ENSG00000083720

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000196371 ENSG00000083720 HEK293_OSMI2_2hA HEK293_TMG_2hB OXCT1 protein_coding protein_coding 14.54274 9.336698 22.14025 0.7901121 0.7870271 1.244794 12.823247 9.086843 19.275059 0.8986177 0.4007828 1.084046 0.9006292 0.9717667 0.8729333 -0.09883333 1.451388e-01 3.381994e-10 FALSE TRUE
ENST00000508557 ENSG00000083720 HEK293_OSMI2_2hA HEK293_TMG_2hB OXCT1 protein_coding retained_intron 14.54274 9.336698 22.14025 0.7901121 0.7870271 1.244794 1.167658 0.000000 2.690707 0.0000000 0.7605549 8.077193 0.0542250 0.0000000 0.1196667 0.11966667 3.381994e-10 3.381994e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000083720 E001 237.3287887 0.0020098322 5.871243e-11 1.076131e-09 5 41730065 41730740 676 - 2.283 2.481 0.662
ENSG00000083720 E002 106.5812150 0.0037445562 2.600794e-02 6.396040e-02 5 41730741 41730840 100 - 1.984 2.085 0.338
ENSG00000083720 E003 217.3861836 0.0013177844 1.211377e-01 2.215620e-01 5 41730841 41731369 529 - 2.315 2.362 0.157
ENSG00000083720 E004 100.1647920 0.0034499494 3.471428e-02 8.110144e-02 5 41731370 41731580 211 - 1.957 2.048 0.304
ENSG00000083720 E005 115.8195921 0.0003208231 4.549040e-02 1.010947e-01 5 41731581 41731738 158 - 2.031 2.098 0.225
ENSG00000083720 E006 74.1163267 0.0003234844 1.170107e-01 2.156901e-01 5 41731739 41731770 32 - 1.843 1.908 0.222
ENSG00000083720 E007 136.0510461 0.0002818513 8.774245e-01 9.252584e-01 5 41739390 41739491 102 - 2.131 2.127 -0.013
ENSG00000083720 E008 0.4386386 0.1198021397 1.000000e+00 1.000000e+00 5 41739492 41739721 230 - 0.169 0.159 -0.108
ENSG00000083720 E009 118.1868241 0.0019099660 3.313768e-01 4.749818e-01 5 41749527 41749600 74 - 2.084 2.046 -0.126
ENSG00000083720 E010 65.7453450 0.0028476184 4.473664e-01 5.887739e-01 5 41749601 41749607 7 - 1.835 1.801 -0.114
ENSG00000083720 E011 130.7708559 0.0041977553 5.887163e-01 7.119001e-01 5 41762111 41762200 90 - 2.121 2.104 -0.059
ENSG00000083720 E012 115.6078671 0.0003167905 2.759318e-01 4.153366e-01 5 41794003 41794078 76 - 2.076 2.041 -0.119
ENSG00000083720 E013 0.2955422 0.0283169145 6.507190e-01   5 41794079 41794135 57 - 0.093 0.160 0.898
ENSG00000083720 E014 0.2955422 0.0283169145 6.507190e-01   5 41794167 41794380 214 - 0.093 0.160 0.898
ENSG00000083720 E015 0.0000000       5 41794422 41794540 119 -      
ENSG00000083720 E016 0.0000000       5 41794541 41794676 136 -      
ENSG00000083720 E017 107.4698690 0.0002888189 5.129876e-01 6.478495e-01 5 41794677 41794749 73 - 2.039 2.017 -0.072
ENSG00000083720 E018 95.9477670 0.0003455268 8.178763e-01 8.848313e-01 5 41801022 41801070 49 - 1.986 1.978 -0.024
ENSG00000083720 E019 106.5763403 0.0003159320 3.214274e-01 4.646688e-01 5 41803069 41803163 95 - 2.011 2.046 0.119
ENSG00000083720 E020 113.9503376 0.0002868257 2.835279e-01 4.236683e-01 5 41805567 41805681 115 - 2.038 2.075 0.123
ENSG00000083720 E021 94.1698590 0.0003208954 5.856695e-01 7.093248e-01 5 41807331 41807438 108 - 1.964 1.985 0.070
ENSG00000083720 E022 82.2788583 0.0007606243 5.511816e-01 6.806932e-01 5 41840451 41840511 61 - 1.921 1.896 -0.083
ENSG00000083720 E023 121.2842521 0.0057784311 8.069239e-02 1.606310e-01 5 41842675 41842781 107 - 2.111 2.018 -0.312
ENSG00000083720 E024 0.0000000       5 41843575 41843657 83 -      
ENSG00000083720 E025 130.3662516 0.0020813492 1.969519e-05 1.223623e-04 5 41850030 41850179 150 - 2.167 1.997 -0.571
ENSG00000083720 E026 113.6134366 0.0070663118 1.819089e-03 6.660628e-03 5 41853419 41853554 136 - 2.109 1.934 -0.587
ENSG00000083720 E027 92.9313499 0.0004898218 7.760768e-07 6.601061e-06 5 41861314 41861404 91 - 2.030 1.833 -0.662
ENSG00000083720 E028 89.9829659 0.0037171367 1.923911e-03 6.989992e-03 5 41862642 41862750 109 - 2.004 1.850 -0.521
ENSG00000083720 E029 86.3497221 0.0206533170 7.722615e-01 8.529870e-01 5 41870281 41870425 145 - 1.943 1.908 -0.117