ENSG00000083312

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000337273 ENSG00000083312 HEK293_OSMI2_2hA HEK293_TMG_2hB TNPO1 protein_coding protein_coding 57.56822 6.502978 96.27809 0.2172261 5.203303 3.885968 6.856050 2.7773988 12.664055 0.9082383 0.6014099 2.1848868 0.20894583 0.41903333 0.13210000 -0.28693333 3.552969e-02 2.528379e-24 FALSE TRUE
ENST00000505082 ENSG00000083312 HEK293_OSMI2_2hA HEK293_TMG_2hB TNPO1 protein_coding processed_transcript 57.56822 6.502978 96.27809 0.2172261 5.203303 3.885968 2.062526 0.0000000 5.680364 0.0000000 3.0648446 9.1523772 0.01847500 0.00000000 0.05583333 0.05583333 4.551067e-01 2.528379e-24 FALSE FALSE
ENST00000506351 ENSG00000083312 HEK293_OSMI2_2hA HEK293_TMG_2hB TNPO1 protein_coding protein_coding 57.56822 6.502978 96.27809 0.2172261 5.203303 3.885968 5.367493 0.5437483 6.774794 0.2875320 1.8813086 3.6150027 0.12316250 0.08606667 0.06926667 -0.01680000 9.544687e-01 2.528379e-24 FALSE TRUE
ENST00000509030 ENSG00000083312 HEK293_OSMI2_2hA HEK293_TMG_2hB TNPO1 protein_coding processed_transcript 57.56822 6.502978 96.27809 0.2172261 5.203303 3.885968 10.406340 0.0000000 15.634432 0.0000000 1.4472515 10.6114336 0.09917500 0.00000000 0.16170000 0.16170000 2.528379e-24 2.528379e-24 FALSE FALSE
ENST00000523768 ENSG00000083312 HEK293_OSMI2_2hA HEK293_TMG_2hB TNPO1 protein_coding protein_coding 57.56822 6.502978 96.27809 0.2172261 5.203303 3.885968 15.706186 0.4061005 24.393865 0.4061005 1.9044391 5.8740339 0.20936667 0.06570000 0.25650000 0.19080000 1.261079e-01 2.528379e-24 FALSE TRUE
ENST00000605210 ENSG00000083312 HEK293_OSMI2_2hA HEK293_TMG_2hB TNPO1 protein_coding protein_coding 57.56822 6.502978 96.27809 0.2172261 5.203303 3.885968 2.143362 1.4410615 2.830225 0.3899636 0.9000430 0.9688963 0.10161250 0.22216667 0.02876667 -0.19340000 5.710377e-05 2.528379e-24 FALSE TRUE
ENST00000679378 ENSG00000083312 HEK293_OSMI2_2hA HEK293_TMG_2hB TNPO1 protein_coding protein_coding 57.56822 6.502978 96.27809 0.2172261 5.203303 3.885968 4.177149 0.5005359 8.315976 0.1284665 0.7244412 4.0275351 0.07609583 0.07596667 0.08693333 0.01096667 8.677934e-01 2.528379e-24 FALSE TRUE
MSTRG.26375.13 ENSG00000083312 HEK293_OSMI2_2hA HEK293_TMG_2hB TNPO1 protein_coding   57.56822 6.502978 96.27809 0.2172261 5.203303 3.885968 9.883983 0.8206703 18.067757 0.2655809 1.0609759 4.4437958 0.15187917 0.12900000 0.18840000 0.05940000 5.076521e-01 2.528379e-24 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000083312 E001 0.1472490 0.0443273805 6.084196e-01   5 72816312 72816375 64 + 0.040 0.000 -8.936
ENSG00000083312 E002 0.2924217 0.0273332543 1.000000e+00   5 72816376 72816623 248 + 0.077 0.000 -9.876
ENSG00000083312 E003 0.4439371 0.0215601734 1.000000e+00 1.000000e+00 5 72816624 72816632 9 + 0.111 0.000 -10.462
ENSG00000083312 E004 1.1888288 0.0124215182 4.949305e-01 6.318226e-01 5 72816633 72816648 16 + 0.249 0.000 -11.877
ENSG00000083312 E005 1.4875932 0.0096711330 3.534343e-01 4.976815e-01 5 72816649 72816660 12 + 0.294 0.000 -12.199
ENSG00000083312 E006 4.3005414 0.0038324257 3.026256e-02 7.248221e-02 5 72816661 72816668 8 + 0.580 0.000 -13.735
ENSG00000083312 E007 5.1778066 0.0031195920 1.507979e-02 4.066883e-02 5 72816669 72816671 3 + 0.642 0.000 -14.006
ENSG00000083312 E008 29.0505759 0.0192138753 1.494366e-03 5.617460e-03 5 72816672 72816694 23 + 1.287 0.877 -1.493
ENSG00000083312 E009 44.5045235 0.0104536821 3.665016e-04 1.644660e-03 5 72816695 72816752 58 + 1.462 1.114 -1.222
ENSG00000083312 E010 0.0000000       5 72816793 72816954 162 +      
ENSG00000083312 E011 0.4439371 0.0215601734 1.000000e+00 1.000000e+00 5 72825735 72825821 87 + 0.111 0.000 -10.462
ENSG00000083312 E012 52.9061735 0.0010427124 3.610284e-03 1.203960e-02 5 72848121 72848169 49 + 1.524 1.339 -0.639
ENSG00000083312 E013 66.2178418 0.0012955342 3.761749e-04 1.681973e-03 5 72848170 72848183 14 + 1.620 1.400 -0.757
ENSG00000083312 E014 108.5420265 0.0002877814 9.387913e-05 4.931817e-04 5 72848184 72848251 68 + 1.827 1.662 -0.560
ENSG00000083312 E015 224.3006065 0.0004536031 2.363996e-08 2.716724e-07 5 72848385 72848498 114 + 2.139 1.968 -0.574
ENSG00000083312 E016 0.2966881 0.0271030829 1.000000e+00   5 72851205 72851237 33 + 0.077 0.000 -9.877
ENSG00000083312 E017 10.6550524 0.0027000438 7.273140e-01 8.200671e-01 5 72851238 72851243 6 + 0.863 0.879 0.063
ENSG00000083312 E018 177.1148744 0.0002114256 7.700376e-05 4.138712e-04 5 72851244 72851319 76 + 2.033 1.925 -0.361
ENSG00000083312 E019 278.9202637 0.0020792662 3.358224e-07 3.075388e-06 5 72855774 72855923 150 + 2.232 2.077 -0.520
ENSG00000083312 E020 226.9961664 0.0002722473 1.101934e-07 1.110888e-06 5 72861808 72861914 107 + 2.144 1.993 -0.505
ENSG00000083312 E021 0.2966881 0.0271030829 1.000000e+00   5 72861915 72861915 1 + 0.077 0.000 -9.877
ENSG00000083312 E022 0.2924217 0.0273332543 1.000000e+00   5 72862354 72862396 43 + 0.077 0.000 -9.876
ENSG00000083312 E023 234.4727259 0.0002325917 8.795562e-07 7.391620e-06 5 72865596 72865729 134 + 2.156 2.030 -0.422
ENSG00000083312 E024 0.2903454 0.3496580472 1.000000e+00   5 72865730 72865731 2 + 0.077 0.000 -9.872
ENSG00000083312 E025 0.2998086 0.0283047900 1.076924e-01   5 72871747 72871889 143 + 0.040 0.321 3.498
ENSG00000083312 E026 144.7168754 0.0002803894 8.895035e-03 2.601846e-02 5 72872639 72872667 29 + 1.942 1.890 -0.176
ENSG00000083312 E027 178.6412018 0.0005723147 2.676533e-03 9.302510e-03 5 72872668 72872720 53 + 2.034 1.973 -0.203
ENSG00000083312 E028 260.7557613 0.0005582151 3.955972e-07 3.569815e-06 5 72875615 72875737 123 + 2.201 2.072 -0.432
ENSG00000083312 E029 297.7175462 0.0001697586 1.140351e-09 1.672753e-08 5 72877228 72877346 119 + 2.260 2.111 -0.500
ENSG00000083312 E030 249.3962823 0.0021923368 1.000235e-09 1.483300e-08 5 72882467 72882527 61 + 2.189 1.963 -0.756
ENSG00000083312 E031 375.0783381 0.0001946115 1.588838e-12 3.765332e-11 5 72883064 72883232 169 + 2.361 2.200 -0.535
ENSG00000083312 E032 321.2300107 0.0001776562 5.629490e-05 3.131302e-04 5 72887070 72887222 153 + 2.286 2.229 -0.191
ENSG00000083312 E033 365.2818499 0.0001765005 6.309631e-03 1.942759e-02 5 72888078 72888303 226 + 2.337 2.334 -0.012
ENSG00000083312 E034 314.6416326 0.0057938485 1.063490e-01 2.001520e-01 5 72889786 72889957 172 + 2.272 2.264 -0.027
ENSG00000083312 E035 224.6911750 0.0015426414 4.661570e-01 6.057192e-01 5 72891810 72891896 87 + 2.122 2.172 0.168
ENSG00000083312 E036 274.5184797 0.0001501812 6.794118e-01 7.836045e-01 5 72893139 72893246 108 + 2.206 2.275 0.228
ENSG00000083312 E037 330.0130283 0.0002948403 8.684462e-01 9.194316e-01 5 72893377 72893535 159 + 2.284 2.361 0.257
ENSG00000083312 E038 229.1157390 0.0126976212 7.731941e-01 8.536389e-01 5 72893616 72893675 60 + 2.124 2.213 0.298
ENSG00000083312 E039 184.9525861 0.0002177617 6.060834e-01 7.263271e-01 5 72893676 72893703 28 + 2.036 2.096 0.202
ENSG00000083312 E040 1.5198585 0.0088102577 1.000000e+00 1.000000e+00 5 72895459 72896457 999 + 0.272 0.321 0.331
ENSG00000083312 E041 297.2942386 0.0021846899 4.021934e-01 5.459063e-01 5 72896458 72896556 99 + 2.235 2.345 0.367
ENSG00000083312 E042 305.1898836 0.0073668014 5.848756e-01 7.086852e-01 5 72897056 72897151 96 + 2.247 2.346 0.330
ENSG00000083312 E043 266.7839416 0.0071607720 3.640881e-01 5.084957e-01 5 72900006 72900081 76 + 2.187 2.306 0.399
ENSG00000083312 E044 0.0000000       5 72900151 72900224 74 +      
ENSG00000083312 E045 0.2944980 0.3900066278 1.000000e+00   5 72900874 72900973 100 + 0.077 0.000 -9.876
ENSG00000083312 E046 316.7975108 0.0001512436 7.462247e-02 1.509299e-01 5 72900974 72901073 100 + 2.259 2.397 0.460
ENSG00000083312 E047 246.9222513 0.0001825788 1.495826e-01 2.611024e-01 5 72903709 72903783 75 + 2.154 2.287 0.446
ENSG00000083312 E048 312.8592004 0.0001625758 5.060887e-02 1.102389e-01 5 72905303 72905445 143 + 2.255 2.399 0.480
ENSG00000083312 E049 3.3469986 0.0769329149 8.682944e-02 1.703172e-01 5 72905446 72905580 135 + 0.407 0.814 1.829
ENSG00000083312 E050 1795.2742687 0.0019516528 1.913352e-03 6.957100e-03 5 72908709 72911816 3108 + 3.010 3.159 0.494
ENSG00000083312 E051 1313.5362738 0.0392737041 1.016297e-02 2.916612e-02 5 72911817 72916154 4338 + 2.845 3.177 1.102
ENSG00000083312 E052 2.4336423 0.0061450099 7.142565e-01 8.105207e-01 5 72916155 72916733 579 + 0.372 0.504 0.693