ENSG00000083799

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000398568 ENSG00000083799 HEK293_OSMI2_2hA HEK293_TMG_2hB CYLD protein_coding protein_coding 5.57896 1.670778 9.215513 0.1076502 0.2193831 2.4565 0.5706468 0.1023598 1.5132322 0.05816249 0.15280100 3.7609381 0.07410417 0.06076667 0.16386667 0.103100000 4.745344e-02 2.067671e-07 FALSE TRUE
ENST00000427738 ENSG00000083799 HEK293_OSMI2_2hA HEK293_TMG_2hB CYLD protein_coding protein_coding 5.57896 1.670778 9.215513 0.1076502 0.2193831 2.4565 1.1365575 0.7246071 1.7210712 0.07794768 0.17476442 1.2366203 0.27695833 0.43223333 0.18770000 -0.244533333 8.441397e-04 2.067671e-07 FALSE TRUE
ENST00000562884 ENSG00000083799 HEK293_OSMI2_2hA HEK293_TMG_2hB CYLD protein_coding protein_coding 5.57896 1.670778 9.215513 0.1076502 0.2193831 2.4565 0.2181032 0.0734385 0.3762982 0.07343850 0.15315884 2.2109300 0.05405417 0.03900000 0.04156667 0.002566667 8.752121e-01 2.067671e-07 FALSE FALSE
ENST00000563629 ENSG00000083799 HEK293_OSMI2_2hA HEK293_TMG_2hB CYLD protein_coding retained_intron 5.57896 1.670778 9.215513 0.1076502 0.2193831 2.4565 0.1760816 0.1361108 0.1848557 0.06555534 0.05468617 0.4153426 0.04334167 0.08570000 0.02000000 -0.065700000 1.773158e-01 2.067671e-07 FALSE TRUE
ENST00000566206 ENSG00000083799 HEK293_OSMI2_2hA HEK293_TMG_2hB CYLD protein_coding protein_coding 5.57896 1.670778 9.215513 0.1076502 0.2193831 2.4565 1.8263661 0.5617555 2.3272474 0.04711015 0.08629877 2.0313403 0.32846250 0.34056667 0.25316667 -0.087400000 4.163274e-01 2.067671e-07 FALSE TRUE
ENST00000566679 ENSG00000083799 HEK293_OSMI2_2hA HEK293_TMG_2hB CYLD protein_coding protein_coding 5.57896 1.670778 9.215513 0.1076502 0.2193831 2.4565 0.1657676 0.0000000 0.4784205 0.00000000 0.22880074 5.6100517 0.02172500 0.00000000 0.05186667 0.051866667 6.580610e-02 2.067671e-07 FALSE TRUE
MSTRG.12631.10 ENSG00000083799 HEK293_OSMI2_2hA HEK293_TMG_2hB CYLD protein_coding   5.57896 1.670778 9.215513 0.1076502 0.2193831 2.4565 0.9914389 0.0000000 2.0441600 0.00000000 0.37004735 7.6824048 0.11022083 0.00000000 0.22013333 0.220133333 2.067671e-07 2.067671e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000083799 E001 0.1472490 0.0426552618 1.000000e+00   16 50741899 50741942 44 + 0.068 0.000 -7.478
ENSG00000083799 E002 0.0000000       16 50742050 50742069 20 +      
ENSG00000083799 E003 0.0000000       16 50742070 50742073 4 +      
ENSG00000083799 E004 0.0000000       16 50742074 50742080 7 +      
ENSG00000083799 E005 0.4783925 0.0221886363 6.201819e-01 7.374496e-01 16 50742081 50742085 5 + 0.127 0.211 0.883
ENSG00000083799 E006 0.4783925 0.0221886363 6.201819e-01 7.374496e-01 16 50742086 50742093 8 + 0.127 0.211 0.883
ENSG00000083799 E007 1.3747996 0.2101926162 5.399301e-01 6.711379e-01 16 50742094 50742109 16 + 0.373 0.211 -1.118
ENSG00000083799 E008 1.7016766 0.3853335435 8.852042e-01 9.306076e-01 16 50742110 50742114 5 + 0.403 0.354 -0.281
ENSG00000083799 E009 2.1456138 0.1451919530 5.890552e-01 7.121690e-01 16 50742115 50742117 3 + 0.482 0.353 -0.700
ENSG00000083799 E010 2.1456138 0.1451919530 5.890552e-01 7.121690e-01 16 50742118 50742119 2 + 0.482 0.353 -0.700
ENSG00000083799 E011 2.1456138 0.1451919530 5.890552e-01 7.121690e-01 16 50742120 50742124 5 + 0.482 0.353 -0.700
ENSG00000083799 E012 4.9626129 0.0033995318 1.604438e-01 2.757195e-01 16 50742125 50742216 92 + 0.772 0.544 -0.976
ENSG00000083799 E013 13.6909055 0.0014195041 2.190163e-02 5.547354e-02 16 50742762 50742822 61 + 1.158 0.896 -0.962
ENSG00000083799 E014 12.8470384 0.0016169627 4.659218e-02 1.031054e-01 16 50742823 50742841 19 + 1.126 0.896 -0.848
ENSG00000083799 E015 6.4735467 0.0178433157 1.136473e-01 2.108429e-01 16 50744730 50744866 137 + 0.871 0.615 -1.043
ENSG00000083799 E016 1.0267042 0.0167234764 1.358794e-01 2.423228e-01 16 50749549 50749575 27 + 0.340 0.000 -12.579
ENSG00000083799 E017 57.7330617 0.0006089003 1.443886e-06 1.159018e-05 16 50749576 50749962 387 + 1.760 1.473 -0.978
ENSG00000083799 E018 49.7820011 0.0005006455 3.516645e-05 2.055213e-04 16 50749963 50750202 240 + 1.694 1.435 -0.885
ENSG00000083799 E019 61.7540008 0.0004941829 6.145587e-05 3.386553e-04 16 50751604 50751906 303 + 1.783 1.563 -0.745
ENSG00000083799 E020 32.8147036 0.0005813777 4.895774e-02 1.073049e-01 16 50754319 50754424 106 + 1.498 1.359 -0.480
ENSG00000083799 E021 0.0000000       16 50775166 50775174 9 +      
ENSG00000083799 E022 21.4270426 0.0008963304 3.739963e-01 5.184125e-01 16 50776179 50776200 22 + 1.308 1.237 -0.250
ENSG00000083799 E023 27.3700231 0.0014017170 2.054516e-01 3.329756e-01 16 50776201 50776277 77 + 1.416 1.322 -0.328
ENSG00000083799 E024 41.0955547 0.0005771117 1.029527e-01 1.949667e-01 16 50777825 50777941 117 + 1.583 1.482 -0.344
ENSG00000083799 E025 0.7458221 0.0190623397 1.000000e+00 1.000000e+00 16 50777942 50778294 353 + 0.225 0.211 -0.120
ENSG00000083799 E026 76.5883823 0.0003408057 2.432210e-01 3.779600e-01 16 50779665 50780044 380 + 1.838 1.790 -0.162
ENSG00000083799 E027 41.7038346 0.0005961331 1.007221e-02 2.893943e-02 16 50781246 50781411 166 + 1.602 1.435 -0.571
ENSG00000083799 E028 38.2707513 0.0079311145 2.180531e-01 3.480769e-01 16 50782325 50782466 142 + 1.551 1.456 -0.327
ENSG00000083799 E029 38.7806493 0.0375881280 6.889459e-01 7.909363e-01 16 50784329 50784451 123 + 1.543 1.502 -0.139
ENSG00000083799 E030 3.3427599 0.0497581589 7.303573e-01 8.223522e-01 16 50784452 50786781 2330 + 0.608 0.543 -0.296
ENSG00000083799 E031 31.6048218 0.0297390326 9.563786e-01 9.766807e-01 16 50786855 50786946 92 + 1.444 1.454 0.035
ENSG00000083799 E032 3.2378625 0.0333148128 2.010367e-02 5.170358e-02 16 50786947 50787639 693 + 0.430 0.824 1.743
ENSG00000083799 E033 0.4438354 0.0515400269 1.036624e-01 1.960735e-01 16 50787640 50787785 146 + 0.068 0.351 2.874
ENSG00000083799 E034 19.2996733 0.0009556490 3.704091e-01 5.148377e-01 16 50787786 50787852 67 + 1.224 1.309 0.297
ENSG00000083799 E035 26.8407042 0.0007769283 2.897957e-01 4.305313e-01 16 50791558 50791690 133 + 1.359 1.445 0.298
ENSG00000083799 E036 21.9008229 0.0009305739 3.638215e-01 5.082506e-01 16 50792597 50792705 109 + 1.278 1.359 0.284
ENSG00000083799 E037 30.0859403 0.0009069159 6.565922e-03 2.009847e-02 16 50793546 50793616 71 + 1.378 1.571 0.663
ENSG00000083799 E038 29.3726976 0.0007146181 9.416036e-05 4.945357e-04 16 50793617 50793664 48 + 1.343 1.612 0.927
ENSG00000083799 E039 39.4611135 0.0007264102 2.765779e-04 1.284386e-03 16 50794212 50794293 82 + 1.484 1.707 0.760
ENSG00000083799 E040 47.6850961 0.0063929613 3.349381e-03 1.128957e-02 16 50794294 50794428 135 + 1.570 1.769 0.677
ENSG00000083799 E041 1.3390966 0.0136333208 4.308611e-01 5.734775e-01 16 50794429 50794470 42 + 0.305 0.458 0.879
ENSG00000083799 E042 2.0860645 0.0575515696 9.566658e-01 9.768291e-01 16 50794471 50794888 418 + 0.457 0.456 -0.008
ENSG00000083799 E043 1.0674006 0.0120352795 2.153037e-01 3.447768e-01 16 50795548 50795724 177 + 0.225 0.458 1.466
ENSG00000083799 E044 205.1670621 0.0002429478 2.202323e-01 3.506935e-01 16 50796324 50800678 4355 + 2.243 2.282 0.131
ENSG00000083799 E045 9.4440332 0.0919199836 6.589950e-01 7.679485e-01 16 50800679 50800819 141 + 0.936 1.019 0.306
ENSG00000083799 E046 9.4386220 0.0024453827 7.484276e-01 8.356753e-01 16 50800820 50800872 53 + 0.944 0.989 0.167
ENSG00000083799 E047 47.5947885 0.0085965270 2.564911e-07 2.406353e-06 16 50800873 50801754 882 + 1.510 1.863 1.198
ENSG00000083799 E048 8.2666862 0.0213363360 4.649411e-05 2.639469e-04 16 50801755 50801935 181 + 0.719 1.248 1.981