ENSG00000085377

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369110 ENSG00000085377 HEK293_OSMI2_2hA HEK293_TMG_2hB PREP protein_coding protein_coding 35.2481 37.67372 33.62781 3.252156 0.09538605 -0.1638574 8.370717 12.392693 5.570873 1.1093636 0.39787736 -1.1520908 0.2355250 0.3289667 0.1656000 -0.16336667 8.866710e-10 8.86671e-10 FALSE TRUE
ENST00000448705 ENSG00000085377 HEK293_OSMI2_2hA HEK293_TMG_2hB PREP protein_coding protein_coding 35.2481 37.67372 33.62781 3.252156 0.09538605 -0.1638574 3.535388 4.348057 3.106437 0.6209688 0.09317265 -0.4837873 0.1000708 0.1152333 0.0924000 -0.02283333 4.267800e-01 8.86671e-10   FALSE
MSTRG.28702.3 ENSG00000085377 HEK293_OSMI2_2hA HEK293_TMG_2hB PREP protein_coding   35.2481 37.67372 33.62781 3.252156 0.09538605 -0.1638574 15.540348 16.468537 15.022918 1.1529450 0.84693791 -0.1324631 0.4407667 0.4389667 0.4467667 0.00780000 9.605409e-01 8.86671e-10 TRUE TRUE
MSTRG.28702.5 ENSG00000085377 HEK293_OSMI2_2hA HEK293_TMG_2hB PREP protein_coding   35.2481 37.67372 33.62781 3.252156 0.09538605 -0.1638574 2.546024 2.145272 3.448658 0.5082963 0.19976946 0.6823421 0.0726875 0.0558000 0.1025667 0.04676667 5.259438e-02 8.86671e-10 FALSE TRUE
MSTRG.28702.6 ENSG00000085377 HEK293_OSMI2_2hA HEK293_TMG_2hB PREP protein_coding   35.2481 37.67372 33.62781 3.252156 0.09538605 -0.1638574 4.011110 1.117718 5.454392 1.1177180 0.68410680 2.2766545 0.1148167 0.0287000 0.1622333 0.13353333 8.061685e-02 8.86671e-10 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000085377 E001 12.810550 0.0015195647 1.114664e-02 3.151788e-02 6 105273218 105277269 4052 - 1.253 1.029 -0.801
ENSG00000085377 E002 159.189880 0.0025682314 2.789778e-08 3.160408e-07 6 105277270 105277872 603 - 2.035 2.263 0.765
ENSG00000085377 E003 208.026530 0.0032754741 6.479215e-10 9.955940e-09 6 105277873 105277929 57 - 2.133 2.383 0.835
ENSG00000085377 E004 259.536224 0.0014498083 5.390153e-21 3.884170e-19 6 105277930 105277998 69 - 2.194 2.489 0.985
ENSG00000085377 E005 242.545232 0.0016848703 2.067307e-13 5.619011e-12 6 105277999 105278032 34 - 2.206 2.447 0.806
ENSG00000085377 E006 201.810690 0.0017912608 2.044240e-09 2.856432e-08 6 105278033 105278048 16 - 2.149 2.361 0.708
ENSG00000085377 E007 600.098943 0.0032864750 1.025528e-06 8.485838e-06 6 105278049 105278438 390 - 2.659 2.814 0.516
ENSG00000085377 E008 359.438699 0.0012462066 8.654887e-09 1.079351e-07 6 105281746 105281902 157 - 2.437 2.596 0.528
ENSG00000085377 E009 352.924750 0.0002245765 1.137985e-03 4.430405e-03 6 105282451 105282582 132 - 2.487 2.565 0.259
ENSG00000085377 E010 258.081771 0.0001789360 8.554318e-01 9.106044e-01 6 105285486 105285571 86 - 2.397 2.405 0.027
ENSG00000085377 E011 147.145781 0.0061741586 6.336062e-01 7.482766e-01 6 105285572 105285580 9 - 2.166 2.150 -0.055
ENSG00000085377 E012 292.887792 0.0024198574 3.392007e-01 4.831250e-01 6 105288758 105288894 137 - 2.468 2.445 -0.077
ENSG00000085377 E013 3.123926 0.0054856431 1.241486e-01 2.258999e-01 6 105313270 105313393 124 - 0.726 0.499 -1.002
ENSG00000085377 E014 44.811459 0.0046184955 1.596291e-01 2.746209e-01 6 105322255 105322698 444 - 1.584 1.687 0.350
ENSG00000085377 E015 62.014685 0.0063498590 3.542676e-01 4.985473e-01 6 105322699 105323005 307 - 1.742 1.808 0.222
ENSG00000085377 E016 40.171467 0.0005558297 4.699239e-01 6.091432e-01 6 105323006 105323111 106 - 1.622 1.594 -0.096
ENSG00000085377 E017 285.166908 0.0013805604 5.299653e-01 6.626866e-01 6 105323665 105323768 104 - 2.426 2.452 0.087
ENSG00000085377 E018 389.855581 0.0012732272 9.601297e-02 1.843866e-01 6 105328829 105329017 189 - 2.598 2.566 -0.105
ENSG00000085377 E019 135.525045 0.0021596176 2.953518e-02 7.104396e-02 6 105329018 105329026 9 - 2.166 2.093 -0.244
ENSG00000085377 E020 424.961217 0.0002022147 5.226016e-15 1.792276e-13 6 105333314 105333505 192 - 2.692 2.565 -0.423
ENSG00000085377 E021 331.325652 0.0001626762 1.390516e-13 3.871110e-12 6 105352972 105353077 106 - 2.589 2.455 -0.445
ENSG00000085377 E022 313.820885 0.0002715632 2.300218e-12 5.320100e-11 6 105368903 105369024 122 - 2.566 2.432 -0.448
ENSG00000085377 E023 334.520827 0.0035156831 4.431950e-04 1.940554e-03 6 105373369 105373578 210 - 2.578 2.466 -0.373
ENSG00000085377 E024 212.101319 0.0041169699 8.559876e-03 2.518900e-02 6 105376125 105376255 131 - 2.372 2.276 -0.322
ENSG00000085377 E025 191.003524 0.0012025404 5.830351e-13 1.485399e-11 6 105377386 105377519 134 - 2.389 2.184 -0.686
ENSG00000085377 E026 117.128516 0.0003389249 1.729724e-18 9.251582e-17 6 105397853 105397927 75 - 2.215 1.939 -0.925
ENSG00000085377 E027 100.151718 0.0100229877 4.543433e-16 1.793955e-14 6 105402847 105403197 351 - 2.233 1.744 -1.644
ENSG00000085377 E028 0.000000       6 105448925 105449044 120 -      
ENSG00000085377 E029 0.000000       6 105450624 105451241 618 -      
ENSG00000085377 E030 0.000000       6 105453991 105454062 72 -