ENSG00000084710

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264719 ENSG00000084710 HEK293_OSMI2_2hA HEK293_TMG_2hB EFR3B protein_coding protein_coding 2.648299 3.44675 2.303838 0.1941228 0.02919867 -0.5791281 0.5933277 0.8709811 0.1522729 0.4355443 0.1522729 -2.4406894 0.1922833 0.2644 0.0648000 -0.1996000 0.54042592 0.03282186 FALSE TRUE
ENST00000403714 ENSG00000084710 HEK293_OSMI2_2hA HEK293_TMG_2hB EFR3B protein_coding protein_coding 2.648299 3.44675 2.303838 0.1941228 0.02919867 -0.5791281 1.7321062 1.6383261 2.1479283 0.3145823 0.1293402 0.3886453 0.7112458 0.4719 0.9335667 0.4616667 0.03282186 0.03282186 FALSE TRUE
ENST00000405108 ENSG00000084710 HEK293_OSMI2_2hA HEK293_TMG_2hB EFR3B protein_coding protein_coding 2.648299 3.44675 2.303838 0.1941228 0.02919867 -0.5791281 0.3104581 0.9310812 0.0000000 0.6446930 0.0000000 -6.5562473 0.0911375 0.2620 0.0000000 -0.2620000 0.22502177 0.03282186 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000084710 E001 0.5181333 0.0206371021 3.926421e-01 5.365742e-01 2 25042076 25042129 54 + 0.221 0.120 -1.055
ENSG00000084710 E002 6.6054732 0.0054191793 4.231343e-03 1.378933e-02 2 25042130 25042319 190 + 0.984 0.739 -0.947
ENSG00000084710 E003 0.0000000       2 25042463 25042666 204 +      
ENSG00000084710 E004 10.5618895 0.0115809043 8.879577e-04 3.572176e-03 2 25091325 25091401 77 + 1.174 0.923 -0.920
ENSG00000084710 E005 15.0893906 0.0012837636 1.211952e-02 3.382220e-02 2 25093003 25093130 128 + 1.254 1.158 -0.337
ENSG00000084710 E006 16.0699822 0.0039720948 1.182894e-02 3.312081e-02 2 25103637 25103787 151 + 1.277 1.178 -0.350
ENSG00000084710 E007 0.0000000       2 25115988 25116103 116 +      
ENSG00000084710 E008 14.3288401 0.0307848042 1.589297e-01 2.737085e-01 2 25121673 25121794 122 + 1.202 1.154 -0.170
ENSG00000084710 E009 17.6568538 0.0010757016 4.128279e-05 2.371983e-04 2 25128183 25128332 150 + 1.366 1.159 -0.730
ENSG00000084710 E010 14.0141037 0.0028608440 3.306260e-04 1.503182e-03 2 25129975 25130109 135 + 1.269 1.062 -0.739
ENSG00000084710 E011 8.8463978 0.0407892002 2.534046e-02 6.257283e-02 2 25130552 25130630 79 + 1.089 0.889 -0.740
ENSG00000084710 E012 12.8965000 0.0387586928 7.423500e-02 1.503058e-01 2 25131368 25131503 136 + 1.193 1.089 -0.372
ENSG00000084710 E013 14.8643676 0.0467258312 2.265732e-01 3.583179e-01 2 25131750 25131911 162 + 1.211 1.182 -0.105
ENSG00000084710 E014 12.9830469 0.0041944193 1.694880e-03 6.267005e-03 2 25132903 25133014 112 + 1.229 1.050 -0.640
ENSG00000084710 E015 8.7832730 0.0025287778 6.280728e-02 1.313868e-01 2 25133383 25133434 52 + 1.026 0.938 -0.329
ENSG00000084710 E016 20.2596019 0.0011219443 2.140624e-04 1.024310e-03 2 25135467 25135639 173 + 1.402 1.245 -0.546
ENSG00000084710 E017 14.3376699 0.0020751442 2.790722e-03 9.646291e-03 2 25136523 25136598 76 + 1.254 1.108 -0.519
ENSG00000084710 E018 19.5289385 0.0180348683 2.119576e-01 3.408200e-01 2 25137341 25137502 162 + 1.306 1.312 0.020
ENSG00000084710 E019 20.0712415 0.0009817535 3.735472e-01 5.179784e-01 2 25139059 25139190 132 + 1.285 1.337 0.185
ENSG00000084710 E020 16.3096468 0.0018247592 1.942345e-01 3.190623e-01 2 25141366 25141433 68 + 1.220 1.230 0.034
ENSG00000084710 E021 20.0903373 0.0009512982 1.112698e-02 3.146980e-02 2 25143735 25143862 128 + 1.354 1.283 -0.246
ENSG00000084710 E022 18.7813570 0.0009972795 2.581611e-02 6.356126e-02 2 25144960 25145051 92 + 1.320 1.268 -0.182
ENSG00000084710 E023 0.5149242 0.2049688228 8.201851e-01 8.865476e-01 2 25145052 25147888 2837 + 0.125 0.215 0.947
ENSG00000084710 E024 12.4489031 0.0014551698 4.503314e-02 1.002632e-01 2 25149694 25149742 49 + 1.165 1.096 -0.245
ENSG00000084710 E025 16.6863181 0.0011942043 6.576442e-01 7.669629e-01 2 25151914 25152020 107 + 1.193 1.276 0.291
ENSG00000084710 E026 11.3983209 0.0015498746 8.051899e-01 8.760672e-01 2 25153712 25153761 50 + 0.998 1.139 0.511
ENSG00000084710 E027 454.7501879 0.0095364412 1.090738e-11 2.258576e-10 2 25154235 25159135 4901 + 2.467 2.763 0.983