.820247 0.06316667 0.2875333 0.0000000 -0.28753333 6.207339e-01 4.844841e-06 FALSE TRUE
ENST00000416246 ENSG00000086300 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX10 protein_coding protein_coding 2.91267 1.021697 5.404869 0.1639215 0.5055359 2.391908 0.38445962 0.04340973 0.8138044 0.04340973 0.3267661 3.947127 0.09383333 0.0458000 0.1435333 0.09773333 3.600678e-01 4.844841e-06 FALSE FALSE
ENST00000619420 ENSG00000086300 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX10 protein_coding protein_coding 2.91267 1.021697 5.404869 0.1639215 0.5055359 2.391908 0.27277867 0.57750084 0.0000000 0.30822262 0.0000000 -5.876519 0.17015000 0.5525000 0.0000000 -0.55250000 6.026701e-02 4.844841e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000086300 E001 1.0309706 0.0123435594 2.735473e-01 4.125914e-01 7 26291862 26291894 33 + 0.300 0.000 -11.372
ENSG00000086300 E002 1.4728315 0.0315551108 1.458877e-01 2.560780e-01 7 26291895 26291920 26 + 0.384 0.000 -13.165
ENSG00000086300 E003 7.3774319 0.0024234476 1.012331e-03 4.001150e-03 7 26291921 26292010 90 + 0.901 0.242 -3.220
ENSG00000086300 E004 11.2932551 0.0021213280 3.865599e-03 1.276452e-02 7 26292011 26292086 76 + 1.050 0.600 -1.775
ENSG00000086300 E005 0.1515154 0.0441558684 1.000000e+00   7 26292087 26292133 47 + 0.058 0.000 -10.183
ENSG00000086300 E006 0.0000000       7 26293054 26293158 105 +      
ENSG00000086300 E007 12.8756817 0.0014512472 3.178180e-02 7.542992e-02 7 26346420 26346466 47 + 1.087 0.794 -1.102
ENSG00000086300 E008 0.2924217 0.0277128096 1.000000e+00   7 26354057 26354184 128 + 0.108 0.000 -11.215
ENSG00000086300 E009 1.6825347 0.0841698377 8.057570e-01 8.765080e-01 7 26357007 26357127 121 + 0.357 0.397 0.231
ENSG00000086300 E010 0.0000000       7 26360454 26360464 11 +      
ENSG00000086300 E011 0.0000000       7 26360606 26360618 13 +      
ENSG00000086300 E012 16.4535913 0.0012289636 7.649379e-02 1.538893e-01 7 26360975 26361061 87 + 1.173 0.964 -0.761
ENSG00000086300 E013 0.1451727 0.0436869340 1.000000e+00   7 26364325 26364502 178 + 0.058 0.000 -10.185
ENSG00000086300 E014 21.3905091 0.0010555699 3.342254e-02 7.862367e-02 7 26364535 26364635 101 + 1.283 1.059 -0.798
ENSG00000086300 E015 23.6433293 0.0010192185 3.480241e-03 1.166734e-02 7 26365047 26365145 99 + 1.334 1.029 -1.085
ENSG00000086300 E016 0.1451727 0.0436869340 1.000000e+00   7 26370388 26370724 337 + 0.058 0.000 -10.185
ENSG00000086300 E017 34.8059296 0.0008331305 6.566998e-03 2.010014e-02 7 26371821 26372033 213 + 1.484 1.259 -0.782
ENSG00000086300 E018 123.2042824 0.0004495376 6.397517e-18 3.209720e-16 7 26372491 26374383 1893 + 1.942 2.159 0.725