ENSG00000085760

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263629 ENSG00000085760 HEK293_OSMI2_2hA HEK293_TMG_2hB MTIF2 protein_coding protein_coding 26.60515 10.80374 41.02436 0.1292828 1.819089 1.923967 14.651530 3.1619634 24.037735 0.2001670 0.7672470 2.9224530 0.47455000 0.2923333 0.58656667 0.2942333 5.046899e-20 5.046899e-20 FALSE TRUE
ENST00000394600 ENSG00000085760 HEK293_OSMI2_2hA HEK293_TMG_2hB MTIF2 protein_coding protein_coding 26.60515 10.80374 41.02436 0.1292828 1.819089 1.923967 4.497345 5.4251794 3.904804 0.4386753 1.3846840 -0.4733875 0.25949583 0.5031000 0.09263333 -0.4104667 5.570752e-06 5.046899e-20 FALSE TRUE
MSTRG.18425.3 ENSG00000085760 HEK293_OSMI2_2hA HEK293_TMG_2hB MTIF2 protein_coding   26.60515 10.80374 41.02436 0.1292828 1.819089 1.923967 1.871584 0.6244832 3.504364 0.1915079 0.6242344 2.4696098 0.06922083 0.0574000 0.08690000 0.0295000 5.852321e-01 5.046899e-20 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000085760 E001 8.7265618 0.0020365923 3.973219e-01 5.410813e-01 2 55236595 55236620 26 - 0.908 1.008 0.377
ENSG00000085760 E002 137.5404060 0.0015120910 1.795162e-08 2.111168e-07 2 55236621 55236820 200 - 2.021 2.227 0.689
ENSG00000085760 E003 166.7655149 0.0003140281 1.060588e-15 3.988987e-14 2 55237288 55237428 141 - 2.091 2.329 0.794
ENSG00000085760 E004 185.0810749 0.0002555616 1.110282e-15 4.165141e-14 2 55240011 55240175 165 - 2.141 2.366 0.751
ENSG00000085760 E005 175.0135324 0.0021615252 4.143754e-04 1.829504e-03 2 55242940 55243080 141 - 2.150 2.278 0.426
ENSG00000085760 E006 263.0901068 0.0003214136 7.459353e-06 5.101080e-05 2 55243416 55243668 253 - 2.331 2.441 0.367
ENSG00000085760 E007 187.2597459 0.0002023437 3.430926e-03 1.152608e-02 2 55244029 55244154 126 - 2.192 2.276 0.281
ENSG00000085760 E008 152.5222246 0.0003104215 1.020692e-01 1.936556e-01 2 55244155 55244233 79 - 2.112 2.165 0.177
ENSG00000085760 E009 186.0035759 0.0002578907 6.696687e-01 7.763834e-01 2 55246337 55246461 125 - 2.216 2.202 -0.047
ENSG00000085760 E010 191.8154224 0.0007983734 3.713193e-01 5.157584e-01 2 55249395 55249534 140 - 2.218 2.245 0.090
ENSG00000085760 E011 123.7781278 0.0016250925 8.475525e-01 9.053302e-01 2 55252477 55252541 65 - 2.039 2.030 -0.032
ENSG00000085760 E012 136.0457767 0.0002159769 9.900239e-01 9.978570e-01 2 55252542 55252653 112 - 2.077 2.077 -0.002
ENSG00000085760 E013 164.0339495 0.0002719636 8.304762e-01 8.936481e-01 2 55254041 55254201 161 - 2.158 2.150 -0.027
ENSG00000085760 E014 144.4677700 0.0002276100 1.593664e-01 2.742648e-01 2 55254654 55254766 113 - 2.114 2.063 -0.169
ENSG00000085760 E015 119.9872159 0.0002525721 1.224255e-01 2.234040e-01 2 55254767 55254825 59 - 2.037 1.977 -0.203
ENSG00000085760 E016 148.0428055 0.0008069514 2.610934e-02 6.416813e-02 2 55262316 55262427 112 - 2.134 2.051 -0.278
ENSG00000085760 E017 68.5863426 0.0003890834 2.226433e-01 3.535482e-01 2 55263640 55263640 1 - 1.798 1.735 -0.213
ENSG00000085760 E018 67.8241630 0.0003871939 1.469403e-01 2.575105e-01 2 55263641 55263646 6 - 1.796 1.720 -0.256
ENSG00000085760 E019 64.9296317 0.0004163998 2.220921e-01 3.529075e-01 2 55263647 55263647 1 - 1.775 1.710 -0.220
ENSG00000085760 E020 157.4109604 0.0025792936 2.735994e-03 9.481339e-03 2 55263648 55263779 132 - 2.170 2.042 -0.428
ENSG00000085760 E021 115.5484570 0.0011582991 1.686280e-05 1.063479e-04 2 55263780 55263827 48 - 2.047 1.855 -0.645
ENSG00000085760 E022 94.9646536 0.0048733614 3.551642e-04 1.600066e-03 2 55263828 55263836 9 - 1.964 1.757 -0.699
ENSG00000085760 E023 106.1397523 0.0003100578 3.979429e-07 3.589102e-06 2 55263837 55263865 29 - 2.015 1.790 -0.757
ENSG00000085760 E024 0.2955422 0.0291747795 3.558367e-01   2 55263866 55263868 3 - 0.069 0.207 1.825
ENSG00000085760 E025 15.6625343 0.0010964497 7.416371e-01 8.307127e-01 2 55266381 55266518 138 - 1.176 1.142 -0.121
ENSG00000085760 E026 137.3971015 0.0002534312 5.601654e-07 4.909857e-06 2 55267569 55267635 67 - 2.122 1.929 -0.644
ENSG00000085760 E027 0.7437457 0.0153787590 9.406177e-01 9.666865e-01 2 55267636 55267787 152 - 0.228 0.207 -0.174
ENSG00000085760 E028 106.7345078 0.0002757246 1.003347e-06 8.321200e-06 2 55268578 55268649 72 - 2.018 1.803 -0.722
ENSG00000085760 E029 111.5808033 0.0005588096 1.309878e-06 1.060752e-05 2 55268650 55268739 90 - 2.035 1.824 -0.712
ENSG00000085760 E030 5.8849400 0.0027656815 8.951628e-01 9.369949e-01 2 55268740 55268816 77 - 0.791 0.771 -0.080
ENSG00000085760 E031 31.4280914 0.0006698501 5.761698e-01 7.016549e-01 2 55268817 55268991 175 - 1.460 1.417 -0.146
ENSG00000085760 E032 21.6918924 0.0008624572 2.375422e-01 3.713008e-01 2 55268992 55269168 177 - 1.319 1.213 -0.374
ENSG00000085760 E033 72.5321336 0.0086616413 1.546248e-04 7.675610e-04 2 55269169 55269212 44 - 1.858 1.588 -0.916
ENSG00000085760 E034 23.7309705 0.0483083826 1.929921e-02 4.998398e-02 2 55269213 55269347 135 - 1.392 1.069 -1.143