ENSG00000084234

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263574 ENSG00000084234 HEK293_OSMI2_2hA HEK293_TMG_2hB APLP2 protein_coding protein_coding 196.1455 150.0089 214.4467 14.51242 2.126023 0.5155421 13.898798 9.694798 18.63401 1.110026 1.0164021 0.9419424 0.069700000 0.06460000 0.08693333 0.02233333 6.774711e-02 2.512639e-81 FALSE  
ENST00000338167 ENSG00000084234 HEK293_OSMI2_2hA HEK293_TMG_2hB APLP2 protein_coding protein_coding 196.1455 150.0089 214.4467 14.51242 2.126023 0.5155421 30.163633 22.235189 29.93345 2.344231 3.1793389 0.4287469 0.156745833 0.15140000 0.13936667 -0.01203333 9.098292e-01 2.512639e-81 FALSE  
ENST00000528499 ENSG00000084234 HEK293_OSMI2_2hA HEK293_TMG_2hB APLP2 protein_coding protein_coding 196.1455 150.0089 214.4467 14.51242 2.126023 0.5155421 118.905982 82.043987 128.88105 10.739704 1.3766961 0.6515068 0.601791667 0.54783333 0.60123333 0.05340000 6.981170e-01 2.512639e-81 FALSE  
ENST00000534001 ENSG00000084234 HEK293_OSMI2_2hA HEK293_TMG_2hB APLP2 protein_coding processed_transcript 196.1455 150.0089 214.4467 14.51242 2.126023 0.5155421 2.763321 0.000000 12.06622 0.000000 0.3579945 10.2379530 0.011954167 0.00000000 0.05626667 0.05626667 2.512639e-81 2.512639e-81 FALSE  
MSTRG.6575.12 ENSG00000084234 HEK293_OSMI2_2hA HEK293_TMG_2hB APLP2 protein_coding   196.1455 150.0089 214.4467 14.51242 2.126023 0.5155421 1.309605 8.636582 0.00000 5.610033 0.0000000 -9.7559862 0.007808333 0.05203333 0.00000000 -0.05203333 1.187892e-01 2.512639e-81 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000084234 E001 0.4470576 2.145019e-02 7.397201e-01 8.293598e-01 11 130068147 130068158 12 + 0.190 0.142 -0.504
ENSG00000084234 E002 0.3686942 3.425371e-02 8.376979e-01 8.985503e-01 11 130069837 130069859 23 + 0.105 0.142 0.502
ENSG00000084234 E003 3.8125945 4.154506e-03 7.936417e-04 3.236879e-03 11 130069860 130069885 26 + 0.847 0.335 -2.376
ENSG00000084234 E004 6.6053897 2.757518e-03 1.000110e-02 2.876521e-02 11 130069886 130069890 5 + 0.990 0.687 -1.179
ENSG00000084234 E005 6.8268349 3.077731e-03 1.888967e-02 4.909040e-02 11 130069891 130069893 3 + 0.990 0.721 -1.041
ENSG00000084234 E006 6.8268349 3.077731e-03 1.888967e-02 4.909040e-02 11 130069894 130069895 2 + 0.990 0.721 -1.041
ENSG00000084234 E007 21.9499234 9.797540e-03 1.461818e-03 5.512721e-03 11 130069896 130069905 10 + 1.457 1.197 -0.906
ENSG00000084234 E008 165.2458712 1.859140e-02 5.597715e-03 1.754787e-02 11 130069906 130069915 10 + 2.292 2.114 -0.594
ENSG00000084234 E009 406.6904649 1.608235e-02 1.652341e-02 4.389292e-02 11 130069916 130070014 99 + 2.664 2.534 -0.433
ENSG00000084234 E010 212.0186838 1.150831e-02 4.004241e-02 9.111225e-02 11 130070015 130070018 4 + 2.368 2.275 -0.309
ENSG00000084234 E011 258.3475445 1.055544e-02 5.766637e-03 1.800027e-02 11 130070019 130070037 19 + 2.467 2.339 -0.427
ENSG00000084234 E012 445.4950277 8.262405e-03 2.787425e-04 1.293242e-03 11 130070038 130070082 45 + 2.711 2.561 -0.499
ENSG00000084234 E013 1.4864579 1.116823e-01 9.015951e-01 9.412945e-01 11 130070568 130070747 180 + 0.375 0.407 0.178
ENSG00000084234 E014 0.0000000       11 130100270 130100425 156 +      
ENSG00000084234 E015 0.0000000       11 130101370 130101513 144 +      
ENSG00000084234 E016 0.0000000       11 130101926 130102000 75 +      
ENSG00000084234 E017 0.4396707 2.749753e-02 1.390297e-01 2.467538e-01 11 130108605 130108983 379 + 0.260 0.000 -10.249
ENSG00000084234 E018 0.4449813 2.144446e-02 7.398412e-01 8.294465e-01 11 130109161 130109426 266 + 0.190 0.142 -0.503
ENSG00000084234 E019 2.0098026 1.481116e-01 8.103468e-01 8.796461e-01 11 130109427 130109428 2 + 0.505 0.462 -0.212
ENSG00000084234 E020 1063.8719658 3.424582e-03 1.254605e-06 1.020397e-05 11 130109429 130109549 121 + 3.079 2.955 -0.412
ENSG00000084234 E021 688.9277831 1.498918e-03 2.502123e-12 5.751968e-11 11 130109550 130109581 32 + 2.896 2.760 -0.454
ENSG00000084234 E022 704.2606231 5.260437e-04 2.590341e-17 1.197492e-15 11 130109582 130109602 21 + 2.900 2.781 -0.396
ENSG00000084234 E023 0.1451727 4.361443e-02 6.378712e-01   11 130109603 130109617 15 + 0.105 0.000 -8.664
ENSG00000084234 E024 0.0000000       11 130109618 130109823 206 +      
ENSG00000084234 E025 814.4909029 1.716548e-03 1.458307e-09 2.095986e-08 11 130110538 130110564 27 + 2.961 2.844 -0.391
ENSG00000084234 E026 715.7128862 1.315761e-03 4.332965e-12 9.567216e-11 11 130110565 130110573 9 + 2.909 2.783 -0.421
ENSG00000084234 E027 745.3445854 9.432104e-04 1.748750e-16 7.302081e-15 11 130110574 130110585 12 + 2.931 2.795 -0.453
ENSG00000084234 E028 1099.4340357 1.525238e-03 3.278456e-09 4.415567e-08 11 130110586 130110661 76 + 3.085 2.984 -0.337
ENSG00000084234 E029 1013.0454212 1.254718e-03 1.230710e-06 1.002556e-05 11 130120706 130120765 60 + 3.038 2.965 -0.241
ENSG00000084234 E030 1076.0958168 4.812280e-04 7.240303e-09 9.154123e-08 11 130120766 130120818 53 + 3.059 3.001 -0.193
ENSG00000084234 E031 1.3016330 3.273743e-02 3.093764e-01 4.516653e-01 11 130120819 130120823 5 + 0.422 0.249 -1.084
ENSG00000084234 E032 2.0670364 8.610099e-03 9.086152e-02 1.765047e-01 11 130121232 130121297 66 + 0.603 0.334 -1.378
ENSG00000084234 E033 1259.6603448 6.503685e-04 2.237175e-04 1.065104e-03 11 130121614 130121712 99 + 3.115 3.084 -0.102
ENSG00000084234 E034 879.5264029 1.134679e-03 4.117834e-03 1.347343e-02 11 130121713 130121745 33 + 2.959 2.928 -0.104
ENSG00000084234 E035 1250.7083510 3.258497e-04 5.125844e-03 1.627165e-02 11 130121746 130121810 65 + 3.102 3.095 -0.024
ENSG00000084234 E036 2073.5040790 2.995163e-04 1.575516e-03 5.879694e-03 11 130122305 130122513 209 + 3.321 3.316 -0.017
ENSG00000084234 E037 526.5583817 1.197993e-04 7.980697e-01 8.711319e-01 11 130123612 130123779 168 + 2.712 2.739 0.090
ENSG00000084234 E038 1549.6962001 6.369937e-05 8.219247e-04 3.337788e-03 11 130126700 130126830 131 + 3.193 3.192 -0.003
ENSG00000084234 E039 1121.2292945 8.314279e-05 1.025621e-01 1.944117e-01 11 130127766 130127840 75 + 3.029 3.079 0.165
ENSG00000084234 E040 1674.9294030 1.654675e-04 9.992589e-01 1.000000e+00 11 130129048 130129206 159 + 3.212 3.242 0.101
ENSG00000084234 E041 1600.1078769 8.185363e-05 1.660783e-01 2.831014e-01 11 130130038 130130166 129 + 3.198 3.215 0.058
ENSG00000084234 E042 1316.6650656 6.443139e-05 6.756683e-01 7.808748e-01 11 130133629 130133728 100 + 3.105 3.141 0.118
ENSG00000084234 E043 1401.4499775 4.957532e-04 6.053603e-01 7.257681e-01 11 130135563 130135715 153 + 3.131 3.167 0.118
ENSG00000084234 E044 83.9856245 3.336172e-04 1.736624e-03 6.398006e-03 11 130137256 130137291 36 + 1.972 1.881 -0.308
ENSG00000084234 E045 18.5548071 9.504416e-04 5.378460e-01 6.693438e-01 11 130138778 130139655 878 + 1.261 1.340 0.275
ENSG00000084234 E046 1357.6222182 1.317770e-04 2.314588e-02 5.805100e-02 11 130140398 130140483 86 + 3.109 3.164 0.183
ENSG00000084234 E047 70.2604756 3.631391e-03 6.111242e-01 7.303167e-01 11 130140495 130141411 917 + 1.852 1.855 0.010
ENSG00000084234 E048 21.4552627 8.565036e-04 5.643041e-01 6.916197e-01 11 130141412 130141497 86 + 1.360 1.348 -0.043
ENSG00000084234 E049 1357.8174702 6.896673e-04 1.563918e-07 1.530369e-06 11 130141498 130141572 75 + 3.080 3.190 0.368
ENSG00000084234 E050 16.9561265 1.136492e-03 1.306372e-01 2.350427e-01 11 130141573 130141918 346 + 1.293 1.196 -0.341
ENSG00000084234 E051 1723.9712892 2.157003e-04 2.363293e-06 1.809257e-05 11 130141919 130142074 156 + 3.199 3.280 0.269
ENSG00000084234 E052 6485.6119847 3.737139e-03 3.781174e-16 1.509975e-14 11 130143347 130144811 1465 + 3.687 3.921 0.777