ENSG00000083750

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262850 ENSG00000083750 HEK293_OSMI2_2hA HEK293_TMG_2hB RRAGB protein_coding protein_coding 7.117769 6.291941 8.86185 0.808295 0.5436587 0.4934387 0.2774823 0.1286408 0.7028876 0.03088195 0.06162732 2.3623227 0.03796667 0.01980000 0.08056667 0.060766667 0.002773344 0.002773344 FALSE  
ENST00000374941 ENSG00000083750 HEK293_OSMI2_2hA HEK293_TMG_2hB RRAGB protein_coding protein_coding 7.117769 6.291941 8.86185 0.808295 0.5436587 0.4934387 4.0525532 3.5171032 5.2558468 0.33365827 0.05809092 0.5781818 0.56541250 0.56443333 0.59746667 0.033033333 0.807436276 0.002773344 FALSE  
ENST00000475061 ENSG00000083750 HEK293_OSMI2_2hA HEK293_TMG_2hB RRAGB protein_coding processed_transcript 7.117769 6.291941 8.86185 0.808295 0.5436587 0.4934387 0.5251583 0.7189036 0.2809951 0.38233153 0.19277818 -1.3247333 0.07911250 0.10576667 0.02943333 -0.076333333 0.349728250 0.002773344    
ENST00000498762 ENSG00000083750 HEK293_OSMI2_2hA HEK293_TMG_2hB RRAGB protein_coding processed_transcript 7.117769 6.291941 8.86185 0.808295 0.5436587 0.4934387 0.7145535 0.9630683 0.8400949 0.20654321 0.33521158 -0.1949172 0.10608750 0.15026667 0.09136667 -0.058900000 0.447545829 0.002773344 FALSE  
MSTRG.34323.1 ENSG00000083750 HEK293_OSMI2_2hA HEK293_TMG_2hB RRAGB protein_coding   7.117769 6.291941 8.86185 0.808295 0.5436587 0.4934387 0.5370330 0.4064301 0.5931117 0.10731239 0.04044246 0.5343509 0.07227917 0.06373333 0.06790000 0.004166667 0.994509644 0.002773344 TRUE  
MSTRG.34323.7 ENSG00000083750 HEK293_OSMI2_2hA HEK293_TMG_2hB RRAGB protein_coding   7.117769 6.291941 8.86185 0.808295 0.5436587 0.4934387 0.6710494 0.2249530 0.7171655 0.11951822 0.10424022 1.6299113 0.09285417 0.03310000 0.08106667 0.047966667 0.325303831 0.002773344 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000083750 E001 1.3232906 0.0266215724 0.23136303 0.36410863 X 55717724 55717748 25 + 0.463 0.249 -1.296
ENSG00000083750 E002 10.5101984 0.0036015126 0.04168916 0.09416933 X 55717749 55717788 40 + 0.949 1.165 0.786
ENSG00000083750 E003 24.0925802 0.0016983735 0.07672026 0.15424412 X 55717789 55717884 96 + 1.331 1.463 0.457
ENSG00000083750 E004 49.5112553 0.0042304732 0.43002292 0.57265958 X 55717885 55718088 204 + 1.679 1.728 0.166
ENSG00000083750 E005 17.6223269 0.0011537205 0.17126228 0.28982577 X 55718089 55718107 19 + 1.314 1.209 -0.369
ENSG00000083750 E006 43.4056858 0.0005448583 0.15431362 0.26751694 X 55718108 55718243 136 + 1.677 1.609 -0.230
ENSG00000083750 E007 50.0473663 0.0005081035 0.06992582 0.14325009 X 55718244 55718419 176 + 1.742 1.660 -0.276
ENSG00000083750 E008 22.6070663 0.0010603249 0.48157670 0.61978608 X 55719314 55719347 34 + 1.388 1.343 -0.155
ENSG00000083750 E009 16.6485164 0.0028402822 0.23253144 0.36546167 X 55722186 55722190 5 + 1.284 1.188 -0.341
ENSG00000083750 E010 36.9558225 0.0006675736 0.63588278 0.75005543 X 55722191 55722285 95 + 1.586 1.566 -0.069
ENSG00000083750 E011 4.2469641 0.0037621668 0.09398396 0.18135591 X 55727307 55727390 84 + 0.809 0.571 -0.999
ENSG00000083750 E012 38.7054308 0.0005424844 0.63541316 0.74972072 X 55729294 55729360 67 + 1.607 1.588 -0.065
ENSG00000083750 E013 33.6448715 0.0007315207 0.22350688 0.35457559 X 55731364 55731400 37 + 1.567 1.502 -0.225
ENSG00000083750 E014 66.1843483 0.0005298391 0.76964798 0.85124674 X 55731401 55731586 186 + 1.832 1.827 -0.018
ENSG00000083750 E015 4.5875657 0.0120916966 0.16350401 0.27971485 X 55731587 55731708 122 + 0.630 0.836 0.840
ENSG00000083750 E016 40.0745912 0.0005763439 0.66838502 0.77540914 X 55751101 55751196 96 + 1.621 1.605 -0.055
ENSG00000083750 E017 2.2292732 0.2144975511 0.60942662 0.72893637 X 55751197 55751623 427 + 0.572 0.409 -0.804
ENSG00000083750 E018 3.7844767 0.0383216402 0.55478174 0.68372303 X 55752241 55752245 5 + 0.706 0.616 -0.383
ENSG00000083750 E019 9.7857505 0.0692091461 0.67257869 0.77850304 X 55752246 55752353 108 + 1.044 1.003 -0.148
ENSG00000083750 E020 4.9498972 0.0083842126 0.07747224 0.15540302 X 55752354 55752401 48 + 0.861 0.615 -1.006
ENSG00000083750 E021 39.3643344 0.0006363068 0.28670581 0.42712661 X 55753392 55753514 123 + 1.627 1.575 -0.178
ENSG00000083750 E022 10.5391881 0.0020778363 0.31593566 0.45871378 X 55755068 55755206 139 + 1.095 0.998 -0.352
ENSG00000083750 E023 2.0734663 0.0070621357 0.04398381 0.09835111 X 55755207 55755208 2 + 0.601 0.250 -1.942
ENSG00000083750 E024 4.0608109 0.0041649100 0.01448866 0.03933525 X 55755810 55755840 31 + 0.502 0.859 1.516
ENSG00000083750 E025 35.8976561 0.0006627410 0.64966798 0.76086571 X 55755841 55755932 92 + 1.551 1.584 0.112
ENSG00000083750 E026 43.5215143 0.0058981483 0.28700185 0.42746344 X 55757216 55757331 116 + 1.616 1.693 0.261
ENSG00000083750 E027 69.7353203 0.0106216669 0.12819182 0.23163990 X 55758246 55758553 308 + 1.800 1.908 0.365
ENSG00000083750 E028 31.0082560 0.0038783051 0.01036497 0.02966183 X 55758554 55758774 221 + 1.416 1.596 0.618
ENSG00000083750 E029 0.6224193 0.0170936812 0.73651838 0.82698440 X 55762056 55762090 35 + 0.189 0.250 0.515