ENSG00000086189

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000506390 ENSG00000086189 HEK293_OSMI2_2hA HEK293_TMG_2hB DIMT1 protein_coding protein_coding 33.48424 24.48615 50.58531 2.190168 0.9896837 1.046449 2.827857 0.7226491 5.321306 0.1935471 0.5852333 2.8632945 0.07491250 0.02933333 0.1048333 0.07550000 0.0001692167 0.0001692167 FALSE  
ENST00000514911 ENSG00000086189 HEK293_OSMI2_2hA HEK293_TMG_2hB DIMT1 protein_coding nonsense_mediated_decay 33.48424 24.48615 50.58531 2.190168 0.9896837 1.046449 2.569588 0.4167574 3.412364 0.2480232 0.4672755 3.0035050 0.06934167 0.01720000 0.0676000 0.05040000 0.1961878998 0.0001692167 TRUE  
ENST00000679751 ENSG00000086189 HEK293_OSMI2_2hA HEK293_TMG_2hB DIMT1 protein_coding protein_coding 33.48424 24.48615 50.58531 2.190168 0.9896837 1.046449 4.286467 5.4277122 6.588295 1.3040552 1.5338166 0.2790934 0.14105417 0.22300000 0.1315333 -0.09146667 0.4421632227 0.0001692167 FALSE  
ENST00000681192 ENSG00000086189 HEK293_OSMI2_2hA HEK293_TMG_2hB DIMT1 protein_coding protein_coding 33.48424 24.48615 50.58531 2.190168 0.9896837 1.046449 14.225985 10.1314883 18.707904 2.1545653 1.7913168 0.8841495 0.42672500 0.41006667 0.3687000 -0.04136667 0.8717021758 0.0001692167 FALSE  
ENST00000681672 ENSG00000086189 HEK293_OSMI2_2hA HEK293_TMG_2hB DIMT1 protein_coding nonsense_mediated_decay 33.48424 24.48615 50.58531 2.190168 0.9896837 1.046449 5.480611 5.5391082 10.199149 0.2701415 1.1893083 0.8795347 0.16502083 0.22953333 0.2018000 -0.02773333 0.7685546871 0.0001692167 TRUE  
MSTRG.26267.3 ENSG00000086189 HEK293_OSMI2_2hA HEK293_TMG_2hB DIMT1 protein_coding   33.48424 24.48615 50.58531 2.190168 0.9896837 1.046449 1.660854 1.3769898 2.206358 0.3475493 0.1273067 0.6762338 0.05010417 0.05490000 0.0436000 -0.01130000 0.6826848530 0.0001692167 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000086189 E001 0.0000000       5 62347284 62349212 1929 -      
ENSG00000086189 E002 0.0000000       5 62351107 62351223 117 -      
ENSG00000086189 E003 0.2966881 0.0271289404 4.226054e-01   5 62352586 62352683 98 - 0.173 0.000 -10.589
ENSG00000086189 E004 0.2966881 0.0271289404 4.226054e-01   5 62354279 62354348 70 - 0.173 0.000 -10.586
ENSG00000086189 E005 0.3332198 0.0322418330 6.661493e-01   5 62372833 62373043 211 - 0.095 0.157 0.833
ENSG00000086189 E006 8.1326434 0.0022482391 8.347110e-01 8.965292e-01 5 62387254 62387964 711 - 0.945 0.966 0.080
ENSG00000086189 E007 33.1528082 0.0006646752 4.314252e-02 9.680699e-02 5 62387965 62388526 562 - 1.477 1.598 0.413
ENSG00000086189 E008 345.6965186 0.0003463019 7.744515e-32 1.465709e-29 5 62388527 62389026 500 - 2.428 2.659 0.769
ENSG00000086189 E009 174.2995493 0.0004789722 6.209953e-02 1.301707e-01 5 62389027 62389052 26 - 2.218 2.269 0.168
ENSG00000086189 E010 297.6959955 0.0002697525 5.576057e-03 1.749054e-02 5 62390876 62390982 107 - 2.447 2.503 0.186
ENSG00000086189 E011 20.5460959 0.0029052619 6.260897e-08 6.617061e-07 5 62390983 62391716 734 - 1.467 0.966 -1.778
ENSG00000086189 E012 15.5053017 0.0634439951 2.598183e-01 3.972799e-01 5 62391717 62392006 290 - 1.270 1.103 -0.593
ENSG00000086189 E013 9.5299856 0.0201556397 3.345117e-03 1.127678e-02 5 62392007 62392170 164 - 1.136 0.728 -1.543
ENSG00000086189 E014 147.9218909 0.0003005647 2.202292e-02 5.572634e-02 5 62392171 62392177 7 - 2.141 2.206 0.218
ENSG00000086189 E015 220.7210476 0.0001795586 1.196803e-02 3.345393e-02 5 62392178 62392234 57 - 2.317 2.375 0.193
ENSG00000086189 E016 14.9055143 0.0011548062 1.034169e-05 6.851891e-05 5 62392235 62392925 691 - 1.322 0.876 -1.618
ENSG00000086189 E017 241.2669713 0.0001775237 3.618847e-02 8.394613e-02 5 62392926 62392990 65 - 2.361 2.406 0.152
ENSG00000086189 E018 3.4877912 0.0225467226 2.187603e-01 3.489214e-01 5 62392991 62393729 739 - 0.712 0.502 -0.931
ENSG00000086189 E019 304.2287798 0.0008821145 7.844726e-01 8.617276e-01 5 62393955 62394047 93 - 2.483 2.471 -0.040
ENSG00000086189 E020 324.6137544 0.0019107922 1.867887e-01 3.096994e-01 5 62394484 62394607 124 - 2.523 2.479 -0.147
ENSG00000086189 E021 24.2259713 0.0194606786 1.652954e-09 2.352721e-08 5 62396174 62398428 2255 - 1.564 0.850 -2.551
ENSG00000086189 E022 6.8208567 0.0470360125 5.227275e-01 6.564777e-01 5 62398429 62398510 82 - 0.920 0.823 -0.374
ENSG00000086189 E023 185.3040168 0.0002805063 1.497091e-01 2.612824e-01 5 62398511 62398536 26 - 2.283 2.241 -0.139
ENSG00000086189 E024 178.4738417 0.0002052695 5.046037e-02 1.099850e-01 5 62398537 62398560 24 - 2.271 2.215 -0.187
ENSG00000086189 E025 2.6710097 0.0057111939 2.432717e-03 8.560170e-03 5 62398561 62398645 85 - 0.711 0.157 -3.255
ENSG00000086189 E026 262.2522189 0.0001661391 3.018687e-01 4.436902e-01 5 62398646 62398739 94 - 2.427 2.401 -0.085
ENSG00000086189 E027 3.6864620 0.0555979306 1.815375e-01 3.031605e-01 5 62398740 62398819 80 - 0.752 0.500 -1.104
ENSG00000086189 E028 138.8717103 0.0002568530 2.096871e-01 3.381796e-01 5 62398820 62398823 4 - 2.159 2.118 -0.137
ENSG00000086189 E029 219.3883246 0.0002271022 1.182670e-01 2.174473e-01 5 62398824 62398881 58 - 2.356 2.315 -0.137
ENSG00000086189 E030 1.7274724 0.0087498413 5.526802e-01 6.819350e-01 5 62399781 62399878 98 - 0.470 0.362 -0.582
ENSG00000086189 E031 2.0724487 0.0665969171 1.031307e-01 1.952432e-01 5 62401113 62401277 165 - 0.594 0.270 -1.763
ENSG00000086189 E032 239.8542230 0.0025321258 2.659615e-02 6.515070e-02 5 62402036 62402122 87 - 2.407 2.330 -0.257
ENSG00000086189 E033 221.1185073 0.0001972465 2.245233e-04 1.068499e-03 5 62403273 62403346 74 - 2.378 2.284 -0.313
ENSG00000086189 E034 1.1448321 0.5173974060 8.603127e-01 9.138776e-01 5 62403347 62403450 104 - 0.297 0.365 0.426
ENSG00000086189 E035 0.4502799 0.0295305239 2.257117e-01 3.572388e-01 5 62403451 62403624 174 - 0.239 0.000 -11.172
ENSG00000086189 E036 0.4439371 0.0215550631 2.237849e-01 3.549335e-01 5 62403668 62403693 26 - 0.238 0.000 -11.171
ENSG00000086189 E037 204.6951136 0.0001888551 1.144273e-05 7.502304e-05 5 62403694 62403943 250 - 2.351 2.236 -0.387