ENSG00000085721

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000198767 ENSG00000085721 HEK293_OSMI2_2hA HEK293_TMG_2hB RRN3 protein_coding protein_coding 23.30732 10.61232 36.61309 1.407141 0.7383499 1.785654 18.868931 10.259714 29.452088 1.53903829 1.1621684 1.520464 0.8512042 0.96280000 0.8039000 -0.1589 0.02093608 0.02093608 FALSE TRUE
ENST00000429751 ENSG00000085721 HEK293_OSMI2_2hA HEK293_TMG_2hB RRN3 protein_coding protein_coding 23.30732 10.61232 36.61309 1.407141 0.7383499 1.785654 3.615761 0.167897 5.603958 0.08592025 0.8083902 4.979904 0.1125208 0.01816667 0.1533667 0.1352 0.02459672 0.02093608 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000085721 E001 1.7733775 0.0082456231 1.337801e-04 6.757187e-04 16 15060033 15060034 2 - 0.133 0.800 3.888
ENSG00000085721 E002 49.9885202 0.0060288055 1.593278e-11 3.208352e-10 16 15060035 15060173 139 - 1.478 1.954 1.614
ENSG00000085721 E003 819.8151585 0.0052990017 9.436975e-12 1.975259e-10 16 15060174 15061427 1254 - 2.780 3.033 0.843
ENSG00000085721 E004 217.1860423 0.0002426916 9.296580e-03 2.702492e-02 16 15061428 15061628 201 - 2.253 2.381 0.428
ENSG00000085721 E005 220.7522902 0.0001703294 3.007452e-01 4.424887e-01 16 15061629 15061788 160 - 2.272 2.360 0.292
ENSG00000085721 E006 184.9446672 0.0002342244 8.992074e-01 9.396976e-01 16 15061789 15061905 117 - 2.204 2.261 0.190
ENSG00000085721 E007 127.5893388 0.0002861372 7.060704e-01 8.043035e-01 16 15063196 15063283 88 - 2.040 2.113 0.245
ENSG00000085721 E008 128.7696777 0.0026252316 1.063800e-01 2.001962e-01 16 15065219 15065371 153 - 2.067 2.058 -0.030
ENSG00000085721 E009 64.4757628 0.0226109445 4.593231e-01 5.995120e-01 16 15068169 15068277 109 - 1.769 1.762 -0.027
ENSG00000085721 E010 87.0853502 0.0063657806 4.976631e-01 6.342055e-01 16 15070070 15070254 185 - 1.890 1.911 0.069
ENSG00000085721 E011 108.0240031 0.0005627938 4.628064e-02 1.025501e-01 16 15071121 15071251 131 - 1.993 1.975 -0.063
ENSG00000085721 E012 137.0047635 0.0030111393 1.769487e-03 6.502133e-03 16 15072950 15073080 131 - 2.110 2.028 -0.275
ENSG00000085721 E013 1.9531865 0.0070393435 9.640627e-02 1.849694e-01 16 15074677 15074722 46 - 0.498 0.202 -1.864
ENSG00000085721 E014 154.3984515 0.0008162781 8.091942e-10 1.220731e-08 16 15074723 15074861 139 - 2.178 2.014 -0.552
ENSG00000085721 E015 1.0685319 0.0240242540 2.099320e-01 3.384564e-01 16 15076435 15076557 123 - 0.187 0.444 1.727
ENSG00000085721 E016 114.9427370 0.0003331834 1.632044e-05 1.032857e-04 16 15076558 15076650 93 - 2.040 1.932 -0.362
ENSG00000085721 E017 106.6654228 0.0003167333 6.018377e-06 4.208017e-05 16 15079998 15080096 99 - 2.011 1.888 -0.415
ENSG00000085721 E018 103.4829185 0.0036068058 8.910953e-03 2.605939e-02 16 15083513 15083582 70 - 1.987 1.910 -0.259
ENSG00000085721 E019 1.6432613 0.0824387801 3.267468e-02 7.715275e-02 16 15083583 15083750 168 - 0.474 0.000 -12.038
ENSG00000085721 E020 114.7122331 0.0009060221 2.468117e-04 1.162029e-03 16 15084642 15084705 64 - 2.036 1.946 -0.300
ENSG00000085721 E021 91.7808978 0.0003085198 7.212249e-04 2.974764e-03 16 15085639 15085698 60 - 1.941 1.857 -0.283
ENSG00000085721 E022 95.9030804 0.0022598574 1.667295e-04 8.211085e-04 16 15086129 15086258 130 - 1.967 1.845 -0.412
ENSG00000085721 E023 57.2866331 0.0005746054 1.235652e-02 3.438916e-02 16 15086365 15086454 90 - 1.737 1.662 -0.256
ENSG00000085721 E024 64.4790438 0.0028466896 2.555078e-06 1.943047e-05 16 15091315 15091371 57 - 1.817 1.595 -0.755
ENSG00000085721 E025 97.0286572 0.0005135218 1.350469e-10 2.333476e-09 16 15092509 15092614 106 - 1.991 1.761 -0.773
ENSG00000085721 E026 0.4439371 0.0215655736 4.262848e-01 5.691458e-01 16 15093952 15094144 193 - 0.187 0.000 -10.160
ENSG00000085721 E027 75.9666160 0.0006830624 1.582635e-08 1.879430e-07 16 15094145 15094311 167 - 1.885 1.656 -0.774