ENSG00000084090

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000337288 ENSG00000084090 HEK293_OSMI2_2hA HEK293_TMG_2hB STARD7 protein_coding protein_coding 175.751 194.9578 176.1257 30.56727 4.476831 -0.1465489 131.43184 130.4105909 136.92592 14.7444908 4.921897 0.07032932 0.7567833 0.683700000 0.77713333 0.09343333 0.5561344182 2.32294e-21 FALSE TRUE
MSTRG.18873.2 ENSG00000084090 HEK293_OSMI2_2hA HEK293_TMG_2hB STARD7 protein_coding   175.751 194.9578 176.1257 30.56727 4.476831 -0.1465489 19.10900 61.0831704 1.97636 22.9704983 1.976360 -4.94281205 0.0979500 0.298900000 0.01176667 -0.28713333 0.0157503973 2.32294e-21 FALSE TRUE
MSTRG.18873.5 ENSG00000084090 HEK293_OSMI2_2hA HEK293_TMG_2hB STARD7 protein_coding   175.751 194.9578 176.1257 30.56727 4.476831 -0.1465489 15.87215 0.2738367 26.38232 0.2738367 2.099276 6.53891319 0.0912375 0.001466667 0.14993333 0.14846667 0.0005883626 2.32294e-21 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000084090 E001 10.576207 0.0612176626 7.724692e-06 5.265615e-05 2 96184859 96184866 8 - 0.409 1.309 3.629
ENSG00000084090 E002 17.338419 0.0151492990 9.244315e-03 2.689603e-02 2 96184867 96184869 3 - 1.030 1.419 1.378
ENSG00000084090 E003 2618.049807 0.0048903577 1.085352e-22 9.329248e-21 2 96184870 96185196 327 - 3.137 3.572 1.447
ENSG00000084090 E004 10323.306693 0.0024936326 1.893796e-16 7.867849e-15 2 96185197 96186749 1553 - 3.874 4.108 0.778
ENSG00000084090 E005 1658.156055 0.0013412944 1.326333e-11 2.707941e-10 2 96186750 96186914 165 - 3.232 3.211 -0.070
ENSG00000084090 E006 1184.424980 0.0017337788 4.873789e-10 7.645601e-09 2 96187217 96187301 85 - 3.092 3.060 -0.107
ENSG00000084090 E007 23.256980 0.0096257701 2.871181e-05 1.715834e-04 2 96187302 96188117 816 - 1.501 1.265 -0.818
ENSG00000084090 E008 1238.364248 0.0019401460 3.076922e-07 2.839880e-06 2 96192369 96192468 100 - 3.101 3.088 -0.042
ENSG00000084090 E009 3.312065 0.0126866714 1.065164e-04 5.519933e-04 2 96193076 96193077 2 - 0.842 0.304 -2.553
ENSG00000084090 E010 938.775038 0.0025753542 4.688552e-09 6.149063e-08 2 96193078 96193130 53 - 3.001 2.949 -0.172
ENSG00000084090 E011 761.350647 0.0033318591 9.681917e-11 1.712170e-09 2 96193131 96193160 30 - 2.930 2.837 -0.311
ENSG00000084090 E012 35.713024 0.0005915469 1.635177e-20 1.111515e-18 2 96193161 96193205 45 - 1.749 1.307 -1.517
ENSG00000084090 E013 20.178674 0.0008825265 1.725046e-11 3.453866e-10 2 96193206 96193241 36 - 1.497 1.085 -1.446
ENSG00000084090 E014 957.906437 0.0027056022 4.881688e-10 7.656438e-09 2 96193242 96193301 60 - 3.016 2.951 -0.213
ENSG00000084090 E015 905.554003 0.0032042029 4.356108e-08 4.755945e-07 2 96193302 96193352 51 - 2.988 2.931 -0.189
ENSG00000084090 E016 874.647828 0.0023260301 2.206091e-08 2.552600e-07 2 96194958 96195007 50 - 2.964 2.924 -0.133
ENSG00000084090 E017 1.991795 0.0813100472 1.126050e-02 3.178568e-02 2 96195008 96195009 2 - 0.648 0.225 -2.347
ENSG00000084090 E018 1.711115 0.0105808292 1.522709e-03 5.710407e-03 2 96195203 96195340 138 - 0.616 0.127 -3.211
ENSG00000084090 E019 1383.772609 0.0023958016 3.319628e-14 1.011245e-12 2 96195341 96195549 209 - 3.185 3.099 -0.286
ENSG00000084090 E020 999.842045 0.0118995822 1.115040e-06 9.165657e-06 2 96208145 96208538 394 - 3.079 2.915 -0.543
ENSG00000084090 E021 722.931981 0.0150502249 1.187482e-03 4.599097e-03 2 96208539 96208827 289 - 2.909 2.809 -0.334