ENSG00000086102

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000318524 ENSG00000086102 HEK293_OSMI2_2hA HEK293_TMG_2hB NFX1 protein_coding protein_coding 22.84641 20.68829 24.87787 0.5741789 0.4887966 0.2659308 6.148281 5.331161 8.058544 0.2899426 0.4402510 0.5951551 0.2651792 0.25773333 0.3242667 0.066533333 1.825603e-01 8.136752e-23 FALSE TRUE
ENST00000379540 ENSG00000086102 HEK293_OSMI2_2hA HEK293_TMG_2hB NFX1 protein_coding protein_coding 22.84641 20.68829 24.87787 0.5741789 0.4887966 0.2659308 8.667877 7.182572 8.825699 0.7486465 0.3534666 0.2968364 0.3796917 0.34593333 0.3554000 0.009466667 9.462128e-01 8.136752e-23 FALSE TRUE
MSTRG.32533.12 ENSG00000086102 HEK293_OSMI2_2hA HEK293_TMG_2hB NFX1 protein_coding   22.84641 20.68829 24.87787 0.5741789 0.4887966 0.2659308 1.888408 5.216859 0.000000 0.8319365 0.0000000 -9.0298003 0.0947375 0.25433333 0.0000000 -0.254333333 8.136752e-23 8.136752e-23 FALSE TRUE
MSTRG.32533.2 ENSG00000086102 HEK293_OSMI2_2hA HEK293_TMG_2hB NFX1 protein_coding   22.84641 20.68829 24.87787 0.5741789 0.4887966 0.2659308 2.187286 0.433022 4.182985 0.4330220 0.1773360 3.2425275 0.0867000 0.02143333 0.1681667 0.146733333 5.528511e-02 8.136752e-23 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000086102 E001 0.5870335 0.1387196071 6.976886e-02 1.429884e-01 9 33290461 33290479 19 + 0.341 0.000 -10.593
ENSG00000086102 E002 3.0927070 0.0049156972 4.602368e-02 1.020775e-01 9 33290480 33290511 32 + 0.738 0.443 -1.332
ENSG00000086102 E003 3.2442224 0.0049021798 3.080413e-02 7.353516e-02 9 33290512 33290515 4 + 0.761 0.443 -1.425
ENSG00000086102 E004 21.2841192 0.0008691328 1.420468e-07 1.401872e-06 9 33290516 33290544 29 + 1.501 1.117 -1.346
ENSG00000086102 E005 53.0882332 0.0069717779 4.422998e-05 2.524703e-04 9 33290545 33290597 53 + 1.833 1.601 -0.788
ENSG00000086102 E006 6.9407918 0.0071521076 8.136331e-01 8.818509e-01 9 33291421 33291578 158 + 0.861 0.910 0.187
ENSG00000086102 E007 118.1553585 0.0032103867 1.442008e-14 4.643620e-13 9 33294420 33294567 148 + 2.203 1.897 -1.024
ENSG00000086102 E008 539.2709232 0.0004592628 8.313494e-48 4.499904e-45 9 33294568 33295427 860 + 2.831 2.605 -0.754
ENSG00000086102 E009 168.1964804 0.0013839125 1.829609e-04 8.906487e-04 9 33301263 33301421 159 + 2.273 2.177 -0.318
ENSG00000086102 E010 94.3451315 0.0087933122 7.968484e-01 8.703604e-01 9 33303191 33303268 78 + 1.973 1.987 0.048
ENSG00000086102 E011 103.4253992 0.0055097304 8.293049e-01 8.928282e-01 9 33307194 33307299 106 + 2.000 2.038 0.128
ENSG00000086102 E012 94.4162354 0.0003072599 3.060264e-01 4.481740e-01 9 33311106 33311177 72 + 1.984 1.970 -0.046
ENSG00000086102 E013 121.4205447 0.0002703998 9.888193e-02 1.887653e-01 9 33313654 33313793 140 + 2.101 2.072 -0.099
ENSG00000086102 E014 120.3689392 0.0002422797 7.574112e-01 8.422512e-01 9 33318731 33318830 100 + 2.076 2.090 0.046
ENSG00000086102 E015 127.3787972 0.0031647871 6.215613e-01 7.385129e-01 9 33318910 33319020 111 + 2.083 2.129 0.154
ENSG00000086102 E016 150.6381444 0.0036277844 6.666298e-01 7.740602e-01 9 33319021 33319127 107 + 2.175 2.185 0.031
ENSG00000086102 E017 148.2745590 0.0015756255 2.564867e-01 3.934496e-01 9 33328581 33328678 98 + 2.181 2.167 -0.047
ENSG00000086102 E018 113.4533127 0.0003329576 3.176969e-01 4.605907e-01 9 33332472 33332502 31 + 2.062 2.053 -0.032
ENSG00000086102 E019 0.0000000       9 33332503 33332657 155 +      
ENSG00000086102 E020 19.0293325 0.0009512634 8.526741e-01 9.086883e-01 9 33338507 33338509 3 + 1.283 1.320 0.130
ENSG00000086102 E021 153.4350961 0.0020764828 6.379936e-01 7.517616e-01 9 33338510 33338589 80 + 2.185 2.193 0.026
ENSG00000086102 E022 146.9100870 0.0012067509 6.156588e-01 7.338732e-01 9 33342746 33342811 66 + 2.167 2.174 0.026
ENSG00000086102 E023 116.7581093 0.0017993252 7.301318e-01 8.221762e-01 9 33342812 33342854 43 + 2.065 2.076 0.036
ENSG00000086102 E024 167.1120187 0.0002139749 1.041778e-01 1.968600e-01 9 33344069 33344188 120 + 2.237 2.216 -0.069
ENSG00000086102 E025 114.5678525 0.0031063620 7.775356e-01 8.568436e-01 9 33347038 33347117 80 + 2.057 2.068 0.038
ENSG00000086102 E026 23.8589526 0.0007690059 1.038507e-01 1.963765e-01 9 33347663 33347665 3 + 1.440 1.349 -0.316
ENSG00000086102 E027 309.4385413 0.0051959952 6.654021e-01 7.730896e-01 9 33347666 33348723 1058 + 2.488 2.496 0.024
ENSG00000086102 E028 108.6920798 0.0002903623 1.275570e-01 2.307455e-01 9 33351560 33351790 231 + 1.999 2.074 0.254
ENSG00000086102 E029 0.0000000       9 33351791 33351882 92 +      
ENSG00000086102 E030 77.4213724 0.0071891296 2.463305e-02 6.112511e-02 9 33352646 33352719 74 + 1.806 1.959 0.514
ENSG00000086102 E031 87.6009385 0.0008036512 8.203631e-04 3.332090e-03 9 33354086 33354187 102 + 1.859 2.015 0.523
ENSG00000086102 E032 77.9211764 0.0003457386 6.362993e-04 2.667161e-03 9 33354851 33354892 42 + 1.807 1.969 0.542
ENSG00000086102 E033 98.5234828 0.0003385830 2.037162e-03 7.342110e-03 9 33364010 33364108 99 + 1.925 2.060 0.451
ENSG00000086102 E034 83.3768897 0.0034153695 1.989016e-04 9.590559e-04 9 33364708 33364774 67 + 1.816 2.016 0.674
ENSG00000086102 E035 19.7736264 0.0010543006 4.522506e-02 1.006042e-01 9 33364775 33365232 458 + 1.379 1.248 -0.459
ENSG00000086102 E036 24.2325177 0.0229914778 2.657559e-01 4.038427e-01 9 33365233 33366009 777 + 1.445 1.355 -0.313
ENSG00000086102 E037 122.5169149 0.0080016763 2.025798e-04 9.749055e-04 9 33366629 33366774 146 + 1.967 2.187 0.740
ENSG00000086102 E038 107.3178356 0.0003799029 2.677672e-10 4.389347e-09 9 33367515 33367619 105 + 1.892 2.137 0.824
ENSG00000086102 E039 464.0981325 0.0051923500 2.701591e-22 2.222355e-20 9 33369906 33371157 1252 + 2.437 2.816 1.259