ENSG00000084093

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000309042 ENSG00000084093 HEK293_OSMI2_2hA HEK293_TMG_2hB REST protein_coding protein_coding 4.860095 1.951863 7.466052 0.008155692 0.3667036 1.930052 3.4269840 0.01674893 6.39277690 0.01674893 0.43537768 7.903073 0.4858667 0.008566667 0.856033333 0.84746667 1.932392e-17 7.98928e-27 FALSE TRUE
ENST00000611211 ENSG00000084093 HEK293_OSMI2_2hA HEK293_TMG_2hB REST protein_coding nonsense_mediated_decay 4.860095 1.951863 7.466052 0.008155692 0.3667036 1.930052 0.1815756 0.17461445 0.00000000 0.10581801 0.00000000 -4.206444 0.0797750 0.089833333 0.000000000 -0.08983333 2.633229e-02 7.98928e-27 TRUE TRUE
ENST00000622863 ENSG00000084093 HEK293_OSMI2_2hA HEK293_TMG_2hB REST protein_coding protein_coding 4.860095 1.951863 7.466052 0.008155692 0.3667036 1.930052 0.2535771 0.78348497 0.00000000 0.05529279 0.00000000 -6.310131 0.1285667 0.401533333 0.000000000 -0.40153333 7.989280e-27 7.98928e-27 FALSE TRUE
ENST00000675341 ENSG00000084093 HEK293_OSMI2_2hA HEK293_TMG_2hB REST protein_coding protein_coding 4.860095 1.951863 7.466052 0.008155692 0.3667036 1.930052 0.3946103 0.76044321 0.06218926 0.02881194 0.06218926 -3.415833 0.1882292 0.389533333 0.008466667 -0.38106667 2.420789e-05 7.98928e-27 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000084093 E001 0.2903454 0.2648953312 1.000000e+00   4 56907876 56907899 24 + 0.087 0.001 -6.870
ENSG00000084093 E002 4.0845060 0.0090065661 2.976581e-02 7.150115e-02 4 56907900 56908035 136 + 0.589 0.292 -1.591
ENSG00000084093 E003 4.6618608 0.0033713116 7.318824e-02 1.486241e-01 4 56908036 56908093 58 + 0.625 0.464 -0.749
ENSG00000084093 E004 10.7747962 0.0016881322 5.836466e-04 2.473660e-03 4 56908094 56908213 120 + 0.937 0.587 -1.414
ENSG00000084093 E005 0.9137968 0.0600101609 1.000000e+00 1.000000e+00 4 56908887 56909015 129 + 0.191 0.292 0.790
ENSG00000084093 E006 0.9170165 0.0154967778 3.465141e-02 8.098631e-02 4 56909016 56909039 24 + 0.087 0.588 3.698
ENSG00000084093 E007 2.2529951 0.0065136911 6.693114e-01 7.761495e-01 4 56909190 56909560 371 + 0.387 0.464 0.408
ENSG00000084093 E008 1.2178718 0.0104237026 5.926401e-01 7.151451e-01 4 56909561 56909587 27 + 0.221 0.464 1.524
ENSG00000084093 E009 37.8915239 0.0007867914 5.697458e-08 6.064878e-07 4 56910630 56910939 310 + 1.435 1.186 -0.872
ENSG00000084093 E010 32.3536446 0.0010378472 1.994981e-09 2.793165e-08 4 56910940 56911089 150 + 1.381 0.982 -1.421
ENSG00000084093 E011 38.7899462 0.0005319660 1.419029e-12 3.390047e-11 4 56911090 56911335 246 + 1.461 0.982 -1.698
ENSG00000084093 E012 35.7820030 0.0008515389 6.334504e-11 1.154341e-09 4 56911336 56911536 201 + 1.423 0.983 -1.566
ENSG00000084093 E013 0.0000000       4 56912583 56913693 1111 +      
ENSG00000084093 E014 0.0000000       4 56916031 56916271 241 +      
ENSG00000084093 E015 27.0894559 0.0073914558 9.659909e-06 6.445394e-05 4 56919787 56919870 84 + 1.299 1.024 -0.984
ENSG00000084093 E016 0.1451727 0.0425120502 1.000000e+00   4 56922359 56922456 98 + 0.046 0.000 -7.395
ENSG00000084093 E017 0.4449813 0.0227957846 4.808039e-01 6.190250e-01 4 56927615 56927664 50 + 0.087 0.291 2.107
ENSG00000084093 E018 224.7488995 0.0020626684 1.033803e-11 2.147488e-10 4 56929841 56931793 1953 + 2.168 2.186 0.059
ENSG00000084093 E019 59.5817498 0.0105653191 1.463102e-01 2.566584e-01 4 56931794 56932067 274 + 1.581 1.724 0.488
ENSG00000084093 E020 437.3748853 0.0186204292 2.879535e-14 8.847213e-13 4 56932068 56935844 3777 + 2.356 2.861 1.681
ENSG00000084093 E021 0.7708142 0.0152590747 8.806101e-01 9.274252e-01 4 56966656 56966808 153 + 0.159 0.291 1.110