ENSG00000084754

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000380649 ENSG00000084754 HEK293_OSMI2_2hA HEK293_TMG_2hB HADHA protein_coding protein_coding 103.3413 102.562 105.1556 16.41899 1.550913 0.0360251 50.81684 47.6197465 49.31948 7.5971113 0.5206137 0.05058734 0.49242917 0.464600000 0.4693667 0.004766667 0.98055934 8.791069e-07 FALSE  
ENST00000643233 ENSG00000084754 HEK293_OSMI2_2hA HEK293_TMG_2hB HADHA protein_coding nonsense_mediated_decay 103.3413 102.562 105.1556 16.41899 1.550913 0.0360251 42.91091 50.6809853 40.98133 10.2394770 3.8563276 -0.30641055 0.41422500 0.490166667 0.3888000 -0.101366667 0.22691051 8.791069e-07 FALSE  
ENST00000646483 ENSG00000084754 HEK293_OSMI2_2hA HEK293_TMG_2hB HADHA protein_coding nonsense_mediated_decay 103.3413 102.562 105.1556 16.41899 1.550913 0.0360251 5.40944 0.7683612 10.70046 0.6809719 1.6855197 3.78243638 0.05044167 0.007166667 0.1022000 0.095033333 0.01180533 8.791069e-07 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000084754 E001 5.0056770 3.400521e-03 1.031375e-02 2.954098e-02 2 26190635 26190654 20 - 0.536 0.918 1.578
ENSG00000084754 E002 8.6058038 2.506212e-03 1.045918e-01 1.975022e-01 2 26190655 26190670 16 - 0.862 1.065 0.761
ENSG00000084754 E003 108.7929291 2.718420e-04 1.969282e-16 8.156419e-15 2 26190671 26190880 210 - 1.834 2.156 1.082
ENSG00000084754 E004 113.2847961 2.575845e-04 1.543168e-19 9.358148e-18 2 26190881 26190888 8 - 1.832 2.180 1.167
ENSG00000084754 E005 242.0689966 1.343529e-03 1.430743e-16 6.042132e-15 2 26190889 26190921 33 - 2.213 2.483 0.901
ENSG00000084754 E006 644.2340879 6.341388e-03 2.225216e-08 2.571589e-07 2 26190922 26191058 137 - 2.639 2.897 0.859
ENSG00000084754 E007 1207.5053373 4.893992e-03 1.180324e-08 1.436152e-07 2 26191059 26191249 191 - 2.938 3.157 0.727
ENSG00000084754 E008 1027.2444422 3.536358e-03 1.154362e-08 1.407456e-07 2 26191250 26191395 146 - 2.889 3.078 0.628
ENSG00000084754 E009 15.9387513 1.975410e-03 2.782926e-04 1.291344e-03 2 26191396 26191482 87 - 0.987 1.342 1.267
ENSG00000084754 E010 1162.1031238 1.033002e-03 2.826467e-07 2.629859e-06 2 26191483 26191628 146 - 2.999 3.105 0.351
ENSG00000084754 E011 1282.4956886 7.344905e-04 6.102588e-02 1.283633e-01 2 26192310 26192424 115 - 3.081 3.124 0.144
ENSG00000084754 E012 1326.1819364 8.169477e-05 8.352769e-01 8.969342e-01 2 26193577 26193772 196 - 3.114 3.135 0.070
ENSG00000084754 E013 741.3820160 1.045258e-04 8.521143e-01 9.083417e-01 2 26194570 26194638 69 - 2.862 2.883 0.069
ENSG00000084754 E014 995.3844506 1.712525e-04 7.445320e-01 8.328423e-01 2 26195092 26195232 141 - 2.986 3.011 0.085
ENSG00000084754 E015 735.1018746 1.142311e-04 1.179187e-01 2.169521e-01 2 26197691 26197777 87 - 2.869 2.870 0.005
ENSG00000084754 E016 0.4031496 2.860013e-02 2.502651e-01 3.862483e-01 2 26199243 26199366 124 - 0.000 0.207 10.233
ENSG00000084754 E017 923.1744051 2.708747e-04 1.437700e-01 2.531442e-01 2 26201149 26201320 172 - 2.967 2.968 0.003
ENSG00000084754 E018 793.7501479 1.300024e-03 6.724091e-01 7.783758e-01 2 26204062 26204196 135 - 2.895 2.903 0.026
ENSG00000084754 E019 734.3345078 2.657151e-03 4.467908e-01 5.882573e-01 2 26209780 26209889 110 - 2.869 2.860 -0.031
ENSG00000084754 E020 6.1065109 3.050183e-02 5.482611e-03 1.724210e-02 2 26210545 26210694 150 - 1.032 0.638 -1.547
ENSG00000084754 E021 7.6716443 2.752708e-03 2.907412e-04 1.342237e-03 2 26210695 26210814 120 - 1.120 0.721 -1.519
ENSG00000084754 E022 10.5214403 1.648409e-03 2.954363e-09 4.013303e-08 2 26211937 26212569 633 - 1.305 0.695 -2.277
ENSG00000084754 E023 619.6933550 1.054405e-03 1.690252e-01 2.869241e-01 2 26212570 26212626 57 - 2.800 2.787 -0.041
ENSG00000084754 E024 792.0305866 7.018920e-04 3.754241e-02 8.648432e-02 2 26214443 26214561 119 - 2.911 2.890 -0.069
ENSG00000084754 E025 1.5092468 9.330829e-03 5.459988e-01 6.762454e-01 2 26214562 26214576 15 - 0.438 0.346 -0.517
ENSG00000084754 E026 831.8955793 4.557607e-04 3.812171e-06 2.786927e-05 2 26215053 26215175 123 - 2.951 2.896 -0.184
ENSG00000084754 E027 659.1094082 3.537567e-04 8.107121e-10 1.222632e-08 2 26230192 26230294 103 - 2.864 2.784 -0.266
ENSG00000084754 E028 434.4358363 1.407697e-04 9.427143e-11 1.670512e-09 2 26232160 26232201 42 - 2.691 2.601 -0.299
ENSG00000084754 E029 575.8242572 1.911570e-03 2.923369e-06 2.192753e-05 2 26232202 26232279 78 - 2.819 2.710 -0.361
ENSG00000084754 E030 752.6767683 1.581070e-03 2.465718e-08 2.823689e-07 2 26234217 26234355 139 - 2.938 2.823 -0.382
ENSG00000084754 E031 0.4772466 2.196021e-02 6.844826e-01 7.874443e-01 2 26235091 26235304 214 - 0.130 0.206 0.802
ENSG00000084754 E032 674.1664251 9.589729e-04 4.740813e-18 2.407863e-16 2 26236855 26236988 134 - 2.912 2.756 -0.521
ENSG00000084754 E033 432.6913523 8.518381e-04 1.261174e-18 6.867651e-17 2 26238934 26239004 71 - 2.730 2.555 -0.580
ENSG00000084754 E034 307.5859082 7.216981e-03 3.419608e-07 3.127369e-06 2 26239102 26239143 42 - 2.604 2.374 -0.765
ENSG00000084754 E035 1.7799237 1.409336e-02 5.481151e-01 6.779998e-01 2 26244525 26244529 5 - 0.490 0.401 -0.461
ENSG00000084754 E036 304.2838115 5.544984e-03 1.075310e-08 1.318112e-07 2 26244530 26244672 143 - 2.600 2.370 -0.765