ENSG00000085511

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000348824 ENSG00000085511 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K4 protein_coding protein_coding 14.72034 9.748924 17.12818 0.6441965 0.3294483 0.8124202 5.1541274 3.3941526 6.1532884 0.2518246 0.45135649 0.8564046 0.35313333 0.35073333 0.359566667 0.008833333 9.658840e-01 8.813988e-13 FALSE TRUE
ENST00000366919 ENSG00000085511 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K4 protein_coding protein_coding 14.72034 9.748924 17.12818 0.6441965 0.3294483 0.8124202 2.9219133 1.7002632 4.1733589 0.7854153 0.11740418 1.2904434 0.19196250 0.17296667 0.243566667 0.070600000 5.676394e-01 8.813988e-13 FALSE TRUE
ENST00000366920 ENSG00000085511 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K4 protein_coding protein_coding 14.72034 9.748924 17.12818 0.6441965 0.3294483 0.8124202 0.8769512 0.2985008 0.6845309 0.1493604 0.42217454 1.1707647 0.05316250 0.02880000 0.040066667 0.011266667 1.000000e+00 8.813988e-13 FALSE TRUE
ENST00000536852 ENSG00000085511 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K4 protein_coding retained_intron 14.72034 9.748924 17.12818 0.6441965 0.3294483 0.8124202 0.7534340 2.0784212 0.1089219 0.5136426 0.03901611 -4.1343263 0.06739583 0.21353333 0.006366667 -0.207166667 7.443874e-10 8.813988e-13 FALSE TRUE
ENST00000539610 ENSG00000085511 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K4 protein_coding retained_intron 14.72034 9.748924 17.12818 0.6441965 0.3294483 0.8124202 0.7109421 0.0000000 1.5815534 0.0000000 0.20839850 7.3142918 0.04825833 0.00000000 0.092800000 0.092800000 8.813988e-13 8.813988e-13   FALSE
ENST00000541901 ENSG00000085511 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K4 protein_coding retained_intron 14.72034 9.748924 17.12818 0.6441965 0.3294483 0.8124202 1.3349912 0.8329564 1.5330415 0.4358020 0.77493978 0.8722469 0.08387500 0.08906667 0.091266667 0.002200000 1.000000e+00 8.813988e-13 FALSE TRUE
ENST00000544733 ENSG00000085511 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K4 protein_coding retained_intron 14.72034 9.748924 17.12818 0.6441965 0.3294483 0.8124202 1.6097520 0.6982363 1.2720918 0.6982363 1.27209177 0.8561967 0.10826667 0.06530000 0.071533333 0.006233333 9.494726e-01 8.813988e-13 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000085511 E001 3.3957258 0.0046661774 5.579096e-03 1.749790e-02 6 160991727 160991768 42 + 0.784 0.340 -2.094
ENSG00000085511 E002 8.2319041 0.0020483436 2.437734e-07 2.297848e-06 6 160991769 160991813 45 + 1.149 0.475 -2.724
ENSG00000085511 E003 8.5704094 0.0018698449 9.970728e-08 1.012448e-06 6 160991814 160991843 30 + 1.165 0.475 -2.781
ENSG00000085511 E004 22.7711843 0.0008056520 3.890632e-08 4.288773e-07 6 160991844 160992083 240 + 1.516 1.097 -1.468
ENSG00000085511 E005 0.6319842 0.0260894173 5.115623e-01 6.465627e-01 6 161022194 161022227 34 + 0.256 0.145 -1.017
ENSG00000085511 E006 25.9053667 0.0018680650 1.267573e-06 1.029783e-05 6 161034259 161034357 99 + 1.553 1.206 -1.206
ENSG00000085511 E007 33.8496780 0.0104698936 3.139740e-06 2.338566e-05 6 161034358 161034449 92 + 1.671 1.301 -1.273
ENSG00000085511 E008 0.0000000       6 161048246 161048291 46 +      
ENSG00000085511 E009 283.9026679 0.0002213881 6.416302e-29 9.834540e-27 6 161048616 161049979 1364 + 2.541 2.313 -0.761
ENSG00000085511 E010 0.1817044 0.0397657228 3.439858e-01   6 161067199 161067296 98 + 0.000 0.145 9.870
ENSG00000085511 E011 90.3425014 0.0013803270 1.045575e-03 4.116654e-03 6 161070608 161070850 243 + 2.011 1.891 -0.403
ENSG00000085511 E012 0.9577154 0.0176332284 6.663994e-01 7.738398e-01 6 161073329 161073465 137 + 0.256 0.340 0.567
ENSG00000085511 E013 72.0801345 0.0025092365 1.397328e-03 5.297994e-03 6 161073466 161073612 147 + 1.919 1.779 -0.474
ENSG00000085511 E014 0.6696487 0.0297227526 5.157082e-01 6.503363e-01 6 161080683 161080880 198 + 0.256 0.145 -1.014
ENSG00000085511 E015 58.3185750 0.0058958309 2.487085e-01 3.843970e-01 6 161080881 161081038 158 + 1.794 1.740 -0.182
ENSG00000085511 E016 58.1254558 0.0174789999 9.798118e-01 9.914297e-01 6 161084501 161084617 117 + 1.762 1.774 0.040
ENSG00000085511 E017 62.9591666 0.0145543182 5.334298e-01 6.656217e-01 6 161086379 161086478 100 + 1.817 1.781 -0.123
ENSG00000085511 E018 63.6027750 0.0169200555 6.908032e-01 7.923868e-01 6 161086584 161086667 84 + 1.814 1.794 -0.066
ENSG00000085511 E019 95.1326743 0.0070164435 2.857614e-01 4.261312e-01 6 161087688 161087954 267 + 1.998 1.954 -0.150
ENSG00000085511 E020 76.9804600 0.0005454924 3.242369e-02 7.667574e-02 6 161089322 161089471 150 + 1.923 1.850 -0.249
ENSG00000085511 E021 89.3719221 0.0003043824 5.551062e-03 1.742151e-02 6 161091379 161091540 162 + 1.995 1.904 -0.304
ENSG00000085511 E022 89.3143160 0.0002904274 5.996659e-01 7.210263e-01 6 161092010 161092143 134 + 1.957 1.951 -0.019
ENSG00000085511 E023 73.8754721 0.0016680607 8.725734e-01 9.220418e-01 6 161092978 161093056 79 + 1.872 1.879 0.024
ENSG00000085511 E024 64.9471572 0.0062643923 4.613560e-01 6.013244e-01 6 161093773 161093839 67 + 1.833 1.808 -0.086
ENSG00000085511 E025 18.4894370 0.0011141577 5.683727e-01 6.950683e-01 6 161093840 161093851 12 + 1.306 1.275 -0.110
ENSG00000085511 E026 2.8612324 0.0476505110 4.938971e-02 1.080754e-01 6 161096697 161097079 383 + 0.700 0.342 -1.745
ENSG00000085511 E027 71.7117215 0.0097789545 4.342379e-01 5.766271e-01 6 161097080 161097165 86 + 1.877 1.848 -0.097
ENSG00000085511 E028 36.9976968 0.0006395545 4.197237e-01 5.629807e-01 6 161097166 161097176 11 + 1.596 1.564 -0.110
ENSG00000085511 E029 0.1515154 0.0431560080 6.832718e-01   6 161098240 161098277 38 + 0.103 0.000 -10.032
ENSG00000085511 E030 18.1382434 0.0129137997 9.225603e-01 9.551608e-01 6 161098278 161098427 150 + 1.283 1.290 0.025
ENSG00000085511 E031 1.2576127 0.0103145250 3.470480e-01 4.912152e-01 6 161101033 161101891 859 + 0.416 0.253 -1.016
ENSG00000085511 E032 89.3185774 0.0005962890 5.385169e-01 6.699333e-01 6 161101892 161101992 101 + 1.962 1.953 -0.031
ENSG00000085511 E033 99.4014297 0.0003356583 6.584753e-01 7.676032e-01 6 161102699 161102779 81 + 2.002 2.000 -0.005
ENSG00000085511 E034 149.3706267 0.0002212778 6.445209e-02 1.341300e-01 6 161106514 161106705 192 + 2.145 2.212 0.224
ENSG00000085511 E035 100.5026622 0.0003284377 7.374397e-02 1.495172e-01 6 161107899 161107969 71 + 1.972 2.049 0.258
ENSG00000085511 E036 110.3915496 0.0005421542 1.658968e-02 4.403683e-02 6 161108743 161108859 117 + 2.003 2.099 0.323
ENSG00000085511 E037 2.8680104 0.1080700712 9.226141e-01 9.551852e-01 6 161108860 161108878 19 + 0.564 0.584 0.089
ENSG00000085511 E038 2.9336909 0.0739383835 1.362124e-01 2.427773e-01 6 161108879 161108950 72 + 0.699 0.413 -1.331
ENSG00000085511 E039 6.9019629 0.0024952178 6.062947e-02 1.276911e-01 6 161108951 161109041 91 + 0.980 0.760 -0.846
ENSG00000085511 E040 130.5660716 0.0047456466 1.063890e-02 3.030384e-02 6 161109755 161109914 160 + 2.058 2.182 0.416
ENSG00000085511 E041 118.2738621 0.0033794286 1.150742e-08 1.403313e-07 6 161111836 161111958 123 + 1.942 2.194 0.844
ENSG00000085511 E042 114.2123784 0.0014635610 2.112476e-12 4.914074e-11 6 161112668 161112774 107 + 1.914 2.187 0.915
ENSG00000085511 E043 133.5888186 0.0010334600 1.895033e-11 3.770699e-10 6 161115123 161115302 180 + 2.004 2.241 0.793
ENSG00000085511 E044 202.0673323 0.0056246663 4.538871e-10 7.164434e-09 6 161116850 161117385 536 + 2.161 2.440 0.931