ENSG00000083896

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355665 ENSG00000083896 HEK293_OSMI2_2hA HEK293_TMG_2hB YTHDC1 protein_coding protein_coding 46.07887 23.13346 66.52717 1.167057 1.146251 1.523556 6.127906 4.67078079 7.670036 0.20995537 1.49498957 0.7143638 0.14960833 0.202033333 0.1147000 -0.08733333 6.392012e-02 2.152028e-16 FALSE TRUE
ENST00000506175 ENSG00000083896 HEK293_OSMI2_2hA HEK293_TMG_2hB YTHDC1 protein_coding retained_intron 46.07887 23.13346 66.52717 1.167057 1.146251 1.523556 4.377894 1.05942564 7.759492 0.27700262 0.24555165 2.8609841 0.08047917 0.045000000 0.1166667 0.07166667 3.858004e-03 2.152028e-16 FALSE TRUE
ENST00000579690 ENSG00000083896 HEK293_OSMI2_2hA HEK293_TMG_2hB YTHDC1 protein_coding protein_coding 46.07887 23.13346 66.52717 1.167057 1.146251 1.523556 18.797220 11.19270456 25.585238 0.16311737 0.74081732 1.1920283 0.42781250 0.487066667 0.3849000 -0.10216667 1.155044e-01 2.152028e-16 FALSE TRUE
MSTRG.24989.5 ENSG00000083896 HEK293_OSMI2_2hA HEK293_TMG_2hB YTHDC1 protein_coding   46.07887 23.13346 66.52717 1.167057 1.146251 1.523556 4.060558 1.39192801 5.719188 0.32463663 0.05129099 2.0309183 0.08335000 0.059500000 0.0860000 0.02650000 2.634642e-01 2.152028e-16 FALSE TRUE
MSTRG.24989.7 ENSG00000083896 HEK293_OSMI2_2hA HEK293_TMG_2hB YTHDC1 protein_coding   46.07887 23.13346 66.52717 1.167057 1.146251 1.523556 4.678867 0.04824912 8.597337 0.04824912 1.00755549 7.2071869 0.07050000 0.001933333 0.1291667 0.12723333 2.152028e-16 2.152028e-16 FALSE TRUE
MSTRG.24989.9 ENSG00000083896 HEK293_OSMI2_2hA HEK293_TMG_2hB YTHDC1 protein_coding   46.07887 23.13346 66.52717 1.167057 1.146251 1.523556 6.008709 4.06280166 7.455006 0.60361576 1.22027053 0.8741219 0.14929167 0.173966667 0.1121667 -0.06180000 2.381428e-01 2.152028e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000083896 E001 54.3966281 0.0055841438 7.224550e-01 8.165486e-01 4 68310387 68313320 2934 - 1.713 1.751 0.129
ENSG00000083896 E002 9.2414824 0.0150372336 3.447607e-01 4.888544e-01 4 68313321 68313323 3 - 0.945 1.069 0.458
ENSG00000083896 E003 424.6256745 0.0107923081 1.432355e-08 1.715170e-07 4 68313324 68313872 549 - 2.474 2.785 1.036
ENSG00000083896 E004 143.6794100 0.0002593721 8.671007e-16 3.303894e-14 4 68313873 68313893 21 - 2.032 2.289 0.861
ENSG00000083896 E005 139.6552620 0.0002477740 1.127271e-11 2.328047e-10 4 68313894 68313903 10 - 2.036 2.259 0.745
ENSG00000083896 E006 242.7676993 0.0014965849 1.559786e-15 5.748963e-14 4 68313904 68314068 165 - 2.265 2.511 0.823
ENSG00000083896 E007 82.1090739 0.0032519675 2.957852e-10 4.819025e-09 4 68314069 68314080 12 - 1.766 2.079 1.055
ENSG00000083896 E008 475.5133605 0.0001287296 2.390116e-06 1.828241e-05 4 68314081 68314323 243 - 2.622 2.716 0.313
ENSG00000083896 E009 10.6332811 0.0015870574 5.039808e-06 3.584277e-05 4 68315855 68316313 459 - 1.173 0.594 -2.246
ENSG00000083896 E010 359.5743259 0.0001439877 1.259945e-01 2.285651e-01 4 68316314 68316448 135 - 2.541 2.525 -0.054
ENSG00000083896 E011 236.4472722 0.0002143986 7.347416e-02 1.490849e-01 4 68318519 68318581 63 - 2.363 2.333 -0.101
ENSG00000083896 E012 171.9939970 0.0032840900 7.247891e-01 8.182318e-01 4 68318690 68318729 40 - 2.205 2.233 0.092
ENSG00000083896 E013 38.3125188 0.0007893885 5.223091e-01 6.561447e-01 4 68318730 68318753 24 - 1.556 1.608 0.177
ENSG00000083896 E014 159.8313100 0.0017434289 2.447686e-01 3.797682e-01 4 68318826 68318862 37 - 2.163 2.218 0.183
ENSG00000083896 E015 218.3289574 0.0001880063 1.548644e-01 2.682362e-01 4 68320123 68320205 83 - 2.328 2.305 -0.074
ENSG00000083896 E016 55.4118204 0.0004301463 2.560148e-10 4.206526e-09 4 68321372 68321950 579 - 1.820 1.481 -1.153
ENSG00000083896 E017 36.1240911 0.0005788801 2.238729e-09 3.109616e-08 4 68322492 68322748 257 - 1.652 1.245 -1.402
ENSG00000083896 E018 315.7736329 0.0001959387 6.189872e-02 1.298130e-01 4 68322749 68322915 167 - 2.489 2.464 -0.086
ENSG00000083896 E019 218.9988047 0.0002220664 8.929518e-01 9.355931e-01 4 68324139 68324223 85 - 2.315 2.333 0.059
ENSG00000083896 E020 245.7416737 0.0001841150 5.385893e-01 6.700032e-01 4 68330002 68330119 118 - 2.372 2.371 -0.002
ENSG00000083896 E021 200.0913906 0.0001778657 4.566913e-01 5.970808e-01 4 68330202 68330310 109 - 2.284 2.278 -0.018
ENSG00000083896 E022 184.5875566 0.0002532727 5.576024e-01 6.859844e-01 4 68332103 68332197 95 - 2.248 2.246 -0.007
ENSG00000083896 E023 146.7213456 0.0002228212 8.163756e-01 8.838104e-01 4 68332794 68332847 54 - 2.140 2.161 0.072
ENSG00000083896 E024 203.1606792 0.0003247869 9.188448e-01 9.527435e-01 4 68333308 68333397 90 - 2.281 2.298 0.056
ENSG00000083896 E025 6.5594954 0.0026295056 7.336868e-02 1.489142e-01 4 68336448 68336540 93 - 0.923 0.691 -0.918
ENSG00000083896 E026 192.0133078 0.0041505523 1.979351e-01 3.236482e-01 4 68337027 68337183 157 - 2.275 2.238 -0.126
ENSG00000083896 E027 190.6229272 0.0002064390 4.665257e-07 4.152114e-06 4 68337184 68337297 114 - 2.303 2.174 -0.429
ENSG00000083896 E028 284.2620831 0.0002959283 4.091933e-07 3.682857e-06 4 68337298 68337450 153 - 2.468 2.362 -0.353
ENSG00000083896 E029 335.5783619 0.0030716438 1.866504e-04 9.064203e-04 4 68337572 68337765 194 - 2.541 2.430 -0.369
ENSG00000083896 E030 197.9446678 0.0004403526 2.248501e-12 5.209499e-11 4 68337766 68337839 74 - 2.335 2.142 -0.644
ENSG00000083896 E031 160.1104600 0.0002152231 8.109404e-13 2.021320e-11 4 68337840 68337900 61 - 2.248 2.035 -0.714
ENSG00000083896 E032 174.1339859 0.0032188546 3.478384e-05 2.034736e-04 4 68338283 68338384 102 - 2.268 2.116 -0.510
ENSG00000083896 E033 0.1515154 0.0423743121 1.000000e+00   4 68338385 68338412 28 - 0.085 0.000 -8.611
ENSG00000083896 E034 0.1482932 0.0412285940 2.250104e-01   4 68344049 68344080 32 - 0.000 0.172 10.668
ENSG00000083896 E035 223.8343287 0.0069471490 2.839467e-07 2.640788e-06 4 68349726 68350090 365 - 2.397 2.165 -0.778