ENSG00000084676

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000288599 ENSG00000084676 HEK293_OSMI2_2hA HEK293_TMG_2hB NCOA1 protein_coding protein_coding 6.086102 4.657888 7.547155 0.09882957 0.1690546 0.6950732 2.0773636 1.31279696 3.50266654 0.18207995 0.40623713 1.4089750 0.33432917 0.282566667 0.466166667 0.183600000 1.501233e-01 8.425113e-06 FALSE TRUE
ENST00000348332 ENSG00000084676 HEK293_OSMI2_2hA HEK293_TMG_2hB NCOA1 protein_coding protein_coding 6.086102 4.657888 7.547155 0.09882957 0.1690546 0.6950732 0.7943952 0.04262994 1.46460930 0.02262027 0.39281839 4.8083052 0.11620000 0.008966667 0.194833333 0.185866667 8.425113e-06 8.425113e-06 FALSE TRUE
ENST00000395856 ENSG00000084676 HEK293_OSMI2_2hA HEK293_TMG_2hB NCOA1 protein_coding protein_coding 6.086102 4.657888 7.547155 0.09882957 0.1690546 0.6950732 0.4660796 0.40914140 0.29166240 0.21298269 0.14606129 -0.4745022 0.08482917 0.089133333 0.038566667 -0.050566667 8.549002e-01 8.425113e-06 FALSE TRUE
ENST00000407230 ENSG00000084676 HEK293_OSMI2_2hA HEK293_TMG_2hB NCOA1 protein_coding protein_coding 6.086102 4.657888 7.547155 0.09882957 0.1690546 0.6950732 0.2178571 0.43279701 0.18839259 0.16200534 0.18839259 -1.1582873 0.04473333 0.092166667 0.025900000 -0.066266667 2.140156e-01 8.425113e-06 FALSE TRUE
ENST00000493773 ENSG00000084676 HEK293_OSMI2_2hA HEK293_TMG_2hB NCOA1 protein_coding retained_intron 6.086102 4.657888 7.547155 0.09882957 0.1690546 0.6950732 0.4041679 1.12452028 0.03277691 0.61790907 0.01893182 -4.7291062 0.08083333 0.236100000 0.004266667 -0.231833333 2.021784e-01 8.425113e-06 FALSE FALSE
MSTRG.18053.15 ENSG00000084676 HEK293_OSMI2_2hA HEK293_TMG_2hB NCOA1 protein_coding   6.086102 4.657888 7.547155 0.09882957 0.1690546 0.6950732 0.6967332 0.89839605 0.24933323 0.19340159 0.24933323 -1.8085144 0.12214583 0.194333333 0.033166667 -0.161166667 9.674478e-02 8.425113e-06 FALSE TRUE
MSTRG.18053.3 ENSG00000084676 HEK293_OSMI2_2hA HEK293_TMG_2hB NCOA1 protein_coding   6.086102 4.657888 7.547155 0.09882957 0.1690546 0.6950732 0.1567838 0.00000000 0.53440522 0.00000000 0.33634147 5.7666090 0.02101250 0.000000000 0.068900000 0.068900000 2.662711e-01 8.425113e-06 FALSE TRUE
MSTRG.18053.4 ENSG00000084676 HEK293_OSMI2_2hA HEK293_TMG_2hB NCOA1 protein_coding   6.086102 4.657888 7.547155 0.09882957 0.1690546 0.6950732 0.3201795 0.18359554 0.28277014 0.18359554 0.14276503 0.5967227 0.05408750 0.041133333 0.036766667 -0.004366667 7.707486e-01 8.425113e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000084676 E001 2.5861899 0.0084281606 4.664169e-03 1.499606e-02 2 24491254 24491291 38 + 0.655 0.171 -2.867
ENSG00000084676 E002 4.2176961 0.0471816191 2.476066e-03 8.691877e-03 2 24491292 24491369 78 + 0.827 0.293 -2.567
ENSG00000084676 E003 5.8271675 0.0113858592 1.741892e-05 1.095241e-04 2 24491370 24491545 176 + 0.960 0.293 -3.076
ENSG00000084676 E004 3.9742160 0.0078042798 3.956155e-06 2.881181e-05 2 24491546 24491602 57 + 0.841 0.000 -13.915
ENSG00000084676 E005 0.1451727 0.0433363479 8.857225e-01   2 24491914 24491931 18 + 0.086 0.000 -9.469
ENSG00000084676 E006 0.1451727 0.0433363479 8.857225e-01   2 24491932 24492022 91 + 0.086 0.000 -9.469
ENSG00000084676 E007 0.0000000       2 24492023 24492057 35 +      
ENSG00000084676 E008 0.4417591 0.1819060398 3.220355e-01 4.653065e-01 2 24492058 24492188 131 + 0.086 0.289 2.106
ENSG00000084676 E009 0.5159433 0.2463501165 1.000000e+00 1.000000e+00 2 24554386 24554388 3 + 0.158 0.173 0.157
ENSG00000084676 E010 0.9704895 0.0777936402 3.538332e-01 4.981025e-01 2 24554389 24554421 33 + 0.322 0.172 -1.184
ENSG00000084676 E011 1.7413037 0.0079281278 2.224555e-01 3.533246e-01 2 24554422 24554502 81 + 0.474 0.293 -1.037
ENSG00000084676 E012 0.9922594 0.0121989077 9.329007e-01 9.617197e-01 2 24554503 24554520 18 + 0.274 0.293 0.134
ENSG00000084676 E013 1.4727282 0.0088762717 9.169887e-01 9.515713e-01 2 24554521 24554573 53 + 0.365 0.389 0.134
ENSG00000084676 E014 1.6597181 0.0084217312 7.414356e-01 8.306205e-01 2 24556015 24556055 41 + 0.405 0.389 -0.088
ENSG00000084676 E015 0.4847352 0.2427095191 1.000000e+00 1.000000e+00 2 24563930 24563961 32 + 0.159 0.171 0.132
ENSG00000084676 E016 0.4847352 0.2427095191 1.000000e+00 1.000000e+00 2 24563962 24564013 52 + 0.159 0.171 0.132
ENSG00000084676 E017 3.7966999 0.0040076589 3.579434e-02 8.318363e-02 2 24564295 24564309 15 + 0.749 0.466 -1.260
ENSG00000084676 E018 14.0409077 0.0020701474 8.870268e-05 4.689528e-04 2 24564310 24564430 121 + 1.253 0.915 -1.227
ENSG00000084676 E019 8.8196630 0.0023574031 1.019538e-02 2.924676e-02 2 24584476 24584476 1 + 1.046 0.799 -0.931
ENSG00000084676 E020 14.5070927 0.0012764571 3.352020e-04 1.521249e-03 2 24584477 24584540 64 + 1.253 0.963 -1.047
ENSG00000084676 E021 10.5140535 0.0016154429 1.713029e-03 6.323004e-03 2 24584541 24584560 20 + 1.124 0.831 -1.090
ENSG00000084676 E022 27.2660580 0.0016403980 6.136860e-05 3.382334e-04 2 24643966 24644122 157 + 1.496 1.264 -0.804
ENSG00000084676 E023 27.8913833 0.0025188822 2.967611e-04 1.366798e-03 2 24658661 24658766 106 + 1.499 1.297 -0.699
ENSG00000084676 E024 0.4427912 0.2067397185 1.000000e+00 1.000000e+00 2 24658767 24659129 363 + 0.158 0.169 0.116
ENSG00000084676 E025 43.1626044 0.0202288236 2.878072e-03 9.905029e-03 2 24665749 24665915 167 + 1.681 1.495 -0.635
ENSG00000084676 E026 33.3628521 0.0007226846 5.941841e-04 2.512236e-03 2 24673366 24673463 98 + 1.569 1.416 -0.525
ENSG00000084676 E027 47.1553743 0.0005084799 1.049675e-03 4.131423e-03 2 24682951 24683128 178 + 1.699 1.592 -0.365
ENSG00000084676 E028 45.8382840 0.0007330728 1.967826e-06 1.533016e-05 2 24691481 24691660 180 + 1.716 1.516 -0.682
ENSG00000084676 E029 33.3433373 0.0006442934 1.072778e-05 7.079932e-05 2 24693252 24693347 96 + 1.586 1.365 -0.762
ENSG00000084676 E030 0.1515154 0.0432978965 8.855242e-01   2 24693768 24693797 30 + 0.086 0.000 -9.470
ENSG00000084676 E031 32.0997039 0.0006779342 4.717790e-04 2.052193e-03 2 24697658 24697798 141 + 1.553 1.391 -0.557
ENSG00000084676 E032 37.4553713 0.0193760554 7.106547e-03 2.150275e-02 2 24705086 24705233 148 + 1.621 1.447 -0.596
ENSG00000084676 E033 26.3537487 0.0020715340 6.142910e-06 4.286394e-05 2 24706568 24706625 58 + 1.499 1.216 -0.986
ENSG00000084676 E034 167.9851275 0.0014152293 2.435704e-07 2.296162e-06 2 24706626 24707726 1101 + 2.238 2.144 -0.317
ENSG00000084676 E035 20.3829095 0.0154494630 5.534388e-01 6.825819e-01 2 24707727 24707730 4 + 1.299 1.312 0.044
ENSG00000084676 E036 55.1860990 0.0004803396 1.112934e-01 2.074522e-01 2 24707731 24707888 158 + 1.729 1.721 -0.026
ENSG00000084676 E037 56.7298328 0.0060125264 6.748510e-01 7.803015e-01 2 24710931 24711111 181 + 1.725 1.771 0.156
ENSG00000084676 E038 0.0000000       2 24711112 24711483 372 +      
ENSG00000084676 E039 43.1622331 0.0125490138 7.590958e-01 8.435350e-01 2 24726589 24726706 118 + 1.610 1.657 0.160
ENSG00000084676 E040 59.2068405 0.0006007917 7.876687e-01 8.639727e-01 2 24728308 24728476 169 + 1.736 1.794 0.197
ENSG00000084676 E041 83.4669340 0.0004281742 7.841120e-01 8.615154e-01 2 24729501 24729815 315 + 1.881 1.941 0.204
ENSG00000084676 E042 41.3797488 0.0005456154 3.001528e-01 4.417988e-01 2 24739432 24739533 102 + 1.556 1.683 0.435
ENSG00000084676 E043 98.0310529 0.0019173667 8.102887e-01 8.796042e-01 2 24741784 24742186 403 + 1.941 2.023 0.274
ENSG00000084676 E044 66.6890636 0.0030257085 3.304781e-03 1.116230e-02 2 24751982 24752156 175 + 1.718 1.935 0.732
ENSG00000084676 E045 77.9167060 0.0079658625 2.293335e-02 5.760613e-02 2 24757973 24758156 184 + 1.794 1.995 0.678
ENSG00000084676 E046 50.0008607 0.0020552081 1.122006e-01 2.087571e-01 2 24762687 24762776 90 + 1.624 1.780 0.529
ENSG00000084676 E047 0.9598924 0.0213144316 4.606483e-01 6.006500e-01 2 24767771 24768078 308 + 0.220 0.388 1.131
ENSG00000084676 E048 27.2188060 0.0007643741 4.070294e-01 5.506556e-01 2 24768079 24768135 57 + 1.427 1.439 0.043
ENSG00000084676 E049 21.7451186 0.0008765187 5.484337e-01 6.782769e-01 2 24768221 24768223 3 + 1.294 1.408 0.395
ENSG00000084676 E050 377.8646230 0.0107586988 3.607644e-13 9.481927e-12 2 24768224 24770702 2479 + 2.381 2.767 1.284