ENSG00000083097

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000349129 ENSG00000083097 HEK293_OSMI2_2hA HEK293_TMG_2hB DOP1A protein_coding protein_coding 3.412564 1.235295 4.111306 0.1007759 0.1123273 1.726614 1.1240986 0.06034407 1.7063785 0.06034407 0.07138643 4.6087951 0.24845417 0.04856667 0.41560000 0.36703333 5.549649e-03 5.954758e-12 FALSE TRUE
ENST00000484282 ENSG00000083097 HEK293_OSMI2_2hA HEK293_TMG_2hB DOP1A protein_coding processed_transcript 3.412564 1.235295 4.111306 0.1007759 0.1123273 1.726614 0.8542815 0.81594876 0.4936542 0.04508079 0.10455274 -0.7136187 0.36051667 0.66343333 0.11916667 -0.54426667 5.954758e-12 5.954758e-12 TRUE TRUE
ENST00000604380 ENSG00000083097 HEK293_OSMI2_2hA HEK293_TMG_2hB DOP1A protein_coding protein_coding 3.412564 1.235295 4.111306 0.1007759 0.1123273 1.726614 0.3051392 0.00000000 0.1712797 0.00000000 0.17127970 4.1801454 0.05500417 0.00000000 0.04020000 0.04020000 1.000000e+00 5.954758e-12 FALSE TRUE
MSTRG.28595.1 ENSG00000083097 HEK293_OSMI2_2hA HEK293_TMG_2hB DOP1A protein_coding   3.412564 1.235295 4.111306 0.1007759 0.1123273 1.726614 0.3011563 0.04602193 0.3238621 0.03292020 0.08577305 2.5751886 0.08193333 0.04130000 0.07833333 0.03703333 6.998178e-01 5.954758e-12 TRUE TRUE
MSTRG.28595.2 ENSG00000083097 HEK293_OSMI2_2hA HEK293_TMG_2hB DOP1A protein_coding   3.412564 1.235295 4.111306 0.1007759 0.1123273 1.726614 0.5097300 0.19693425 1.1329791 0.13353336 0.09997926 2.4655546 0.14954167 0.15090000 0.27703333 0.12613333 5.102590e-01 5.954758e-12 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000083097 E001 0.0000000       6 83067649 83067651 3 +      
ENSG00000083097 E002 0.1472490 0.0440941505 1.000000e+00   6 83067652 83067665 14 + 0.069 0.001 -7.211
ENSG00000083097 E003 0.1472490 0.0440941505 1.000000e+00   6 83067666 83067670 5 + 0.069 0.000 -9.662
ENSG00000083097 E004 0.1472490 0.0440941505 1.000000e+00   6 83067671 83067678 8 + 0.069 0.000 -9.662
ENSG00000083097 E005 4.0759732 0.0039045463 7.143768e-03 2.159718e-02 6 83067679 83067779 101 + 0.736 0.210 -2.841
ENSG00000083097 E006 0.3289534 0.0297638173 3.549614e-01   6 83096729 83096730 2 + 0.069 0.210 1.860
ENSG00000083097 E007 5.2916549 0.0031790353 3.595327e-02 8.349256e-02 6 83096731 83096823 93 + 0.811 0.456 -1.556
ENSG00000083097 E008 11.0804670 0.0016197473 1.484459e-03 5.586650e-03 6 83096925 83097115 191 + 1.101 0.674 -1.644
ENSG00000083097 E009 10.6633803 0.0016762118 1.950754e-01 3.200829e-01 6 83100705 83100886 182 + 1.045 0.893 -0.564
ENSG00000083097 E010 12.9615402 0.0013918296 1.394375e-01 2.472623e-01 6 83108910 83109080 171 + 1.118 0.957 -0.590
ENSG00000083097 E011 17.0565430 0.0010709404 4.735290e-03 1.519224e-02 6 83110125 83110314 190 + 1.253 0.957 -1.070
ENSG00000083097 E012 9.7623852 0.0017222514 1.937037e-02 5.013606e-02 6 83113323 83113421 99 + 1.038 0.727 -1.192
ENSG00000083097 E013 12.9958622 0.0013748072 5.233280e-04 2.247018e-03 6 83118888 83118987 100 + 1.166 0.727 -1.656
ENSG00000083097 E014 8.7843805 0.0019534299 2.139376e-02 5.442125e-02 6 83119748 83119774 27 + 0.995 0.674 -1.256
ENSG00000083097 E015 12.1813529 0.0014794980 5.213411e-03 1.651200e-02 6 83119775 83119857 83 + 1.124 0.775 -1.310
ENSG00000083097 E016 11.6729103 0.0092540203 1.277894e-02 3.539530e-02 6 83120683 83120791 109 + 1.107 0.775 -1.248
ENSG00000083097 E017 9.7752585 0.0091629559 1.162243e-02 3.263282e-02 6 83121930 83122050 121 + 1.038 0.674 -1.412
ENSG00000083097 E018 7.7965143 0.0022026243 5.871369e-03 1.827419e-02 6 83122863 83122982 120 + 0.964 0.541 -1.726
ENSG00000083097 E019 10.1020626 0.0073688055 6.514435e-03 1.995892e-02 6 83124705 83124819 115 + 1.058 0.674 -1.487
ENSG00000083097 E020 0.0000000       6 83125166 83125195 30 +      
ENSG00000083097 E021 17.6374468 0.0081744226 8.129853e-04 3.305525e-03 6 83125500 83125733 234 + 1.281 0.893 -1.409
ENSG00000083097 E022 33.7881805 0.0006210704 2.184875e-03 7.794918e-03 6 83128887 83129508 622 + 1.529 1.306 -0.772
ENSG00000083097 E023 9.8100500 0.0020622680 2.102056e-01 3.387902e-01 6 83130123 83130213 91 + 1.010 0.857 -0.574
ENSG00000083097 E024 17.5541235 0.0013400745 1.535736e-02 4.130039e-02 6 83130214 83130397 184 + 1.257 1.013 -0.877
ENSG00000083097 E025 14.7834901 0.0012009459 8.423060e-04 3.409985e-03 6 83132176 83132328 153 + 1.210 0.818 -1.447
ENSG00000083097 E026 12.9057083 0.0119015185 2.563094e-02 6.318584e-02 6 83134187 83134287 101 + 1.141 0.857 -1.050
ENSG00000083097 E027 0.1451727 0.0432384479 1.000000e+00   6 83134288 83134480 193 + 0.068 0.000 -9.665
ENSG00000083097 E028 22.8582971 0.0008582315 1.177122e-01 2.166753e-01 6 83135619 83135878 260 + 1.346 1.217 -0.451
ENSG00000083097 E029 36.7137676 0.0021758606 2.302474e-04 1.092678e-03 6 83137173 83137675 503 + 1.569 1.292 -0.954
ENSG00000083097 E030 90.4752634 0.0004291353 1.046633e-04 5.435644e-04 6 83137676 83139162 1487 + 1.935 1.768 -0.562
ENSG00000083097 E031 18.3899702 0.0010418254 4.907007e-01 6.280437e-01 6 83140000 83140111 112 + 1.241 1.183 -0.202
ENSG00000083097 E032 25.5678820 0.0007731904 7.125114e-01 8.092272e-01 6 83140221 83140403 183 + 1.366 1.344 -0.075
ENSG00000083097 E033 23.9131281 0.0034049583 3.840663e-01 5.282584e-01 6 83141921 83142046 126 + 1.311 1.391 0.276
ENSG00000083097 E034 19.0388986 0.0033436999 4.977231e-01 6.342593e-01 6 83145524 83145658 135 + 1.223 1.292 0.243
ENSG00000083097 E035 8.2212288 0.0020130173 9.005998e-01 9.405814e-01 6 83147236 83147291 56 + 0.903 0.926 0.087
ENSG00000083097 E036 10.5849282 0.0016566424 5.315796e-01 6.640034e-01 6 83148759 83148863 105 + 1.024 0.957 -0.248
ENSG00000083097 E037 12.5551396 0.0014936190 4.548561e-01 5.954375e-01 6 83151593 83151659 67 + 1.089 1.013 -0.278
ENSG00000083097 E038 17.8642904 0.0303026978 5.763730e-01 7.018166e-01 6 83151883 83152027 145 + 1.191 1.269 0.275
ENSG00000083097 E039 17.5364153 0.0013753038 2.564280e-02 6.320685e-02 6 83152288 83152367 80 + 1.140 1.344 0.719
ENSG00000083097 E040 0.0000000       6 83153392 83153510 119 +      
ENSG00000083097 E041 19.9299616 0.0070211129 2.263295e-02 5.698831e-02 6 83153511 83153620 110 + 1.191 1.403 0.743
ENSG00000083097 E042 0.8470867 0.0136968632 3.667586e-01 5.110987e-01 6 83153621 83153893 273 + 0.180 0.350 1.276
ENSG00000083097 E043 27.5196870 0.0012001640 5.451704e-02 1.171477e-01 6 83153894 83154043 150 + 1.349 1.497 0.509
ENSG00000083097 E044 21.5084078 0.0008751007 4.471816e-01 5.886041e-01 6 83154180 83154241 62 + 1.273 1.344 0.246
ENSG00000083097 E045 0.1472490 0.0440941505 1.000000e+00   6 83154242 83154273 32 + 0.069 0.000 -9.662
ENSG00000083097 E046 28.9685001 0.0007319519 3.595630e-01 5.038889e-01 6 83155951 83156103 153 + 1.397 1.470 0.253
ENSG00000083097 E047 28.9404438 0.0007495519 1.171114e-02 3.284296e-02 6 83157182 83157318 137 + 1.363 1.545 0.629
ENSG00000083097 E048 23.1306992 0.0008832322 2.030055e-01 3.299847e-01 6 83158567 83158622 56 + 1.293 1.401 0.376
ENSG00000083097 E049 33.9279274 0.0006674639 8.211615e-04 3.335180e-03 6 83159796 83159960 165 + 1.414 1.635 0.757
ENSG00000083097 E050 32.9758798 0.0006463790 2.055398e-06 1.594549e-05 6 83162790 83162919 130 + 1.369 1.677 1.055
ENSG00000083097 E051 2.2445735 0.0070788822 2.440788e-01 3.789883e-01 6 83164660 83164719 60 + 0.404 0.613 1.012
ENSG00000083097 E052 0.5911862 0.0172671820 3.534885e-01 4.977356e-01 6 83164720 83167861 3142 + 0.226 0.000 -11.600
ENSG00000083097 E053 70.8001864 0.0003940185 5.667019e-16 2.211784e-14 6 83167862 83168756 895 + 1.678 2.029 1.184
ENSG00000083097 E054 3.5380670 0.0982292629 6.836301e-01 7.867757e-01 6 83168757 83169477 721 + 0.593 0.670 0.333
ENSG00000083097 E055 7.1715561 0.0915522739 3.848419e-02 8.825356e-02 6 83169478 83169534 57 + 0.737 1.116 1.438
ENSG00000083097 E056 35.4896958 0.0167467331 6.375470e-06 4.431856e-05 6 83170289 83171350 1062 + 1.373 1.759 1.321