ENSG00000085733

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000301843 ENSG00000085733 HEK293_OSMI2_2hA HEK293_TMG_2hB CTTN protein_coding protein_coding 81.02621 87.64378 77.05127 2.536872 0.318269 -0.1858104 56.605899 71.305739 49.873473 2.2053757 1.1610501 -0.5156586 0.69380000 0.81350000 0.64720000 -0.166300000 1.328517e-14 1.328517e-14 FALSE TRUE
ENST00000346329 ENSG00000085733 HEK293_OSMI2_2hA HEK293_TMG_2hB CTTN protein_coding protein_coding 81.02621 87.64378 77.05127 2.536872 0.318269 -0.1858104 4.569115 5.884924 4.467800 0.4887933 0.6703998 -0.3966833 0.05587500 0.06696667 0.05793333 -0.009033333 7.215256e-01 1.328517e-14 FALSE TRUE
ENST00000525852 ENSG00000085733 HEK293_OSMI2_2hA HEK293_TMG_2hB CTTN protein_coding retained_intron 81.02621 87.64378 77.05127 2.536872 0.318269 -0.1858104 4.785818 2.971639 4.839525 0.4693760 0.2021382 0.7017377 0.05942083 0.03416667 0.06283333 0.028666667 3.692848e-02 1.328517e-14   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000085733 E001 2.1336407 0.0244389623 8.741438e-01 9.230885e-01 11 70398404 70398527 124 + 0.465 0.506 0.203
ENSG00000085733 E002 3.3546210 0.1176330362 3.442946e-01 4.883726e-01 11 70398528 70398528 1 + 0.748 0.541 -0.894
ENSG00000085733 E003 4.8919950 0.0047369737 5.712224e-02 1.216748e-01 11 70398529 70398536 8 + 0.898 0.662 -0.943
ENSG00000085733 E004 5.4778826 0.0089242273 2.849153e-02 6.899699e-02 11 70398537 70398540 4 + 0.957 0.687 -1.060
ENSG00000085733 E005 107.2238623 0.0072394386 4.870796e-02 1.068687e-01 11 70398541 70398577 37 + 2.072 1.983 -0.297
ENSG00000085733 E006 190.1882030 0.0034171903 3.999516e-03 1.314099e-02 11 70398578 70398614 37 + 2.322 2.231 -0.305
ENSG00000085733 E007 352.6519477 0.0066296781 1.740715e-02 4.583938e-02 11 70405265 70405361 97 + 2.585 2.500 -0.285
ENSG00000085733 E008 0.7415677 0.1525825563 9.508614e-01 9.732551e-01 11 70405362 70405406 45 + 0.247 0.258 0.077
ENSG00000085733 E009 348.7761008 0.0029807664 1.169067e-03 4.536122e-03 11 70407298 70407352 55 + 2.581 2.495 -0.285
ENSG00000085733 E010 321.1348955 0.0035793430 1.654819e-02 4.394580e-02 11 70407353 70407384 32 + 2.532 2.468 -0.215
ENSG00000085733 E011 464.3617585 0.0012455391 9.872474e-04 3.915159e-03 11 70407518 70407591 74 + 2.689 2.631 -0.193
ENSG00000085733 E012 43.8406612 0.0005091159 1.949045e-06 1.519759e-05 11 70407592 70408342 751 + 1.767 1.537 -0.783
ENSG00000085733 E013 574.2874370 0.0007830862 1.550056e-05 9.860763e-05 11 70409831 70409960 130 + 2.786 2.721 -0.217
ENSG00000085733 E014 1.0308674 0.0374353552 6.640291e-01 7.719417e-01 11 70410300 70410430 131 + 0.333 0.263 -0.468
ENSG00000085733 E015 446.8809910 0.0001544437 1.453605e-05 9.300274e-05 11 70414542 70414610 69 + 2.671 2.616 -0.184
ENSG00000085733 E016 345.7787675 0.0018772647 1.846085e-03 6.746675e-03 11 70414611 70414652 42 + 2.568 2.499 -0.229
ENSG00000085733 E017 383.1978185 0.0001457898 1.664871e-03 6.169529e-03 11 70415663 70415717 55 + 2.595 2.557 -0.127
ENSG00000085733 E018 5.3216258 0.0184317983 4.330812e-04 1.901632e-03 11 70415718 70416204 487 + 1.025 0.542 -1.947
ENSG00000085733 E019 4.7421075 0.0058753336 8.941429e-04 3.593472e-03 11 70416740 70417012 273 + 0.975 0.542 -1.765
ENSG00000085733 E020 533.5089971 0.0011780830 2.755455e-05 1.653508e-04 11 70417013 70417123 111 + 2.759 2.685 -0.245
ENSG00000085733 E021 523.1787800 0.0012738978 1.051798e-03 4.138867e-03 11 70419746 70419856 111 + 2.739 2.683 -0.185
ENSG00000085733 E022 38.1430176 0.0121742364 1.024740e-11 2.129595e-10 11 70419857 70420124 268 + 1.823 1.305 -1.772
ENSG00000085733 E023 21.3832841 0.0036250598 2.498054e-07 2.349912e-06 11 70420125 70420222 98 + 1.531 1.146 -1.343
ENSG00000085733 E024 27.9224423 0.0007861146 8.707269e-12 1.831223e-10 11 70420223 70420385 163 + 1.661 1.231 -1.485
ENSG00000085733 E025 11.0360563 0.0120975518 1.291492e-04 6.551242e-04 11 70420386 70420399 14 + 1.271 0.867 -1.470
ENSG00000085733 E026 501.6954842 0.0009617935 7.417335e-04 3.049332e-03 11 70420400 70420510 111 + 2.719 2.667 -0.176
ENSG00000085733 E027 441.6350461 0.0001205710 3.014439e-02 7.225066e-02 11 70421470 70421580 111 + 2.643 2.627 -0.056
ENSG00000085733 E028 19.0199759 0.0010056199 5.564148e-06 3.918920e-05 11 70421581 70421595 15 + 1.468 1.137 -1.160
ENSG00000085733 E029 158.5339223 0.0088454555 2.322630e-11 4.559743e-10 11 70421596 70422502 907 + 2.368 2.026 -1.144
ENSG00000085733 E030 13.1851717 0.1043596546 1.254547e-01 2.277995e-01 11 70422503 70422508 6 + 1.262 1.026 -0.847
ENSG00000085733 E031 26.1246115 0.0190670704 1.347015e-03 5.133135e-03 11 70422509 70422592 84 + 1.568 1.284 -0.983
ENSG00000085733 E032 19.2165745 0.0280516811 1.373861e-02 3.762760e-02 11 70422593 70422631 39 + 1.438 1.173 -0.927
ENSG00000085733 E033 60.1414620 0.0011403335 9.986883e-13 2.452028e-11 11 70422632 70422939 308 + 1.941 1.622 -1.076
ENSG00000085733 E034 446.2602780 0.0001579164 1.409800e-03 5.339405e-03 11 70422940 70422995 56 + 2.659 2.623 -0.117
ENSG00000085733 E035 451.1202874 0.0001600999 2.956269e-04 1.362038e-03 11 70425332 70425401 70 + 2.668 2.626 -0.141
ENSG00000085733 E036 305.6589132 0.0001655189 3.044634e-05 1.808707e-04 11 70429051 70429052 2 + 2.513 2.447 -0.221
ENSG00000085733 E037 465.7647527 0.0001353307 2.299134e-04 1.091475e-03 11 70429053 70429121 69 + 2.683 2.641 -0.139
ENSG00000085733 E038 429.6177606 0.0001655711 1.272006e-02 3.525385e-02 11 70429122 70429199 78 + 2.636 2.612 -0.079
ENSG00000085733 E039 415.8325202 0.0005981091 7.843953e-01 8.616902e-01 11 70431191 70431280 90 + 2.596 2.610 0.048
ENSG00000085733 E040 654.8767519 0.0001852212 6.518837e-01 7.626639e-01 11 70433101 70433278 178 + 2.785 2.813 0.092
ENSG00000085733 E041 5.2066359 0.0733580168 8.780589e-01 9.256852e-01 11 70433625 70433646 22 + 0.777 0.777 0.003
ENSG00000085733 E042 478.3847871 0.0001206997 8.136431e-01 8.818509e-01 11 70433647 70433718 72 + 2.657 2.674 0.057
ENSG00000085733 E043 455.6533735 0.0002077441 2.462627e-01 3.815632e-01 11 70435026 70435119 94 + 2.620 2.662 0.140
ENSG00000085733 E044 838.4820783 0.0003205408 8.433982e-25 9.073212e-23 11 70435120 70435465 346 + 2.791 2.969 0.589
ENSG00000085733 E045 585.1777807 0.0029729200 2.290208e-05 1.400358e-04 11 70435466 70435555 90 + 2.655 2.804 0.496
ENSG00000085733 E046 863.4758310 0.0004072301 1.976490e-20 1.330633e-18 11 70435556 70435744 189 + 2.813 2.979 0.553
ENSG00000085733 E047 1642.3633280 0.0021088667 2.974409e-15 1.058998e-13 11 70435745 70436281 537 + 3.067 3.266 0.663
ENSG00000085733 E048 780.7991424 0.0042569716 5.460033e-12 1.186088e-10 11 70436282 70436584 303 + 2.701 2.959 0.861