ENSG00000085224

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373344 ENSG00000085224 HEK293_OSMI2_2hA HEK293_TMG_2hB ATRX protein_coding protein_coding 10.13118 2.451335 16.69872 0.1740872 1.185759 2.763088 1.1451227 0.3762554 1.2394107 0.17731243 0.14592129 1.693621 0.12827500 0.1458333 0.07386667 -0.07196667 4.737556e-01 1.349326e-38 FALSE TRUE
ENST00000395603 ENSG00000085224 HEK293_OSMI2_2hA HEK293_TMG_2hB ATRX protein_coding protein_coding 10.13118 2.451335 16.69872 0.1740872 1.185759 2.763088 3.1164280 0.1339086 4.8176296 0.13390864 0.26998085 5.068090 0.21729167 0.0630000 0.28936667 0.22636667 1.115758e-01 1.349326e-38 FALSE TRUE
ENST00000460639 ENSG00000085224 HEK293_OSMI2_2hA HEK293_TMG_2hB ATRX protein_coding retained_intron 10.13118 2.451335 16.69872 0.1740872 1.185759 2.763088 0.5280134 0.0000000 1.4588409 0.00000000 0.64479138 7.198534 0.05453333 0.0000000 0.08366667 0.08366667 1.011052e-02 1.349326e-38 FALSE FALSE
ENST00000493470 ENSG00000085224 HEK293_OSMI2_2hA HEK293_TMG_2hB ATRX protein_coding protein_coding 10.13118 2.451335 16.69872 0.1740872 1.185759 2.763088 0.7862143 0.4426331 1.4412523 0.05606266 0.10079064 1.680884 0.09386250 0.1804333 0.08720000 -0.09323333 1.848329e-02 1.349326e-38 FALSE TRUE
ENST00000623321 ENSG00000085224 HEK293_OSMI2_2hA HEK293_TMG_2hB ATRX protein_coding protein_coding 10.13118 2.451335 16.69872 0.1740872 1.185759 2.763088 0.3971644 0.0000000 0.9132616 0.00000000 0.24630134 6.528668 0.02330417 0.0000000 0.05453333 0.05453333 5.427719e-03 1.349326e-38 FALSE TRUE
ENST00000675732 ENSG00000085224 HEK293_OSMI2_2hA HEK293_TMG_2hB ATRX protein_coding protein_coding 10.13118 2.451335 16.69872 0.1740872 1.185759 2.763088 1.0587856 1.3897424 0.6940176 0.12886288 0.07348197 -0.991478 0.26367083 0.5662667 0.04143333 -0.52483333 1.349326e-38 1.349326e-38 FALSE TRUE
MSTRG.34503.2 ENSG00000085224 HEK293_OSMI2_2hA HEK293_TMG_2hB ATRX protein_coding   10.13118 2.451335 16.69872 0.1740872 1.185759 2.763088 0.5576351 0.0232004 1.2625522 0.02320040 0.46134960 5.260380 0.04270417 0.0109000 0.07313333 0.06223333 7.376776e-02 1.349326e-38 FALSE TRUE
MSTRG.34503.6 ENSG00000085224 HEK293_OSMI2_2hA HEK293_TMG_2hB ATRX protein_coding   10.13118 2.451335 16.69872 0.1740872 1.185759 2.763088 0.7299640 0.0000000 1.4082358 0.00000000 0.70660223 7.147954 0.04402917 0.0000000 0.09080000 0.09080000 4.460699e-01 1.349326e-38 FALSE TRUE
MSTRG.34503.9 ENSG00000085224 HEK293_OSMI2_2hA HEK293_TMG_2hB ATRX protein_coding   10.13118 2.451335 16.69872 0.1740872 1.185759 2.763088 0.6106135 0.0000000 1.2549052 0.00000000 0.63911985 6.982885 0.03505417 0.0000000 0.07100000 0.07100000 1.898171e-02 1.349326e-38 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000085224 E001 12.4811241 0.0178625661 5.414110e-07 4.757140e-06 X 77504880 77505712 833 - 0.776 1.482 2.562
ENSG00000085224 E002 209.4201979 0.0490483183 1.864885e-12 4.371403e-11 X 77505713 77506904 1192 - 1.899 2.742 2.815
ENSG00000085224 E003 187.2687895 0.0003319160 1.104956e-18 6.067552e-17 X 77506905 77508194 1290 - 1.985 2.398 1.381
ENSG00000085224 E004 58.6451670 0.0004422998 5.016401e-03 1.597563e-02 X 77508195 77508480 286 - 1.514 1.806 0.993
ENSG00000085224 E005 52.3258800 0.0005209423 1.264440e-01 2.292005e-01 X 77508481 77508629 149 - 1.506 1.497 -0.031
ENSG00000085224 E006 61.1504056 0.0231892540 9.930658e-01 9.997946e-01 X 77520788 77520916 129 - 1.558 1.674 0.394
ENSG00000085224 E007 3.2893781 0.0055328917 3.151929e-01 4.579429e-01 X 77520917 77521035 119 - 0.484 0.319 -0.913
ENSG00000085224 E008 2.9090280 0.0189478224 9.909033e-01 9.984419e-01 X 77521036 77521102 67 - 0.424 0.502 0.394
ENSG00000085224 E009 5.4254018 0.0035399834 2.958361e-01 4.369796e-01 X 77521103 77521402 300 - 0.635 0.502 -0.608
ENSG00000085224 E010 49.7145179 0.0063639615 2.747821e-01 4.140023e-01 X 77521403 77521498 96 - 1.457 1.660 0.694
ENSG00000085224 E011 5.6774148 0.0038171759 9.504332e-01 9.729711e-01 X 77521499 77522262 764 - 0.625 0.728 0.435
ENSG00000085224 E012 56.0814868 0.0005572139 5.602808e-02 1.197494e-01 X 77522263 77522388 126 - 1.501 1.743 0.824
ENSG00000085224 E013 0.1515154 0.0425850334 6.607332e-01   X 77522389 77522468 80 - 0.040 0.000 -8.440
ENSG00000085224 E014 63.4601683 0.0014486172 6.978085e-01 7.978522e-01 X 77523252 77523401 150 - 1.567 1.708 0.482
ENSG00000085224 E015 62.5194862 0.0004017730 7.419917e-01 8.310165e-01 X 77557451 77557645 195 - 1.568 1.659 0.310
ENSG00000085224 E016 42.8770710 0.0005324369 7.380211e-02 1.495949e-01 X 77558669 77558808 140 - 1.425 1.377 -0.167
ENSG00000085224 E017 26.7555536 0.0014037241 8.979206e-02 1.748144e-01 X 77558809 77558846 38 - 1.232 1.148 -0.301
ENSG00000085224 E018 0.0000000       X 77561647 77561708 62 -      
ENSG00000085224 E019 21.2270368 0.0009532666 1.740933e-01 2.934947e-01 X 77574250 77574256 7 - 1.136 1.074 -0.221
ENSG00000085224 E020 30.6600162 0.0010098597 4.091453e-02 9.272581e-02 X 77574257 77574310 54 - 1.293 1.180 -0.398
ENSG00000085224 E021 29.9165935 0.0119633281 2.082036e-01 3.363310e-01 X 77574311 77574358 48 - 1.277 1.239 -0.134
ENSG00000085224 E022 0.2966881 0.0290785164 1.000000e+00   X 77575554 77575605 52 - 0.077 0.000 -9.509
ENSG00000085224 E023 0.2966881 0.0290785164 1.000000e+00   X 77575693 77575753 61 - 0.077 0.000 -9.509
ENSG00000085224 E024 38.6096596 0.0070883501 9.048238e-01 9.433958e-01 X 77589834 77589940 107 - 1.366 1.467 0.351
ENSG00000085224 E025 43.9644558 0.0045644872 1.578072e-01 2.722058e-01 X 77593696 77593849 154 - 1.433 1.415 -0.062
ENSG00000085224 E026 3.5578399 0.0043790831 4.083527e-02 9.258494e-02 X 77593850 77595711 1862 - 0.524 0.000 -12.854
ENSG00000085224 E027 4.1647182 0.1127921951 2.507524e-01 3.868238e-01 X 77595712 77595785 74 - 0.561 0.318 -1.289
ENSG00000085224 E028 0.7686241 0.1564611601 5.157799e-01 6.504159e-01 X 77595786 77596875 1090 - 0.143 0.320 1.484
ENSG00000085224 E029 55.4998838 0.0092541804 4.305915e-01 5.732153e-01 X 77599411 77599580 170 - 1.524 1.569 0.154
ENSG00000085224 E030 22.5836664 0.0008304051 1.942851e-01 3.191289e-01 X 77599732 77599734 3 - 1.160 1.112 -0.170
ENSG00000085224 E031 36.8366013 0.0006835785 2.347593e-01 3.680776e-01 X 77599735 77599820 86 - 1.357 1.357 0.000
ENSG00000085224 E032 53.3156678 0.0013765549 4.785695e-02 1.053688e-01 X 77600434 77600564 131 - 1.517 1.466 -0.173
ENSG00000085224 E033 0.1515154 0.0425850334 6.607332e-01   X 77600565 77600755 191 - 0.040 0.000 -8.440
ENSG00000085224 E034 0.2924217 0.0273911248 1.000000e+00   X 77613261 77616244 2984 - 0.077 0.000 -9.521
ENSG00000085224 E035 1.2555363 0.0108647759 2.477496e-01 3.832840e-01 X 77616245 77616511 267 - 0.200 0.502 1.894
ENSG00000085224 E036 0.7500885 0.1150126646 5.171646e-01 6.516188e-01 X 77616512 77616612 101 - 0.143 0.318 1.466
ENSG00000085224 E037 48.9158667 0.0004465306 5.929103e-01 7.153735e-01 X 77616613 77616730 118 - 1.469 1.540 0.243
ENSG00000085224 E038 54.6140086 0.0004020689 4.965269e-01 6.331608e-01 X 77618806 77618981 176 - 1.517 1.579 0.213
ENSG00000085224 E039 52.7586677 0.0010630503 2.447652e-01 3.797678e-01 X 77620395 77620532 138 - 1.505 1.527 0.073
ENSG00000085224 E040 53.9498980 0.0032756837 1.538474e-01 2.668992e-01 X 77633207 77633352 146 - 1.517 1.513 -0.014
ENSG00000085224 E041 31.4077472 0.0070060079 9.354769e-01 9.633956e-01 X 77633353 77633384 32 - 1.278 1.397 0.417
ENSG00000085224 E042 51.3383780 0.0008822956 3.248396e-01 4.682546e-01 X 77633566 77633712 147 - 1.492 1.527 0.120
ENSG00000085224 E043 4.8103694 0.0063092540 1.191368e-01 2.187068e-01 X 77633713 77634256 544 - 0.604 0.320 -1.475
ENSG00000085224 E044 4.5327095 0.0158125720 1.512232e-01 2.633402e-01 X 77634422 77634593 172 - 0.583 0.320 -1.378
ENSG00000085224 E045 39.9958977 0.0040370836 8.142956e-02 1.617907e-01 X 77634594 77634703 110 - 1.396 1.336 -0.208
ENSG00000085224 E046 43.8001789 0.0020373639 3.120085e-03 1.061967e-02 X 77635915 77636056 142 - 1.444 1.265 -0.624
ENSG00000085224 E047 0.0000000       X 77651983 77652113 131 -      
ENSG00000085224 E048 64.8423213 0.0030829526 2.945929e-05 1.756459e-04 X 77652114 77652353 240 - 1.614 1.357 -0.880
ENSG00000085224 E049 38.4824174 0.0005519635 1.854493e-02 4.833174e-02 X 77654098 77654157 60 - 1.385 1.265 -0.422
ENSG00000085224 E050 35.3644758 0.0020260050 5.822660e-02 1.235913e-01 X 77654158 77654200 43 - 1.347 1.265 -0.288
ENSG00000085224 E051 49.2008425 0.0041499245 1.599019e-01 2.749811e-01 X 77656560 77656653 94 - 1.478 1.468 -0.035
ENSG00000085224 E052 58.9085492 0.0010995440 1.691364e-02 4.474382e-02 X 77663382 77663558 177 - 1.560 1.482 -0.264
ENSG00000085224 E053 51.0297003 0.0004478647 1.480470e-03 5.573963e-03 X 77664645 77664778 134 - 1.506 1.336 -0.590
ENSG00000085224 E054 56.0123297 0.0261020109 4.071176e-09 5.389742e-08 X 77673954 77676225 2272 - 1.404 2.072 2.264
ENSG00000085224 E055 37.6078689 0.0006796949 1.338560e-02 3.681297e-02 X 77676226 77676298 73 - 1.377 1.238 -0.484
ENSG00000085224 E056 156.4243913 0.0002344143 2.665111e-12 6.105167e-11 X 77681520 77682304 785 - 1.992 1.726 -0.896
ENSG00000085224 E057 195.1954723 0.0002324033 1.285599e-11 2.629026e-10 X 77682305 77683451 1147 - 2.082 1.881 -0.676
ENSG00000085224 E058 22.6138763 0.0139749224 2.354068e-01 3.688462e-01 X 77683452 77683506 55 - 1.159 1.115 -0.160
ENSG00000085224 E059 17.0567940 0.0135214681 4.100683e-01 5.536912e-01 X 77683507 77683538 32 - 1.046 1.034 -0.046
ENSG00000085224 E060 143.2631095 0.0002820314 1.750480e-15 6.415616e-14 X 77683539 77684477 939 - 1.960 1.591 -1.245
ENSG00000085224 E061 36.6319156 0.0005416497 1.968427e-07 1.888165e-06 X 77684478 77684593 116 - 1.389 0.808 -2.112
ENSG00000085224 E062 24.3293700 0.0015475929 1.350992e-03 5.146516e-03 X 77684939 77684997 59 - 1.212 0.876 -1.231
ENSG00000085224 E063 13.0457754 0.0015401351 4.686381e-02 1.035890e-01 X 77684998 77685006 9 - 0.959 0.728 -0.896
ENSG00000085224 E064 23.8403684 0.0008227865 4.439238e-04 1.943476e-03 X 77688818 77688901 84 - 1.207 0.808 -1.475
ENSG00000085224 E065 17.2465393 0.0129503417 4.130020e-04 1.824248e-03 X 77688902 77688924 23 - 1.084 0.501 -2.356
ENSG00000085224 E066 8.7809384 0.0055311299 8.026915e-03 2.384961e-02 X 77688925 77688927 3 - 0.823 0.319 -2.379
ENSG00000085224 E067 0.4439371 0.0215640121 1.000000e+00 1.000000e+00 X 77690803 77690925 123 - 0.111 0.000 -10.125
ENSG00000085224 E068 0.0000000       X 77691225 77691291 67 -      
ENSG00000085224 E069 24.9186171 0.0036117988 1.524311e-06 1.216975e-05 X 77693824 77693937 114 - 1.235 0.502 -2.895
ENSG00000085224 E070 34.8306583 0.0117894170 2.516954e-05 1.524976e-04 X 77696577 77696687 111 - 1.367 0.876 -1.777
ENSG00000085224 E071 21.1292274 0.0086735032 1.848466e-04 8.986049e-04 X 77696688 77696704 17 - 1.166 0.629 -2.067
ENSG00000085224 E072 20.1200266 0.0105049009 1.660924e-03 6.156560e-03 X 77697583 77697602 20 - 1.142 0.727 -1.567
ENSG00000085224 E073 19.0877843 0.0011035821 3.338817e-04 1.515838e-03 X 77697603 77697635 33 - 1.123 0.629 -1.913
ENSG00000085224 E074 20.3653567 0.0009149474 7.715658e-04 3.155742e-03 X 77698574 77698629 56 - 1.145 0.728 -1.576
ENSG00000085224 E075 0.5954526 0.0183013486 1.000000e+00 1.000000e+00 X 77699510 77699547 38 - 0.143 0.000 -10.541
ENSG00000085224 E076 24.0902278 0.0007622252 1.434529e-05 9.190328e-05 X 77717131 77717243 113 - 1.217 0.629 -2.249
ENSG00000085224 E077 4.7599057 0.0033851995 1.171986e-01 2.159481e-01 X 77785845 77785981 137 - 0.604 0.319 -1.475
ENSG00000085224 E078 30.0997555 0.0068842246 1.193837e-03 4.619746e-03 X 77785982 77786233 252 - 1.299 0.986 -1.123