ENSG00000086015

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361297 ENSG00000086015 HEK293_OSMI2_2hA HEK293_TMG_2hB MAST2 protein_coding protein_coding 16.85796 23.42408 11.03826 0.8048373 0.6877395 -1.084788 8.1169469 8.8650394 7.0138818 1.5578875 0.1587110 -0.337484964 0.51288333 0.37466667 0.6404667 0.26580000 1.529459e-02 2.132361e-22 FALSE TRUE
ENST00000498668 ENSG00000086015 HEK293_OSMI2_2hA HEK293_TMG_2hB MAST2 protein_coding processed_transcript 16.85796 23.42408 11.03826 0.8048373 0.6877395 -1.084788 0.8252611 0.7475047 0.7863731 0.2139913 0.1615704 0.072189704 0.05422917 0.03133333 0.0708000 0.03946667 1.741244e-01 2.132361e-22   FALSE
ENST00000674079 ENSG00000086015 HEK293_OSMI2_2hA HEK293_TMG_2hB MAST2 protein_coding protein_coding 16.85796 23.42408 11.03826 0.8048373 0.6877395 -1.084788 3.6447726 8.9441009 0.0000000 0.9982229 0.0000000 -9.806404773 0.16780417 0.38556667 0.0000000 -0.38556667 2.132361e-22 2.132361e-22 FALSE TRUE
MSTRG.1095.6 ENSG00000086015 HEK293_OSMI2_2hA HEK293_TMG_2hB MAST2 protein_coding   16.85796 23.42408 11.03826 0.8048373 0.6877395 -1.084788 1.3948457 1.2076519 1.2049140 0.6529653 0.3139067 -0.003247483 0.09434583 0.05200000 0.1066333 0.05463333 6.229283e-01 2.132361e-22 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000086015 E001 0.0000000       1 45786987 45787132 146 +      
ENSG00000086015 E002 14.9488252 0.0209496627 9.062197e-05 4.779394e-04 1 45803612 45803695 84 + 1.395 1.008 -1.376
ENSG00000086015 E003 14.2801955 0.0044733675 3.811090e-06 2.786352e-05 1 45803696 45803772 77 + 1.377 0.986 -1.394
ENSG00000086015 E004 33.2576119 0.0144920497 1.157532e-06 9.483263e-06 1 45803773 45804072 300 + 1.711 1.350 -1.239
ENSG00000086015 E005 0.9211837 0.0131911580 6.704990e-02 1.384624e-01 1 45812494 45812557 64 + 0.463 0.160 -2.098
ENSG00000086015 E006 0.8104664 0.0152382505 6.349734e-01 7.493540e-01 1 45812558 45812589 32 + 0.290 0.222 -0.513
ENSG00000086015 E007 57.3593865 0.0077284517 6.983399e-05 3.792198e-04 1 45824433 45824580 148 + 1.857 1.646 -0.711
ENSG00000086015 E008 67.4361555 0.0004488565 3.766454e-04 1.683918e-03 1 45829439 45829581 143 + 1.868 1.745 -0.416
ENSG00000086015 E009 43.4747493 0.0017766843 4.911104e-06 3.501803e-05 1 45882364 45882395 32 + 1.746 1.523 -0.760
ENSG00000086015 E010 0.0000000       1 45913588 45913646 59 +      
ENSG00000086015 E011 0.0000000       1 45913647 45913714 68 +      
ENSG00000086015 E012 0.0000000       1 45913715 45913879 165 +      
ENSG00000086015 E013 3.3109405 0.0047574748 6.454552e-02 1.342890e-01 1 45917339 45917533 195 + 0.760 0.509 -1.096
ENSG00000086015 E014 67.5436109 0.0015415894 5.892295e-04 2.494085e-03 1 45959386 45959477 92 + 1.871 1.744 -0.429
ENSG00000086015 E015 67.6182330 0.0024391379 3.882934e-03 1.281528e-02 1 45997724 45997799 76 + 1.857 1.750 -0.360
ENSG00000086015 E016 5.8979920 0.0028256216 3.672830e-01 5.116506e-01 1 46000959 46000979 21 + 0.857 0.771 -0.338
ENSG00000086015 E017 36.9653562 0.0044252820 1.753722e-03 6.452214e-03 1 46002805 46002810 6 + 1.642 1.472 -0.581
ENSG00000086015 E018 64.8729937 0.0042157634 1.116294e-04 5.752639e-04 1 46002811 46002883 73 + 1.882 1.711 -0.576
ENSG00000086015 E019 83.7971149 0.0024521853 1.578131e-07 1.542684e-06 1 46006241 46006395 155 + 2.010 1.810 -0.673
ENSG00000086015 E020 0.0000000       1 46006396 46006595 200 +      
ENSG00000086015 E021 63.9816854 0.0010619150 8.363458e-05 4.452027e-04 1 46008296 46008371 76 + 1.865 1.716 -0.504
ENSG00000086015 E022 103.3313800 0.0072883281 9.072882e-03 2.646186e-02 1 46010730 46010939 210 + 2.039 1.940 -0.334
ENSG00000086015 E023 0.4031496 0.0245194763 5.455004e-01 6.758264e-01 1 46010940 46011109 170 + 0.000 0.160 14.712
ENSG00000086015 E024 83.5494225 0.0081075845 7.570229e-01 8.419825e-01 1 46019596 46019697 102 + 1.860 1.884 0.082
ENSG00000086015 E025 57.9383815 0.0060125308 3.237024e-01 4.670382e-01 1 46021950 46021964 15 + 1.735 1.715 -0.068
ENSG00000086015 E026 107.7247427 0.0126586551 5.054711e-01 6.412341e-01 1 46021965 46022082 118 + 1.985 1.988 0.010
ENSG00000086015 E027 83.4999521 0.0195976009 8.747415e-01 9.234932e-01 1 46022910 46022971 62 + 1.830 1.893 0.212
ENSG00000086015 E028 100.9155791 0.0118281540 5.329963e-01 6.652604e-01 1 46023233 46023318 86 + 1.952 1.959 0.023
ENSG00000086015 E029 5.0896812 0.0067861907 4.919227e-04 2.129548e-03 1 46023319 46023516 198 + 1.002 0.565 -1.758
ENSG00000086015 E030 164.3221659 0.0014461731 1.097808e-02 3.111091e-02 1 46023772 46023980 209 + 2.199 2.152 -0.156
ENSG00000086015 E031 13.8022267 0.0329437083 1.917337e-01 3.159351e-01 1 46023981 46024364 384 + 0.959 1.180 0.804
ENSG00000086015 E032 132.5886031 0.0004698958 2.734541e-04 1.271664e-03 1 46025677 46025815 139 + 2.134 2.051 -0.277
ENSG00000086015 E033 122.4919012 0.0005921698 4.362869e-01 5.783870e-01 1 46027731 46027863 133 + 2.032 2.043 0.037
ENSG00000086015 E034 111.0593795 0.0005491041 7.469493e-01 8.345953e-01 1 46028768 46028933 166 + 1.959 2.010 0.173
ENSG00000086015 E035 6.9580995 0.0024534447 5.681447e-06 3.992630e-05 1 46029165 46029465 301 + 1.156 0.659 -1.904
ENSG00000086015 E036 101.5939753 0.0004239269 7.363988e-02 1.493604e-01 1 46029466 46029567 102 + 1.983 1.953 -0.100
ENSG00000086015 E037 133.2101334 0.0022386641 2.557714e-01 3.926990e-01 1 46029831 46029953 123 + 2.081 2.075 -0.019
ENSG00000086015 E038 143.5323337 0.0002525897 6.721773e-01 7.782407e-01 1 46030129 46030238 110 + 2.069 2.122 0.178
ENSG00000086015 E039 2.9515972 0.0078929974 4.331996e-02 9.714762e-02 1 46030239 46030502 264 + 0.760 0.477 -1.252
ENSG00000086015 E040 146.7292564 0.0020042429 4.568258e-01 5.971906e-01 1 46030607 46030761 155 + 2.111 2.123 0.040
ENSG00000086015 E041 198.7059311 0.0012732068 9.394315e-02 1.812956e-01 1 46031007 46031290 284 + 2.180 2.275 0.317
ENSG00000086015 E042 156.2113441 0.0002721856 6.557794e-01 7.656094e-01 1 46031391 46031585 195 + 2.107 2.161 0.179
ENSG00000086015 E043 195.3244804 0.0012638552 8.317579e-01 8.945759e-01 1 46032178 46032404 227 + 2.209 2.257 0.159
ENSG00000086015 E044 157.3022914 0.0038759827 3.632784e-01 5.077016e-01 1 46032596 46032718 123 + 2.091 2.173 0.272
ENSG00000086015 E045 132.2063546 0.0002668847 3.159623e-01 4.587391e-01 1 46033802 46033867 66 + 2.022 2.096 0.248
ENSG00000086015 E046 119.3759416 0.0033774075 2.674309e-01 4.057436e-01 1 46033868 46033938 71 + 1.966 2.057 0.307
ENSG00000086015 E047 62.7217131 0.0069475797 8.081897e-01 8.781263e-01 1 46034073 46034075 3 + 1.716 1.773 0.193
ENSG00000086015 E048 160.7993111 0.0074913794 1.498596e-02 4.045664e-02 1 46034076 46034266 191 + 2.032 2.204 0.576
ENSG00000086015 E049 2.2109599 0.0447309287 1.544439e-01 2.676775e-01 1 46034267 46034420 154 + 0.637 0.406 -1.105
ENSG00000086015 E050 195.9393228 0.0035391020 2.630107e-05 1.586026e-04 1 46034538 46034826 289 + 2.082 2.297 0.718
ENSG00000086015 E051 814.7410305 0.0090636076 1.486383e-07 1.460154e-06 1 46034827 46036122 1296 + 2.658 2.924 0.886