ENSG00000085982

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000427112 ENSG00000085982 HEK293_OSMI2_2hA HEK293_TMG_2hB USP40 protein_coding protein_coding 6.309679 5.197365 8.100703 0.3033629 0.06806108 0.6392735 0.3757685 0.0000000 0.94177226 0.0000000 0.48153093 6.5725445 0.0526250 0.00000000 0.116066667 0.11606667 2.379847e-01 5.938813e-11 FALSE TRUE
ENST00000464956 ENSG00000085982 HEK293_OSMI2_2hA HEK293_TMG_2hB USP40 protein_coding processed_transcript 6.309679 5.197365 8.100703 0.3033629 0.06806108 0.6392735 0.1215988 0.3062882 0.00000000 0.3062882 0.00000000 -4.9831678 0.0210250 0.05336667 0.000000000 -0.05336667 7.247296e-01 5.938813e-11   FALSE
ENST00000483519 ENSG00000085982 HEK293_OSMI2_2hA HEK293_TMG_2hB USP40 protein_coding retained_intron 6.309679 5.197365 8.100703 0.3033629 0.06806108 0.6392735 0.6072942 1.2454005 0.03710028 0.2681724 0.01855442 -4.7362682 0.1128167 0.23726667 0.004566667 -0.23270000 5.938813e-11 5.938813e-11 FALSE TRUE
ENST00000678225 ENSG00000085982 HEK293_OSMI2_2hA HEK293_TMG_2hB USP40 protein_coding protein_coding 6.309679 5.197365 8.100703 0.3033629 0.06806108 0.6392735 3.8624943 3.0696135 5.18589067 0.2607102 0.33297531 0.7546218 0.6106250 0.60046667 0.640300000 0.03983333 9.015727e-01 5.938813e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000085982 E001 1.6628506 0.0089135355 2.045424e-01 3.318428e-01 2 233475520 233475525 6 - 0.312 0.533 1.198
ENSG00000085982 E002 250.6183349 0.0015290410 1.105323e-24 1.172453e-22 2 233475526 233477391 1866 - 2.258 2.531 0.911
ENSG00000085982 E003 37.4825375 0.0006121363 1.956476e-03 7.090902e-03 2 233477392 233477503 112 - 1.495 1.675 0.613
ENSG00000085982 E004 27.1434999 0.0007581794 3.496633e-02 8.159068e-02 2 233481203 233481235 33 - 1.383 1.526 0.493
ENSG00000085982 E005 27.4592057 0.0007708190 1.467096e-01 2.572110e-01 2 233481236 233481297 62 - 1.410 1.510 0.344
ENSG00000085982 E006 0.2214452 0.0434746933 3.251590e-01   2 233481520 233481642 123 - 0.000 0.147 11.277
ENSG00000085982 E007 16.5737115 0.0012393498 1.983080e-01 3.241041e-01 2 233485531 233485540 10 - 1.197 1.308 0.390
ENSG00000085982 E008 21.6777005 0.0008703743 1.291124e-01 2.329386e-01 2 233485541 233485565 25 - 1.305 1.421 0.400
ENSG00000085982 E009 21.6047163 0.0008907801 9.237922e-01 9.560081e-01 2 233485566 233485586 21 - 1.359 1.357 -0.007
ENSG00000085982 E010 20.5474324 0.0010000918 8.942478e-01 9.364000e-01 2 233485587 233485605 19 - 1.338 1.333 -0.018
ENSG00000085982 E011 21.5783144 0.0010644730 7.899189e-01 8.656164e-01 2 233485606 233485626 21 - 1.364 1.349 -0.051
ENSG00000085982 E012 47.5930679 0.0005079060 6.078023e-01 7.277056e-01 2 233485767 233485977 211 - 1.672 1.703 0.105
ENSG00000085982 E013 1.2649996 0.0129090441 8.937762e-01 9.360614e-01 2 233487681 233488006 326 - 0.365 0.344 -0.125
ENSG00000085982 E014 32.3948924 0.0006363387 4.266077e-01 5.694205e-01 2 233488239 233488304 66 - 1.499 1.552 0.182
ENSG00000085982 E015 44.1295271 0.0005388376 7.014072e-01 8.005994e-01 2 233489365 233489483 119 - 1.642 1.667 0.085
ENSG00000085982 E016 1.9865821 0.0775029679 7.124780e-01 8.092135e-01 2 233489484 233489640 157 - 0.492 0.420 -0.368
ENSG00000085982 E017 1.9187286 0.0078213425 2.881154e-01 4.286570e-01 2 233489662 233489869 208 - 0.527 0.344 -0.970
ENSG00000085982 E018 0.4439371 0.0215634547 1.705027e-01 2.888061e-01 2 233491032 233491071 40 - 0.253 0.000 -13.119
ENSG00000085982 E019 43.2272898 0.0005010903 7.774583e-02 1.558429e-01 2 233491167 233491261 95 - 1.599 1.696 0.333
ENSG00000085982 E020 0.3268771 0.0295680831 7.611911e-01   2 233491262 233491339 78 - 0.101 0.147 0.614
ENSG00000085982 E021 0.1515154 0.0431923967 7.180115e-01   2 233492664 233493424 761 - 0.101 0.000 -11.387
ENSG00000085982 E022 48.4308706 0.0005023597 8.004023e-01 8.727819e-01 2 233493425 233493551 127 - 1.694 1.686 -0.027
ENSG00000085982 E023 28.0358680 0.0006912769 6.718028e-01 7.779450e-01 2 233496758 233496793 36 - 1.445 1.477 0.111
ENSG00000085982 E024 28.9559790 0.0090655550 6.125678e-01 7.314789e-01 2 233496794 233496832 39 - 1.492 1.457 -0.119
ENSG00000085982 E025 36.9772307 0.0025030819 9.385318e-01 9.654077e-01 2 233498548 233498612 65 - 1.572 1.580 0.029
ENSG00000085982 E026 31.3125581 0.0006764788 8.197580e-01 8.862216e-01 2 233499879 233499915 37 - 1.509 1.500 -0.033
ENSG00000085982 E027 45.0660341 0.0005711530 2.430877e-01 3.778174e-01 2 233510049 233510135 87 - 1.634 1.700 0.222
ENSG00000085982 E028 47.5463112 0.0035151629 5.350758e-01 6.670209e-01 2 233511709 233511797 89 - 1.667 1.706 0.133
ENSG00000085982 E029 1.7370348 0.0110047774 5.170857e-01 6.515414e-01 2 233511798 233512502 705 - 0.365 0.479 0.616
ENSG00000085982 E030 34.7701945 0.0053590421 7.109951e-01 8.080513e-01 2 233512569 233512622 54 - 1.559 1.537 -0.076
ENSG00000085982 E031 0.9158732 0.2572522661 3.605181e-01 5.048384e-01 2 233512623 233512892 270 - 0.364 0.147 -1.701
ENSG00000085982 E032 0.5932625 0.1636017784 1.239268e-01 2.255680e-01 2 233519426 233519613 188 - 0.312 0.000 -12.778
ENSG00000085982 E033 34.5492915 0.0006421497 5.325192e-01 6.648708e-01 2 233519614 233519671 58 - 1.559 1.527 -0.112
ENSG00000085982 E034 41.4843560 0.0005728180 1.160384e-01 2.143003e-01 2 233520991 233521114 124 - 1.658 1.576 -0.279
ENSG00000085982 E035 73.7328563 0.0009412876 2.000771e-02 5.150350e-02 2 233523170 233523489 320 - 1.913 1.818 -0.319
ENSG00000085982 E036 37.7276024 0.0150061441 8.478734e-02 1.670658e-01 2 233524492 233524562 71 - 1.644 1.503 -0.482
ENSG00000085982 E037 27.7694390 0.0007488387 2.404282e-01 3.746497e-01 2 233525478 233525510 33 - 1.488 1.414 -0.252
ENSG00000085982 E038 28.7928523 0.0007086510 8.367032e-01 8.978682e-01 2 233525511 233525562 52 - 1.465 1.483 0.062
ENSG00000085982 E039 36.3780194 0.0005982768 1.910524e-01 3.150700e-01 2 233527407 233527578 172 - 1.598 1.526 -0.246
ENSG00000085982 E040 25.4442321 0.0007993394 3.494979e-02 8.155811e-02 2 233529431 233529512 82 - 1.476 1.333 -0.495
ENSG00000085982 E041 48.1574650 0.0011547285 2.254037e-03 8.011494e-03 2 233533479 233533779 301 - 1.752 1.594 -0.537
ENSG00000085982 E042 25.9747354 0.0198672663 1.169454e-01 2.156011e-01 2 233540662 233540766 105 - 1.487 1.347 -0.484
ENSG00000085982 E043 9.4554688 0.0086074256 2.265421e-01 3.582807e-01 2 233540767 233540769 3 - 1.071 0.937 -0.495
ENSG00000085982 E044 22.5182534 0.0010859057 1.050777e-01 1.982004e-01 2 233542268 233542363 96 - 1.415 1.299 -0.402
ENSG00000085982 E045 0.8168978 0.0139978656 3.517570e-01 4.959869e-01 2 233542451 233542616 166 - 0.312 0.147 -1.385
ENSG00000085982 E046 26.8491474 0.0048175122 1.189757e-02 3.328693e-02 2 233549101 233549229 129 - 1.516 1.332 -0.636
ENSG00000085982 E047 31.5518669 0.0116885726 2.665889e-02 6.528292e-02 2 233551376 233551519 144 - 1.581 1.405 -0.604
ENSG00000085982 E048 0.5901540 0.0208315416 5.422063e-01 6.730090e-01 2 233554325 233554379 55 - 0.253 0.147 -0.973
ENSG00000085982 E049 35.8540216 0.0043769640 4.127249e-02 9.338066e-02 2 233554380 233554526 147 - 1.618 1.488 -0.447
ENSG00000085982 E050 2.5056709 0.0061461526 2.958956e-01 4.370369e-01 2 233556586 233556854 269 - 0.454 0.625 0.807
ENSG00000085982 E051 38.2107359 0.0034439080 3.521591e-03 1.178865e-02 2 233556855 233557019 165 - 1.660 1.477 -0.625
ENSG00000085982 E052 30.2960448 0.0276190062 5.883408e-03 1.830564e-02 2 233559811 233559924 114 - 1.596 1.309 -0.991
ENSG00000085982 E053 0.9684132 0.0173326544 2.283704e-01 3.604769e-01 2 233560743 233561033 291 - 0.365 0.147 -1.707
ENSG00000085982 E054 26.8775939 0.0008242805 2.001852e-06 1.557218e-05 2 233562736 233562803 68 - 1.559 1.223 -1.167
ENSG00000085982 E055 43.0142796 0.0004921069 1.579931e-05 1.002993e-04 2 233565356 233565573 218 - 1.729 1.494 -0.801
ENSG00000085982 E056 0.1451727 0.0432342465 7.185611e-01   2 233565574 233565590 17 - 0.101 0.000 -11.386
ENSG00000085982 E057 18.4753817 0.0036780434 7.376315e-02 1.495461e-01 2 233566684 233566782 99 - 1.348 1.201 -0.517