ENSG00000085788

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000397166 ENSG00000085788 HEK293_OSMI2_2hA HEK293_TMG_2hB DDHD2 protein_coding protein_coding 22.51951 10.56684 34.0537 1.41301 0.1782006 1.687326 6.1523551 3.2678881 11.6265334 0.5404551 0.9021258 1.8278228 0.27729167 0.31443333 0.34153333 0.02710000 8.757915e-01 4.052306e-05 FALSE TRUE
ENST00000526144 ENSG00000085788 HEK293_OSMI2_2hA HEK293_TMG_2hB DDHD2 protein_coding protein_coding 22.51951 10.56684 34.0537 1.41301 0.1782006 1.687326 1.5030906 1.3689315 1.0919773 0.2814014 0.2627897 -0.3234563 0.07915417 0.12726667 0.03213333 -0.09513333 8.483937e-05 4.052306e-05 FALSE TRUE
ENST00000528504 ENSG00000085788 HEK293_OSMI2_2hA HEK293_TMG_2hB DDHD2 protein_coding retained_intron 22.51951 10.56684 34.0537 1.41301 0.1782006 1.687326 1.6900560 0.6252722 3.3834636 0.3131467 0.3139283 2.4173117 0.07531250 0.05526667 0.09946667 0.04420000 6.050729e-01 4.052306e-05 FALSE FALSE
ENST00000529642 ENSG00000085788 HEK293_OSMI2_2hA HEK293_TMG_2hB DDHD2 protein_coding protein_coding 22.51951 10.56684 34.0537 1.41301 0.1782006 1.687326 0.5401323 0.0000000 2.4662168 0.0000000 1.3086046 7.9519938 0.01564167 0.00000000 0.07246667 0.07246667 3.101547e-01 4.052306e-05 FALSE FALSE
ENST00000531344 ENSG00000085788 HEK293_OSMI2_2hA HEK293_TMG_2hB DDHD2 protein_coding retained_intron 22.51951 10.56684 34.0537 1.41301 0.1782006 1.687326 2.6312863 1.0740938 2.9190272 0.2247343 0.5625134 1.4339320 0.11750833 0.10960000 0.08563333 -0.02396667 8.588475e-01 4.052306e-05   FALSE
ENST00000532222 ENSG00000085788 HEK293_OSMI2_2hA HEK293_TMG_2hB DDHD2 protein_coding protein_coding 22.51951 10.56684 34.0537 1.41301 0.1782006 1.687326 1.5217390 0.2143861 1.3362560 0.2143861 0.8629761 2.5848976 0.05452917 0.01616667 0.03923333 0.02306667 7.329610e-01 4.052306e-05 FALSE TRUE
MSTRG.31415.11 ENSG00000085788 HEK293_OSMI2_2hA HEK293_TMG_2hB DDHD2 protein_coding   22.51951 10.56684 34.0537 1.41301 0.1782006 1.687326 2.3941072 1.9317434 0.7396168 1.0375488 0.7396168 -1.3731274 0.11880833 0.17733333 0.02163333 -0.15570000 3.626395e-01 4.052306e-05 FALSE TRUE
MSTRG.31415.15 ENSG00000085788 HEK293_OSMI2_2hA HEK293_TMG_2hB DDHD2 protein_coding   22.51951 10.56684 34.0537 1.41301 0.1782006 1.687326 1.7984373 0.5228436 3.1530495 0.2361804 0.8600140 2.5695320 0.06466250 0.05103333 0.09233333 0.04130000 5.419938e-01 4.052306e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000085788 E001 0.1482932 0.0411597534 0.2059158022   8 38225218 38225308 91 + 0.000 0.176 10.511
ENSG00000085788 E002 2.0963966 0.1112472808 0.0811191815 0.1612924735 8 38231484 38231584 101 + 0.574 0.176 -2.457
ENSG00000085788 E003 13.6851406 0.3057802832 0.0602090040 0.1269622465 8 38231585 38231670 86 + 1.244 0.847 -1.453
ENSG00000085788 E004 16.3066130 0.1737060617 0.1193047158 0.2189450890 8 38231671 38231694 24 + 1.293 1.006 -1.031
ENSG00000085788 E005 18.5929296 0.0939260489 0.1477589309 0.2586364922 8 38231695 38231714 20 + 1.333 1.113 -0.779
ENSG00000085788 E006 22.3365222 0.0490335391 0.1261765334 0.2288303326 8 38231715 38231746 32 + 1.404 1.203 -0.703
ENSG00000085788 E007 18.7131076 0.0386224565 0.2079445368 0.3360213298 8 38231747 38231751 5 + 1.321 1.161 -0.561
ENSG00000085788 E008 31.6698512 0.0425621947 0.0986402626 0.1884217291 8 38231752 38231816 65 + 1.551 1.350 -0.691
ENSG00000085788 E009 29.4254539 0.0142425242 0.0068546998 0.0208483545 8 38231817 38231838 22 + 1.532 1.278 -0.879
ENSG00000085788 E010 35.5633920 0.0142175981 0.0010225461 0.0040367229 8 38231839 38231859 21 + 1.620 1.322 -1.023
ENSG00000085788 E011 0.5149242 0.3067208839 0.2668460912 0.4051036003 8 38231953 38232144 192 + 0.084 0.302 2.245
ENSG00000085788 E012 32.1216843 0.0185496520 0.0014926815 0.0056122420 8 38232987 38232998 12 + 1.581 1.267 -1.083
ENSG00000085788 E013 79.1858461 0.0028015766 0.0198354417 0.0511385771 8 38232999 38233138 140 + 1.918 1.805 -0.380
ENSG00000085788 E014 76.2346655 0.0003803110 0.0108128678 0.0307153086 8 38233139 38233214 76 + 1.902 1.796 -0.359
ENSG00000085788 E015 51.0098562 0.0004746994 0.0150613488 0.0406289047 8 38234394 38234399 6 + 1.737 1.612 -0.423
ENSG00000085788 E016 114.7548047 0.0002646854 0.0016609489 0.0061565600 8 38234400 38234510 111 + 2.078 1.971 -0.360
ENSG00000085788 E017 94.8685106 0.0003475782 0.0109789361 0.0311124053 8 38234511 38234584 74 + 1.992 1.897 -0.319
ENSG00000085788 E018 0.3697384 0.0250398784 0.0540890822 0.1164036619 8 38234585 38234585 1 + 0.000 0.301 14.279
ENSG00000085788 E019 93.5821640 0.0051213443 0.1160945957 0.2143851532 8 38237538 38237627 90 + 1.981 1.900 -0.272
ENSG00000085788 E020 92.5801738 0.0097839849 0.2486640083 0.3843439236 8 38238089 38238209 121 + 1.974 1.899 -0.253
ENSG00000085788 E021 2.9411810 0.0187931178 0.0375782653 0.0865448111 8 38238210 38239058 849 + 0.682 0.301 -1.933
ENSG00000085788 E022 74.3103288 0.0003909546 0.0406586565 0.0922430124 8 38240275 38240364 90 + 1.884 1.799 -0.287
ENSG00000085788 E023 0.8179419 0.0162457200 0.6395045354 0.7528770109 8 38240365 38240367 3 + 0.214 0.301 0.654
ENSG00000085788 E024 3.7299793 0.0041106094 0.0074583764 0.0224070636 8 38241965 38242227 263 + 0.769 0.301 -2.285
ENSG00000085788 E025 2.5079548 0.0060552198 0.0010311833 0.0040659058 8 38242228 38242249 22 + 0.663 0.000 -15.698
ENSG00000085788 E026 121.3319460 0.0004439706 0.1611355702 0.2765890353 8 38242250 38242385 136 + 2.081 2.037 -0.146
ENSG00000085788 E027 162.0570292 0.0002176683 0.2552524529 0.3920928520 8 38245742 38245950 209 + 2.201 2.173 -0.093
ENSG00000085788 E028 13.0456604 0.0026347450 0.4512437728 0.5922269726 8 38245951 38246157 207 + 1.150 1.079 -0.256
ENSG00000085788 E029 6.5903001 0.0480402287 0.6298629132 0.7451572959 8 38246184 38246232 49 + 0.890 0.810 -0.310
ENSG00000085788 E030 78.6013740 0.0003155688 0.1446866608 0.2544082514 8 38246233 38246300 68 + 1.901 1.845 -0.189
ENSG00000085788 E031 12.7898610 0.0019053145 0.9376796886 0.9648088419 8 38246804 38247712 909 + 1.130 1.130 -0.002
ENSG00000085788 E032 101.0894369 0.0003967698 0.5729633015 0.6989856372 8 38247713 38247835 123 + 1.993 1.977 -0.053
ENSG00000085788 E033 0.2987644 0.0274985858 0.5677714908   8 38247836 38247836 1 + 0.153 0.000 -12.730
ENSG00000085788 E034 83.4397656 0.0007789672 0.1383626559 0.2458225538 8 38249708 38249774 67 + 1.924 1.866 -0.197
ENSG00000085788 E035 52.6108493 0.0004380684 0.3098395161 0.4521852462 8 38249775 38249778 4 + 1.723 1.677 -0.159
ENSG00000085788 E036 61.8320715 0.0003696733 0.6377547667 0.7515689875 8 38249779 38249803 25 + 1.783 1.767 -0.056
ENSG00000085788 E037 0.7665478 0.0212618268 0.6291048015 0.7445432570 8 38249804 38251911 2108 + 0.266 0.176 -0.760
ENSG00000085788 E038 96.2370665 0.0006037049 0.0446949542 0.0996425503 8 38251912 38252028 117 + 1.938 2.021 0.277
ENSG00000085788 E039 0.7374030 0.0155948776 0.6239287922 0.7403878401 8 38252098 38252131 34 + 0.267 0.176 -0.762
ENSG00000085788 E040 55.0155962 0.0071161246 0.2957296181 0.4368768634 8 38252132 38252165 34 + 1.705 1.772 0.225
ENSG00000085788 E041 69.6903646 0.0044996873 0.9026679588 0.9420253002 8 38252166 38252210 45 + 1.826 1.834 0.026
ENSG00000085788 E042 92.7437363 0.0003025498 0.4061212067 0.5497684427 8 38252211 38252287 77 + 1.939 1.977 0.128
ENSG00000085788 E043 66.6189076 0.0003973535 0.4519467122 0.5928620310 8 38252722 38252741 20 + 1.798 1.839 0.136
ENSG00000085788 E044 110.7065968 0.0003222965 0.4647101000 0.6044361209 8 38252742 38252824 83 + 2.019 2.051 0.108
ENSG00000085788 E045 155.3585409 0.0016823466 0.2106686920 0.3393350425 8 38252957 38253127 171 + 2.157 2.205 0.160
ENSG00000085788 E046 0.1482932 0.0411597534 0.2059158022   8 38253128 38253475 348 + 0.000 0.176 13.164
ENSG00000085788 E047 58.3352412 0.0003963107 0.0290342207 0.0700756246 8 38253556 38253560 5 + 1.713 1.823 0.371
ENSG00000085788 E048 130.0738591 0.0004306703 0.0003230865 0.0014732175 8 38253561 38253718 158 + 2.052 2.176 0.412
ENSG00000085788 E049 62.2869651 0.0040138428 0.0007287634 0.0030023276 8 38260040 38260060 21 + 1.709 1.898 0.637
ENSG00000085788 E050 60.7408705 0.0053318217 0.0013857893 0.0052607537 8 38260061 38260072 12 + 1.698 1.889 0.643
ENSG00000085788 E051 92.0836685 0.0042699145 0.0001171307 0.0006006569 8 38260073 38260147 75 + 1.875 2.065 0.640
ENSG00000085788 E052 2.7657387 0.0055012054 0.0530735316 0.1146152332 8 38260148 38260254 107 + 0.430 0.740 1.408
ENSG00000085788 E053 2.1841070 0.0068386659 0.6565436593 0.7660630890 8 38260564 38260599 36 + 0.463 0.544 0.390
ENSG00000085788 E054 311.7241530 0.0014970270 0.0078522442 0.0234106686 8 38260600 38261537 938 + 2.448 2.522 0.247
ENSG00000085788 E055 60.7539523 0.0060171997 0.7222751661 0.8164251992 8 38261538 38261599 62 + 1.776 1.764 -0.042
ENSG00000085788 E056 273.3190431 0.0088815231 0.0216822443 0.0550149487 8 38261600 38262836 1237 + 2.373 2.492 0.396
ENSG00000085788 E057 19.3875670 0.0010010156 0.6910093885 0.7925608642 8 38267613 38269027 1415 + 1.274 1.312 0.132
ENSG00000085788 E058 15.9761565 0.0241270860 0.9132665704 0.9490291812 8 38269707 38270977 1271 + 1.206 1.226 0.070
ENSG00000085788 E059 1.2157810 0.0251628649 0.4736200180 0.6125554114 8 38271122 38271393 272 + 0.267 0.399 0.830
ENSG00000085788 E060 0.4772466 0.0204353267 0.1958254515 0.3210077469 8 38273370 38273372 3 + 0.083 0.301 2.238
ENSG00000085788 E061 2.1453983 0.0068900578 0.9014555810 0.9412059536 8 38273373 38273442 70 + 0.494 0.477 -0.084
ENSG00000085788 E062 1.8027258 0.0082380238 0.2873782058 0.4278726115 8 38273443 38273626 184 + 0.356 0.544 0.977
ENSG00000085788 E063 1.1394067 0.0110767138 0.1430137631 0.2521323609 8 38275359 38275558 200 + 0.214 0.477 1.654