ENSG00000084112

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000326495 ENSG00000084112 HEK293_OSMI2_2hA HEK293_TMG_2hB SSH1 protein_coding protein_coding 6.95005 5.638026 8.387182 0.4607097 0.5661575 0.5721585 1.3122923 1.77433455 0.8703495 0.09506817 0.04683274 -1.01923786 0.20425000 0.31766667 0.10553333 -0.21213333 1.848765e-06 1.848765e-06 FALSE TRUE
ENST00000546433 ENSG00000084112 HEK293_OSMI2_2hA HEK293_TMG_2hB SSH1 protein_coding nonsense_mediated_decay 6.95005 5.638026 8.387182 0.4607097 0.5661575 0.5721585 1.2479074 0.36271459 1.7975506 0.12292242 0.11929664 2.27789282 0.16870417 0.06323333 0.21453333 0.15130000 2.703679e-03 1.848765e-06 FALSE TRUE
ENST00000547381 ENSG00000084112 HEK293_OSMI2_2hA HEK293_TMG_2hB SSH1 protein_coding retained_intron 6.95005 5.638026 8.387182 0.4607097 0.5661575 0.5721585 0.5135263 0.53837298 0.5605199 0.03697793 0.14384046 0.05711973 0.07217500 0.09693333 0.06573333 -0.03120000 4.808262e-01 1.848765e-06   FALSE
ENST00000548522 ENSG00000084112 HEK293_OSMI2_2hA HEK293_TMG_2hB SSH1 protein_coding nonsense_mediated_decay 6.95005 5.638026 8.387182 0.4607097 0.5661575 0.5721585 0.1656605 0.05100983 0.7246698 0.05100983 0.40174879 3.58998236 0.02116667 0.00780000 0.08053333 0.07273333 5.062810e-01 1.848765e-06 FALSE FALSE
ENST00000551165 ENSG00000084112 HEK293_OSMI2_2hA HEK293_TMG_2hB SSH1 protein_coding protein_coding 6.95005 5.638026 8.387182 0.4607097 0.5661575 0.5721585 0.4899429 0.64007665 0.4935100 0.18769062 0.07524183 -0.36858939 0.07308333 0.11063333 0.05843333 -0.05220000 2.543978e-01 1.848765e-06 FALSE TRUE
MSTRG.7967.3 ENSG00000084112 HEK293_OSMI2_2hA HEK293_TMG_2hB SSH1 protein_coding   6.95005 5.638026 8.387182 0.4607097 0.5661575 0.5721585 3.0838767 2.10556176 3.7429983 0.20778287 0.21952789 0.82700285 0.44108750 0.37246667 0.44913333 0.07666667 3.786041e-01 1.848765e-06 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000084112 E001 0.0000000       12 108778144 108778190 47 -      
ENSG00000084112 E002 153.5217696 0.0068424744 3.038292e-16 1.231483e-14 12 108778191 108783301 5111 - 1.923 2.353 1.439
ENSG00000084112 E003 359.4998307 0.0062786794 4.698797e-06 3.365494e-05 12 108783302 108784796 1495 - 2.444 2.647 0.674
ENSG00000084112 E004 134.6533858 0.0014195163 9.683909e-01 9.842545e-01 12 108784797 108785455 659 - 2.115 2.154 0.129
ENSG00000084112 E005 47.8621488 0.0005048932 1.404606e-01 2.486624e-01 12 108785456 108785597 142 - 1.629 1.740 0.376
ENSG00000084112 E006 104.3746551 0.0011965846 1.087475e-01 2.036888e-01 12 108785598 108786182 585 - 1.971 2.067 0.321
ENSG00000084112 E007 107.6554042 0.0005057318 1.178365e-03 4.567993e-03 12 108786183 108786852 670 - 2.070 1.995 -0.251
ENSG00000084112 E008 171.2760658 0.0090920654 3.185009e-02 7.556265e-02 12 108786853 108788040 1188 - 2.270 2.197 -0.245
ENSG00000084112 E009 108.9570217 0.0028976053 3.595122e-06 2.644785e-05 12 108788041 108788899 859 - 2.111 1.955 -0.522
ENSG00000084112 E010 45.0944306 0.0080381457 9.726264e-05 5.092056e-04 12 108788900 108789244 345 - 1.762 1.537 -0.764
ENSG00000084112 E011 0.2214452 0.0477172938 4.460300e-01   12 108791919 108791925 7 - 0.000 0.132 9.929
ENSG00000084112 E012 13.1383985 0.0066210445 4.189762e-05 2.403372e-04 12 108791926 108792285 360 - 0.879 1.332 1.638
ENSG00000084112 E013 32.5070658 0.0129276044 9.284140e-01 9.589574e-01 12 108792286 108792420 135 - 1.506 1.557 0.173
ENSG00000084112 E014 60.5901260 0.0004387000 6.608996e-02 1.368635e-01 12 108792421 108792829 409 - 1.814 1.769 -0.153
ENSG00000084112 E015 44.5995698 0.0012219282 1.801279e-01 3.013298e-01 12 108799000 108799200 201 - 1.675 1.639 -0.121
ENSG00000084112 E016 50.7156203 0.0019758855 5.546477e-02 1.187840e-01 12 108800780 108800926 147 - 1.746 1.683 -0.213
ENSG00000084112 E017 26.3654395 0.0200702491 7.641400e-01 8.472818e-01 12 108802322 108802368 47 - 1.432 1.445 0.048
ENSG00000084112 E018 41.4274359 0.0006162182 1.374484e-01 2.445292e-01 12 108805056 108805184 129 - 1.649 1.606 -0.148
ENSG00000084112 E019 29.0368889 0.0007815818 1.573738e-01 2.716091e-01 12 108806301 108806394 94 - 1.510 1.457 -0.182
ENSG00000084112 E020 0.0000000       12 108807612 108807632 21 -      
ENSG00000084112 E021 21.9304330 0.0008502311 1.251821e-01 2.274028e-01 12 108807633 108807674 42 - 1.401 1.326 -0.260
ENSG00000084112 E022 36.1414331 0.0006343189 3.527795e-03 1.180670e-02 12 108807675 108807792 118 - 1.635 1.503 -0.450
ENSG00000084112 E023 21.0260789 0.0036241306 1.314159e-03 5.024390e-03 12 108807793 108807827 35 - 1.441 1.220 -0.768
ENSG00000084112 E024 21.4268585 0.0009601293 5.674018e-02 1.210120e-01 12 108809693 108809718 26 - 1.401 1.296 -0.365
ENSG00000084112 E025 23.2778910 0.0008394471 6.866262e-01 7.891101e-01 12 108809719 108809758 40 - 1.380 1.387 0.025
ENSG00000084112 E026 0.0000000       12 108811258 108811259 2 -      
ENSG00000084112 E027 31.5736881 0.0087015881 5.243378e-01 6.578904e-01 12 108811260 108811328 69 - 1.522 1.507 -0.048
ENSG00000084112 E028 5.6973507 0.0032950683 8.049278e-01 8.758775e-01 12 108811329 108811634 306 - 0.824 0.824 0.000
ENSG00000084112 E029 38.2696352 0.0044483593 3.910440e-02 8.937940e-02 12 108817038 108817159 122 - 1.640 1.545 -0.326
ENSG00000084112 E030 0.0000000       12 108817160 108817380 221 -      
ENSG00000084112 E031 26.9159126 0.0007625313 3.934053e-05 2.271616e-04 12 108818249 108818313 65 - 1.552 1.312 -0.830
ENSG00000084112 E032 26.9189561 0.0081466157 3.775702e-03 1.251370e-02 12 108823258 108823361 104 - 1.533 1.341 -0.665
ENSG00000084112 E033 0.1482932 0.0415660373 4.490901e-01   12 108826104 108826394 291 - 0.000 0.132 9.920
ENSG00000084112 E034 0.0000000       12 108827263 108827551 289 -      
ENSG00000084112 E035 18.7186699 0.0010705106 2.241714e-02 5.654564e-02 12 108852638 108852678 41 - 1.364 1.220 -0.503
ENSG00000084112 E036 18.1327769 0.0090456530 2.924608e-04 1.349091e-03 12 108857428 108857620 193 - 1.411 1.115 -1.044