ENSG00000083857

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000441802 ENSG00000083857 HEK293_OSMI2_2hA HEK293_TMG_2hB FAT1 protein_coding protein_coding 11.73692 12.64429 9.507446 1.183263 0.6161237 -0.4109799 2.4549481 0.74867801 3.6313092 0.26270344 0.24069414 2.2628976 0.21908750 0.056666667 0.38200000 0.32533333 1.605845e-10 1.526942e-14 FALSE TRUE
ENST00000500085 ENSG00000083857 HEK293_OSMI2_2hA HEK293_TMG_2hB FAT1 protein_coding retained_intron 11.73692 12.64429 9.507446 1.183263 0.6161237 -0.4109799 4.0017379 7.78616160 0.9163029 0.20560974 0.09667969 -3.0732081 0.32572500 0.624766667 0.09776667 -0.52700000 1.526942e-14 1.526942e-14 FALSE TRUE
MSTRG.25836.2 ENSG00000083857 HEK293_OSMI2_2hA HEK293_TMG_2hB FAT1 protein_coding   11.73692 12.64429 9.507446 1.183263 0.6161237 -0.4109799 2.1926208 2.18026940 1.3692744 0.24309675 0.04951358 -0.6671989 0.18461667 0.172166667 0.14600000 -0.02616667 6.382861e-01 1.526942e-14 FALSE TRUE
MSTRG.25836.4 ENSG00000083857 HEK293_OSMI2_2hA HEK293_TMG_2hB FAT1 protein_coding   11.73692 12.64429 9.507446 1.183263 0.6161237 -0.4109799 0.4341162 0.04302468 0.7964267 0.02216278 0.11664644 3.9268075 0.04038333 0.003533333 0.08620000 0.08266667 2.661034e-08 1.526942e-14 FALSE TRUE
MSTRG.25836.9 ENSG00000083857 HEK293_OSMI2_2hA HEK293_TMG_2hB FAT1 protein_coding   11.73692 12.64429 9.507446 1.183263 0.6161237 -0.4109799 1.3071894 0.86084513 1.6601204 0.22259810 0.35861925 0.9394640 0.11214583 0.066533333 0.17106667 0.10453333 1.606044e-02 1.526942e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000083857 E001 11.4823495 0.0015575141 5.157152e-11 9.561424e-10 4 186587794 186587826 33 - 0.648 1.313 2.508
ENSG00000083857 E002 67.5702416 0.0119643256 6.476271e-18 3.245794e-16 4 186587827 186587988 162 - 1.473 2.041 1.923
ENSG00000083857 E003 156.3142742 0.0183721430 2.477146e-14 7.686942e-13 4 186587989 186588391 403 - 1.880 2.387 1.698
ENSG00000083857 E004 169.8291728 0.0026162355 2.120024e-27 2.850477e-25 4 186588392 186588806 415 - 2.022 2.375 1.181
ENSG00000083857 E005 85.2105829 0.0003674836 1.247713e-18 6.804129e-17 4 186588807 186588880 74 - 1.753 2.057 1.023
ENSG00000083857 E006 90.5770493 0.0028193288 1.186641e-11 2.440091e-10 4 186588881 186588989 109 - 1.811 2.073 0.880
ENSG00000083857 E007 79.2371141 0.0063913258 4.053598e-07 3.650609e-06 4 186588990 186589071 82 - 1.772 2.009 0.795
ENSG00000083857 E008 105.3582918 0.0004574105 8.439577e-14 2.424708e-12 4 186589072 186589220 149 - 1.902 2.124 0.742
ENSG00000083857 E009 2.2059640 0.0149962676 8.378367e-01 8.986056e-01 4 186590368 186590403 36 - 0.518 0.455 -0.308
ENSG00000083857 E010 1.1834165 0.0107117652 7.746467e-02 1.553905e-01 4 186590505 186590695 191 - 0.478 0.136 -2.444
ENSG00000083857 E011 0.2934659 0.0321865580 7.988105e-01   4 186592693 186592752 60 - 0.110 0.136 0.362
ENSG00000083857 E012 89.6496956 0.0003173670 1.051211e-12 2.569994e-11 4 186595689 186595826 138 - 1.828 2.054 0.761
ENSG00000083857 E013 160.9501881 0.0002805570 5.479506e-24 5.429268e-22 4 186596540 186597033 494 - 2.066 2.311 0.821
ENSG00000083857 E014 57.5372508 0.0070494721 6.492298e-03 1.990248e-02 4 186597034 186597110 77 - 1.694 1.822 0.430
ENSG00000083857 E015 53.4636125 0.0071182409 2.430495e-03 8.553779e-03 4 186597111 186597171 61 - 1.652 1.800 0.502
ENSG00000083857 E016 2.2842519 0.1958425658 7.866702e-01 8.633799e-01 4 186597172 186597271 100 - 0.479 0.555 0.361
ENSG00000083857 E017 51.2389554 0.0005020737 7.079256e-03 2.143293e-02 4 186597682 186597729 48 - 1.663 1.754 0.309
ENSG00000083857 E018 53.1625163 0.0004810279 2.057412e-02 5.270019e-02 4 186597730 186597792 63 - 1.689 1.760 0.239
ENSG00000083857 E019 74.3345642 0.0007413504 2.006022e-02 5.161412e-02 4 186597972 186598125 154 - 1.844 1.900 0.187
ENSG00000083857 E020 0.1482932 0.0436022507 3.498844e-01   4 186598126 186598127 2 - 0.000 0.136 11.435
ENSG00000083857 E021 0.1515154 0.0429904388 6.686534e-01   4 186598527 186598821 295 - 0.110 0.000 -10.985
ENSG00000083857 E022 132.6628702 0.0006598911 4.808530e-03 1.539775e-02 4 186599898 186600330 433 - 2.097 2.145 0.162
ENSG00000083857 E023 32.7151181 0.0006733146 3.771756e-01 5.215145e-01 4 186600331 186600360 30 - 1.513 1.525 0.043
ENSG00000083857 E024 70.4212492 0.0021365428 1.016871e-01 1.930645e-01 4 186601269 186601426 158 - 1.831 1.869 0.126
ENSG00000083857 E025 0.5827671 0.1876687427 1.147207e-01 2.124237e-01 4 186601427 186601700 274 - 0.331 0.000 -12.980
ENSG00000083857 E026 63.7190322 0.0113225162 2.870726e-01 4.275386e-01 4 186602903 186603034 132 - 1.793 1.831 0.128
ENSG00000083857 E027 186.2830940 0.0017638728 4.764296e-01 6.150471e-01 4 186603176 186603977 802 - 2.299 2.235 -0.212
ENSG00000083857 E028 50.7247350 0.0017127347 4.507555e-01 5.917941e-01 4 186604377 186604574 198 - 1.744 1.664 -0.272
ENSG00000083857 E029 53.9158842 0.0005122364 3.604113e-03 1.202198e-02 4 186606070 186606213 144 - 1.813 1.627 -0.628
ENSG00000083857 E030 41.8987363 0.0018210135 8.408426e-04 3.404760e-03 4 186609183 186609249 67 - 1.724 1.486 -0.810
ENSG00000083857 E031 42.4039062 0.0047306557 9.185090e-03 2.674795e-02 4 186609250 186609320 71 - 1.719 1.513 -0.703
ENSG00000083857 E032 64.4267519 0.0004441912 6.777207e-05 3.693994e-04 4 186609801 186610015 215 - 1.904 1.681 -0.755
ENSG00000083857 E033 0.1515154 0.0429904388 6.686534e-01   4 186610016 186610070 55 - 0.110 0.000 -10.985
ENSG00000083857 E034 70.0983242 0.0003968707 6.502350e-01 7.613180e-01 4 186611386 186611775 390 - 1.878 1.817 -0.206
ENSG00000083857 E035 54.7663147 0.0013410703 7.140604e-01 8.103736e-01 4 186613109 186613342 234 - 1.766 1.707 -0.199
ENSG00000083857 E036 46.7036835 0.0049273282 4.771210e-02 1.051073e-01 4 186614191 186614344 154 - 1.744 1.585 -0.541
ENSG00000083857 E037 57.7210507 0.0006786776 4.713741e-04 2.050573e-03 4 186617005 186617201 197 - 1.853 1.642 -0.713
ENSG00000083857 E038 70.4931536 0.0008637852 4.151768e-06 3.007916e-05 4 186617708 186617986 279 - 1.952 1.704 -0.839
ENSG00000083857 E039 389.9794463 0.0157003541 5.527109e-10 8.596833e-09 4 186617987 186621775 3789 - 2.738 2.349 -1.295
ENSG00000083857 E040 33.1468684 0.0005758632 1.161495e-17 5.652242e-16 4 186628154 186628364 211 - 1.735 1.095 -2.221
ENSG00000083857 E041 34.4364162 0.0006635185 3.877693e-14 1.168842e-12 4 186628488 186628763 276 - 1.733 1.188 -1.881
ENSG00000083857 E042 23.3267583 0.0009327398 8.071622e-11 1.446957e-09 4 186633684 186633823 140 - 1.573 1.010 -1.980
ENSG00000083857 E043 30.0956058 0.0173617954 1.422453e-07 1.403466e-06 4 186636025 186636235 211 - 1.676 1.134 -1.881
ENSG00000083857 E044 34.4046368 0.0035332306 1.359901e-12 3.259891e-11 4 186636585 186636914 330 - 1.733 1.178 -1.916
ENSG00000083857 E045 17.2147239 0.0010205066 1.870292e-10 3.148962e-09 4 186639722 186639783 62 - 1.460 0.816 -2.328
ENSG00000083857 E046 37.1317461 0.0005676134 7.191353e-13 1.805050e-11 4 186663299 186663613 315 - 1.751 1.255 -1.704
ENSG00000083857 E047 22.7881332 0.0008349615 4.072779e-07 3.666314e-06 4 186706563 186706720 158 - 1.531 1.095 -1.527
ENSG00000083857 E048 114.3148239 0.0451073275 4.530037e-09 5.951883e-08 4 186706721 186708362 1642 - 2.266 1.612 -2.202
ENSG00000083857 E049 77.3792343 0.0987328810 6.401440e-07 5.542404e-06 4 186708363 186709615 1253 - 2.119 1.336 -2.657
ENSG00000083857 E050 22.7725178 0.0013701113 9.842029e-20 6.065527e-18 4 186709616 186709845 230 - 1.614 0.735 -3.180
ENSG00000083857 E051 6.9268345 0.0908105506 4.269928e-04 1.878251e-03 4 186723664 186723784 121 - 1.115 0.395 -3.020
ENSG00000083857 E052 2.2519510 0.0065239740 2.541116e-03 8.886158e-03 4 186723785 186723856 72 - 0.700 0.136 -3.443
ENSG00000083857 E053 4.3502205 0.0047757870 2.075283e-02 5.306682e-02 4 186726354 186726722 369 - 0.881 0.507 -1.576